FlyBase Gene Report: Dmel\modSP

General Information

Symbol

Dmel\modSP

Species

D. melanogaster

Name

modular serine protease

Annotation Symbol

CG31217

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051217

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

Gene Summary

modular serine protease (modSP) encodes a protein that functions downstream of microbial sensing receptors encoded by PGRP-SA and GNBP3 in the extracellular proteolytic cascade leading to Toll pathway activation during the immune response. It initiates the proteolytic cascade leading to the cleavage of the Toll ligand encoded by spz. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

W, X, Ser89E, SP53

Key Links

Genomic Location

Cytogenetic map

89D6-89D6

Sequence location

3R:16,652,446..16,655,662 [-]

Recombination map

3-59

RefSeq locus

NT_033777 REGION:16652446..16655662

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

inferred from sequence model

(Cao and Jiang, 2018, Ross et al., 2003)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in defense response to fungus

inferred from genetic interaction with FLYBASE:GNBP3; FB:FBgn0040321

(Buchon et al., 2009)

involved_in defense response to Gram-positive bacterium

inferred from mutant phenotype

(Yamamoto-Hino and Goto, 2016)

inferred from mutant phenotype

(Dudzic et al., 2019)

involved_in innate immune response

inferred from mutant phenotype

(Yamamoto-Hino and Goto, 2016)

involved_in positive regulation of melanization defense response

inferred from genetic interaction with FLYBASE:Sp7; FB:FBgn0037515

(Dudzic et al., 2019)

involved_in receptor guanylyl cyclase signaling pathway

inferred from genetic interaction with FLYBASE:Gyc76C; FB:FBgn0266136

(Kanoh et al., 2021)

involved_in Toll receptor ligand protein activation cascade

inferred from direct assay

(Kanoh et al., 2021)

inferred from mutant phenotype

(Yamamoto-Hino and Goto, 2016)

inferred from genetic interaction with FLYBASE:PGRP-SA; FB:FBgn0030310,FLYBASE:GNBP1; FB:FBgn0040323,FLYBASE:SPE; FB:FBgn0039102,FLYBASE:grass; FB:FBgn0039494

(Buchon et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in innate immune response

inferred from biological aspect of ancestor with PANTHER:PTN000667087

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from sequence model

(Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000667087

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

S1A SERINE PROTEASES - CHYMOTRYPSIN-LIKE

Pathway (FlyBase)

EXTRACELLULAR SPATZLE ACTIVATING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Belongs to the peptidase S1 family. (Q9VER6)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Summaries

Gene Snapshot

Pathway (FlyBase)

EXTRACELLULAR SPATZLE ACTIVATING PATHWAY CORE COMPONENTS -: In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).

Gene Group (FlyBase)

S1A SERINE PROTEASES - CHYMOTRYPSIN-LIKE -: Chymotrypsin-like serine proteases cleave substrates following one of the hydrophobic amino acids at the P1 position. (Adapted from FBrf0239469). Chymotrypsin-like serine proteases of the S1A family are endopeptidases that cleave substrates following one of the hydrophobic amino acids at the P1 position. (Adapted from FBrf0239469).

Protein Function (UniProtKB)

Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi (PubMed:19590012, PubMed:24794300). During Gram-positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation (PubMed:19590012). Functions in a separate pathway to the psh-mediated activation of the Toll pathway (PubMed:19590012).

(UniProt, Q9VER6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\modSP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VER6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

modSP-RA

FBtr0083353

NM_080515

2289

628

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

modSP-PA

FBpp0082798

69.4

628

5.40

Q9VER6

NP_536776

AAF55354

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

May be proteolytically cleaved via an autocatalytic mechanism.

(UniProt, Q9VER6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S01.950

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\modSP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

modSP_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\modSP in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\modSP

View exonic expression by tissue for Dmel\modSP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42032/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051217

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051217

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051217

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31217

Flygut - An atlas of the Drosophila adult midgut

FBgn0051217

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of modSP

Transgenic constructs containing regulatory region of modSP

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3R)Exel6270

(Ryder, 2004.4.26)

Df(3R)P-10

(Buchon et al., 2009)

Df(3R)Spf

(Buchon et al., 2009)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

modSP^GD4963

lethal, with Scer\GAL4^da.G32

modSP^UAS.cBa

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

modSP^GD4963

viable

viable, with Scer\GAL4^Mef2.PR

modSP^GD4963

viable, with Scer\GAL4^pnr-MD237

modSP^GD4963

Sterility

Allele

fertile

modSP^f01711

Other Phenotypes

Allele

abnormal immune response

modSP¹

abnormal immune response, with Scer\GAL4^da.G32

modSP^GD4963

abnormal immune response (with Df(3R)P-10)

modSP¹

abnormal immune response (with Df(3R)Spf)

modSP¹

abnormal immune response | larval stage

modSP¹

increased cell number | third instar larval stage, with Scer\GAL4^c564

modSP^UAS.cBa

increased mortality | larval stage | conditional

modSP¹

Phenotype manifest in

Allele

embryonic/larval hemocyte | increased number | third instar larval stage, with Scer\GAL4^c564

modSP^UAS.cBa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (50)

Hsap\PAMR1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Pamr1

2 of 14

Yes

Rnor\C1rl

1 of 14

Yes

Rnor\C1r

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\C1ra

1 of 14

Yes

Mmus\C1rl

1 of 14

Yes

Mmus\Corin

1 of 14

Yes

Mmus\Csmd1

1 of 14

Yes

Mmus\Csmd2

1 of 14

Yes

Mmus\Csmd3

1 of 14

Yes

Mmus\F2

1 of 14

Yes

Mmus\F9

1 of 14

Yes

Mmus\F10

1 of 14

Yes

Mmus\Hpn

1 of 14

Yes

Mmus\Klk1b9

1 of 14

Yes

Mmus\Klkb1

1 of 14

Yes

Mmus\Ldlr

1 of 14

Yes

Mmus\Lrp1

1 of 14

Yes

Mmus\Masp1

1 of 14

Yes

Mmus\Masp2

1 of 14

Yes

Mmus\Pamr1

1 of 14

Yes

Mmus\Prss21

1 of 14

Yes

Mmus\Prss45

1 of 14

Yes

Mmus\Prss55

1 of 14

Yes

Mmus\St14

1 of 14

Yes

Mmus\Tmprss2

1 of 14

Yes

Mmus\Tmprss4

1 of 14

Yes

Mmus\Tmprss6

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (39)

Xtro\pamr1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (32)

Drer\pamr1a

2 of 14

Yes

Drer\pamr1b

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\sez6b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\try-5

2 of 14

Yes

Cele\try-9

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\T22A3.6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (91)

Agam\AgaP_AGAP001798

9 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009849

1 of 12

Agam\AgaP_AGAP010260

1 of 12

Agam\AgaP_AGAP010528

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:modSP. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (147)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

MP1

3 of 13

snk

3 of 13

SPE

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

psh

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mgl

1 of 13

Sp7

1 of 13

Sp212

1 of 13

sphe

1 of 13

teq

1 of 13

tpr

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

modSP

inferred by author, enzymatic study, anti tag western blot

(Shan et al., 2023, Buchon et al., 2009)

modSP - CG3700

enzymatic study, anti tag western blot

(Shan et al., 2023)

modSP - nec

enzymatic study, western blot, Identification by mass spectrometry

(Shan et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

modSP

suppressible

Gyc76C

(Iwashita et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

psh

enhanceable

modSP

(Buchon et al., 2009)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67077

DroID - A comprehensive database of gene and protein interactions.

FBgn0051217

MIST (protein-protein) - An integrated Molecular Interaction Database

42032

Pathways

Signaling Pathways (FlyBase)

EXTRACELLULAR SPATZLE ACTIVATING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Toll and Imd signaling pathway

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-59

Cytogenetic map

89D6-89D6

Sequence location

3R:16,652,446..16,655,662 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

89D6-89D6

Limits computationally determined from genome sequence between P{lacW}CSN5^L4032 and P{EP}MESK4^EP1015

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-59

(FlyBase, 2016)

3-58.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

55717

w^*; TI{TI}modSP¹

32023

w¹¹¹⁸; P{EP}modSP^G4511

18462

w¹¹¹⁸; PBac{WH}modSP^f01711

44476

y¹ v¹; P{TRiP.HMC02363}attP2

63756

w¹¹¹⁸; PBac{IT.GAL4}modSP^0715-G4

NIG-Fly

HMC02363

y¹ v¹; P{TRiP.HMC02363}attP2

VDRC

v43972

w¹¹¹⁸; P{GD4963}v43972

v37808

w¹¹¹⁸; P{GD4963}v37808/TM3

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (27)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051217

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051217

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

modSP is required for Tl pathway activity in a step downstream of the recognition of lysine-type peptidoglycan.

(Buchon et al., 2009)

modSP is involved in the activation of the Tl pathway by Gram-positive bacteria.

(Buchon et al., 2009)

Epistatic analysis indicates that modSP functions downstream of PGRP-SA and GNBP1 and upstream of grass in the pathway that links Gram-positive bacterial recognition to Tl activation.

(Buchon et al., 2009)

Identified as one of 10 highest fold cycling genes as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

(McDonald and Rosbash, 2001)

The complete sequence of the bithorax complex is available.

(Martin et al., 1995)

Relationship to Other Genes

Source for database merge of

Additional comments

Annotations CG17557, CG10100 merged as CG31217 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: modSP CG31217

(Buchon et al., 2009)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

CG10100

CG17557

CG31217

(Ballard et al., 2010, Kong et al., 2010, Ni et al., 2010.12.1, Buchon et al., 2009, Shah et al., 2008, Negre and Ruiz, 2007, Park et al., 2007, Sackton et al., 2007)

CT28389

(Hynes and Zhao, 2000)

Dm-SP

(Park et al., 2007)

LDL

(Martin et al., 1995)

Ldlr

SP172

(Ross et al., 2003)

SP53

(Cao and Jiang, 2018, Ross et al., 2003)

Ser89E

(Shah et al., 2008, Ross et al., 2003)

Tep6

(Lu et al., 2020)

(Lupo et al., 2001, Paro, 1998, Martin et al., 1995)

Name Synonyms

Serine protease like 89E

Serine protease-like

(Martin et al., 1995)

low density lipoprotein receptor-like 'a' repeats

(Martin et al., 1995)

modular serine protease

(Bowman et al., 2014, Kounatidis and Ligoxygakis, 2012, Buchon et al., 2009)

predicted gene W

(Martin et al., 1995)

predicted gene X

(Martin et al., 1995)

Secondary FlyBase IDs

FBgn0013291
FBgn0015294

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42032

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VER6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VER6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VER6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42032/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051217

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051217

FlyMine - An integrated database for Drosophila genomics

FBgn0051217

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31217

MARRVEL_MODEL - MARRVEL (model organism gene)

42032

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S01.950

Linkouts

BioGRID - A database of protein and genetic interactions.

67077

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051217

DroID - A comprehensive database of gene and protein interactions.

FBgn0051217

DRSC - Results frm RNAi screens

FBgn0051217

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

modSP_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051217

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051217

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31217

Flygut - An atlas of the Drosophila adult midgut

FBgn0051217

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Toll and Imd signaling pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

42032

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

-0.79

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