FlyBase Gene Report: Dmel\LpR2

General Information

Symbol

Dmel\LpR2

Species

D. melanogaster

Name

Lipophorin receptor 2

Annotation Symbol

CG31092

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051092

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Lipophorin receptor 2 (LpR2) encodes a transmembrane receptor. A subset of LpR2-encoded isoforms are involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

96E10-96F1

Sequence location

3R:25,698,727..25,740,465 [-]

Recombination map

3-89

RefSeq locus

NT_033777 REGION:25698727..25740465

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables lipoprotein particle binding

inferred from physical interaction with FLYBASE:Apoltp; FB:FBgn0032136

(Rodríguez-Vázquez et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in mushroom body development

inferred from mutant phenotype

(Rojo-Cortés et al., 2022)

involved_in positive regulation of lipid transport

inferred from mutant phenotype

(Rodríguez-Vázquez et al., 2015)

involved_in receptor-mediated endocytosis

inferred from direct assay

(Rojo-Cortés et al., 2022)

involved_in transport across blood-brain barrier

inferred from genetic interaction with FLYBASE:LpR1; FB:FBgn0066101

(Singh et al., 2024, Brankatschk et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Parra-Peralbo and Culi, 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002557696

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Summary (Interactive Fly)

a secreted receptor that promotes the extracellular lipolysis of lipophorins - neutral lipid uptake - LpR1 facilitates uptake of the serpin Necrotic in oocytes and cells of imaginal discs

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\LpR2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7YU01)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transposon inserted in intron

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

LpR2-RA

FBtr0084927

NM_170239

4081

1028

LpR2-RB

FBtr0084928

NM_176565

3476

826

LpR2-RC

FBtr0113384

NM_001104456

4581

1029

LpR2-RD

FBtr0113385

NM_001104457

2634

380

LpR2-RE

FBtr0113386

NM_001104458

4189

1064

LpR2-RF

FBtr0113387

NM_001104459

4145

861

LpR2-RG

FBtr0113388

NM_001104460

4186

1063

LpR2-RH

FBtr0336451

NM_001276041

3397

862

LpR2-RI

FBtr0336452

NM_001276042

3844

834

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

LpR2-PA

FBpp0084301

113.2

1028

4.99

FBpp0084302

91.6

826

4.93

FBpp0112296

113.2

1029

4.99

FBpp0112297

41.1

380

5.53

FBpp0112298

117.0

1064

5.03

FBpp0112299

95.4

861

4.97

FBpp0112300

116.9

1063

5.03

FBpp0307557

95.5

862

4.98

FBpp0307558

92.5

834

4.93

A0A0B4KGZ9

NP_001262971

AGB96351

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\LpR2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.78

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

embryonic/larval oenocyte

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

third instar larval stage

wing pouch

(Parra-Peralbo and Culi, 2011)

oogenesis stage S8 -- S14

nurse cell

(Parra-Peralbo and Culi, 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

epitope tag

Stage

Tissue/Position (including subcellular localization)

Reference

• plasma membrane

Comment: expression assayed in cultured S2 cells

(Culi et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval garland cell

(Soukup et al., 2009)

larval pericardial cell

(Soukup et al., 2009)

third instar larval stage

wing pouch | restricted

(Parra-Peralbo and Culi, 2011)

adult stage

adult garland cell

(Soukup et al., 2009)

adult pericardial cell

(Soukup et al., 2009)

oogenesis stage S8 -- S11

nurse cell

(Parra-Peralbo and Culi, 2011)

oocyte

(Parra-Peralbo and Culi, 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

LpR2 protein is associated with the cell membrane in nurse cells and oocytes. Expression is first observed at oogenesis stage 8, and peaks at oogenesis stage 11. LpR2 protein is also expressed in the wing pouch of the wing disk in third instar larvae; expression is minimal at the anterior/posterior and dorsal/ventral compartment boundaries.

(Parra-Peralbo and Culi, 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Parra-Peralbo and Culi, 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\LpR2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\LpR2

View exonic expression by tissue for Dmel\LpR2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051092

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43105/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051092

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051092

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051092

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31092

Flygut - An atlas of the Drosophila adult midgut

FBgn0051092

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\LpR2

Stages(s) 4-6
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of LpR2

Transgenic constructs containing regulatory region of LpR2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)LpR1-2-c02106-d10508

(Wicker-Thomas et al., 2015)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

LpR2^GD10161

viable, with Scer\GAL4^Mef2.PR

LpR2^GD10161

viable, with Scer\GAL4^pnr-MD237

LpR2^GD10161

viable, with Scer\GAL4^tin.CΔ4

LpR2^GD10161

Sterility

Allele

female sterile

LpR2^Df

fertile

LpR2^EY07715b

Other Phenotypes

Allele

abnormal immune response | larval stage | conditional, with Scer\GAL4^GMR54C07

LpR2^KK105712

Phenotype manifest in

Allele

larval brain | larval stage | conditional, with Scer\GAL4^GMR54C07

LpR2^KK105712

lipid droplet

LpR2^Df

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (60)

Hsap\LDLR

12 of 14

Yes

Hsap\VLDLR

12 of 14

Yes

Hsap\LRP8

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (37)

Rnor\Ldlr

12 of 14

Yes

Rnor\Lrp8

12 of 14

Yes

Rnor\Vldlr

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

Rnor\Oit3

1 of 14

Yes

Rnor\Pamr1

1 of 14

Rnor\Pros1

1 of 14

Yes

Rnor\Prss21

1 of 14

Rnor\Shbg

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (47)

Mmus\Ldlr

12 of 14

Yes

Mmus\Vldlr

12 of 14

Yes

Mmus\Lrp8

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Pros1

1 of 14

Yes

Mmus\Proz

1 of 14

Mmus\Prss21

1 of 14

Mmus\Shbg

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (50)

Xtro\ldlr

10 of 13

Yes

Xtro\vldlr

10 of 13

Yes

Xtro\lrp8

7 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\masp2

1 of 13

Xtro\megf6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB5809687

1 of 13

Danio rerio (Zebrafish) (47)

Drer\lrp8

12 of 14

Yes

Drer\vldlr

12 of 14

Yes

Drer\ldlra

9 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\c1s.1

1 of 14

Drer\cd248b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\hpn

1 of 14

Drer\lama1

1 of 14

Drer\ldlrad3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\shbg

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\T13C2.6

13 of 14

Yes

Cele\egg-1

2 of 14

Yes

Cele\egg-2

2 of 14

Yes

Cele\F32E10.8

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\mua-3

1 of 14

Cele\mup-4

1 of 14

Cele\slt-1

1 of 14

Anopheles gambiae (African malaria mosquito) (59)

Agam\AgaP_AGAP002186

10 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010897

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\TRY5_ANOGA

1 of 12

Agam\TRY7_ANOGA

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:LpR2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (41)

LpR1

11 of 13

Lrp4

4 of 13

arr

3 of 13

cue

3 of 13

mgl

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Ndg

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

crb

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

ndl

1 of 13

SPE

1 of 13

tpr

1 of 13

trol

1 of 13

uif

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

VLDLR; very low density lipoprotein receptor

model of cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1

IEA

(FlyBase, 2019-)

LDLR; low density lipoprotein receptor

model of familial hypercholesterolemia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

LpR2^Df

exacerbates Alzheimer's disease

modeled by Psn^RNAi.UAS.3

(Kang et al., 2024)

LpR2^HMS03722

ameliorates prostate cancer

modeled by btl::Egfr^λ.UAS

(Vialat et al., 2024)

exacerbates Alzheimer's disease

modeled by Psn^RNAi.UAS.3

(Kang et al., 2024)

LpR2^NIG.4823R

exacerbates Alzheimer's disease

modeled by Psn^RNAi.UAS.3

(Kang et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

LDLR; low density lipoprotein receptor

12 of 14

606945

HYPERCHOLESTEROLEMIA, FAMILIAL, 1; FHCL1

familial hypercholesterolemia

VLDLR; very low density lipoprotein receptor

12 of 14

192977

CEREBELLAR ATAXIA, IMPAIRED INTELLECTUAL DEVELOPMENT, AND DYSEQUILIBRIUM SYNDROME 1; CAMRQ1

cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1

LRP8; LDL receptor related protein 8

11 of 14

602600

MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

LpR2 - Apoltp

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Rodríguez-Vázquez et al., 2015)

LpR2 - CG8507

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Rodríguez-Vázquez et al., 2015)

LpR2 - Pxn

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Rodríguez-Vázquez et al., 2015)

LpR2 - boca

anti tag coimmunoprecipitation, anti tag western blot

(Culi et al., 2004)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68016

DroID - A comprehensive database of gene and protein interactions.

FBgn0051092

MIST (protein-protein) - An integrated Molecular Interaction Database

43105

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

LDL clearance

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-89

Cytogenetic map

96E10-96F1

Sequence location

3R:25,698,727..25,740,465 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96E10-96F1

Limits computationally determined from genome sequence between P{EP}EP3354 and P{PZ}l(3)rQ197^rQ197

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-89

(FlyBase, 2016)

3-86.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85439

w¹¹¹⁸; P{XP}LpR2^d04404

605830

y¹ w^*; M{UAS-LpR2.F}ZH-22A

605831

y¹ w^*; M{UAS-LpR2.E}ZH-22A

31150

y¹ v¹; P{TRiP.JF01627}attP2

38052

y¹ w^*; Mi{MIC}LpR2^MI04745

43774

y¹ w^*; Mi{MIC}LpR2^MI04473

60219

y¹ w^*; Mi{PT-GFSTF.1}LpR2^{MI04745-GFSTF.1}

54461

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03722}attP2

11095

4823R-2

v107597

v25684

w¹¹¹⁸; P{GD10161}v25684

More stocks available...

Genomic Clones (30)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (70)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE61404

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051092

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051092

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Parra-Peralbo and Culi, 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG4823 CG4834

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG4823 and CG4834 merged as CG31092 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG31092

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Sepp et al., 2008, Giot et al., 2003)

CG4823

(Johansson et al., 2005, Asha et al., 2003, Silverman et al., 2003, De Gregorio et al., 2002)

CG4834

LpR2

(Gera et al., 2024, Vialat et al., 2024, Vonolfen et al., 2024, Olivares et al., 2023, Rojo-Cortés et al., 2022, Wu et al., 2022, Lindsey et al., 2021, Cho et al., 2020, McGough et al., 2020, Toprak et al., 2020, Xu et al., 2020, Hudry et al., 2019, Matsuo et al., 2019, Mirth et al., 2019, Xu et al., 2019, Baron et al., 2018, Gene Disruption Project members, 2018-, Palmer et al., 2018, Yin et al., 2018, Sieber and Spradling, 2017, Crocker et al., 2016, Danielsen et al., 2016, Gene Disruption Project members, 2015-, Sieber and Spradling, 2015, Wicker-Thomas et al., 2015, Ashwal-Fluss et al., 2014, Chatterjee et al., 2014, Heimiller et al., 2014, Short and Lazzaro, 2013, Japanese National Institute of Genetics, 2012.5.21, Parvy et al., 2012, Rodriguez et al., 2012, Hazelett et al., 2009, Khaliullina et al., 2009, Soukup et al., 2009, Callejo et al., 2008, Sepp et al., 2008, Gutierrez et al., 2007)

Lpr2

(Pang et al., 2023, Sepp et al., 2008)

Lpr2-E

(Wang et al., 2018)

lpr2

(Rodríguez-Vázquez et al., 2015, Parra-Peralbo and Culi, 2011)

Name Synonyms

Lipophorin receptor 2

(Shafer, 2025)

LpR2

a2M-receptor-like

(De Gregorio et al., 2001)

lipophorin receptor 2

(Chatterjee et al., 2014, Parra-Peralbo and Culi, 2011)

Secondary FlyBase IDs

FBgn0039361
FBgn0039362

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 94 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43105

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7YU01

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7YU01

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051092

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43105/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051092

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051092

FlyMine - An integrated database for Drosophila genomics

FBgn0051092

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31092

MARRVEL_MODEL - MARRVEL (model organism gene)

43105

Linkouts

BioGRID - A database of protein and genetic interactions.

68016

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051092

DroID - A comprehensive database of gene and protein interactions.

FBgn0051092

DRSC - Results frm RNAi screens

FBgn0051092

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051092

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051092

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31092

Flygut - An atlas of the Drosophila adult midgut

FBgn0051092

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0051092

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014957

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

43105

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

LDL clearance

References (102)

The following external sites may use different assemblies or annotations than FlyBase.

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