FlyBase Allele Report: Dmel\LpR2[CR70220-TG4.0]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Dmel\LpR2^{CR70220-TG4.0}

General Information

Symbol

Dmel\LpR2^{CR70220-TG4.0}

Species

D. melanogaster

Name

FlyBase ID

FBal0371292

Feature type

allele

Associated gene

Associated Insertion(s)

TI{CRIMIC.TG4.0}LpR2^{CR70220-TG4.0}

Carried in Construct

Key Links

Genomic Maps

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

(Gene Disruption Project members, 2018-)

gene targeting by homologous recombination

(Gene Disruption Project members, 2018-)

Progenitor genotype

Associated Insertion(s)

TI{CRIMIC.TG4.0}LpR2^{CR70220-TG4.0}

Cytology

Description

A TI{CRIMIC.TG4.0} DNA cassette has been inserted into LpR2, in a coding intron, and is predicted to gene trap a subset of the annotated transcripts of the gene. The TI{CRIMIC.TG4.0} cassette was inserted via the CRISPR/Cas-9 drop-in technique, using a dsDNA donor vector with homology arms of length 200bp. The sgRNA sequence used to target the gene was: AAGAGCACGCATTTCAAAGCGGG.

(Gene Disruption Project members, 2018-)

Allele components

Component

Use(s)

Inserted element

TI{CRIMIC.TG4.0}

RMCE target element

Encoded product / tool

binary expression system - driver

Also carries

integrase target site

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

3R:25,700,849..25,700,850 [-]

(Rojo-Cortés et al., 2026, Deger et al., 2025, Kanca et al., 2022, Rojo-Cortés et al., 2022, Gene Disruption Project members, 2018-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | dominant

(Rojo-Cortés et al., 2026)

Phenotype Manifest In

(Rojo-Cortés et al., 2026)

(Rojo-Cortés et al., 2026)

mushroom body medial lobe

(Rojo-Cortés et al., 2026)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

LpR2^{CR70220-TG4.0} has abnormal neuroanatomy | dominant phenotype, enhanceable by Drosp^{CR70269-KO-TG4.1}

(Rojo-Cortés et al., 2026)

Enhancer of

Statement

Reference

LpR2^{CR70220-TG4.0} is an enhancer of abnormal neuroanatomy | dominant phenotype of Drosp^{CR70269-KO-TG4.1}

(Rojo-Cortés et al., 2026)

Phenotype Manifest In

Enhanced by

Statement

Reference

LpR2^{CR70220-TG4.0} has mushroom body phenotype, enhanceable by Drosp^{CR70269-KO-TG4.1}

(Rojo-Cortés et al., 2026)

LpR2^{CR70220-TG4.0} has axon phenotype, enhanceable by Drosp^{CR70269-KO-TG4.1}

(Rojo-Cortés et al., 2026)

Enhancer of

Statement

Reference

LpR2^{CR70220-TG4.0} is an enhancer of mushroom body phenotype of Drosp^{CR70269-KO-TG4.1}

(Rojo-Cortés et al., 2026)

LpR2^{CR70220-TG4.0} is an enhancer of axon phenotype of Drosp^{CR70269-KO-TG4.1}

(Rojo-Cortés et al., 2026)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

LpR2^{CR70220-TG4.0}

LpR2^CR70220

(Rojo-Cortés et al., 2026)

LpR2^T2A

(Deger et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections