FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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Term receptor-mediated endocytosis ID (Ontology) GO:0006898 (Gene Ontology)
Definition An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.[ ISBN:0716731363 ]
Also Known As "receptor mediated endocytosis"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 receptor-mediated endocytosis (all annotations which use CV term, excluding "NOT" statements)
     involved_in | receptor-mediated endocytosis
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transport
 |__vesicle-mediated transport__
cellular process                |
 |__vesicle-mediated transport__|
import into cell                |
 |__endocytosis_________________|
                                receptor-mediated endocytosis  70 rec.
                                 |__clathrin-dependent endocytosis 32 rec.
                                 |   |__clathrin coat assembly involved in endocytosis
                                 |   |__clathrin coat disassembly(+)
                                 |   |__clathrin-dependent endocytosis involved in vitellogenesis 6 rec.
                                 |   |__clathrin-dependent endocytosis of virus by host cell
                                 |   |__clathrin-dependent extracellular exosome endocytosis
                                 |   |__clathrin-dependent synaptic vesicle endocytosis 7 rec.
                                 |   |__regulation of clathrin-dependent endocytosis(+) 9 rec.
                                 |__endocytic hemoglobin import into cell
                                 |__endocytic iron import into cell
                                 |   |__endocytic heme import into cell
                                 |__Fc receptor-mediated immune complex endocytosis
                                 |__receptor internalization 17 rec.
                                 |   |__B cell receptor internalization(+)
                                 |   |__G protein-coupled receptor internalization(+) 4 rec.
                                 |   |__insulin receptor internalization(+)
                                 |   |__neurotransmitter receptor internalization(+) 1 rec.
                                 |   |__regulation of receptor internalization(+) 8 rec.
                                 |   |__regulation of signal transduction by receptor internalization(+) 1 rec.
                                 |   |__Wnt receptor internalization
                                 |__receptor-mediated endocytosis involved in cholesterol transport
                                 |__receptor-mediated endocytosis of virus by host cell
                                 |   |__caveolin-mediated endocytosis of virus by host cell
                                 |   |__clathrin-dependent endocytosis of virus by host cell
                                 |__regulation of receptor-mediated endocytosis 29 rec.
                                     |__negative regulation of receptor-mediated endocytosis(+) 3 rec.
                                     |__positive regulation of receptor-mediated endocytosis(+) 20 rec.
                                     |__regulation of clathrin-dependent endocytosis(+) 9 rec.
                                     |__regulation of receptor internalization(+) 8 rec.
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Is a endocytosis
vesicle-mediated transport
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Reactome:R-HSA-2173782 "Binding and Uptake of Ligands by Scavenger Receptors"
Wikipedia:Receptor-mediated_endocytosis