FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term transmembrane signaling receptor activity ID (Ontology) GO:0004888 (Gene Ontology)
Definition Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Also Known As "transmembrane signalling receptor activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      60
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 transmembrane signaling receptor activity (all annotations which use CV term, excluding "NOT" statements)       6     60
     enables | transmembrane signaling receptor activity       --      60
Spanning Tree (Parents/Children)
Only view relationship: 
  molecular transducer activity
   |__signaling receptor activity
       |__transmembrane signaling receptor activity  379 rec.
           |__acetylcholine receptor activity 8 rec.
           |   |__G protein-coupled acetylcholine receptor activity 4 rec.
           |__apolipoprotein A-I receptor activity
           |__axon guidance receptor activity 9 rec.
           |__collagen receptor activity 1 rec.
           |   |__protein tyrosine kinase collagen receptor activity 1 rec.
           |__complement receptor activity
           |   |__complement component C1q receptor activity
           |   |__complement component C3a receptor activity
           |   |__complement component C3b receptor activity
           |   |__complement component C3d receptor activity
           |   |__complement component C3dg receptor activity
           |   |__complement component C4b receptor activity
           |   |__complement component C5a receptor activity
           |   |__complement component iC3b receptor activity
           |__cytokine receptor activity 3 rec.
           |   |__chemokine receptor activity(+)
           |   |__ciliary neurotrophic factor receptor activity(+)
           |   |__erythropoietin receptor activity
           |   |__glial cell-derived neurotrophic factor receptor activity
           |   |__granulocyte colony-stimulating factor receptor activity
           |   |__granulocyte macrophage colony-stimulating factor receptor activity
           |   |__growth hormone receptor activity
           |   |__high mobility group box 1 receptor activity
           |   |__interferon receptor activity(+)
           |   |__interleukin-1 receptor activity(+)
           |   |__interleukin-2 receptor activity
           |   |__interleukin-3 receptor activity
           |   |__interleukin-4 receptor activity
           |   |__interleukin-5 receptor activity
           |   |__interleukin-6 receptor activity
           |   |__interleukin-7 receptor activity
           |   |__interleukin-9 receptor activity
           |   |__interleukin-10 receptor activity
           |   |__interleukin-11 receptor activity
           |   |__interleukin-12 receptor activity
           |   |__interleukin-13 receptor activity
           |   |__interleukin-15 receptor activity
           |   |__interleukin-16 receptor activity
           |   |__interleukin-17 receptor activity(+)
           |   |__interleukin-18 receptor activity
           |   |__interleukin-19 receptor activity
           |   |__interleukin-20 receptor activity
           |   |__interleukin-21 receptor activity
           |   |__interleukin-22 receptor activity
           |   |__interleukin-23 receptor activity
           |   |__interleukin-24 receptor activity
           |   |__interleukin-26 receptor activity
           |   |__interleukin-33 receptor activity
           |   |__interleukin-35 receptor activity
           |   |__leptin receptor activity
           |   |__oncostatin-M receptor activity
           |   |__prolactin receptor activity
           |   |__thrombopoietin receptor activity
           |__cytokinin receptor activity
           |   |__G protein-coupled cytokinin receptor activity
           |   |__transmembrane histidine kinase cytokinin receptor activity
           |__death receptor activity 3 rec.
           |   |__TRAIL receptor activity
           |   |__tumor necrosis factor receptor activity 3 rec.
           |__G protein-coupled receptor activity 134 rec.
           |   |__bioactive lipid receptor activity(+)
           |   |__cannabinoid receptor activity
           |   |__choriogonadotropin hormone receptor activity
           |   |__corticotrophin-releasing factor receptor activity
           |   |__ecdysis-triggering hormone receptor activity 1 rec.
           |   |__G protein-coupled adenosine receptor activity 2 rec.
           |   |__G protein-coupled amine receptor activity(+) 28 rec.
           |   |__G protein-coupled bile acid receptor activity
           |   |__G protein-coupled chemoattractant receptor activity(+)
           |   |__G protein-coupled chemorepellent receptor activity
           |   |__G protein-coupled cytokinin receptor activity
           |   |__G protein-coupled estrogen receptor activity
           |   |__G protein-coupled folate receptor activity
           |   |__G protein-coupled GABA receptor activity 4 rec.
           |   |__G protein-coupled glucose receptor activity
           |   |__G protein-coupled glutamate receptor activity(+) 2 rec.
           |   |__G protein-coupled neurotransmitter receptor activity(+) 4 rec.
           |   |__G protein-coupled nucleotide receptor activity
           |   |__G protein-coupled olfactory receptor activity
           |   |__G protein-coupled opioid receptor activity(+)
           |   |__G protein-coupled peptide receptor activity(+) 60 rec.
           |   |__G protein-coupled photoreceptor activity 8 rec.
           |   |__G protein-coupled purinergic nucleotide receptor activity(+)
           |   |__G protein-coupled pyrimidinergic nucleotide receptor activity(+)
           |   |__G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
           |   |__gastric inhibitory peptide receptor activity
           |   |__gonadotropin-releasing hormone receptor activity
           |   |__GPCR taste receptor activity(+)
           |   |__growth hormone secretagogue receptor activity
           |   |__growth hormone-releasing hormone receptor activity
           |   |__icosanoid receptor activity(+) 1 rec.
           |   |__luteinizing hormone receptor activity
           |   |__mast cell secretagogue receptor activity
           |   |__melanin-concentrating hormone receptor activity
           |   |__melatonin receptor activity
           |   |__nicotinic acid receptor activity
           |   |__parathyroid hormone receptor activity
           |   |__pheromone receptor activity(+)
           |   |__pituitary adenylate cyclase-activating polypeptide receptor activity
           |   |__platelet activating factor receptor activity
           |   |__prosaposin receptor activity
           |   |__secretin receptor activity
           |   |__thyroid-stimulating hormone receptor activity
           |   |__thyrotropin-releasing hormone receptor activity 1 rec.
           |   |__vasoactive intestinal polypeptide receptor activity
           |__GABA receptor activity 8 rec.
           |   |__G protein-coupled GABA receptor activity 4 rec.
           |   |__GABA-A receptor activity 4 rec.
           |__glutamate receptor activity 27 rec.
           |   |__G protein-coupled glutamate receptor activity(+) 2 rec.
           |   |__glutamate-gated receptor activity(+) 16 rec.
           |__hedgehog receptor activity 1 rec.
           |__ICAM-3 receptor activity
           |__immunoglobulin receptor activity
           |   |__IgA receptor activity(+)
           |   |__IgE receptor activity(+)
           |   |__IgG receptor activity(+)
           |   |__IgM receptor activity(+)
           |   |__polymeric immunoglobulin receptor activity
           |__latrotoxin receptor activity
           |__mechanoreceptor activity 3 rec.
           |__MHC class I receptor activity
           |   |__activating MHC class I receptor activity(+)
           |   |__inhibitory MHC class I receptor activity(+)
           |__MHC class Ib receptor activity
           |   |__activating MHC class Ib receptor activity
           |   |__inhibitory MHC class Ib receptor activity(+)
           |__MHC class II receptor activity
           |__netrin receptor activity 2 rec.
           |   |__netrin receptor activity involved in chemoattraction
           |   |__netrin receptor activity involved in chemorepulsion 1 rec.
           |__neuregulin receptor activity
           |__neurotensin receptor activity, non-G protein-coupled
           |__non-tyrosine kinase fibroblast growth factor receptor activity
           |__nucleotide receptor activity
           |   |__G protein-coupled pyrimidinergic nucleotide receptor activity(+)
           |   |__purinergic nucleotide receptor activity(+)
           |__olfactory receptor activity 70 rec.
           |   |__G protein-coupled olfactory receptor activity
           |   |__ionotropic olfactory receptor activity 60 rec.
           |__opsonin receptor activity
           |   |__collectin receptor activity
           |   |__complement component C1q receptor activity
           |   |__complement component C3b receptor activity
           |   |__complement component C4b receptor activity
           |   |__complement component C5a receptor activity
           |   |__complement component iC3b receptor activity
           |   |__pentraxin receptor activity(+)
           |__osmosensor activity 1 rec.
           |   |__osmolarity-sensing monoatomic cation channel activity
           |__phosphatidylserine receptor activity
           |__reelin receptor activity
           |__semaphorin receptor activity 3 rec.
           |__serotonin receptor activity
           |   |__serotonin-gated chloride channel activity
           |   |__serotonin-gated monoatomic cation channel activity
           |__sulfonylurea receptor activity
           |__taste receptor activity 58 rec.
           |   |__bitter taste receptor activity(+)
           |   |__contact chemoreceptor activity
           |   |__GPCR taste receptor activity(+)
           |   |__ionotropic taste receptor activity(+) 15 rec.
           |   |__sour taste receptor activity 1 rec.
           |   |__sweet taste receptor activity(+) 9 rec.
           |__tiggrin receptor activity
           |__transmembrane receptor protein kinase activity 26 rec.
           |   |__transmembrane receptor histidine kinase activity(+)
           |   |__transmembrane receptor protein serine/threonine kinase activity(+) 8 rec.
           |   |__transmembrane receptor protein tyrosine kinase activity(+) 18 rec.
           |__transmembrane receptor protein phosphatase activity 8 rec.
           |   |__transmembrane receptor protein tyrosine phosphatase activity 8 rec.
           |__Wnt receptor activity 5 rec.
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Is a signaling receptor activity
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Synonyms
  • "transmembrane receptor activity" BROAD
    "transmembrane signalling receptor activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex"