FlyBase Gene Report: Dmel\yl

General Information

Symbol

Dmel\yl

Species

D. melanogaster

Name

yolkless

Annotation Symbol

CG1372

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004649

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

Cell surface receptor involved in uptake of vitellogenins (yolk proteins) into developing oocytes by receptor-mediated endocytosis (PubMed:10679010, PubMed:2886508, PubMed:7878005). May also mediate uptake of apolpp/apolipophorins and their incorporation into yolk granules (PubMed:33891588). Along with its ligands, required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis of vitellogenin receptor ligands is critical for osk (isoform A) mediated actin reorganization and the anchoring of germ plasm components to the oocyte cortex (PubMed:33891588). (UniProt, P98163)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Also Known As

fs(1)M25, fs(1)L186

Key Links

Genomic Location

Cytogenetic map

12E3-12E3

Sequence location

X:14,193,214..14,199,958 [+]

Recombination map

1-48

RefSeq locus

NC_004354 REGION:14193214..14199958

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097

(InterPro Project Members, 2004-)

enables vitellogenin receptor activity

inferred from sequence or structural similarity

(Schonbaum et al., 1995)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in coated vesicle

inferred from direct assay

(Sommer et al., 2005)

located_in cytoplasmic vesicle

inferred from direct assay

(Sommer et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002557696

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the LDLR family. (P98163)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

(UniProt, P98163)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

yl: yolkless

Female-sterile locus affecting late oogenesis. Eggs of mutants lack proteinaceous yolk and collapse; ultrastructurally abnormal chorion at anterior end and especially at base of respiratory filaments. No abnormality detectable in chorion protein synthesis. Uptake of the three yolk proteins by yl oocytes is severely reduced, although the proteins accumulate in the hemolymph.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\yl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P98163)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

yl-RA

FBtr0073897

NM_078596

6351

1937

yl-RB

FBtr0073898

NM_206710

6274

1984

Additional Transcript Data and Comments

Reported size (kB)

6.5 (northern blot)

(Schonbaum et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

yl-PA

FBpp0073714

215.0

1937

6.18

FBpp0073715

219.5

1984

6.15

P98163

NP_996433

AAS65339

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1984 (aa); 210 (kD observed); 220 (kD predicted)

(Schonbaum et al., 1995)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with osk (isoform A).

(UniProt, P98163)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P98163

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\yl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

yl_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.29

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

ovary

(Schonbaum et al., 1995)

Additional Descriptive Data

yl transcripts are ovary specific.

(Schonbaum et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in coated vesicle

inferred from direct assay

(Sommer et al., 2005)

located_in cytoplasmic vesicle

inferred from direct assay

(Sommer et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\yl in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\yl

View exonic expression by tissue for Dmel\yl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004649

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32367/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004649

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004649

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004649

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1372

Flygut - An atlas of the Drosophila adult midgut

FBgn0004649

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 39 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of yl

Transgenic constructs containing regulatory region of yl

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(1)g

(Schonbaum et al., 1995, Waring et al., 1983)

Df(1)KA9

(Mitchell et al., 1996, Schonbaum et al., 1995, Waring et al., 1983)

Gene not disrupted in

Df(1)NP5

(Mitchell, 1997.2.17, Mitchell et al., 1996)

Df(1)RK4

(Mitchell et al., 1996)

Df(1)RK5

(Mitchell et al., 1996)

Inferred from location ( 17 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

yl^GD2644

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

yl^GD14480

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

yl^GD14480

Sterility

Allele

female sterile

female sterile | recessive

female sterile soma-dependent

yl¹¹

Phenotype manifest in

Allele

adult hemolymph | female

clathrin-coated endocytic vesicle

yl¹⁵

clathrin-coated pit

coated vesicle

egg

yl⁹

egg chorion

oocyte | oogenesis stage S10

oocyte | oogenesis stage S13

yl^262b

oocyte | oogenesis stage S14

yl^262b

yolk granule

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (43)

Hsap\LDLR

3 of 14

Yes

Hsap\LRP1B

3 of 14

Yes

Hsap\LRP1

3 of 14

Yes

Hsap\LRP4

3 of 14

Yes

Hsap\LRP5

3 of 14

Yes

Hsap\LRP6

3 of 14

Yes

Hsap\LRP8

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SORCS2

1 of 14

Yes

Hsap\SORCS3

1 of 14

Yes

Hsap\SORT1

1 of 14

Yes

Hsap\SSPOP

1 of 14

Hsap\THBD

1 of 14

Hsap\TMPRSS6

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Lrp1

3 of 14

Yes

Rnor\Lrp4

3 of 14

Yes

Rnor\Lrp5

3 of 14

Yes

Rnor\Lrp6

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

Rnor\Slit3

1 of 14

Rnor\Sorl1

1 of 14

Rnor\Tmprss6

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\Gm19410

3 of 14

Yes

Mmus\Ldlr

3 of 14

Yes

Mmus\Lrp1b

3 of 14

Yes

Mmus\Lrp1

3 of 14

Yes

Mmus\Lrp2

3 of 14

Yes

Mmus\Lrp4

3 of 14

Yes

Mmus\Lrp5

3 of 14

Yes

Mmus\Lrp6

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Masp2

1 of 14

Xenopus tropicalis (Western clawed frog) (35)

Xtro\emx2

2 of 13

Yes

Xtro\ldlr

2 of 13

Yes

Xtro\camk2b

1 of 13

Xtro\ccbe1

1 of 13

Xtro\dlk1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gria1

1 of 13

Xtro\jag2

1 of 13

Xtro\LOC100488932

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\sorcs2

1 of 13

Yes

Xtro\sorl1

1 of 13

Xtro\sort1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\vldlr

1 of 13

Xtro\vwce

1 of 13

Yes

Xtro\XB5809687

1 of 13

Danio rerio (Zebrafish) (26)

Drer\ldlra

3 of 14

Yes

Drer\lrp1ab

3 of 14

Yes

Drer\lrp1bb

3 of 14

Yes

Drer\lrp2b

3 of 14

Yes

Drer\lrp5

3 of 14

Yes

Drer\lrp13

3 of 14

Yes

Drer\c1s.1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ldlrb

1 of 14

Drer\LOC100536757

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (22)

Cele\lrp-1

3 of 14

Yes

Cele\lrp-2

3 of 14

Yes

Cele\T13C2.6

3 of 14

Yes

Cele\egg-2

2 of 14

Yes

Cele\F32E10.8

2 of 14

Yes

Cele\rme-2

2 of 14

Cele\bli-1

1 of 14

Yes

Cele\clec-78

1 of 14

Cele\clec-180

1 of 14

Yes

Cele\col-108

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\M03E7.4

1 of 14

Yes

Cele\mec-5

1 of 14

Yes

Cele\mua-3

1 of 14

Cele\mup-4

1 of 14

Cele\Y64G10A.7

1 of 14

Anopheles gambiae (African malaria mosquito) (22)

Agam\AgaP_AGAP000427

10 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010897

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:yl. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

arr

4 of 13

LpR2

4 of 13

Lrp4

4 of 13

mgl

4 of 13

cue

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Ndg

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

crb

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

ndl

1 of 13

pwn

1 of 13

Ser

1 of 13

slow

1 of 13

trol

1 of 13

wry

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 11 )

Human Ortholog

Disease

Evidence

References

LRP4; LDL receptor related protein 4

model of sclerosteosis 2

IEA

(FlyBase, 2019-)

model of congenital myasthenic syndrome 17

IEA

(FlyBase, 2019-)

model of Cenani-Lenz syndactyly syndrome

IEA

(FlyBase, 2019-)

LDLR; low density lipoprotein receptor

model of familial hypercholesterolemia

IEA

(FlyBase, 2019-)

LRP1; LDL receptor related protein 1

model of keratosis pilaris atrophicans

IEA

(FlyBase, 2019-)

LRP6; LDL receptor related protein 6

model of coronary artery disease

IEA

(FlyBase, 2019-)

LRP5; LDL receptor related protein 5

model of autosomal dominant osteopetrosis 1

IEA

(FlyBase, 2019-)

model of exudative vitreoretinopathy 4

IEA

(FlyBase, 2019-)

model of polycystic liver disease 4

IEA

(FlyBase, 2019-)

model of osteoporosis-pseudoglioma syndrome

IEA

(FlyBase, 2019-)

model of Worth syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

LDLR; low density lipoprotein receptor

3 of 14

606945

HYPERCHOLESTEROLEMIA, FAMILIAL, 1; FHCL1

familial hypercholesterolemia

LRP1B; LDL receptor related protein 1B

3 of 14

608766

LRP1; LDL receptor related protein 1

3 of 14

107770

keratosis pilaris atrophicans

LRP4; LDL receptor related protein 4

3 of 14

604270

LRP5; LDL receptor related protein 5

3 of 14

603506

LRP6; LDL receptor related protein 6

3 of 14

603507

coronary artery disease

LRP8; LDL receptor related protein 8

3 of 14

602600

MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

yl - osk

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Tanaka et al., 2021)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with osk (isoform A).

(UniProt, P98163 )

Linkouts

BioGRID - A database of protein and genetic interactions.

58737

DroID - A comprehensive database of gene and protein interactions.

FBgn0004649

MIST (protein-protein) - An integrated Molecular Interaction Database

32367

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Transport of RCbl within the body

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Transport of RCbl within the body

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-48

Cytogenetic map

12E3-12E3

Sequence location

X:14,193,214..14,199,958 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

12E3-12E3

Limits computationally determined from genome sequence between P{EP}EP1595^EP1595 and P{EP}l(1)G0007^EP764

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

12E4-12E8

(Schonbaum, 1994.8.15)

Experimentally Determined Recombination Data

Location

1-48

(FlyBase, 2016)

1-45.4

(Comeron et al., 2012)

(Mohler, 1977)

Left of (cM)

(Mohler, 1977)

Right of (cM)

(Mohler, 1977)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4320

yl¹³ v²⁴/FM3

85512

w¹¹¹⁸ P{XP}yl^d10478

59958

y¹ v¹ yl¹⁷/FM7a

31152

y¹ v¹; P{TRiP.JF01629}attP2

56922

y¹ v¹; P{TRiP.HMS04361}attP2

63696

y¹ v¹; P{TRiP.HMJ30264}attP40/CyO

Kyoto

107686

yl¹³ v²⁴/FM3

NIG-Fly

1372R-1

P{NIG.1372R}1

HMJ30264

y¹ v¹; P{TRiP.HMJ30264}attP40/CyO

VDRC

v109716

P{KK104639}VIE-260B

v36345

w¹¹¹⁸; P{GD14480}v36345

v342799

P{hsFLP}1, y1 w1118; P{HD_CFD01955}attP40/CyO-GFP

More stocks available...

Genomic Clones (5)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (64)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE59172

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004649

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004649

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Tanaka et al., 2021, Liu et al., 2015, Tsai et al., 2014, Schonbaum et al., 1995)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

yl is part of a phylogenetic reconstruction of the LDLR-family class A clusters using parsimony.

(Sappington and Raikhel, 1998)

yl has been molecularly characterised: the yl protein is the yolk protein receptor and is a member of the low density lipoprotein receptor (LDLR) superfamily.

(Schonbaum et al., 1995)

Whereas in wild type ovarian follicles the Golgi apparatus and yolk spheres are preferentially labelled by osmium zinc iodide, in mutant follicles the Golgi apparatus and nearby vesicles showed dramatically reduced staining.

(Giorgi et al., 1993)

Located in 12E1-12F1 by deficiency mapping.

(DiMario and Mahowald, 1987)

Females homozygous for amorphic alleles of yl lack coated vesicles which are involved in receptor mediated exocytosis.

(Perrimon et al., 1986)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: yl CG1372

(Zhong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

CG1372

(Çiçek et al., 2016, Müller et al., 2010, Ni et al., 2010.12.1, Gruber and Long, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008)

CT3114

(Hynes and Zhao, 2000)

DmYPR

(Sappington and Raikhel, 1998)

LR13

(Sappington and Raikhel, 1998)

(Compagnon et al., 2009)

(Kelkar and Dobberstein, 2009, Bokel et al., 2006, D'Alterio et al., 2005)

fs(1)148

(Mohler and Carroll, 1984)

fs(1)5

fs(1)A148

(Perrimon et al., 1986)

fs(1)K184

(Perrimon and Gans, 1983)

fs(1)L186

(Giorgi et al., 1993)

fs(1)L193

fs(1)L196

fs(1)L211

fs(1)M205

fs(1)M25

(Perrimon et al., 1986, Mohler and Carroll, 1984, Mohler, 1977)

fs(1)yl

fs(1)yolkless

(Perrimon et al., 1986)

(Duan et al., 2025, Berg et al., 2024, Yu et al., 2024, Pang et al., 2023, Dong et al., 2022, Gupta et al., 2022, Tanaka et al., 2021, Bovier et al., 2018, Gene Disruption Project members, 2018-, Sandler and Stathopoulos, 2016, Liu et al., 2015, Hughes et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Chung et al., 2011, Müller et al., 2010, Schotman et al., 2009, Bokel et al., 2006, Kadener et al., 2006)

yokeless

(Pérez-Mojica et al., 2023)

Name Synonyms

Dm Yolkless

(Konikoff et al., 2010)

YP receptor

(Richard et al., 2001)

Yolkless

(Tanaka et al., 2021, Zappia et al., 2011, Kelkar and Dobberstein, 2009, Coutelis and Ephrussi, 2007, Vanzo et al., 2007, Wilhelm, 2007, D'Alterio et al., 2005, Wilhelm et al., 2005)

yolkless

(Gordon et al., 2025, Jang et al., 2021, Tsai et al., 2014, Jha et al., 2012, Lee and Cooley, 2007, Tadros et al., 2007, Richard et al., 2005, Sommer et al., 2005)

Secondary FlyBase IDs

FBgn0000732
FBgn0004043

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32367

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P98163

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P98163

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P98163

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004649

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32367/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004649

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004649

FlyMine - An integrated database for Drosophila genomics

FBgn0004649

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1372

MARRVEL_MODEL - MARRVEL (model organism gene)

32367

Linkouts

BioGRID - A database of protein and genetic interactions.

58737

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004649

DroID - A comprehensive database of gene and protein interactions.

FBgn0004649

DRSC - Results frm RNAi screens

FBgn0004649

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

yl_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004649

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004649

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1372

Flygut - An atlas of the Drosophila adult midgut

FBgn0004649

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031216

MIST (protein-protein) - An integrated Molecular Interaction Database

32367

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Transport of RCbl within the body

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Transport of RCbl within the body

References (101)

The following external sites may use different assemblies or annotations than FlyBase.

-0.29

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