Personal communication from: Kevin Mitchell
To: Bloomington Drosophila Stock Center
Dated: Feb 17, 1997
Background: Generation of the recombinant chromosome is described in
Neuron 17, 203-215 (1996).
Information communicated: In(1)N366.2LP363R has been generated by
recombination between In(1)N366.2 and In(1)P363. The new aberration
is deficient for 12E9-11;17C2 and has the inversion breakpoints
12F2-5;17C2. Another inversion, roughly In(1)2;10, is also present.
This chromosome is named Df(1)NP5.
Df(1)NP5 deletes Netrin-A (NetA), Netrin-B (NetB), and rutabaga (rut).
It does not delete mushroom body defect (mud) or yolkless (yl).
The lethality is rescued by Dp(1;f)LJ9 and Dp(1;f)LJ4.
Hemizygous embryos display a range of phenotypes in the CNS, most notably
a thinning or absence of the commissures in the ventral nerve cord. This
defect can be rescued by restoring midline expression of either Netrin gene.