FB2025_05 , released December 11, 2025
Gene: Dmel\Gyc76C
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General Information
Symbol
Dmel\Gyc76C
Species
D. melanogaster
Name
Guanylyl cyclase at 76C
Annotation Symbol
CG42636
Feature Type
protein_coding_gene
FlyBase ID
FBgn0266136
Gene Model Status
Current
Stock Availability
77 publicly available
Enzyme Name (EC)
guanylate cyclase (4.6.1.2)
Gene Summary
Guanylyl cyclase at 76C (Gyc76C) encodes a membrane-associated guanylate cyclase that catalyzes the conversion of GTP to the second messenger cGMP. It has roles in embryonic development (epithelia and muscle), axonal guidance, Malpighian tubule function, innate immunity and salt stress tolerance. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)76BDl, DrGC-1, gimli, drgc

Key Links
Genomic Location
Cytogenetic map
76C3-76C5
Sequence location
Recombination map
3-46
RefSeq locus
NT_037436 REGION:19750943..19793569
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables guanylate cyclase activity
inferred from direct assay
(Chak and Kolodkin, 2014, Overend et al., 2012, McNeil et al., 1995)
enables peptide receptor activity
inferred from physical interaction with FLYBASE:Nplp1; FB:FBgn0035092
(Overend et al., 2012)
enables semaphorin receptor binding
inferred from physical interaction with FLYBASE:PlexA; FB:FBgn0025741
(Chak and Kolodkin, 2014)
enables signaling receptor activity
inferred from direct assay
(McNeil et al., 1995)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(InterPro Project Members, 2004-)
enables guanylate cyclase activity
inferred from biological aspect of ancestor with PANTHER:PTN000229249
(GO Reference Genome Project, 2011-)
enables peptide receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000229249
(GO Reference Genome Project, 2011-)
enables phosphorus-oxygen lyase activity
inferred from electronic annotation with InterPro:IPR018297
(InterPro Project Members, 2004-)
NOT enables protein kinase activity
inferred from sequence or structural similarity with FLYBASE:EHR; FB:FBgn0036368
(Gene Ontology Curators, 2002-)
Biological Process (14 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from genetic interaction with FLYBASE:PlexA; FB:FBgn0025741
(Chak and Kolodkin, 2014)
involved_in axon midline choice point recognition
inferred from genetic interaction with FLYBASE:Sema1a; FB:FBgn0011259
(Ayoob et al., 2004)
inferred from genetic interaction with FLYBASE:PlexA; FB:FBgn0025741
(Ayoob et al., 2004)
involved_in defense response to Gram-positive bacterium
inferred from mutant phenotype
(Kanoh et al., 2021)
involved_in extracellular matrix organization
inferred from mutant phenotype
(Schleede and Blair, 2015)
involved_in larval somatic muscle development
inferred from mutant phenotype
(Patel et al., 2012)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Chak and Kolodkin, 2014, Ayoob et al., 2004)
involved_in primary branching, open tracheal system
inferred from mutant phenotype
(Myat et al., 2005)
involved_in receptor guanylyl cyclase signaling pathway
inferred from mutant phenotype
(Kanoh et al., 2021)
inferred from direct assay
(Overend et al., 2012)
involved_in regulation of BMP signaling pathway
inferred from mutant phenotype
(Schleede and Blair, 2015)
involved_in response to salt stress
inferred from mutant phenotype
(Overend et al., 2012)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Patel and Myat, 2013)
inferred from genetic interaction with FLYBASE:LanB2; FB:FBgn0267348
(Patel and Myat, 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cGMP biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000229249
(GO Reference Genome Project, 2011-)
involved_in cyclic nucleotide biosynthetic process
inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297
(InterPro Project Members, 2004-)
involved_in intracellular signal transduction
inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297
(InterPro Project Members, 2004-)
involved_in receptor guanylyl cyclase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000229249
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Overend et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000229249
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (Q7JQ32)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
guanylate cyclase activity
GTP = 3',5'-cyclic GMP + diphosphate (4.6.1.2)
RHEA 13665:
Summaries
Gene Snapshot
Guanylyl cyclase at 76C (Gyc76C) encodes a membrane-associated guanylate cyclase that catalyzes the conversion of GTP to the second messenger cGMP. It has roles in embryonic development (epithelia and muscle), axonal guidance, Malpighian tubule function, innate immunity and salt stress tolerance. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
RECEPTOR GUANYLATE CYCLASES -
Receptor guanylate cyclases are single-pass transmembrane receptors with an extracellular ligand-binding domain and intracellular guanylate cyclase and pseudokinase kinase domains. Ligand binding results in the activation of the intracellular guanylyl cyclase domain and the production of cyclic GMP from GTP. The kinase domain may have a regulatory role and may bind ATP. (Adapted from FBrf0228387).
Protein Function (UniProtKB)
Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24284209). Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity (PubMed:15282266, PubMed:24284209). Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscles and for localization of integrin beta-ps at developing dorsal muscle myotendinous junctions (PubMed:23213443). Required for invagination, migration and lumen shape of the embryonic salivary gland by regulating the localization of the integrin-binding protein rhea/Talin to the visceral mesoderm surrounding the gland and maintaining the laminin matrix (PubMed:23862019). Required in the developing wing to regulate extracellular matrix (ECM) organization by activating the cGMP-dependent protein kinase For which represses the activity of matrix metalloproteases such as Mmp2 and decreases ECM matrix reorganization (PubMed:26440503).
(UniProt, Q7JQ32)
Summary (Interactive Fly)

cGMP production - receptor-type protein possessing a single transmembrane domain - required for Semaphorin-1a-Plexin A directed repulsive axon guidance

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Gyc76C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7JQ32)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.48

Shares 5' UTR with downstream gene as a result of gene duplication.

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

A large (31.4 kb) polymorphic duplication flanked by Doc elements, contains the coding exons of Gyc76C and CG42637, which are identical in amino acid sequence and share 5' noncoding exons. (see FBrf0211329)

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gyc76C-RA
FBtr0302280
NM_001170002
6242
1525
Gyc76C-RB
FBtr0302281
NM_001170003
6200
1525
Gyc76C-RC
FBtr0302282
NM_001170004
6363
1525
Gyc76C-RD
FBtr0333879
NM_001275134
6226
1525
Additional Transcript Data and Comments
Reported size (kB)

7.0 (northern blot)

(Liu et al., 1995, McNeil et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gyc76C-PA
FBpp0291486
170.5
1525
7.24
Q7JQ32
NP_001163473
ACZ94744
Gyc76C-PB
FBpp0291487
170.5
1525
7.24
Q7JQ32
NP_001163474
ACZ94745
Gyc76C-PC
FBpp0291488
170.5
1525
7.24
Q7JQ32
NP_001163475
ACZ94746
Gyc76C-PD
FBpp0306011
170.5
1525
7.24
Q7JQ32
NP_001262063
AGB94756
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1525 aa isoforms: Gyc76C-PA, Gyc76C-PB, Gyc76C-PC, Gyc76C-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

1525 (aa)

(Liu et al., 1995, McNeil et al., 1995)
Comments
External Data
Domain

The guanylate cyclase domain is required for Sema-1a-mediated axon repulsion.

The protein kinase domain is predicted to be catalytically inactive.

(UniProt, Q7JQ32)
Subunit Structure (UniProtKB)

Interacts with the semaphorin 1A receptor PlexA; PlexA enhances Gyc76C catalytic activity. Interacts with the PDZ domain-containing protein kermit; kermit increases cell surface expression of Gyc76C.

(UniProt, Q7JQ32)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gyc76C using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Overend et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gyc76C in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 44 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gyc76C
Transgenic constructs containing regulatory region of Gyc76C
Aberrations (Deficiencies and Duplications) ( 64 )
Inferred from experimentation ( 64 )
Gene disrupted in
Df(3L)5126
(Ayoob et al., 2004)
Df(3L)A23
(Cooper et al., 2010)
Df(3L)ash1A16
(Cooper et al., 2010)
Df(3L)ED228
(Cooper et al., 2010)
Df(3L)Exel6135
(Cooper et al., 2010, Ryder, 2004.4.26)
Df(3L)Exel9007
(Cooper et al., 2010)
Df(3L)Exel9008
(Cooper et al., 2010)
Df(3L)Exel9009
(Cooper et al., 2010)
Df(3L)Exel9061
(Schleede and Blair, 2015, Patel et al., 2012)
Df(3L)fln1
(Patel et al., 2012)
Df(3L)kto2
(Patel et al., 2012, Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005)
Df(3L)XS533
(Patel et al., 2012, Cooper et al., 2010)
Df(3L)XS543
(Cooper et al., 2010)
Df(3L)XS572
(Cooper et al., 2010)
Df(3L)XS705
(Cooper et al., 2010)
Df(3L)XS917
(Cooper et al., 2010)
Df(3L)XS2182
(Cooper et al., 2010)
Gene not disrupted in
Df(3L)25-21
(Cooper et al., 2010)
Df(3L)66C-G28
(Myat et al., 2005)
Df(3L)AC1
(Myat et al., 2005)
Df(3L)Ar14-8
(Myat et al., 2005)
Df(3L)brm11
(Myat et al., 2005)
Df(3L)BSC1
(Bloomington Drosophila Stock Center, 1999.2.23)
Df(3L)BSC2
(Cooper et al., 2010, Bloomington Drosophila Stock Center, 1999.2.23)
Df(3L)BSC20
(Cooper et al., 2010)
Df(3L)BSC417
(Cooper et al., 2010)
Df(3L)BSC445
(Cooper et al., 2010)
Df(3L)ED4799
(Cooper et al., 2010)
Df(3L)ED4858
(Patel et al., 2012, Cooper et al., 2010)
Df(3L)emc-E12
(Myat et al., 2005)
Df(3L)Exel9011
(Cooper et al., 2010)
Df(3L)Exel9045
(Cooper et al., 2010)
Df(3L)Exel9046
(Cooper et al., 2010)
Df(3L)fz-GF3b
(Myat et al., 2005)
Df(3L)fz-M21
(Myat et al., 2005)
Df(3L)GN24
(Myat et al., 2005)
Df(3L)hry-i22
(Myat et al., 2005)
Df(3L)kto2
(Myat et al., 2005)
Df(3L)kto22
(Cooper et al., 2010)
Df(3L)M21
(Myat et al., 2005)
Df(3L)ME107
(Myat et al., 2005)
Df(3L)pbl-X1
(Myat et al., 2005)
Df(3L)Pc-2q
(Myat et al., 2005)
Df(3L)pipeA13
(Cooper et al., 2010)
Df(3L)R-G7
(Myat et al., 2005)
Df(3L)ri-79c
(Myat et al., 2005)
Df(3L)st-k3
(Myat et al., 2005)
Df(3L)vin5
(Myat et al., 2005)
Df(3L)vin7
(Myat et al., 2005)
Df(3L)VW3
(Myat et al., 2005)
Df(3L)XS411
(Cooper et al., 2010)
Df(3L)XS533
(Myat et al., 2005)
Df(3L)ZN47
(Myat et al., 2005)
Df(3R)3450
(Myat et al., 2005)
Df(3R)Antp17
(Myat et al., 2005)
Df(3R)Delta-BX12
(Myat et al., 2005)
Df(3R)Dr-rv1
(Myat et al., 2005)
Df(3R)e1025-14
(Myat et al., 2005)
Df(3R)Espl3
(Myat et al., 2005)
Df(3R)mbc-30
(Myat et al., 2005)
Df(3R)mbc-R1
(Myat et al., 2005)
Df(3R)M-Kx1
(Myat et al., 2005)
Df(3R)p-XT103
(Myat et al., 2005)
Df(3R)Scr
(Myat et al., 2005)
Tp(3;2)by62
(Myat et al., 2005)
Gene partially disrupted in
Df(3L)HLH106189
(Kunte et al., 2006)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(3L)Exel9061)
lethal (with Df(3L)XS533)
lethal (with Gyc76C3L043)
lethal (with Gyc76CKG03723ex33)
lethal | recessive
lethal | somatic clone
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile
Other Phenotypes
Allele
abnormal cell migration
abnormal cell migration (with Gyc76C2388)
abnormal cell migration (with Gyc76CKG03723ex173)
abnormal immune response | adult stage
abnormal immune response | adult stage, with Scer\GAL4Cg.PA
abnormal immune response | larval stage, with Scer\GAL4c564
abnormal immune response | larval stage, with Scer\GAL4Cg.PA
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy (with Df(3L)5126)
abnormal neuroanatomy (with Gyc76CKG03723ex33)
abnormal neuroanatomy (with Gyc76CKG03723ex173)
abnormal neuroanatomy | embryonic stage | semidominant
abnormal neuroanatomy | semidominant
abnormal osmotic stress response, with Scer\GAL4Uro.PT
decreased occurrence of cell division | third instar larval stage | conditional
increased cell number | third instar larval stage, with Scer\GAL4Cg.PA
increased mortality | adult stage | conditional
increased mortality | adult stage | conditional, with Scer\GAL4Cg.PA
increased mortality | larval stage | conditional, with Scer\GAL4c564
increased mortality | larval stage | conditional, with Scer\GAL4Cg.PA
increased occurrence of cell division | third instar larval stage, with Scer\GAL4Cg.PA
increased occurrence of cell division | third instar larval stage, with Scer\GAL4srp.D.cCa
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4A9
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4hh.PU
visible | adult stage | somatic clone
visible | somatic clone
Phenotype manifest in
Allele
axon & RP3 neuron, with Scer\GAL4elav.PLu
axon | embryonic stage
chaeta | increased number, with Scer\GAL4pnr-MD237
embryonic/larval hemocyte | increased number | third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4srp.D.cCa
embryonic/larval hemocyte | third instar larval stage | conditional
embryonic/larval salivary gland
embryonic/larval salivary gland (with Gyc76C2388)
embryonic/larval salivary gland (with Gyc76CKG03723ex173)
extracellular matrix | pupal stage, with Scer\GAL4hh.PU
larval abdominal segmental nerve
larval abdominal segmental nerve, with Scer\GAL4elav.PLu
larval abdominal segmental nerve (with Df(3L)5126)
larval abdominal segmental nerve (with Gyc76CKG03723ex33)
larval abdominal segmental nerve (with Gyc76CKG03723ex173)
larval intersegmental nerve
larval intersegmental nerve, with Scer\GAL4elav.PLu
larval intersegmental nerve (with Df(3L)5126)
larval intersegmental nerve (with Gyc76CKG03723ex33)
larval intersegmental nerve (with Gyc76CKG03723ex173)
larval intersegmental nerve branch ISNb of A1-7 | embryonic stage
larval segmental nerve branch SNa of A1-7 | embryonic stage
larval somatic muscle cell
larval somatic muscle cell (with Df(3L)fln1)
larval somatic muscle cell (with Df(3L)XS533)
larval somatic muscle cell (with Gyc76C2388)
larval somatic muscle cell (with Gyc76CKG03723ex173)
posterior crossvein, with Scer\GAL4A9
posterior crossvein, with Scer\GAL4hh.PU
posterior crossvein | somatic clone
presumptive embryonic/larval tracheal system
presumptive wing vein | pupal stage, with Scer\GAL4hh.PU
salivary gland (with Df(3L)Exel9061)
salivary gland (with Df(3L)fln1)
salivary gland (with Df(3L)kto2)
salivary gland (with Df(3L)XS533)
tracheal dorsal trunk primordium
visceral tracheal branch primordium
wing blade, with Scer\GAL4A9
wing blade, with Scer\GAL4en.PU
wing blade, with Scer\GAL4hh.PU
wing blade | somatic clone
wing disc | pupal stage, with Scer\GAL4hh.PU
wing vein, with Scer\GAL4A9
wing vein, with Scer\GAL4en.PU
wing vein, with Scer\GAL4hh.PU
wing vein L5, with Scer\GAL4hh.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (36)
Hsap\GUCY2D
3 of 14
Yes
No
Hsap\GUCY2F
3 of 14
Yes
No
Hsap\NPR1
3 of 14
Yes
No
Hsap\NPR2
3 of 14
Yes
No
Hsap\ADCY1
2 of 14
No
No
Hsap\ADCY2
2 of 14
No
No
1  
Hsap\ADCY3
2 of 14
No
No
Hsap\ADCY4
2 of 14
No
No
Hsap\ADCY5
2 of 14
No
No
1  
Hsap\ADCY6
2 of 14
No
No
Hsap\ADCY8
2 of 14
No
No
Hsap\ADCY9
2 of 14
No
No
Hsap\GUCY1A1
2 of 14
No
No
1  
Hsap\GUCY1A2
2 of 14
No
No
Hsap\GUCY1B1
2 of 14
No
No
Hsap\GUCY2C
2 of 14
No
No
Hsap\NPR3
2 of 14
No
No
Hsap\ACVR1C
1 of 14
No
No
Hsap\ADCY10
1 of 14
No
Yes
Hsap\EPHB2
1 of 14
No
No
1  
Hsap\ERBB4
1 of 14
No
No
Hsap\GABBR1
1 of 14
No
No
Hsap\GABBR2
1 of 14
No
No
Hsap\GRIN1
1 of 14
No
No
Hsap\GRM1
1 of 14
No
No
1  
Hsap\GRM5
1 of 14
No
No
Hsap\GUCY1B2
1 of 14
No
No
Hsap\JAK3
1 of 14
No
No
Hsap\LRRK2
1 of 14
No
No
50  
Hsap\MERTK
1 of 14
No
Yes
Hsap\PHLPP1
1 of 14
No
No
Hsap\PHLPP2
1 of 14
No
No
Hsap\PTK7
1 of 14
No
No
1  
Hsap\ROR1
1 of 14
No
No
Hsap\TEK
1 of 14
No
No
Hsap\TESK2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (28)
Rnor\Gucy2g
4 of 14
Yes
No
Rnor\Npr1
3 of 14
No
No
1  
Rnor\Npr2
3 of 14
No
No
Rnor\Adcy2
2 of 14
No
No
Rnor\Adcy3
2 of 14
No
No
Rnor\Adcy5
2 of 14
No
No
Rnor\Adcy8
2 of 14
No
No
Rnor\Gucy1a1
2 of 14
No
No
Rnor\Gucy1a2
2 of 14
No
No
Rnor\Gucy1b1
2 of 14
No
No
Rnor\Gucy1b2
2 of 14
No
No
Rnor\Gucy2c
2 of 14
No
No
Rnor\Gucy2d
2 of 14
No
No
Rnor\Gucy2e
2 of 14
No
No
Rnor\Gucy2f
2 of 14
No
No
Rnor\Npr3
2 of 14
No
No
Rnor\Adcy1
1 of 14
No
No
Rnor\Adcy4
1 of 14
No
No
Rnor\Adcy6
1 of 14
No
No
Rnor\Adcy7
1 of 14
No
No
Rnor\Adcy9
1 of 14
No
No
Rnor\Gabbr1
1 of 14
No
No
Rnor\Gabbr2
1 of 14
No
No
Rnor\Grin1
1 of 14
No
No
Rnor\Grm1
1 of 14
No
No
Rnor\Grm5
1 of 14
No
No
Rnor\Phlpp1
1 of 14
No
No
Rnor\Phlpp2
1 of 14
No
No
Mus musculus (laboratory mouse) (29)
Mmus\Gucy2g
4 of 14
Yes
No
Mmus\Npr1
3 of 14
No
No
Mmus\Npr2
3 of 14
No
No
Mmus\Adcy1
2 of 14
No
No
Mmus\Adcy2
2 of 14
No
No
Mmus\Adcy3
2 of 14
No
No
Mmus\Adcy5
2 of 14
No
No
Mmus\Adcy6
2 of 14
No
No
Mmus\Adcy8
2 of 14
No
No
Mmus\Adcy9
2 of 14
No
No
Mmus\Gucy1a1
2 of 14
No
No
Mmus\Gucy1a2
2 of 14
No
No
Mmus\Gucy1b1
2 of 14
No
No
Mmus\Gucy1b2
2 of 14
No
No
Mmus\Gucy2c
2 of 14
No
No
Mmus\Gucy2e
2 of 14
No
No
Mmus\Gucy2f
2 of 14
No
No
Mmus\Npr3
2 of 14
No
No
Mmus\Adcy4
1 of 14
No
No
Mmus\Adcy7
1 of 14
No
No
Mmus\Adcy10
1 of 14
No
Yes
Mmus\Gabbr1
1 of 14
No
No
Mmus\Gabbr2
1 of 14
No
No
Mmus\Grin1
1 of 14
No
No
Mmus\Grm1
1 of 14
No
No
Mmus\Grm5
1 of 14
No
No
Mmus\Gucy2d
1 of 14
No
No
Mmus\Phlpp1
1 of 14
No
No
Mmus\Phlpp2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (22)
Xtro\adcy1
1 of 13
Yes
No
Xtro\adcy4
1 of 13
Yes
No
Xtro\adcy7
1 of 13
Yes
No
Xtro\avp
1 of 13
Yes
Yes
Xtro\epha4
1 of 13
Yes
No
Xtro\erbb4
1 of 13
Yes
No
Xtro\gabbr1
1 of 13
Yes
No
Xtro\gabbr2
1 of 13
Yes
No
Xtro\grm1
1 of 13
Yes
No
Xtro\grm5
1 of 13
Yes
No
Xtro\grn
1 of 13
Yes
Yes
Xtro\gucy1a1
1 of 13
Yes
No
Xtro\gucy1a2
1 of 13
Yes
No
Xtro\gucy1b1
1 of 13
Yes
No
Xtro\gucy1b2
1 of 13
Yes
No
Xtro\gucy2d
1 of 13
Yes
No
Xtro\gucy2f
1 of 13
Yes
No
Xtro\LOC100489435
1 of 13
Yes
No
Xtro\map3k20
1 of 13
Yes
No
Xtro\npr1
1 of 13
Yes
No
Xtro\npr3
1 of 13
Yes
No
Xtro\tesk2
1 of 13
Yes
No
Danio rerio (Zebrafish) (41)
Drer\gucy2g
4 of 14
Yes
No
Drer\si:dkey-37g12.1
4 of 14
Yes
No
Drer\npr1a
3 of 14
No
No
Drer\npr1b
3 of 14
No
No
Drer\adcy1a
2 of 14
No
No
Drer\adcy2a
2 of 14
No
No
Drer\adcy5
2 of 14
No
No
Drer\adcy6b
2 of 14
No
No
Drer\gc2
2 of 14
No
No
Drer\gucy1a1
2 of 14
No
No
Drer\gucy1a2
2 of 14
No
No
Drer\gucy1b1
2 of 14
No
No
Drer\gucy1b2
2 of 14
No
No
Drer\gucy2f
2 of 14
No
No
Drer\npr2
2 of 14
No
No
Drer\npr3
2 of 14
No
No
Drer\si:ch211-132f19.7
2 of 14
No
No
Drer\si:dkey-206f10.1
2 of 14
No
No
Drer\adcy1b
1 of 14
No
No
Drer\adcy2b
1 of 14
No
No
Drer\adcy3a
1 of 14
No
No
Drer\adcy3b
1 of 14
No
No
Drer\adcy6a
1 of 14
No
No
Drer\adcy7
1 of 14
No
No
Drer\adcy8
1 of 14
No
No
Drer\bmpr1aa
1 of 14
No
No
Drer\epha5
1 of 14
No
No
Drer\gabbr1a
1 of 14
No
No
Drer\gabbr1b
1 of 14
No
No
Drer\gabbr2
1 of 14
No
No
Drer\grm1a
1 of 14
No
No
Drer\grm1b
1 of 14
No
No
Drer\grm5a
1 of 14
No
No
Drer\grm5b
1 of 14
No
No
Drer\grm8a
1 of 14
No
No
Drer\gucy2ca
1 of 14
No
No
Drer\gucy2cb
1 of 14
No
No
Drer\gucy2d
1 of 14
No
No
Drer\LOC100333871
1 of 14
No
No
Drer\ret
1 of 14
No
No
Drer\tgfbr2a
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (47)
Cele\gcy-12
13 of 14
Yes
Yes
Cele\gcy-1
4 of 14
No
Yes
Cele\gcy-2
4 of 14
No
No
Cele\gcy-3
4 of 14
No
Yes
Cele\gcy-4
4 of 14
No
No
Cele\gcy-13
4 of 14
No
Yes
Cele\gcy-14
4 of 14
No
Yes
Cele\gcy-17
4 of 14
No
No
Cele\gcy-20
4 of 14
No
No
Cele\daf-11
3 of 14
No
Yes
Cele\gcy-5
3 of 14
No
No
Cele\gcy-6
3 of 14
No
No
Cele\gcy-7
3 of 14
No
No
Cele\gcy-8
3 of 14
No
No
Cele\gcy-9
3 of 14
No
No
Cele\gcy-11
3 of 14
No
No
Cele\gcy-15
3 of 14
No
No
Cele\gcy-18
3 of 14
No
No
Cele\gcy-19
3 of 14
No
No
Cele\gcy-21
3 of 14
No
No
Cele\gcy-22
3 of 14
No
No
Cele\gcy-23
3 of 14
No
No
Cele\gcy-25
3 of 14
No
Yes
Cele\gcy-28
3 of 14
No
No
Cele\gcy-29
3 of 14
No
Yes
Cele\acy-1
2 of 14
No
No
Cele\acy-4
2 of 14
No
No
Cele\gcy-32
2 of 14
No
No
Cele\gcy-34
2 of 14
No
No
Cele\gcy-36
2 of 14
No
No
Cele\gcy-37
2 of 14
No
No
Cele\acy-2
1 of 14
No
No
Cele\acy-3
1 of 14
No
No
Cele\dlk-1
1 of 14
No
No
Cele\flr-4
1 of 14
No
Yes
Cele\gbb-1
1 of 14
No
No
Cele\gbb-2
1 of 14
No
No
Cele\gcy-27
1 of 14
No
No
Cele\gcy-31
1 of 14
No
No
Cele\gcy-33
1 of 14
No
No
Cele\gcy-35
1 of 14
No
No
Cele\kin-24
1 of 14
No
No
Cele\let-23
1 of 14
No
No
Cele\odr-1
1 of 14
No
No
Cele\phlp-2
1 of 14
No
No
Cele\R09D1.13
1 of 14
No
No
Cele\trk-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (31)
Agam\AgaP_AGAP012163
11 of 12
Yes
Yes
Agam\AgaP_AGAP008848
4 of 12
No
No
Agam\AgaP_AGAP012161
4 of 12
No
No
Agam\AgaP_AGAP000090
2 of 12
No
No
Agam\AgaP_AGAP000214
2 of 12
No
No
Agam\AgaP_AGAP000727
2 of 12
No
No
Agam\AgaP_AGAP001985
2 of 12
No
No
Agam\AgaP_AGAP002233
2 of 12
No
No
Agam\AgaP_AGAP002262
2 of 12
No
No
Agam\AgaP_AGAP002998
2 of 12
No
No
Agam\AgaP_AGAP003283
2 of 12
No
No
Agam\AgaP_AGAP003284
2 of 12
No
No
Agam\AgaP_AGAP004554
2 of 12
No
No
Agam\AgaP_AGAP004555
2 of 12
No
No
Agam\AgaP_AGAP004564
2 of 12
No
No
Agam\AgaP_AGAP007631
2 of 12
No
No
Agam\AgaP_AGAP008691
2 of 12
No
No
Agam\AgaP_AGAP009315
2 of 12
No
No
Agam\AgaP_AGAP010436
2 of 12
No
No
Agam\AgaP_AGAP012597
2 of 12
No
No
Agam\AgaP_AGAP000280
1 of 12
No
No
Agam\AgaP_AGAP004239
1 of 12
No
No
Agam\AgaP_AGAP006219
1 of 12
No
No
Agam\AgaP_AGAP008683
1 of 12
No
Yes
Agam\AgaP_AGAP009087
1 of 12
No
No
Agam\AgaP_AGAP012805
1 of 12
No
No
Agam\AgaP_AGAP012965
1 of 12
No
No
Agam\EGFR
1 of 12
No
No
Agam\GPRGBB1
1 of 12
No
No
Agam\GPRGBB2
1 of 12
No
No
Agam\GPRGBB3
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (53)
Atha\GLR2
2 of 13
Yes
No
Atha\GLUR2
2 of 13
Yes
No
Atha\ANX2
1 of 13
No
No
Atha\APK2A
1 of 13
No
No
Atha\AT1G06840
1 of 13
No
No
Atha\AT1G07650
1 of 13
No
No
Atha\AT1G17910
1 of 13
No
Yes
Atha\AT1G18160
1 of 13
No
No
Atha\AT1G29720
1 of 13
No
No
Atha\AT1G49730
1 of 13
No
No
Atha\AT1G51805
1 of 13
No
No
Atha\AT1G51850
1 of 13
No
Yes
Atha\AT1G56140
1 of 13
No
No
Atha\AT1G67890
1 of 13
No
No
Atha\AT1G73660
1 of 13
No
No
Atha\AT1G74360
1 of 13
No
Yes
Atha\AT1G78530
1 of 13
No
No
Atha\AT1G80640
1 of 13
No
Yes
Atha\AT2G16250
1 of 13
No
Yes
Atha\AT2G28940
1 of 13
No
No
Atha\AT2G43700
1 of 13
No
Yes
Atha\AT3G45420
1 of 13
No
Yes
Atha\AT3G50730
1 of 13
No
No
Atha\AT3G53590
1 of 13
No
No
Atha\AT3G53810
1 of 13
No
No
Atha\AT3G55550
1 of 13
No
No
Atha\AT4G28350
1 of 13
No
Yes
Atha\AT5G03140
1 of 13
No
Yes
Atha\AT5G10530
1 of 13
No
No
Atha\AT5G24010
1 of 13
No
No
Atha\AT5G48940
1 of 13
No
Yes
Atha\AT5G63930
1 of 13
No
Yes
Atha\CIPK9
1 of 13
No
No
Atha\CR4
1 of 13
No
Yes
Atha\CRK3
1 of 13
No
Yes
Atha\CRK11
1 of 13
No
No
Atha\CRK24
1 of 13
No
No
Atha\CRK27
1 of 13
No
No
Atha\ERL1
1 of 13
No
No
Atha\GLR3.3
1 of 13
No
No
Atha\GLR3.4
1 of 13
No
No
Atha\GLR3.5
1 of 13
No
No
Atha\GLR3.6
1 of 13
No
No
Atha\HSL1
1 of 13
No
No
Atha\IKU2
1 of 13
No
No
Atha\IOS1
1 of 13
No
No
Atha\LECRKA4.2
1 of 13
No
Yes
Atha\MAPKKK9
1 of 13
No
No
Atha\MRLK
1 of 13
No
Yes
Atha\NCRK
1 of 13
No
Yes
Atha\RK2
1 of 13
No
Yes
Atha\RK3
1 of 13
No
Yes
Atha\RKF1
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CYR1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cyr1
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gyc76C. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (37)
Gyc32E
9 of 13
EHR
8 of 13
CG31183
6 of 13
CG3216
4 of 13
CG42637
4 of 13
Gucy2d
4 of 13
Ac3
3 of 13
Ac13E
3 of 13
Ac76E
3 of 13
CG33958
3 of 13
CG43373
3 of 13
Gyc88E
3 of 13
Gyc89Da
3 of 13
Gyc89Db
3 of 13
Gycα99B
3 of 13
Gycβ100B
3 of 13
Ac78C
2 of 13
ACXA
2 of 13
ACXB
2 of 13
ACXC
2 of 13
ACXD
2 of 13
ACXE
2 of 13
Adcy1
2 of 13
CG14877
2 of 13
CG32301
2 of 13
CG32305
2 of 13
Egfr
1 of 13
Fak
1 of 13
GABA-B-R1
1 of 13
GABA-B-R2
1 of 13
KP78b
1 of 13
Nmdar1
1 of 13
Phlpp
1 of 13
sax
1 of 13
sev
1 of 13
tkv
1 of 13
wnd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 5 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GUCY2D; guanylate cyclase 2D, retinal
    3 of 14
    600179
    GUCY2F; guanylate cyclase 2F, retinal
    3 of 14
    300041
        NPR1; natriuretic peptide receptor 1
        3 of 14
        108960
            NPR2; natriuretic peptide receptor 2
            3 of 14
            108961
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Gyc76C
            suppressible
            cv-2|cv|sog
            (Schleede and Blair, 2015)
            Gyc76C
            enhanceable
            LanB2
            (Patel and Myat, 2013)
            Gyc76C
            suppressible
            Mmp2
            (Schleede and Blair, 2015)
            Gyc76C
            suppressible
            Ras85D
            (Iwashita et al., 2020)
            Gyc76C
            enhanceable
            Sema1a
            (Ayoob et al., 2004)
            Gyc76C
            suppressible
            Timp
            (Schleede and Blair, 2015)
            Gyc76C
            suppressible
            trol
            (Schleede and Blair, 2015)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            dpp
            suppressible
            Gyc76C
            (Schleede and Blair, 2015)
            kermit
            enhanceable
            Gyc76C
            (Chak and Kolodkin, 2014)
            LanB2
            enhanceable
            Gyc76C
            (Patel and Myat, 2013)
            modSP
            suppressible
            Gyc76C
            (Iwashita et al., 2020)
            PlexA
            suppressible
            Gyc76C
            (Ayoob et al., 2004)
            Sema1a
            suppressible
            Gyc76C
            (Chak and Kolodkin, 2014)
            sog
            suppressible
            Gyc76C
            (Schleede and Blair, 2015)
            Tl
            enhanceable
            Gyc76C
            (Kanoh et al., 2021)
            trol
            suppressible
            Gyc76C
            (Schleede and Blair, 2015)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with the semaphorin 1A receptor PlexA; PlexA enhances Gyc76C catalytic activity. Interacts with the PDZ domain-containing protein kermit; kermit increases cell surface expression of Gyc76C.
            (UniProt, Q7JQ32 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-46
            Cytogenetic map
            76C3-76C5
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            76C3-76C5
            Limits computationally determined from genome sequence between P{lacW}l(3)L3809L3809 and P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            76C-76C
            (Liu, 1995.3.27)
            76C-76C
            (determined by in situ hybridisation)
            (Liu et al., 1995, McNeil et al., 1995)
            Experimentally Determined Recombination Data
            Location

            3-46

            (FlyBase, 2016)

            3-43.1

            (Comeron et al., 2012)

            3-

            (Liu, 1995.3.27)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (77)
            Genomic Clones (16)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (32)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Gyc76C is required for the accumulation of a laminin matrix surrounding the migrating salivary gland.

                  (Patel and Myat, 2013)

                  Gyc76C is required for proper patterning of the somatic muscles in the embryo and for localisation of mys protein at the developing myotendinous junctions of the DO1/DA1 muscles.

                  (Patel et al., 2012)

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  Area matching Drosophila EST AA392994. This EST matches Drosophila Guanylate cyclase gene, Acc. No. U23485.

                  (Davies, 2001.3.15)

                  Gyc76C has been cloned and sequenced. It encodes a receptor-type guanylate cyclase.

                  (Liu et al., 1995)

                  Isolated using cDNA fragments encoding the kinase-like and cyclase domains from the rat GC-A, GC-B and GC-C genes.

                  (Liu et al., 1995)

                  A Gyc76C cDNA has been cloned and sequenced. Gyc76C encodes a receptor guanylyl cyclase.

                  (McNeil et al., 1995)

                  Isolated from a Drosophila adult head cDNA library, using sequences encoding the cyclase catalytic domain of rat GC-A as a probe, under low stringency conditions.

                  (McNeil et al., 1995)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: Gyc76C l(3)L0090

                  (Ayoob et al., 2004)

                  Source for merge of: Gyc76C l(3)76BDl

                  (Cook, 2008.12.1)

                  Source for merge of: Gyc76C CG32215

                  (FlyBase, 1996-)

                  Source for merge of: Gyc76C gim

                  (Patel et al., 2012)
                  Additional comments

                  The 76BD region of the iso-1 strain used to sequence the D. melanogaster genome contains a duplication that is flanked by Doc elements. This duplication has not been found in any of the other strains tested (Oregon R, Canton-S and a red1 e4 strain). The presence of the middle Doc element that forms the junction between the two duplicated segments in the annotated genome could not be confirmed in the lab copy of the iso-1 strain. The duplication may thus have arisen after the iso-1 strain was constructed in the lab in 1986 (see FBrf0072686) but before the BAC and WGS genomic libraries used to sequence the genome were made in 1998 and 1999 respectively. The duplication in the annotated iso-1 strain is 31.4kb and involves three transcription units. Two of the transcription units are completely duplicated (Trpml/CG42638 and CG42529/ms(3)76Ca pairs), while only the coding exons of the third gene are duplicated, with several non-coding exons proximal to and outside of the tandem duplication (this pair corresponds to Gyc76C (CG42636) and CG42637).

                  (Cooper et al., 2010)

                  The release 5 genome sequence has been assembled with a duplication of 26.68kb on chromosome arm 3L (the two copies of the duplication are at coordinates 19,706,343..19,733,031 and 19,737,759..19,764,445). The duplication is a polymorphic variant that is present in the sequenced strain, but does not exist in other D.melanogaster strains. The duplicated region contains coding sequences, such that duplicated copies of these coding regions exist in the release 5 genome annotation. The order of the duplicated segments is Doc{}1052--duplicated copy 1 (CG8743 CG42637 CG42529)--duplicated copy 2 (CG42638 CG42636 CG14101)--Doc{}1053--(5'UTR sequences of CG42636). The annotations CG8743 (trpml) and CG42638 are sequence-identical, and the annotations CG42529 and CG14101 are sequence-identical. In addition, the coding sequence (but not untranslated sequences) of the CG42636 annotation (Gyc76C) are duplicated, with the second copy of the coding sequences annotated as CG42637.

                  (FlyBase, 1996-)

                  Source for merge of Gyc76C CG32215 was sequence comparison ( date:030210 ).

                  (FlyBase, 1996-)
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                  External Crossreferences and Linkouts ( 65 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (86)