FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Timp
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General Information
Symbol
Dmel\Timp
Species
D. melanogaster
Name
Tissue inhibitor of metalloproteases
Annotation Symbol
CG6281
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025879
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
Tissue inhibitor of metalloproteases (Timp) encodes a member of a family of proteins that are able to block access to the catalytic domain of matrix metalloproteinases, thus regulating extracellular matrix remodelling. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)
All Summaries
Also Known As

tissue inhibitor of metalloproteinases, TIMP1

Key Links
Genomic Location
Cytogenetic map
86A1-86A1
Sequence location
Recombination map
3-49
RefSeq locus
NT_033777 REGION:10203875..10213007
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables metalloendopeptidase inhibitor activity
inferred from direct assay
(Wei et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables metalloendopeptidase inhibitor activity
inferred from sequence or structural similarity with UniProtKB:P01033
(Pohar et al., 1999)
inferred from electronic annotation with InterPro:IPR001820
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000931945
(GO Reference Genome Project, 2011-)
enables zinc ion binding
inferred from sequence or structural similarity with UniProtKB:P01033
(Gene Ontology Curators, 2002-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in basement membrane organization
inferred from mutant phenotype
(Guha et al., 2009)
involved_in cell adhesion
inferred from mutant phenotype
(Godenschwege et al., 2000)
involved_in delamination
inferred from mutant phenotype
(Kiger et al., 2007)
involved_in imaginal disc-derived wing expansion
inferred from mutant phenotype
(Kiger et al., 2007)
involved_in phototaxis
inferred from mutant phenotype
(Godenschwege et al., 2000)
involved_in tracheal outgrowth, open tracheal system
inferred from mutant phenotype
(Guha et al., 2009)
involved_in tracheal pit formation in open tracheal system
inferred from mutant phenotype
(Guha et al., 2009)
involved_in ventral cord development
inferred from mutant phenotype
(Meyer et al., 2014)
involved_in wing disc morphogenesis
inferred from mutant phenotype
(Kiger et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of membrane protein ectodomain proteolysis
inferred from biological aspect of ancestor with PANTHER:PTN000931945
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in dendrite
inferred from mutant phenotype
(Kuo et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in extracellular matrix
inferred from biological aspect of ancestor with PANTHER:PTN000931945
(GO Reference Genome Project, 2011-)
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000931945
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protease inhibitor I35 (TIMP) family. (Q9VH14)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Tissue inhibitor of metalloproteases (Timp) encodes a member of a family of proteins that are able to block access to the catalytic domain of matrix metalloproteinases, thus regulating extracellular matrix remodelling. [Date last reviewed: 2018-10-18]
Protein Function (UniProtKB)
Metalloproteinase inhibitor that acts on both matrix metalloproteinases Mmp1 and Mmp2 in vitro (PubMed:14567681). Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor (By similarity). Required for wing maturation which is the final step in morphogenesis of the adult fly (PubMed:16962574). Involved in the negative regulation of developmental tissue invasion for imaginal disk eversion during metamorphosis by inhibiting Mmp-mediated basement membrane (BM) degradation (PubMed:17301221). Required for oogenesis and for the long-term maintainance of germarial structure and shape in the adult ovaries. Required for maintaining composition and biophysical properties of the extracellular matrix (ECM), and for the normal organization and cyst production of the germline stem cell (GSC) niche (PubMed:26808525).
(UniProt, Q9VH14)
Summary (Interactive Fly)

metalloprotease inhibitor expressed in muscle - neuromuscular junction - limits BMP trans-synaptic signaling and the downstream synapse-to-nucleus signal transduction

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Timp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VH14)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Timp-RB
FBtr0082245
NM_169336
1591
210
Additional Transcript Data and Comments
Reported size (kB)

1.5 (northern blot)

(Pohar et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Timp-PB
FBpp0081722
24.0
210
9.84
Q9VH14
NP_731461
AAN13465
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

210 (aa)

(Pohar et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Timp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.66

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
larval foregut atrium
(Fisher et al., 2012)
embryonic labial sensory complex
(Fisher et al., 2012)
embryonic/larval dorsal vessel
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
salivary gland
(Lee et al., 2003)
Additional Descriptive Data

Transcript is detected in pupal salivary glands prior to the time of head eversion. The expression of this gene is repressed in this tissue at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.

(Lee et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in dendrite
inferred from mutant phenotype
(Kuo et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Timp in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Timp
Transgenic constructs containing regulatory region of Timp
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(3R)ED5472
(Pearson et al., 2016)
Df(3R)Exel6156
(Ryder, 2004.4.26)
Gene partially disrupted in
Df(3R)Timp-Syn28
(Godenschwege et al., 2000)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | pupal stage, with Scer\GAL4dpp.PH
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage, with Scer\GAL4Lsp2.PH
partially lethal - majority die
partially lethal - majority die | larval stage, with Scer\GAL4btl.PS
partially lethal - majority die | larval stage, with Scer\GAL4dpp.PH
partially lethal - majority die | pupal stage, with Scer\GAL4btl.PS
partially lethal - majority live
partially lethal - majority live | cold sensitive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
semi-fertile | cold sensitive
Other Phenotypes
Allele
abnormal cell shape | embryonic stage, with Scer\GAL4prd.RG1
abnormal developmental rate, with Scer\GAL4Lsp2.PH
abnormal locomotor behavior | third instar larval stage
abnormal neuroanatomy | embryonic stage, with Scer\GAL4elav.PU
abnormal neuroanatomy | embryonic stage, with Scer\GAL4repo.PU
abnormal neuroanatomy | pupal stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo.PU
abnormal phototaxis
decreased fecundity | female
decreased fecundity | female, with Scer\GAL4Act.PU
decreased fecundity | female, with Scer\GAL4GMR47A04
melanotic necrosis | adult stage
short lived
some die during embryonic stage
some die during larval stage
visible, with Scer\GAL4Lsp2.PH
visible, with Scer\GAL4Ubx-lac1-GAL4
visible | adult stage
visible | adult stage, with Scer\GAL4rn-GAL4-5
Phenotype manifest in
Allele
adult abdomen
adult tracheal air sac | third instar larval stage | heat sensitive, with Scer\GAL4btl.PS, Scer\GAL80ts.αTub84B
basement membrane | pupal stage, with Scer\GAL4Lsp2.PH
basement membrane | pupal stage, with Scer\GAL4Ubx-lac1-GAL4
dendritic arborizing neuron | P-stage, with Scer\GAL4ppk.PG
dorsal air sac, with Scer\GAL4btl.PS
dorsal air sac primordium | ectopic | third instar larval stage, with Scer\GAL4ap-md544
dorsal air sac primordium | third instar larval stage, with Scer\GAL4btl.PS
dorsal air sac primordium tip cell | third instar larval stage | heat sensitive, with Scer\GAL4btl.PS, Scer\GAL80ts.αTub84B
egg chamber, with Scer\GAL4Act.PU
embryonic/larval dorsal tracheal branch | third instar larval stage, with Scer\GAL4btl.PS
embryonic/larval lymph gland | larval stage, with Scer\GAL4Hand.Δ
embryonic/larval tracheal dorsal trunk, with Scer\GAL4btl.PS
embryonic/larval tracheal transverse connective | ectopic | third instar larval stage, with Scer\GAL4ap-md544
embryonic/larval tracheal transverse connective | third instar larval stage, with Scer\GAL4btl.PS
embryonic heart cardioblast, with Scer\GAL4prd.RG1
fat body, with Scer\GAL4Lsp2.PH
follicle cell, with Scer\GAL4Act.PU
haltere | adult stage, with Scer\GAL4rn-GAL4-5
haltere | P-stage, with Scer\GAL4rn-GAL4-5
heart primordium, with Scer\GAL4prd.RG1
larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4elav.PU
larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4repo.PU
larval segmental nerve branch SNa of A1-7, with Scer\GAL4elav.PU
larval segmental nerve branch SNa of A1-7, with Scer\GAL4repo.PU
larval ventral nerve cord | third instar larval stage, with Scer\GAL4repo.PU
leg | pupal stage, with Scer\GAL4Lsp2.PH
mesonotum | dorsal, with Scer\GAL4Lsp2.PH
neuromuscular junction | third instar larval stage
NMJ bouton | increased number | third instar larval stage
NMJ bouton | increased number | third instar larval stage, with Scer\GAL4da.G32
NMJ bouton | increased number | third instar larval stage, with Scer\GAL4how-24B
ovarian basement membrane | oogenesis stage S14, with Scer\GAL4GMR47A04
stalk follicle cell | increased number, with Scer\GAL4bab1-Agal4-5, Scer\GAL4ptc-559.1
tracheal section, with Scer\GAL4da.G32
wing
wing, with Scer\GAL4Lsp2.PH
wing, with Scer\GAL4rn-GAL4-5
wing | cold sensitive
wing | pupal stage, with Scer\GAL4Lsp2.PH
wing | pupal stage, with Scer\GAL4Ubx-lac1-GAL4
wing disc | P-stage, with Scer\GAL4rn-GAL4-5
wing disc | third instar larval stage, with Scer\GAL4ap-md544
wing disc | third instar larval stage, with Scer\GAL4btl.PS
wing vein | cold sensitive
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\TIMP3
13 of 14
Yes
Yes
1  
Hsap\TIMP2
12 of 14
No
Yes
1  
Hsap\TIMP1
10 of 14
No
Yes
Hsap\TIMP4
10 of 14
No
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Timp3
13 of 14
Yes
Yes
Rnor\Timp2
12 of 14
No
Yes
Rnor\Timp1
11 of 14
No
Yes
Rnor\Timp4
11 of 14
No
Yes
Mus musculus (laboratory mouse) (4)
Mmus\Timp2
12 of 14
Yes
Yes
Mmus\Timp3
12 of 14
Yes
Yes
Mmus\Timp1
11 of 14
No
Yes
Mmus\Timp4
10 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\timp2
10 of 13
Yes
Yes
Xtro\timp3
6 of 13
No
Yes
Xtro\timp-1
5 of 13
No
Yes
Xtro\timp4
5 of 13
No
Yes
Xtro\mrpl30
1 of 13
No
No
Xtro\rom1
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\timp2a
12 of 14
Yes
Yes
Drer\timp2b
11 of 14
No
Yes
Drer\timp4.1
11 of 14
No
Yes
Drer\timp4.2
10 of 14
No
Yes
Drer\timp4.3
9 of 14
No
Yes
Drer\LOC101885062
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\cri-2
5 of 14
Yes
Yes
Cele\timp-1
3 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP003319
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Timp. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TIMP3; TIMP metallopeptidase inhibitor 3
    model of  Sorsby's fundus dystrophy
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TIMP3; TIMP metallopeptidase inhibitor 3
    13 of 14
    188826
     
    TIMP2; TIMP metallopeptidase inhibitor 2
    12 of 14
    188825
         
        TIMP1; TIMP metallopeptidase inhibitor 1
        10 of 14
        305370
            TIMP4; TIMP metallopeptidase inhibitor 4
            10 of 14
            601915
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Timp
                suppressible
                Fmr1
                (Siller and Broadie, 2011)
                Timp
                suppressible
                gbb
                (Shilts and Broadie, 2017)
                Timp
                suppressible
                Mmp2
                (Wang et al., 2010)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                5-HT1B
                suppressible
                Timp
                (Liu et al., 2025)
                Fas2
                suppressible
                Timp
                (Miller et al., 2008)
                Fmr1
                suppressible
                Timp
                (Siller and Broadie, 2011)
                Gyc76C
                suppressible
                Timp
                (Schleede and Blair, 2015)
                Mmp1
                suppressible
                Timp
                (Page-McCaw et al., 2003)
                Mmp2
                suppressible
                Timp
                (Wang and Page-McCaw, 2014, Page-McCaw et al., 2003)
                PGRP-LE
                suppressible
                Timp
                (Winkler et al., 2025)
                Ras85D
                suppressible
                Timp
                (Bangi et al., 2012)
                Ras85D|scrib
                suppressible
                Timp|Reck
                (Srivastava et al., 2007)
                Ras85D|scrib
                suppressible
                Timp
                (Uhlirova and Bohmann, 2006)
                scrib|Ras85D
                enhanceable
                Timp
                (Uhlirova and Bohmann, 2006)
                sds22
                suppressible
                Timp
                (Jiang et al., 2011)
                Sox21a
                suppressible
                Timp
                (Zhai et al., 2015)
                Tak1
                suppressible
                Timp
                (Srivastava et al., 2007)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-49
                Cytogenetic map
                86A1-86A1
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                86A1-86A1
                Limits computationally determined from genome sequence between P{EP}Fmr1EP3517&P{PZ}tws02414 and P{PZ}jumu06439&P{lacW}l(3)j8B6j8B6
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                86A-86A
                (Buchner, 1998.8.12)
                Experimentally Determined Recombination Data
                Location

                3-49

                (FlyBase, 2016)

                3-46.6

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (17)
                Genomic Clones (10)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (20)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 

                monoclonal

                (Palmer et al., 2024)

                polyclonal

                (Dear et al., 2016)
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    Timp mutants suffer from a bloated gut and progressive dissolution of internal tissues and die prematurely.

                    (Godenschwege et al., 2000)
                    Relationship to Other Genes
                    Source for database merge of
                    Additional comments
                    Nomenclature History
                    Source for database identify of
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (11)
                    Reported As
                    Symbol Synonym
                    CG6281
                    (Cammarato et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Kiger et al., 2007, Lee et al., 2003)
                    DTIMP
                    (Pohar et al., 1999)
                    Dtimp
                    (Medioni and Noselli, 2005)
                    TIMP
                    (Sun et al., 2021, Hughes et al., 2020, Krautz et al., 2020, Mageeney and Ware, 2019, Sauerwald et al., 2019, Hughes and Jacobs, 2017, Purice et al., 2017, Raza et al., 2017, Schleede and Blair, 2015, Bangi et al., 2012, Siller and Broadie, 2012, Chatterjee et al., 2011, Miles et al., 2011, Murphy, 2011, Siller and Broadie, 2011, Siekhaus et al., 2010, Guha et al., 2009, Beaucher et al., 2007, Srivastava et al., 2007, Beaucher et al., 2003, Page-McCaw et al., 2002)
                    TIMP1
                    (Mickael et al., 2021, Wang et al., 2017)
                    Timp
                    (Hirooka et al., 2025, Kwon et al., 2024, Li et al., 2024, Pang et al., 2024, Pignataro et al., 2024, Min et al., 2023, Xu et al., 2023, Lodge et al., 2021, López-Varea et al., 2021, Slaidina et al., 2021, Diaz-de-la-Loza et al., 2020, Parra and Johnston, 2020, Ramond et al., 2020, Rushton et al., 2020, Rust et al., 2020, Sun et al., 2020, Paul et al., 2018, LaFever et al., 2017, Rohde et al., 2017, Small and Crawford, 2016, Deady and Sun, 2015, Deady et al., 2015, Ikmi et al., 2014, Jia et al., 2014, Shen et al., 2014, Taylor et al., 2014, Wang and Page-McCaw, 2014, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Lee et al., 2012, Stevens and Page-McCaw, 2012, Sui et al., 2012, Zhai et al., 2012, Cherbas et al., 2011, Jiang et al., 2011, Neisch et al., 2010, Wang et al., 2010, Glasheen et al., 2009, Miller et al., 2008, Pearson and Gonzalez-Reyes, 2008, Kiger et al., 2007, Uhlirova and Bohmann, 2006, Zhang et al., 2006, Godenschwege et al., 2004, Godenschwege et al., 2000)
                    dTIMP
                    (Devine and Krasnow, 2003)
                    timp
                    (Datta and Bangi, 2024, Fangninou et al., 2023, Hu et al., 2021, Khadilkar et al., 2020, Jia et al., 2017, Shilts and Broadie, 2017, Dear et al., 2016, Pearson et al., 2016, Zhai et al., 2015, Wang et al., 2013, Kiger et al., 2004, Kobayashi et al., 2004, Kao et al., 1999, Buchner, 1998.8.12)
                    Name Synonyms
                    Tissue inhibitor of metalloproteases
                    (Cammarato et al., 2011, Chatterjee et al., 2011, Pearson and Gonzalez-Reyes, 2008)
                    tissue inhibitor of metalloproteases
                    (Buchner, 1998.8.12)
                    tissue inhibitor of metalloproteinases
                    (Pearson et al., 2016, Stevens and Page-McCaw, 2012, Godenschwege et al., 2000)
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 44 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (143)