FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TimpP1+P2
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General Information
Symbol
Dmel\TimpP1+P2
Species
D. melanogaster
Name
FlyBase ID
FBal0218944
Feature type
allele
Associated gene
Dmel\Timp
Associated Insertion(s)
P{lacW}Syn-P2
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Godenschwege et al., 2000)
Mutagen
P-element activity
(Godenschwege et al., 2004)
Progenitor genotype
P{lacW}Syn-P1
(Godenschwege et al., 2004)
Associated Insertion(s)
P{lacW}Syn-P2
Cytology
Description

Local hopping of the P{lacW}SynP1 insertion has resulted in a replicative second insertion (P{lacW}SynP2) which is located in intron 9 of Syn (and also in intron 1 of the nested Timp gene).

(Godenschwege et al., 2004)

Local hopping of P{lacW}SynP1 produces a replicative second insertion within the first intron of the Timp gene.

(Godenschwege et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 18[o]C, 23% of TimpP1+P2 flies show wing abnormalities. At 25[o]C, 3.5% exhibit wing abnormalities, indicating that penetrance and expressivity of this defect is cold-sensitive. The dorsal and ventral wing epithelia are often detached, sometimes the wings are permanently inflated with lymph or later become dry and blistered. When raised at 18[o]C, almost 4% (less than 0.5% at 25[o]C) suffer from a bloated gut. Vitality is also strongly reduced compared to wild-type.

      (Godenschwege et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      TimpP1+P2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)