FlyBase Gene Report: Dmel\GABA-B-R1

General Information

Symbol

Dmel\GABA-B-R1

Species

D. melanogaster

Name

metabotropic GABA-B receptor subtype 1

Annotation Symbol

CG15274

Feature Type

protein_coding_gene

FlyBase ID

FBgn0260446

Gene Model Status

Current

Stock Availability

26 publicly available

Gene Summary

metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

GABA_BR1, GABA_B-R1, BG:DS00929.6 , GABAB-R1, GABA

Key Links

Genomic Location

Cytogenetic map

35B8-35B8

Sequence location

2L:15,016,331..15,034,704 [+]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:15016331..15034704

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables G protein-coupled GABA receptor activity

inferred from direct assay

(Mezler et al., 2001)

enables protein heterodimerization activity

inferred from physical interaction with FLYBASE:GABA-B-R2; FB:FBgn0027575

(Mezler et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables G protein-coupled GABA receptor activity

inferred from electronic annotation with InterPro:IPR002455, InterPro:IPR002456

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000054983

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR017978

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

inferred from direct assay

(Mezler et al., 2001)

involved_in gamma-aminobutyric acid signaling pathway

inferred from direct assay

(Mezler et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR002455, InterPro:IPR002456, InterPro:IPR017978

(InterPro Project Members, 2004-)

involved_in gamma-aminobutyric acid signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000054983

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of G protein-coupled receptor heterodimeric complex

inferred from physical interaction with FLYBASE:GABA-B-R2; FB:FBgn0027575

(Mezler et al., 2001)

located_in plasma membrane

inferred from direct assay

(Mezler et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of G protein-coupled receptor heterodimeric complex

inferred from biological aspect of ancestor with PANTHER:PTN000828857

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR002455, InterPro:IPR002456, InterPro:IPR017978

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Gene Group (FlyBase)

GABA(B) RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

GABA(B) RECEPTORS -: Metabotropic GABA(B) receptors are Class C GPCRs. They function as obligate heterodimers, binding the inhibitory neurotransmitter GABA (γ-aminobutyric acid). (Adapted from FBrf0134605).

Summary (Interactive Fly)

G-protein coupled receptor - expressed by pheromone-sensing olfactory receptor neurons which as a consequence exhibit strong presynaptic inhibition - mediates inter-glomerular inhibition - responsible for decreased intracellular calcium of clock neurons blocking their calcium cycling

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\GABA-B-R1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3Q9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

5GWM
5X9X

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

GABA-B-R1-RB

FBtr0304731

NM_078845

4922

841

GABA-B-R1-RC

FBtr0304732

NM_001259104

5642

841

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

GABA-B-R1-PB

FBpp0293273

94.5

841

7.21

FBpp0293274

94.5

841

7.21

Q9V3Q9

NP_001246033

AFH03707

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

841 aa isoforms: GABA-B-R1-PB, GABA-B-R1-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

5GWM
5X9X

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GABA-B-R1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GABA-B-R1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.55

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14 -- 17

larval central nervous system

(Mezler et al., 2001)

larval gnathal ganglion

(Mezler et al., 2001)

larval brain

(Mezler et al., 2001)

larval ventral nerve cord

(Mezler et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of G protein-coupled receptor heterodimeric complex

inferred from physical interaction with FLYBASE:GABA-B-R2; FB:FBgn0027575

(Mezler et al., 2001)

located_in plasma membrane

inferred from direct assay

(Mezler et al., 2001)

Expression Deduced from Reporters

Reporter: TI{2A-GAL4}GABA-B-R1^2A-GAL4

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

larval multidendritic class IV neuron

(Nakamizo-Dojo et al., 2023)

adult stage

neuron of adult brain

(Deng et al., 2019)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\GABA-B-R1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\GABA-B-R1

View exonic expression by tissue for Dmel\GABA-B-R1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0260446

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260446

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260446

Flygut - An atlas of the Drosophila adult midgut

FBgn0260446

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of GABA-B-R1

Transgenic constructs containing regulatory region of GABA-B-R1

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene partially disrupted in

Df(2L)CRIMIC-CR70106

(Gene Disruption Project members, 2018-)

Df(2L)GABA-B-R1^attP

(Rao and Deng, 2019.10.23)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

GABA-B-R1^MI03255

Other Phenotypes

Allele

abnormal feeding behavior | larval stage, with Scer\GAL4^ple.PF

GABA-B-R1^RNAi.UAS.cUa

abnormal touch perception | adult stage, with Scer\GAL4^GMR41E11

GABA-B-R1^KK109166

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (28)

Hsap\GABBR1

14 of 14

Yes

4 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TAS1R1

1 of 14

Yes

Hsap\TAS1R2

1 of 14

Yes

Hsap\TAS1R3

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (46)

Rnor\Gabbr1

14 of 14

Yes

4 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tas1r1

1 of 14

Yes

Rnor\Tas1r2

1 of 14

Yes

Rnor\Vom2r1

1 of 14

Yes

Rnor\Vom2r4

1 of 14

Yes

Rnor\Vom2r5

1 of 14

Yes

Rnor\Vom2r6

1 of 14

Yes

Rnor\Vom2r10

1 of 14

Yes

Rnor\Vom2r11

1 of 14

Yes

Rnor\Vom2r18

1 of 14

Yes

Rnor\Vom2r37

1 of 14

Yes

Rnor\Vom2r44

1 of 14

Yes

Rnor\Vom2r47

1 of 14

Yes

Rnor\Vom2r53

1 of 14

Yes

Rnor\Vom2r54

1 of 14

Yes

Rnor\Vom2r67

1 of 14

Yes

Rnor\Vom2r68

1 of 14

Yes

Rnor\Vom2r70

1 of 14

Yes

Rnor\Vom2r79

1 of 14

Yes

Rnor\Vom2r80

1 of 14

Yes

Rnor\Vom2r-ps27

1 of 14

Yes

Mus musculus (laboratory mouse) (65)

Mmus\Gabbr1

14 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tas1r2

1 of 14

Yes

Mmus\Vmn2r2

1 of 14

Yes

Mmus\Vmn2r4

1 of 14

Yes

Mmus\Vmn2r5

1 of 14

Yes

Mmus\Vmn2r6

1 of 14

Yes

Mmus\Vmn2r7

1 of 14

Yes

Mmus\Vmn2r9

1 of 14

Yes

Mmus\Vmn2r10

1 of 14

Yes

Mmus\Vmn2r11

1 of 14

Yes

Mmus\Vmn2r14

1 of 14

Yes

Mmus\Vmn2r15

1 of 14

Yes

Mmus\Vmn2r61

1 of 14

Yes

Mmus\Vmn2r80

1 of 14

Yes

Mmus\Vmn2r81

1 of 14

Yes

Mmus\Vmn2r82

1 of 14

Yes

Mmus\Vmn2r84

1 of 14

Yes

Mmus\Vmn2r85

1 of 14

Yes

Mmus\Vmn2r86

1 of 14

Yes

Mmus\Vmn2r87

1 of 14

Yes

Mmus\Vmn2r90

1 of 14

Yes

Mmus\Vmn2r91

1 of 14

Yes

Mmus\Vmn2r92

1 of 14

Yes

Mmus\Vmn2r93

1 of 14

Yes

Mmus\Vmn2r94

1 of 14

Yes

Mmus\Vmn2r95

1 of 14

Yes

Mmus\Vmn2r96

1 of 14

Yes

Mmus\Vmn2r100

1 of 14

Yes

Mmus\Vmn2r101

1 of 14

Yes

Mmus\Vmn2r102

1 of 14

Yes

Mmus\Vmn2r104

1 of 14

Yes

Mmus\Vmn2r107

1 of 14

Yes

Mmus\Vmn2r112

1 of 14

Yes

Mmus\Vmn2r113

1 of 14

Yes

Mmus\Vmn2r115

1 of 14

Yes

Mmus\Vmn2r116

1 of 14

Yes

Mmus\Vmn2r117

1 of 14

Yes

Mmus\Vmn2r129

1 of 14

Yes

Mmus\Vmn2r130

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (37)

Xtro\gabbr1

11 of 13

Yes

Xtro\gabbr2

3 of 13

Xtro\acox1

1 of 13

Xtro\c11orf49

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100488863

1 of 13

Yes

Xtro\LOC100490381

1 of 13

Yes

Xtro\LOC100490505

1 of 13

Yes

Xtro\LOC100491800

1 of 13

Yes

Xtro\LOC100493136

1 of 13

Yes

Xtro\LOC100494461

1 of 13

Yes

Xtro\LOC100496766

1 of 13

Yes

Xtro\LOC100496848

1 of 13

Yes

Xtro\LOC100498444

1 of 13

Yes

Xtro\LOC101733546

1 of 13

Yes

Xtro\LOC101734131

1 of 13

Yes

Xtro\LOC105946413

1 of 13

Xtro\LOC108646252

1 of 13

Yes

Xtro\LOC108648105

1 of 13

Yes

Xtro\LOC116409579

1 of 13

Yes

Xtro\npr3

1 of 13

Xtro\podxl

1 of 13

Yes

Xtro\rtp3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB991396

1 of 13

Yes

Danio rerio (Zebrafish) (65)

Drer\gabbr1a

14 of 14

Yes

Drer\gabbr1b

14 of 14

Yes

Drer\gabbr2

4 of 14

Drer\gpr156

2 of 14

Drer\LOC560647

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100007225

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\olfcd2

1 of 14

Yes

Drer\olfcd3

1 of 14

Yes

Drer\olfce2

1 of 14

Yes

Drer\olfcg1

1 of 14

Yes

Drer\olfcg2

1 of 14

Yes

Drer\olfcg3

1 of 14

Yes

Drer\olfcg4

1 of 14

Yes

Drer\olfcg5

1 of 14

Yes

Drer\olfcg6

1 of 14

Yes

Drer\olfcg7

1 of 14

Yes

Drer\olfcg8

1 of 14

Yes

Drer\olfcg9

1 of 14

Yes

Drer\olfcg12

1 of 14

Yes

Drer\olfch1

1 of 14

Yes

Drer\olfcj1

1 of 14

Yes

Drer\olfck1

1 of 14

Yes

Drer\olfck2

1 of 14

Yes

Drer\olfcn1

1 of 14

Yes

Drer\olfcq12

1 of 14

Yes

Drer\olfcu1

1 of 14

Yes

Drer\olfcv1

1 of 14

Yes

Drer\olfcv2

1 of 14

Yes

Drer\olfcv3

1 of 14

Yes

Drer\olfcw1

1 of 14

Yes

Drer\shbg

1 of 14

Yes

Drer\si:dkey-37g12.1

1 of 14

Drer\tas1r1

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\gbb-1

13 of 14

Yes

Cele\gbb-2

4 of 14

Cele\C30A5.10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\GPRGBB1

12 of 12

Yes

Agam\GPRGBB2

3 of 12

Agam\GPRGBB3

3 of 12

Agam\AgaP_AGAP009158

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (17)

Atha\GLR3.4

2 of 13

Yes

Atha\GLR3.5

2 of 13

Yes

Atha\GLR5

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:GABA-B-R1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (20)

6 of 13

5 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

EHR

1 of 13

Gyc32E

1 of 13

Gyc76C

1 of 13

KaiR1D

1 of 13

mtt

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

alcohol, response to, GABBR-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

GABA-B-R1^KK109166

exacerbates amyotrophic lateral sclerosis type 10

modeled by TBPH^Δ23, TBPH^GD6943

(Romano et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GABBR1; gamma-aminobutyric acid type B receptor subunit 1

14 of 14

603540

NEURODEVELOPMENTAL DISORDER WITH LANGUAGE DELAY AND VARIABLE COGNITIVE ABNORMALITIES; NEDLC

GABBR2; gamma-aminobutyric acid type B receptor subunit 2

4 of 14

607340

developmental and epileptic encephalopathy 59

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

GABA-B-R1 - GABA-B-R2

nuclear magnetic resonance

(Zhang et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Gcn2

suppressible

GABA-B-R1

(Bjordal et al., 2014)

Myc

suppressible

GABA-B-R1

(Li et al., 2020)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0260446

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

35B8-35B8

Sequence location

2L:15,016,331..15,034,704 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35B8-35B8

Limits computationally determined from genome sequence between P{EP}elB^EP2039&P{PZ}osp^rJ571 and P{lacW}Su(H)^k07904

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-47.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (26)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

83036

y¹; M{WKO.1-G2}ZH-86Fb

39868

w¹¹¹⁸; P{GMR74G01-GAL4}attP2

47742

w¹¹¹⁸; P{GMR74G04-GAL4}attP2

54943

w¹¹¹⁸; P{GMR74G06-lexA}attP40

69996

w¹¹¹⁸; P{R74G01-p65.AD}attP40

69767

w¹¹¹⁸; P{R74G01-GAL4.DBD}attP2

84390

TI{2A-lexA::p65}GABA-B-R1^2A-lexA

94747

w¹¹¹⁸; PBac{GMR74G01-lexA}VK00022

51817

y¹ v¹; P{TRiP.HMC03388}attP2

Korea

16316

P{GMR74G01-lexA}su(Hw)attP5

VDRC

v330042

P{VSH330042}attP40

v101440

P{KK109166}VIE-260B

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP03705

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0260446

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0260446

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

GABA-B-R1 has a putative role in alcohol induced behavioural impairment.

(Dzitoyeva et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: BG:DS00929.6 CG15274

(Misra, 2000.4.5)

Source for merge of: GABA-B-R1 anon-WO0170980.175 anon-WO0170980.176

(FlyBase, 1996-)

Additional comments

Release 3.2 annotation CG33310 corresponds to a part of the release 2 annotation CG15274 which was deleted in the release 3.0 version of CG15274. CG33310 has been restored as a distinct annotation in release 3.2 of the genome annotation.

(FlyBase Genome Annotators, 2004)

Source for identity of GABA-B-R1 BG:DS00929.6 was sequence comparison ( date:010307 ).

(FlyBase, 1996-)

Source for merge of GABA-B-R1 anon-WO0170980.175 anon-WO0170980.176 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: GABA-B-R1 BG:DS00929.6

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

BG:DS00929.6

(Ashburner et al., 1999, Ashburner et al., 1999)

CG15274

(Mao et al., 2024, Kondo et al., 2020, Meadows, 2017.1.11, Jayakumar et al., 2016, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Quinones-Coello, 2007, de Wit et al., 2005, Vanden Broeck, 2001, Brody and Cravchik, 2000)

D-GABA-B-R1

(Khuong et al., 2019)

D-GABA_BR1

(Mezler et al., 2001)

D-Gaba1

(Mezler et al., 2001)

GABA

(Meschi and Delanoue, 2021, Alpert et al., 2020)

GABA(B)R1

(Bjordal et al., 2014)

GABA-_B-R1

(Pavlou et al., 2016)

GABA-B R1

(Chaturvedi and Emery, 2024)

GABA-B-R1

(Zhao et al., 2025, Zheng et al., 2025, Abu-Salah et al., 2024, Li et al., 2024, Qu et al., 2024, Zhu et al., 2024, Bossen et al., 2023, Corthals et al., 2023, Karki et al., 2022, Schlichting et al., 2022, Jeong et al., 2021, Liu et al., 2021, McLaughlin et al., 2021, Romano et al., 2021, Scaplen and Petruccelli, 2021, Wang et al., 2021, Xie et al., 2021, Kondo et al., 2020, Lathen et al., 2020, Li et al., 2020, Nässel and Zandawala, 2020, Wilson et al., 2020, Deng et al., 2019, Hegazi et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2018-, Sakakibara et al., 2018, Cheung and Scott, 2017, Kim et al., 2017, Park et al., 2017, Crocker et al., 2016, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Kong et al., 2015, Shankar et al., 2015, Okada et al., 2009, FlyBase Curators, 2008-, Roote, 2008.8.22, Quinones-Coello, 2007, de Wit et al., 2005)

GABA-BR1

(Dissel et al., 2015)

GABA1

(Landayan et al., 2021)

GABA_B

(Root et al., 2008)

GABA_B-R

(Nässel and Vanden Broeck, 2016, Tio et al., 2016)

GABA_B-R1

(Ko et al., 2023, Choi et al., 2017, Suh et al., 2017, Hong et al., 2016)

GABA_BR

(Enell et al., 2007)

GABA_BR1

(Slankster et al., 2020, Jeong et al., 2016, Muthukumar et al., 2014, Yuan et al., 2014, Dzitoyeva et al., 2003)

GABAB(R1)

(Mazzotta et al., 2020)

GABAB-R1

(Bae et al., 2023, Jo et al., 2021)

GB1

(Mitri et al., 2004)

Gaba-b-r1

(Fendl et al., 2020)

anon-WO0170980.175

anon-WO0170980.176

dGB1

(Zhang et al., 2020)

Name Synonyms

metabotropic GABA-B receptor subtype 1

(Mezler, 2000.11.2)

Secondary FlyBase IDs

FBgn0032558
FBgn0046567
FBgn0046568
FBgn0028924

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34878

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3Q9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3Q9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0260446

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260446

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260446

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG15274

MARRVEL_MODEL - MARRVEL (model organism gene)

34878

PDB - An information portal to biological macromolecular structures

5GWM
5X9X

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0260446

DroID - A comprehensive database of gene and protein interactions.

FBgn0260446

DRSC - Results frm RNAi screens

FBgn0260446

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GABA-B-R1_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0260446

Flygut - An atlas of the Drosophila adult midgut

FBgn0260446

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0260446

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (129)

The following external sites may use different assemblies or annotations than FlyBase.

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