Nrv, Nervana, Na,K-ATPase
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
309 (aa); 42 (kD observed)
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with nkain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nrv1 using the Feature Mapper tool.
RNA-seq data show that nrv1 is expressed throughout the larval midgut but is enriched in the acidic region of the larval midgut. It is also expressed in the gastric caecum.
nrv1 is detected in adult head (weak), thorax, and abdomen on western blots. It is observed weakly in brain and retina by immunolocalization.
nrv1 protein is observed predominantly in the thorax and abdomen in western blots of dissected tissues in adults. In adult tissue sections, it is detected in muscle tissue (muscle cell surface membranes), digestive system, and Malpighian tubules.
Nervana protein is detected in adult heads, thoraces and abdomens but is significantly enriched in heads on western blots. On developmental westerns, it is first observed in 6hr embryos and then throughout development. The levels of the different mobility components change through development. The 42K component is not observed until 12-24hr and is not prominent until the adult stage. Nervana protein is observed in the CNS and PNS by immunolocalization in a pattern indistinguishable from the anti-HRP pattern. Staining is also observed in the garland cells and the posterior spiracles.
GBrowse - Visual display of RNA-Seq signalsView Dmel\nrv1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Nrv1 CG9258
The product(s) of the Nervana gene(s) were recognised by their epitope(s) which reacts with anti-Horse Radish Peroxidase antibodies. These antibodies label neurons in Drosophila. The nac gene product may be required for the glycosylation of these proteins.