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FB2026_01
,
released March 12, 2026
DmGluRA, mGluRA, Glu-RA, DmGluRA
G-protein coupled receptor - modulates presynaptic excitability properties and synaptic architecture - acts in conjunction with FMRP to regulate presynaptic properties
Please see the JBrowse view of Dmel\mGluR for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.43
Gene model reviewed during 5.46
Gene model reviewed during 5.39
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mGluR using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
mGluR protein is strongly expressed in the ellipsoid body ring in the innervation regions of R3 and R4d ring neurons. In the fan-shaped body expression is detected in the central and ventral layers, in the bulb (lateral triangle) in the nodulus (stronger expression in the dorsal region layer III) and protocerebral bridge. Co-localisation with ScerGAL4VGlut.PD is observed in the ellipsoid body rings R3 and R4d, in the fan-shaped body, nodulus and protocerebral bridge.
There are fourteen mGluR immunopositive cell bodies are found in the third instar larval brain. Expression of mGlu</up>RA is detected in the dorsal and ventral aspect of the adult fan-shaped body of the central complex. Three neurons of the metathoracic neuromere, and four pairs of neurons in the abdominal neuromere are mGluR immunopositive.
JBrowse - Visual display of RNA-Seq signals
View Dmel\mGluR in JBrowse4-0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Fmr1 and mGluR convergently regulate presynaptic properties. At the protein level, Fmr1 is upregulated in mGluR mutants, and mGluR is upregulated in Fmr1 mutants. Null mGluR mutants display defects in coordinated movement behavior, which are rescued by removing Fmr1 expression. Null Fmr1 mutants display increased neuromuscular junction presynaptic structural complexity and elevated presynaptic vesicle pools, which are rescued by blocking mGluR signaling. Null Fmr1 brain neurons similarly display increased presynaptic architectural complexity, which is rescued by blocking mGluR signaling.
When co-expressed in Xenopus oocytes with a mammalian G-protein coupled inwardly rectifying potassium channel protein the Glu-RA protein activates an inwardly rectifying potassium current.
Encodes a G protein-coupled metabotropic glutamate receptor.
Glu-RA is expressed in the adult and in the CNS of late embryos.
Source for identity of: mGluR mGluRA
Removed 'A' suffix from gene symbol to mirror the gene fullname, and because it implies there are additional mGluR genes in the genome (there are not).
