FlyBase Allele Report: Dmel\mGluR[GD707]

General Information

Symbol

Dmel\mGluR^GD707

Species

D. melanogaster

Name

FlyBase ID

FBal0209961

Feature type

allele

Associated gene

Dmel\mGluR

Associated Insertion(s)

Carried in Construct

P{GD707}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD707}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD707

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X syndrome

modeled by Fmr1³

(Kanellopoulos et al., 2012)

ameliorates neurodegenerative disease

modeled by mir-1000^KO1, mir-1000^KO2

(Verma et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of mGluR^GD707 under the control of Scer\GAL4^elav.PU or under the control of Scer\GAL4^c747 does not result in learning defects.

(Kanellopoulos et al., 2012)

Adults expressing mGluR^GD707 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mGluR^GD707/Scer\GAL4^NP6701 is a suppressor of abnormal locomotor behavior | adult stage phenotype of mir-1000^KO2/mir-1000^KO1

(Verma et al., 2015)

mGluR^GD707/Scer\GAL4^NP6701 is a suppressor of short lived phenotype of mir-1000^KO2/mir-1000^KO1

(Verma et al., 2015)

Scer\GAL4^c747/mGluR^GD707 is a suppressor of abnormal learning | dominant | adult stage phenotype of Fmr1³

(Kanellopoulos et al., 2012)

mGluR^GD707/Scer\GAL4^elav.PU is a suppressor of abnormal learning | dominant | adult stage phenotype of Fmr1³

(Kanellopoulos et al., 2012)

mGluR^GD707/Scer\GAL4^elav.PU is a suppressor of abnormal memory | dominant | adult stage phenotype of Fmr1³

(Kanellopoulos et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The climbing defects and shortened lifespan of mir-1000^KO1/mir-1000^KO2 adults are rescued if they are also carrying mGluR^GD707.

(Verma et al., 2015)

Expression of mGluR^GD707 under the control of Scer\GAL4^elav.PU or under the control of Scer\GAL4^c747 (in combination with GAL80ts to limit expression to adult stage) rescues the learning defect phenotype of Fmr1³ mutants.

(Kanellopoulos et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v1793

w¹¹¹⁸; P{GD707}v1793

v1794

w¹¹¹⁸; P{GD707}v1794

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mGluR^GD707

mGluRA^GD707

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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