FlyBase Gene Report: Dmel\CG31183

General Information

Symbol

Dmel\CG31183

Species

D. melanogaster

Name

Annotation Symbol

CG31183

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051183

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

guanylate cyclase (4.6.1.2)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

89A6-89A7

Sequence location

3R:15,857,871..15,875,939 [-]

Recombination map

3-58

RefSeq locus

NT_033777 REGION:15857871..15875939

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(InterPro Project Members, 2004-)

enables guanylate cyclase activity

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

enables peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

enables phosphorus-oxygen lyase activity

inferred from electronic annotation with InterPro:IPR018297

(InterPro Project Members, 2004-)

enables signaling receptor activity

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(Gene Ontology Curators, 2002-)

NOT enables protein kinase activity

inferred from key residues

(Anamika et al., 2009)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cGMP biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

involved_in cyclic nucleotide biosynthetic process

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in receptor guanylyl cyclase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001170

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

RECEPTOR GUANYLATE CYCLASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

guanylate cyclase activity

GTP = 3',5'-cyclic GMP + diphosphate (4.6.1.2)

RHEA 13665:

Summaries

Gene Group (FlyBase)

RECEPTOR GUANYLATE CYCLASES -: Receptor guanylate cyclases are single-pass transmembrane receptors with an extracellular ligand-binding domain and intracellular guanylate cyclase and pseudokinase kinase domains. Ligand binding results in the activation of the intracellular guanylyl cyclase domain and the production of cyclic GMP from GTP. The kinase domain may have a regulatory role and may bind ATP. (Adapted from FBrf0228387).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG31183 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VF17)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG31183-RA

FBtr0083187

NM_142248

5026

1417

CG31183-RB

FBtr0346151

NM_001300413

5256

1417

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG31183-PA

FBpp0082641

158.9

1417

7.14

FBpp0311979

158.9

1417

7.14

Q9VF17

NP_001287342

AHN57341

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1417 aa isoforms: CG31183-PA, CG31183-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG31183 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG31183_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.68

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG31183 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG31183

View exonic expression by tissue for Dmel\CG31183

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41927/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051183

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051183

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051183

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31183

Flygut - An atlas of the Drosophila adult midgut

FBgn0051183

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG31183

Transgenic constructs containing regulatory region of CG31183

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6175

(Ryder, 2004.4.26)

Df(3R)Exel8162

(Ryder, 2004.4.26)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG31183^GD2548

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal gravitaxis | adult stage, with Scer\GAL4^ChAT.7.4

CG31183^HMJ22232

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG31183^GD52

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

CG31183^GD52

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (42)

Hsap\NPR1

11 of 14

Yes

Hsap\NPR2

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (31)

Rnor\Npr1

11 of 14

Yes

Rnor\Npr2

11 of 14

Yes

Rnor\Gucy2g

5 of 14

Yes

Rnor\Gucy2c

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (35)

Mmus\Npr2

11 of 14

Yes

Mmus\Npr1

10 of 14

Yes

Mmus\Gucy2g

5 of 14

Yes

Mmus\Gucy2c

3 of 14

Yes

Mmus\Gucy2e

3 of 14

Mmus\Gucy2f

3 of 14

Mmus\Npr3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Vmn2r112

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (29)

Xtro\npr1

6 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100489435

1 of 13

Xtro\LOC101732477

1 of 13

Yes

Xtro\LOC101732945

1 of 13

Yes

Xtro\map3k20

1 of 13

Xtro\npr2

1 of 13

Yes

Xtro\npr3

1 of 13

Xtro\tesk2

1 of 13

Danio rerio (Zebrafish) (54)

Drer\npr1a

10 of 14

Yes

Drer\npr1b

10 of 14

Yes

Drer\npr2

10 of 14

Yes

Drer\si:dkey-37g12.1

6 of 14

Yes

Drer\gucy2g

5 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\gucy2cb

2 of 14

Yes

Drer\gucy2d

2 of 14

Drer\LOC100333871

2 of 14

Yes

Drer\npr3

2 of 14

Drer\si:ch211-132f19.7

2 of 14

Drer\si:dkey-206f10.1

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100331190

1 of 14

Drer\olfce2

1 of 14

Yes

Drer\olfch1

1 of 14

Yes

Drer\olfcv2

1 of 14

Yes

Drer\ret

1 of 14

Drer\tas1r1

1 of 14

Yes

Drer\tgfbr2a

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (46)

Cele\gcy-28

13 of 14

Yes

Cele\gcy-2

5 of 14

Yes

Cele\gcy-4

5 of 14

Yes

Cele\gcy-12

5 of 14

Cele\gcy-15

5 of 14

Yes

Cele\gcy-17

5 of 14

Yes

Cele\gcy-20

5 of 14

Yes

Cele\gcy-21

5 of 14

Yes

Cele\gcy-1

4 of 14

Yes

Cele\gcy-3

4 of 14

Yes

Cele\gcy-5

4 of 14

Yes

Cele\gcy-6

4 of 14

Yes

Cele\gcy-7

4 of 14

Yes

Cele\gcy-9

4 of 14

Cele\gcy-11

4 of 14

Yes

Cele\gcy-13

4 of 14

Yes

Cele\gcy-14

4 of 14

Yes

Cele\gcy-19

4 of 14

Yes

Cele\gcy-22

4 of 14

Yes

Cele\daf-11

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\gcy-29

3 of 14

Yes

Cele\acy-4

2 of 14

Cele\gcy-27

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (34)

Agam\AgaP_AGAP003283

12 of 12

Yes

5 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (60)

Atha\GLR2.8

2 of 13

Yes

Atha\GLR2.9

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G78530

1 of 13

Atha\AT1G80640

1 of 13

Yes

Atha\AT2G16250

1 of 13

Yes

Atha\AT2G28940

1 of 13

Atha\AT2G43700

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G03140

1 of 13

Yes

Atha\AT5G10530

1 of 13

Atha\AT5G24010

1 of 13

Atha\AT5G48940

1 of 13

Yes

Atha\CIPK9

1 of 13

Atha\CR4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\MAPKKK9

1 of 13

Atha\MRLK

1 of 13

Yes

Atha\NCRK

1 of 13

Yes

Atha\RK2

1 of 13

Yes

Atha\RK3

1 of 13

Yes

Atha\RKF1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG31183. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (41)

8 of 13

7 of 13

6 of 13

6 of 13

EHR

5 of 13

Gucy2d

4 of 13

Ac3

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Fak

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mtt

1 of 13

Nmdar1

1 of 13

Phlpp

1 of 13

sax

1 of 13

sev

1 of 13

tkv

1 of 13

wnd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

NPR2; natriuretic peptide receptor 2

model of acromesomelic dysplasia, Maroteaux type

IEA

(FlyBase, 2019-)

model of Miura type epiphyseal chondrodysplasia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NPR1; natriuretic peptide receptor 1

11 of 14

108960

NPR2; natriuretic peptide receptor 2

11 of 14

108961

GUCY2C; guanylate cyclase 2C

3 of 14

601330

congenital diarrhea 6

GUCY2D; guanylate cyclase 2D, retinal

3 of 14

600179

GUCY2F; guanylate cyclase 2F, retinal

3 of 14

300041

NPR3; natriuretic peptide receptor 3

3 of 14

108962

BOUDIN-MORTIER SYNDROME; BOMOS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0051183

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-58

Cytogenetic map

89A6-89A7

Sequence location

3R:15,857,871..15,875,939 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

89A6-89A7

Limits computationally determined from genome sequence between P{PZ}l(3)06536⁰⁶⁵³⁶ and P{PZ}blp⁰¹⁶¹⁸;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-58

(FlyBase, 2016)

3-57.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

58224

y¹ v¹; P{TRiP.HMJ22232}attP40

33160

y¹ w^*; Mi{MIC}CG31183^MI02001

37264

y¹ w^*; Mi{MIC}CG31183^MI04157

28604

y¹ v¹; P{TRiP.HM05092}attP2/TM3, Sb¹

56937

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04376}attP2

60175

y¹ w^*; Mi{PT-GFSTF.1}CG31183^{MI02001-GFSTF.1}/TM6C, Sb¹ Tb¹

NIG-Fly

HMJ22232

y¹ v¹; P{TRiP.HMJ22232}attP40/CyO

VDRC

v858

w¹¹¹⁸; P{GD52}v858

v4773

w¹¹¹⁸; P{GD2548}v4773

v341009

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00011}attP40/CyO-GFP

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH09326

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051183

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051183

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG11846 CG4224

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG11846 and CG4224 merged as CG31183 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

FlyBase curator comment: A gene called 'DrGC-2' is described that encodes a Receptor Guanylyl Cyclase; it is mapped to 89A but is otherwise uncharacterized. (This gene was originally curated as 'Gyc89A'/'Guanylyl cyclase at 89A' (FBgn0014856) in FlyBase.) A search in 2016 for molecularly-defined genes that encode Receptor Guanylyl Cyclases reveals two candidates in the 89A region: CG31183 (89A6-89A7) and CG14877 (89A7-89A8). Presumably 'DrGC-2' corresponds to one or both of these genes, and so 'DrGC-2' (and its synonyms) have been added as synonyms to CG31183 and CG14877, and the original Gyc89A record has been deleted.

(McNeil et al., 1995)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG11846

(Ayoob et al., 2004)

CG31183

(Klimkowski Arango and Morgante, 2025, Werner et al., 2024, Kanoh et al., 2021, Wu et al., 2020, Abruzzi et al., 2017, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Duvall and Taghert, 2013, Vogel et al., 2013, Ni et al., 2010.12.1, Wasbrough et al., 2010, Biswas et al., 2009, Perkins et al., 2009)

CG4224

(Wang et al., 2004)

DrGC-2

(McNeil et al., 1995)

FBgn0038379

(Mi et al., 2003)

GYC

(Morrison et al., 2000)

Gyc89A

Name Synonyms

Guanylyl cyclase at 89A

Secondary FlyBase IDs

FBgn0038378
FBgn0038379

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41927

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VF17

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VF17

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41927/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051183

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051183

FlyMine - An integrated database for Drosophila genomics

FBgn0051183

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31183

MARRVEL_MODEL - MARRVEL (model organism gene)

41927

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051183

DroID - A comprehensive database of gene and protein interactions.

FBgn0051183

DRSC - Results frm RNAi screens

FBgn0051183

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG31183_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051183

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051183

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31183

Flygut - An atlas of the Drosophila adult midgut

FBgn0051183

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004747

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

References (50)

The following external sites may use different assemblies or annotations than FlyBase.

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