FlyBase Gene Report: Dmel\Ac78C

General Information

Symbol

Dmel\Ac78C

Species

D. melanogaster

Name

Adenylyl cyclase 78C

Annotation Symbol

CG10564

Feature Type

protein_coding_gene

FlyBase ID

FBgn0024150

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

adenylate cyclase (4.6.1.1)

Gene Summary

Adenylyl cyclase 78C (Ac78C) encodes a member of the adenyly cyclase family of proteins. It converts adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. In taste receptor neurons, Ac78C product is involved in the sugar taste transduction pathway. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

78B3-78C1

Sequence location

3L:21,136,447..21,171,930 [-]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:21136447..21171930

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables adenylate cyclase activity

inferred from direct assay

(Cann and Levin, 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables adenylate cyclase activity

inferred from electronic annotation with InterPro:IPR009398

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

enables phosphorus-oxygen lyase activity

inferred from electronic annotation with InterPro:IPR018297

(InterPro Project Members, 2004-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in circadian rhythm

inferred from mutant phenotype

(Duvall and Taghert, 2013)

involved_in detection of chemical stimulus involved in sensory perception of sweet taste

inferred from mutant phenotype

(Ueno and Kidokoro, 2008)

involved_in response to caffeine

inferred from direct assay

(Ueno and Kidokoro, 2008)

involved_in response to sucrose

inferred from direct assay

(Ueno and Kidokoro, 2008)

involved_in response to trehalose

inferred from direct assay

(Ueno and Kidokoro, 2008)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

involved_in cAMP biosynthetic process

inferred from electronic annotation with InterPro:IPR009398

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

involved_in cyclic nucleotide biosynthetic process

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from electronic annotation with InterPro:IPR009398

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

ADENYLATE CYCLASES

Protein Family (UniProt)

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (Q9VP76)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

adenylate cyclase activity

ATP = 3',5'-cyclic AMP + diphosphate (4.6.1.1)

RHEA 15389:

Summaries

Gene Snapshot

Gene Group (FlyBase)

ADENYLATE CYCLASES -: Adenylate cyclases catalyze the synthesis of cAMP from ATP, yielding diphosphate as a by-product. (Adapted from FBrf0238856).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ac78C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VP76)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ac78C-RB

FBtr0301701

NM_079470

6417

1718

Ac78C-RC

FBtr0305501

NM_001259928

4407

1222

Ac78C-RD

FBtr0330066

NM_001275208

6206

1694

Ac78C-RE

FBtr0330067

NM_001275209

6417

1727

Ac78C-RF

FBtr0333358

NM_001275210

6414

1717

Additional Transcript Data and Comments

Reported size (kB)

6.5, 4.5 (northern blot)

(Cann and Levin, 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ac78C-PB

FBpp0290915

189.0

1718

6.86

FBpp0293953

135.3

1222

8.04

FBpp0303099

186.2

1694

7.23

FBpp0303100

190.0

1727

6.92

FBpp0305550

188.9

1717

6.86

M9PD54

NP_001262139

AGB94832

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1718, 1222 (aa)

(Cann and Levin, 2000)

Comments

Ac78C protein Catalyzes the synthesis of cAMP in vitro.

(Cann and Levin, 2000)

No adenylate cyclase activity was demonstrated in vitro for the shorter

Ac78C protein isoform that contains the adenylate cyclase catalytic domains but that lacks the

first six of the 12 transmembrane domains present in the longer isoform.

(Cann and Levin, 2000)

External Data

Domain

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.

(UniProt, Q9VP76)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ac78C using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.26

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4

organism | ubiquitous

(Cann and Levin, 2000)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic hindgut

(Fisher et al., 2012)

embryonic large intestine

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 8

(Cann and Levin, 2000)

embryonic stage 5 -- 9

Comment: reference states 2-4 hr AEL

(Cann and Levin, 2000)

embryonic stage 7 -- 8

anterior transverse furrow

(Cann and Levin, 2000)

cephalic furrow

(Cann and Levin, 2000)

posterior transverse furrow

(Cann and Levin, 2000)

embryonic stage 12 -- 17

Comment: reference states >=8 hr AEL

(Cann and Levin, 2000)

larval stage

(Cann and Levin, 2000)

adult stage

(Cann and Levin, 2000)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ac78C in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ac78C

View exonic expression by tissue for Dmel\Ac78C

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024150

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40333/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024150

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024150

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024150

Flygut - An atlas of the Drosophila adult midgut

FBgn0024150

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Ac78C

Stages(s) 4-6
Stages(s) 7-8

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ac78C

Transgenic constructs containing regulatory region of Ac78C

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Scer\GAL4^tin.CΔ4

Ac78C^GD2764

Other Phenotypes

Allele

abnormal chemosensory behavior

Ac78C^Δ32

abnormal chemosensory behavior, with Scer\GAL4^Gr5a.PU

Ac78C^{RNAi.UAS.2914-3376}

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (23)

Hsap\ADCY8

10 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Adcy8

10 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (23)

Mmus\Adcy8

9 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\adcy8

4 of 13

Yes

Xtro\adcy8

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\grn

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (29)

Drer\adcy8

9 of 14

Yes

Drer\si:ch211-132f19.7

9 of 14

Yes

Drer\si:dkey-206f10.1

9 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (38)

Cele\acy-2

3 of 14

Yes

Cele\acy-4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (25)

Agam\AgaP_AGAP002262

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009087

1 of 12

Agam\AgaP_AGAP012597

1 of 12

Agam\AgaP_AGAP012965

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ac78C. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

Ac3

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

EHR

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADCY8; adenylate cyclase 8

10 of 14

103070

ADCY5; adenylate cyclase 5

4 of 14

600293

ADCY6; adenylate cyclase 6

4 of 14

600294

LETHAL CONGENITAL CONTRACTURE SYNDROME 8; LCCS8

ADCY1; adenylate cyclase 1

3 of 14

103072

DEAFNESS, AUTOSOMAL RECESSIVE 44; DFNB44

autosomal recessive nonsyndromic deafness 44

ADCY2; adenylate cyclase 2

3 of 14

103071

ADCY3; adenylate cyclase 3

3 of 14

600291

BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19; BMIQ19

ADCY4; adenylate cyclase 4

3 of 14

600292

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0024150

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

78B3-78C1

Sequence location

3L:21,136,447..21,171,930 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

78B3-78C1

Limits computationally determined from genome sequence between P{lacW}l(3)L5541^L5541 and P{EP}chb^EP3403

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

78C-78C

(determined by in situ hybridisation)

(Cann and Levin, 2000)

78C-78C

(Cann, 1999.7.13, Cann, 1998.2.9)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

68220

w^*; P{UAS-Ac78C.D}3

25224

w¹¹¹⁸; Mi{ET1}Ac78C^MB05598

65561

w¹¹¹⁸; PBac{IT.GAL4}Ac78C^1340-G4

34156

y¹ w^*; Mi{MIC}Ac78C^MI01144

42990

y¹ w^*; Mi{MIC}Ac78C^MI04997

43003

y¹ w^*; Mi{MIC}Ac78C^MI05462

22667

y¹ w^67c23; Mi{ET1}Ac78C^MB00011

59401

y¹ w^*; Mi{PT-GFSTF.0}Ac78C^{MI01144-GFSTF.0}

VDRC

v51978

w¹¹¹⁸; P{GD2764}v51978/CyO

v51979

w¹¹¹⁸; P{GD2764}v51979/CyO

Genomic Clones (42)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP13601

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0024150

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

May serve to transduce and integrate different developmental signals through the cAMP signalling pathway.

(Cann and Levin, 1997)

Relationship to Other Genes

Source for database merge of

Source for merge of: Ac78C CG10554

(FlyBase, 1996-)

Additional comments

Release 2 annotation CG10554 corresponds to part of release 3.2 annotation CG10564 (which is Ac78C).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

AC 78C

(Morrison et al., 2000)

AC78C

(Duvall and Taghert, 2013, Duvall and Taghert, 2012, Ueno and Kidokoro, 2008, Ueno and Kidokoro, 2007)

Ac78C

(Hertzler et al., 2024, Noyes and Davis, 2023, Khan et al., 2021, Lee et al., 2018, Ugrankar et al., 2018, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Pogson et al., 2014, Saunders et al., 2013, Jungreis et al., 2011, Kwon et al., 2008, Molnar et al., 2006, Wang et al., 2004)

CG10554

(Luschnig, 2003.12.17)

CG10564

(Ni et al., 2010.12.1, Molnar et al., 2006, Morrison et al., 2000)

DAC78C

(Cann and Levin, 2000)

DAC78C-s

(Cann, 1999.7.13)

dADCY8

(Yoon et al., 2022)

Name Synonyms

Adenylyl cyclase

(Ueno and Kidokoro, 2008)

Adenylyl cyclase 78C

Secondary FlyBase IDs

FBgn0040639

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 61 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40333

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VP76

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VP76

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VP76

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024150

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40333/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024150

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024150

FlyMine - An integrated database for Drosophila genomics

FBgn0024150

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10564

MARRVEL_MODEL - MARRVEL (model organism gene)

40333

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0024150

DRSC - Results frm RNAi screens

FBgn0024150

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024150

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0024150

Flygut - An atlas of the Drosophila adult midgut

FBgn0024150

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0024150

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (52)

The following external sites may use different assemblies or annotations than FlyBase.

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