FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term adenylate cyclase activity ID (Ontology) GO:0004016 (Gene Ontology)
Definition Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.[ EC:4 ]
Also Known As"adenylyl cyclase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 adenylate cyclase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | adenylate cyclase activity       --
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catalytic activity
 |__cyclase activity__________________
lyase activity                        |
 |__phosphorus-oxygen lyase activity__|
                                      adenylate cyclase activity  14 rec.
                                       |__calcium- and calmodulin-responsive adenylate cyclase activity 1 rec.
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Is a cyclase activity
phosphorus-oxygen lyase activity
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Synonyms
  • "3',5'-cyclic AMP synthetase activity" RELATED[ EC:4 ]
    "adenyl cyclase activity" RELATED[ EC:4 ]
    "adenylyl cyclase activity" EXACT
    "adenylylcyclase activity" RELATED[ EC:4 ]
    "ATP diphosphate-lyase (cyclizing) activity" RELATED[ EC:4 ]
    "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" RELATED[ EC:4 ]
    "ATP pyrophosphate-lyase activity" RELATED[ EC:4 ]
    "cAMP generating peptide activity" RELATED
Secondary IDs
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EC:4.6.1.1
MetaCyc:ADENYLATECYC-RXN
Reactome:R-HSA-164377 "Activated Adenylate cyclase catalyses cAMP synthesis"
Reactome:R-HSA-170676 "Adenylate cyclase converts ATP into cyclic AMP"
Reactome:R-HSA-381607 "Activated Adenylyl cyclase synthesizes cyclic AMP"
Reactome:R-HSA-392129 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate"
Reactome:R-HSA-5211224 "Anthrax cya catalyzes the conversion of ATP to cAMP"
Reactome:R-HSA-5610727 "GPR161 promotes cAMP production in a G alpha(s)-dependent manner"
Reactome:R-HSA-9712183 "ADCY3:GNAL:GTP converts ATP to cAMP"
RHEA:15389