FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

adenylate cyclase-activating G protein-coupled receptor signaling pathway

ID (Ontology)

GO:0007189 (Gene Ontology)

Definition

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.[ ISBN:0815316194 ]

Also Known As

"adenylate cyclase-activating GPCR signaling pathway" ; "G protein signaling, adenylate cyclase activating pathway" ; "G protein signaling, adenylyl cyclase activating pathway" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
adenylate cyclase-activating G protein-coupled receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| adenylate cyclase-activating G protein-coupled receptor signaling pathway

Spanning Tree (Parents/Children)

  G protein-coupled receptor signaling pathway
   |__adenylate cyclase-modulating G protein-coupled receptor signaling pathway
       |__adenylate cyclase-activating G protein-coupled receptor signaling pathway  44 rec.
           |__adenylate cyclase-activating adrenergic receptor signaling pathway 8 rec.
           |   |__adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
           |__adenylate cyclase-activating dopamine receptor signaling pathway 4 rec.
           |__adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
           |__adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
           |__adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
           |   |__regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway(+)
           |__adenylate cyclase-activating serotonin receptor signaling pathway 1 rec.
           |__ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway
           |__regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2 rec.
               |__negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway(+) 2 rec.
               |__positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
               |__regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway(+)

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"activation of adenylate cyclase activity by G-protein signaling pathway" RELATED "activation of adenylate cyclase activity involved in G-protein signaling" RELATED "adenylate cyclase-activating GPCR signaling pathway" EXACT "G protein signaling, adenylate cyclase activating pathway" EXACT "G protein signaling, adenylyl cyclase activating pathway" EXACT "G protein signalling, adenylate cyclase activating pathway" EXACT "G protein signalling, adenylyl cyclase activating pathway" EXACT "G-protein signaling, adenylate cyclase activating pathway" EXACT "G-protein signaling, adenylyl cyclase activating pathway" EXACT "G-protein signalling, adenylate cyclase activating pathway" EXACT "G-protein signalling, adenylyl cyclase activating pathway" EXACT "GPCR signaling pathway via activation of adenylate cyclase" EXACT "GPCR signaling pathway via activation of adenylate cyclase activity" EXACT "positive regulation of adenylate cyclase activity by G-protein signaling pathway" RELATED "positive regulation of adenylate cyclase activity by G-protein signalling pathway" RELATED "positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-170660 "Adenylate cyclase activating pathway"