dgc1, dgcα1, Gcα1, dgca1, Gycα-99B
Gene model reviewed during 5.46
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Coexpression of Gycα99B protein and
Gycβ100B protein in human kidney cells results in significant guanylyl
cyclase activity. No activity is observed if either is introduced alone.
soluble guanylyl cyclase alpha and beta subunits that are capable of
forming a functional guanylyl cyclase heterodimer.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gycα99B using the Feature Mapper tool.
Gycα99 protein is detected in adult heads and at very low levels in bodies on western blots. Immunolocalization to adult tissue sections shows expression in the optic lobe, central brain, and thoracic ganglia.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Gycα99B in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gyc-89Db shows no guanylyl cyclase activity when expressed in COS-7 cells in the absence of additional subunits, in the presence of either Mg2+ or Mn2+ cofactor. When Gyc-89Db and Gycα99B are co-expressed in COS-7 cells in the presence of either Mg2+ or Mn2+, no guanylyl cyclase activity is detected.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
The function of Gycα99B in the phototactic response is developmental, rather than physiological.
Isolated using cDNA fragments encoding the kinase-like and cyclase domains from the rat GC-A, GC-B and GC-C genes.
Gycα99B has been cloned and sequenced. It encodes a soluble guanylate cyclase subunit.
Gycα99B has been cloned and sequenced. It encodes a soluble guanylyl cyclase α subunit.