FlyBase Gene Report: Dmel\Gycα99B

General Information

Symbol

Dmel\Gycα99B

Species

D. melanogaster

Name

Guanylyl cyclase α-subunit at 99B

Annotation Symbol

CG1912

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013972

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

guanylate cyclase (4.6.1.2)

Gene Summary

Guanylyl cyclase α-subunit at 99B (Gycα99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dgc1, dgcα1, Gycα-99B, Gcα1, dgca1

Key Links

Genomic Location

Cytogenetic map

99B7-99B7

Sequence location

3R:29,682,503..29,685,758 [+]

Recombination map

3-99

RefSeq locus

NT_033777 REGION:29682503..29685758

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables guanylate cyclase activity

inferred from direct assay

(Morton et al., 2005, Shah and Hyde, 1995)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables guanylate cyclase activity

inferred from electronic annotation with InterPro:IPR011645

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002902243

(GO Reference Genome Project, 2011-)

enables heme binding

inferred from electronic annotation with InterPro:IPR011644, InterPro:IPR038158

(InterPro Project Members, 2004-)

enables phosphorus-oxygen lyase activity

inferred from electronic annotation with InterPro:IPR018297

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in G protein-coupled opsin signaling pathway

inferred from mutant phenotype

(Gibbs et al., 2001)

involved_in positive phototaxis

inferred from mutant phenotype

(Gibbs et al., 2001)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cGMP biosynthetic process

inferred from electronic annotation with InterPro:IPR011645

(InterPro Project Members, 2004-)

involved_in cyclic nucleotide biosynthetic process

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in response to oxygen levels

inferred from biological aspect of ancestor with PANTHER:PTN002902243

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of guanylate cyclase complex, soluble

inferred from direct assay

(Shah and Hyde, 1995)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of guanylate cyclase complex, soluble

inferred from biological aspect of ancestor with PANTHER:PTN002902243

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SOLUBLE GUANYLATE CYCLASES

Protein Family (UniProt)

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (Q07093)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

guanylate cyclase activity

GTP = 3',5'-cyclic GMP + diphosphate (4.6.1.2)

RHEA 13665:

Summaries

Gene Snapshot

Guanylyl cyclase α-subunit at 99B (Gycα99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

SOLUBLE GUANYLATE CYCLASES -: Conventional soluble guanylate cyclases are heterodimeric enzymes that synthesize cyclic GMP and are activated by nitric oxide. (Adapted from FBrf0179844).

Protein Function (UniProtKB)

May have a role in phototransduction (PubMed:8095978). Catalyzes the conversion of GTP to cGMP, a common second messenger that is utilized in a wide variety of cells and signal transduction pathways (PubMed:7797526). A second subunit is required for enzyme activity (PubMed:7797526).

(UniProt, Q07093)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gycα99B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q07093)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gycα99B-RA

FBtr0085453

NM_057740

2354

676

Additional Transcript Data and Comments

Reported size (kB)

2.5 (northern blot)

(Liu et al., 1995)

4.1, 2.8, 2.4 (northern blot)

(Shah and Hyde, 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gycα99B-PA

FBpp0084819

75.7

676

5.18

Q07093

NP_477088

AAF56917

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

676 (aa); 76 (kD observed)

(Liu et al., 1995)

676 (aa); 74 (kD observed); 76 (kD predicted)

(Shah and Hyde, 1995)

Comments

Coexpression of Gycα99B protein and

Gycβ100B protein in human kidney cells results in significant guanylyl

cyclase activity. No activity is observed if either is introduced alone.

Results indicate that Gycα99B protein and Gycβ100B protein are

soluble guanylyl cyclase alpha and beta subunits that are capable of

forming a functional guanylyl cyclase heterodimer.

(Shah and Hyde, 1995)

External Data

Subunit Structure (UniProtKB)

Heterodimer.

(UniProt, Q07093)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q07093

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gycα99B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gycalpha99B_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.72

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & pupal stage

(Liu et al., 1995)

adult stage

adult head

(Liu et al., 1995, Shah and Hyde, 1995)

adult brain

(Liu et al., 1995)

adult optic lobe

(Liu et al., 1995)

adult ventral nerve cord

(Liu et al., 1995)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

medulla

(Shah and Hyde, 1995)

adult optic lobe

(Shah and Hyde, 1995)

retina

(Shah and Hyde, 1995)

lamina

(Shah and Hyde, 1995)

lobula plate

(Shah and Hyde, 1995)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult ventral nerve cord

(Liu et al., 1995)

adult head

(Liu et al., 1995)

adult optic lobe

(Liu et al., 1995)

adult brain

(Liu et al., 1995)

Additional Descriptive Data

Gycα99 protein is detected in adult heads and at very low levels in bodies on western blots. Immunolocalization to adult tissue sections shows expression in the optic lobe, central brain, and thoracic ganglia.

(Liu et al., 1995)

Gycα99B protein is expressed in the retina and underlying optic lobes of the adult visual system. In addition, a diffuse pattern of staining is observed throughout the adult brain neuropil.

(Shah and Hyde, 1995)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of guanylate cyclase complex, soluble

inferred from direct assay

(Shah and Hyde, 1995)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gycα99B in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gycα99B

View exonic expression by tissue for Dmel\Gycα99B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013972

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43493/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013972

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013972

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013972

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1912

Flygut - An atlas of the Drosophila adult midgut

FBgn0013972

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gycα99B

Transgenic constructs containing regulatory region of Gycα99B

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gycα99B^GD9678

viable, with Scer\GAL4^Mef2.PR

Gycα99B^GD9678

viable, with Scer\GAL4^pnr-MD237

Gycα99B^GD9678

viable, with Scer\GAL4^tin.CΔ4

Gycα99B^GD9678

Other Phenotypes

Allele

abnormal neuroanatomy | recessive

Gycα99B¹

abnormal phototaxis

abnormal visual behavior | recessive

wild-type

Gycα99B^hs.PG

Phenotype manifest in

Allele

photoreceptor cell R7

Gycα99B¹

photoreceptor cell R8

Gycα99B¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (23)

Hsap\GUCY1A2

12 of 14

Yes

Hsap\GUCY1A1

10 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (22)

Rnor\Gucy1a2

12 of 14

Yes

Rnor\Gucy1a1

10 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\Gucy1a2

12 of 14

Yes

Mmus\Gucy1a1

9 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\gucy1a2

10 of 13

Yes

Xtro\gucy1a1

8 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\grn

1 of 13

Yes

Xtro\gucy2d

1 of 13

Xtro\LOC100496629

1 of 13

Yes

Danio rerio (Zebrafish) (30)

Drer\gucy1a2

11 of 14

Yes

Drer\gucy1a1

10 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch211-132f19.7

2 of 14

Drer\si:dkey-37g12.1

2 of 14

Drer\si:dkey-206f10.1

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\npr2

1 of 14

Drer\npr3

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (39)

Cele\gcy-32

3 of 14

Yes

Cele\gcy-34

3 of 14

Yes

Cele\gcy-36

3 of 14

Yes

Cele\gcy-37

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (25)

Agam\AgaP_AGAP000280

11 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009087

1 of 12

Agam\AgaP_AGAP012805

1 of 12

Agam\AgaP_AGAP012965

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gycα99B. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

5 of 13

5 of 13

5 of 13

5 of 13

Ac3

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

EHR

2 of 13

Gucy2d

2 of 13

CG14877

1 of 13

Phlpp

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GUCY1A1; guanylate cyclase 1 soluble subunit alpha 1

model of Moyamoya disease

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Gycα99B^GL01038

ameliorates Alexander disease

modeled by Hsap\GFAP^R79H.QUAS

(Wang et al., 2015)

Gycα99B^JF03176

ameliorates Alexander disease

modeled by Hsap\GFAP^R79H.QUAS

(Wang et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2

12 of 14

601244

GUCY1A1; guanylate cyclase 1 soluble subunit alpha 1

10 of 14

139396

MOYAMOYA DISEASE 6 WITH OR WITHOUT ACHALASIA; MYMY6

Moyamoya disease

GUCY1B1; guanylate cyclase 1 soluble subunit beta 1

3 of 14

139397

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

foxo

suppressible

Gycα99B

(Kanao et al., 2012)

External Data

Subunit Structure (UniProtKB)

Heterodimer.

(UniProt, Q07093 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0013972

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Smooth Muscle Contraction

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-99

Cytogenetic map

99B7-99B7

Sequence location

3R:29,682,503..29,685,758 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99B7-99B7

Limits computationally determined from genome sequence between P{PZ}l(3)06743⁰⁶⁷⁴³ and P{PZ}ncd⁰⁵⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

63A1-63A2

(Yoshikawa, 1993.5.5)

99B-99B

(Shah, 1995.5.15)

99B-99B

(determined by in situ hybridisation)

(Liu et al., 1995, Shah and Hyde, 1995)

63A1-63A2

(determined by in situ hybridisation)

(Yoshikawa et al., 1993)

Experimentally Determined Recombination Data

Location

3-99

(FlyBase, 2016)

3-96.7

(Comeron et al., 2012)

(Shah, 1995.5.15)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

52802

w¹¹¹⁸; P{GMR65G10-lexA}attP40

68997

w¹¹¹⁸; P{R65G10-GAL4.DBD}attP2

28748

y¹ v¹; P{TRiP.JF03176}attP2

64009

y¹ v¹; P{TRiP.HMJ30322}attP40

70778

w¹¹¹⁸; P{R65G10-p65.AD}attP40; MKRS/TM6B, Tb¹

36817

y¹ sc^* v¹ sev²¹; P{TRiP.GL01038}attP2

NIG-Fly

HMJ30322

y¹ v¹; P{TRiP.HMJ30322}attP40/CyO

VDRC

v107074

P{KK102774}VIE-260B

v43711

w¹¹¹⁸; P{GD9678}v43711

Genomic Clones (5)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (22)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH08311

Other clones

FI19414

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0013972

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013972

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Liu et al., 1995, Shah and Hyde, 1995)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Gyc-89Db shows no guanylyl cyclase activity when expressed in COS-7 cells in the absence of additional subunits, in the presence of either Mg²⁺ or Mn²⁺ cofactor. When Gyc-89Db and Gycα99B are co-expressed in COS-7 cells in the presence of either Mg²⁺ or Mn²⁺, no guanylyl cyclase activity is detected.

(Langlais et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The function of Gycα99B in the phototactic response is developmental, rather than physiological.

(Gibbs et al., 2001)

Isolated using cDNA fragments encoding the kinase-like and cyclase domains from the rat GC-A, GC-B and GC-C genes.

(Liu et al., 1995)

Gycα99B has been cloned and sequenced. It encodes a soluble guanylate cyclase subunit.

(Liu et al., 1995)

Gycα99B has been cloned and sequenced. It encodes a soluble guanylyl cyclase α subunit.

(Shah and Hyde, 1995)

Gycα99B has been cloned and sequenced.

(Yoshikawa et al., 1993)

Relationship to Other Genes

Source for database merge of

Source for merge of: Gycα99B Gycα63A

(FlyBase, 1996-)

Additional comments

Source for merge of Gycα99B Gycα63A was sequence comparison ( date:000202 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Gycα99B CG1912

(Wang, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

CG1912

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Morrison et al., 2000)

Dgc1

(Shah and Hyde, 1995)

Dgcα1

(Zhang et al., 2002)

GCα1

(Zelhof et al., 2003)

GYCa 99B

(Morrison et al., 2000)

Gcα1

(Gibbs, 2001, Gibbs et al., 2001)

Gycalpha99B

(Aradska et al., 2015, Kwon et al., 2013)

Gycα-99B

(Langlais et al., 2004, Morton, 2004)

Gycα63A

Gycα99B

(Amstutz et al., 2022, Wang et al., 2015, Adryan et al., 2007)

SGCα

(Elphick and Jones, 1998, Elphick and Jones, 1997)

dgc1

(Davies, 2000, Gibbs and Truman, 1999, Gibbs and Truman, 1998, Yoshikawa, 1993.5.5, Yoshikawa et al., 1993)

dgca1

(Shah, 1995.5.15)

dgcα1

(Rabinovich et al., 2016, Riedl et al., 2005, Liu et al., 1995, Shah and Hyde, 1995)

gycalpha

(Siddiqi, 1998)

sGC

(Tinette et al., 2007)

sGC-α

(Villegas et al., 2018)

sGCα1

(Zhang et al., 2002)

sGCα99B

(Kanao et al., 2012)

Name Synonyms

Guanyl cyclase α-subunit at 63A

Guanylyl cyclase α-subunit at 99B

Soluble Guanylyl Cyclase α

(Elphick and Jones, 1997)

guanylate cyclase 99B

(Brenman et al., 2001)

soluble guanylate cyclase

(Tinette et al., 2007)

Secondary FlyBase IDs

FBgn0010227

Datasets (0)

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Title

Study result (0)

Result

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External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43493

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q07093

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q07093

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q07093

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013972

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43493/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013972

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013972

FlyMine - An integrated database for Drosophila genomics

FBgn0013972

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1912

MARRVEL_MODEL - MARRVEL (model organism gene)

43493

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0013972

DroID - A comprehensive database of gene and protein interactions.

FBgn0013972

DRSC - Results frm RNAi screens

FBgn0013972

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gycalpha99B_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013972

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013972

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1912

Flygut - An atlas of the Drosophila adult midgut

FBgn0013972

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008018

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Smooth Muscle Contraction

References (63)

The following external sites may use different assemblies or annotations than FlyBase.

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