FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term guanylate cyclase activity ID (Ontology) GO:0004383 (Gene Ontology)
Definition Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.[ EC:4 ]
Also Known As"guanylyl cyclase activity"
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Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 guanylate cyclase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | guanylate cyclase activity       --
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catalytic activity
 |__cyclase activity__________________
lyase activity                        |
 |__phosphorus-oxygen lyase activity__|
                                      guanylate cyclase activity  17 rec.
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Is a cyclase activity
phosphorus-oxygen lyase activity
Part of
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Synonyms
  • "GTP diphosphate-lyase (cyclizing) activity" RELATED[ EC:4 ]
    "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" RELATED[ EC:4 ]
    "guanyl cyclase activity" RELATED[ EC:4 ]
    "guanylyl cyclase activity" EXACT
    "receptor guanylate cyclase activity" NARROW
Secondary IDs
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EC:4.6.1.2
MetaCyc:GUANYLCYC-RXN
Reactome:R-HSA-392152 "Soluble guanylate cyclase converts GTP to cGMP"
Reactome:R-HSA-74885 "GUCYs converts GTP to cGMP"
RHEA:13665