FlyBase Allele Report: Dmel\Gycα99B[JF03176]

General Information

Symbol

Dmel\Gycα99B^JF03176

Species

D. melanogaster

Name

FlyBase ID

FBal0239674

Feature type

allele

Associated gene

Dmel\Gycα99B

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03176}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03176}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03176

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alexander disease

modeled by Hsap\GFAP^R79H.QUAS

(Wang et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav.PU/Gycα99B^JF03176 is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\GFAP^R79H.QUAS, Ncra\QF^sotv-ET31

(Wang et al., 2015)

Scer\GAL4^elav.PU/Gycα99B^JF03176 is a suppressor | partially of increased cell death | cell non-autonomous | adult stage phenotype of Hsap\GFAP^R79H.QUAS, Ncra\QF^sotv-ET31

(Wang et al., 2015)

Gycα99B^JF03176, Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, foxo^UAS.cPa

(Kanao et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^elav.PU/Gycα99B^JF03176 is a suppressor | partially of adult CNS glial cell phenotype of Hsap\GFAP^R79H.QUAS, Ncra\QF^sotv-ET31

(Wang et al., 2015)

Scer\GAL4^elav.PU/Gycα99B^JF03176 is a suppressor | partially of neuron | cell non-autonomous | adult stage phenotype of Hsap\GFAP^R79H.QUAS, Ncra\QF^sotv-ET31

(Wang et al., 2015)

Gycα99B^JF03176, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, foxo^UAS.cPa

(Kanao et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Gycα99B^JF03176 partially suppresses the eye defects caused by expression of foxo^Scer\UAS.cPa under the control of Scer\GAL4^GMR.PF.

(Kanao et al., 2012)

Xenogenetic Interactions

Statement

Reference

Expression of Gycα99B^JF03176 driven pan-neuronally by Scer\GAL4^elav.PU significantly suppresses cell death in Ncra\QF^Ext2-ET31>Hsap\GFAP^{R79H.Ncra\QUAS} flies.

(Wang et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28748

y¹ v¹; P{TRiP.JF03176}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Gycα99B^JF03176

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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