FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gycα99B1
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General Information
Symbol
Dmel\Gycα99B1
Species
D. melanogaster
Name
FlyBase ID
FBal0134231
Feature type
allele
Associated gene
Dmel\Gycα99B
Associated Insertion(s)
Carried in Construct
Also Known As
Gcα11
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gibbs et al., 2001)
Mutagen
ethyl methanesulfonate
(Gibbs, 2001, Gibbs et al., 2001)
Progenitor genotype
Cytology
Description

Nucleotide substitution: AG/GT to AG/AT in the donor sequence at the splice junction of intron 1.

(Gibbs et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Gycα99B1/Gycα99B1 mutants do not exhibit defects in axon pruning or regrowth in the mushroom body gamma-lobe.

      (Rabinovich et al., 2016)

      Greatly attenuates the synthesis of cGMP in the nervous system in response to nitric oxide. The projection pattern of R7/R8 at 48hrs APF is less well organised than in wild type, showing gaps in the pattern and extensions of the retinal axons slightly beyond the medullar margin. When CNS from white puparia were cultured with 10 micromolar L-NAME the projection pattern of retinal axons is severely disrupted. Retinal fibers cause a dense, disorganized tangle in the medulla with many projections extending into the lobula. Shows a reduction is positive phototaxis at 1 week after eclosion, though geotaxis assay behaviour is normal. 82% of ERGs from mutant flies lack off transients or have off transients that are greatly reduced in amplitude.

      (Gibbs et al., 2001)

      Mutant adults show no positive phototaxis.

      (Gibbs, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Gycα99B1 is rescued by Gycα99Bhs.PG

      (Gibbs et al., 2001)
      Partially rescued by

      Gycα99B1 is partially rescued by Gycα99Bhs.PG

      (Gibbs, 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: ca1

      (Gibbs et al., 2001)
      Comments
      Comments

      Identification: by reduction in/loss of Gycα99B protein on a Western Blot. In terms of immunoreactivity on a Western Blot (most to least) Gycα99B2 < Gycα99B1 = Gycα99B3 = Gycα99B5.

      (Gibbs et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      GC 207
      (Gibbs et al., 2001)
      Gcα11
      (Gibbs, 2001, Gibbs et al., 2001)
      Gycα99B1
      dgcα1207
      (Rabinovich et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)