FB2022_02, released March 29, 2022

Gene: Dmel\wnd

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General Information
Symbol
Dmel\wnd
Species
D. melanogaster
Name
wallenda
Annotation Symbol
CG8789
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036896
Gene Model Status
Current
Stock Availability
17 publicly available
Enzyme Name (EC)
Mitogen-activated protein kinase kinase kinase (2.7.11.25)
Gene Summary
wallenda (wnd) encodes a kinase in the mixed lineage family of MAP Kinase Kinase Kinases. Its roles include axonal injury signaling (it becomes activated in neurons after axotomy), and in regulation of the structure of presynaptic boutons. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DLK

Key Links
Genomic Location
Cytogenetic map
76B9-76B9
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:19624406..19635783
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017419
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables MAP kinase kinase kinase activity
inferred from electronic annotation with InterPro:IPR017419
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001148170
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in collateral sprouting of injured axon
inferred from mutant phenotype
(Xiong et al., 2010)
involved_in Golgi organization
inferred from mutant phenotype
(Zacharogianni et al., 2011)
involved_in long-term memory
inferred from genetic interaction with FLYBASE:hiw; FB:FBgn0030600
(Huang et al., 2012)
involved_in medium-term memory
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2018)
involved_in positive regulation of synaptic assembly at neuromuscular junction
inferred from direct assay
(Russo et al., 2019)
involved_in regulation of terminal button organization
inferred from mutant phenotype
(Klinedinst et al., 2013)
involved_in spermatogenesis
inferred from mutant phenotype
(Lindsley et al., 2013)
involved_in sprouting of injured axon
inferred from mutant phenotype
(Hao et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in protein autophosphorylation
inferred from electronic annotation with InterPro:IPR017419
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001148170
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Xiong et al., 2010)
located_in neuromuscular junction
inferred from direct assay
(Russo et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001148170
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a protein = ADP + a phosphoprotein (2.7.11.25)
Summaries
Gene Snapshot
wallenda (wnd) encodes a kinase in the mixed lineage family of MAP Kinase Kinase Kinases. Its roles include axonal injury signaling (it becomes activated in neurons after axotomy), and in regulation of the structure of presynaptic boutons. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
NON-RECEPTOR TLK KINASES -
Non-receptor tyrosine kinase-like (TKL) kinases are a diverse group of intracellular serine-threonine protein kinases with sequence similarity to tyrosine kinases (TK) but lacking TK-specific motifs.
Summary (Interactive Fly)

MapKKK member of the JNK pathway - influences axonal transport by functioning as a kinesin-cargo dissociation factor - suppresses autophagy-induced neuromuscular junction overgrowth - required for normal axon degeneration

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\wnd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VW24)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
wnd-RA
FBtr0074963
NM_140880
4384
977
wnd-RB
FBtr0074964
NM_176362
4307
977
wnd-RC
FBtr0074965
NM_176363
4512
977
wnd-RD
FBtr0302513
NM_001202203
3645
950
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
wnd-PA
FBpp0074731
109.6
977
7.78
NP_649137
AAF49129
wnd-PB
FBpp0074732
109.6
977
7.78
NP_788540
AAO41221
wnd-PC
FBpp0074733
109.6
977
7.78
NP_788541
AAO41222
wnd-PD
FBpp0291675
106.6
950
7.31
NP_001189132
ADV37568
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

977 aa isoforms: wnd-PA, wnd-PB, wnd-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wnd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval dorsal vessel
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Xiong et al., 2010)
located_in neuromuscular junction
inferred from direct assay
(Russo et al., 2019)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.2}wndMI00494-TG4.2
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Lee et al., 2018)
adult mushroom body
(Lee et al., 2018)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wnd in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 31 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of wnd
Transgenic constructs containing regulatory region of wnd
Aberrations (Deficiencies and Duplications) ( 4 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during embryonic stage, with Scer\GAL4unspecified
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
fertile
male sterile
Other Phenotypes
Allele
abnormal memory, with Scer\GAL4ey-OK107
abnormal neuroanatomy, with Scer\GAL4ppk.PG
abnormal neuroanatomy | conditional, with Scer\GAL4tey-5053A
abnormal neuroanatomy | conditional (with wnd1)
abnormal neuroanatomy | conditional (with wnd2)
abnormal neuroanatomy | larval stage (with Df(3L)ED229)
abnormal neuroanatomy | larval stage (with wnd1)
abnormal neuroanatomy | larval stage (with wnd2)
abnormal neuroanatomy | larval stage | RU486 conditional, with Scer\GAL4elav.Switch.PO
abnormal wound healing | recessive | third instar larval stage
abnormal wound healing | third instar larval stage, with Scer\GAL4tey-5053A
decreased cell growth | recessive | third instar larval stage | conditional
decreased cell growth | third instar larval stage | conditional, with Scer\GAL4tey-5053A
some die during embryonic stage, with Scer\GAL4unspecified
Phenotype manifest in
Allele
axon | third instar larval stage | conditional
axon | third instar larval stage | conditional, with Scer\GAL4tey-5053A
bouton, with Scer\GAL4unspecified
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.PG
larval segmental nerve | conditional, with Scer\GAL4tey-5053A
larval segmental nerve | conditional (with wnd1)
larval segmental nerve | conditional (with wnd2)
motor neuron | third instar larval stage | conditional
motor neuron | third instar larval stage | conditional, with Scer\GAL4tey-5053A
neuromuscular junction, with Scer\GAL4unspecified
NMJ bouton | larval stage (with Df(3L)ED229)
NMJ bouton | larval stage (with wnd1)
NMJ bouton | larval stage (with wnd2)
NMJ bouton | larval stage | RU486 conditional, with Scer\GAL4elav.Switch.PO
synapse, with Scer\GAL4ppk.PG
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MAP3K13
10 of 15
Yes
Yes
Hsap\MAP3K12
9 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Map3k12
10 of 15
Yes
Yes
Mmus\Map3k13
10 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Map3k12
8 of 13
Yes
Yes
Rnor\Map3k13
7 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\map3k12
8 of 12
Yes
Yes
Xtro\map3k13
5 of 12
No
Yes
Xtro\gucy2f
1 of 12
No
No
Danio rerio (Zebrafish) (2)
Drer\map3k12
10 of 15
Yes
Yes
Drer\si:ch211-45c16.2
8 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\dlk-1
10 of 15
Yes
Yes
Cele\sid-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (22)
Atha\AT1G18160
1 of 9
Yes
No
Atha\AT1G67890
1 of 9
Yes
Yes
Atha\AT1G73660
1 of 9
Yes
No
Atha\AT2G24360
1 of 9
Yes
No
Atha\AT3G01490
1 of 9
Yes
No
Atha\AT3G06620
1 of 9
Yes
Yes
Atha\AT3G06630
1 of 9
Yes
Yes
Atha\AT3G06640
1 of 9
Yes
Yes
Atha\AT3G22750
1 of 9
Yes
No
Atha\AT3G46930
1 of 9
Yes
Yes
Atha\AT4G14780
1 of 9
Yes
No
Atha\AT4G31170
1 of 9
Yes
No
Atha\AT5G11850
1 of 9
Yes
Yes
Atha\AT5G50000
1 of 9
Yes
No
Atha\AT5G58950
1 of 9
Yes
No
Atha\ATMRK1
1 of 9
Yes
No
Atha\CIPK9
1 of 9
Yes
Yes
Atha\CTR1
1 of 9
Yes
No
Atha\HT1
1 of 9
Yes
No
Atha\STY8
1 of 9
Yes
No
Atha\STY17
1 of 9
Yes
No
Atha\STY46
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ksr
2 of 10
Mos
2 of 10
Tak1
2 of 10
Takl2
2 of 10
cdi
1 of 10
Ilk
1 of 10
LIMK1
1 of 10
Lrrk
1 of 10
Raf
1 of 10
slpr
1 of 10
Takl1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MAP3K13; mitogen-activated protein kinase kinase kinase 13
    10 of 15
    604915
        MAP3K12; mitogen-activated protein kinase kinase kinase 12
        9 of 15
        600447
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            wnd - Rho1
            anti tag coimmunoprecipitation, anti tag western blot
            (Ma et al., 2016)
            wnd - alph
            anti tag coimmunoprecipitation, western blot
            (Baril et al., 2009)
            wnd - hep
            anti tag coimmunoprecipitation, anti tag western blot
            (Horiuchi et al., 2007)
            RNA-protein
            Physical Interaction
            Assay
            References
            wnd - Fmr1
            anti bait coimmunoprecipitation, quantitative reverse transcription pcr
            (Russo and DiAntonio, 2019)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            wnd
            suppressible
            bsk
            (Collins et al., 2006)
            wnd
            suppressible
            Dscam1
            (Kim et al., 2013)
            wnd
            suppressible
            kay
            (Collins et al., 2006)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Aplip1
            suppressible
            wnd
            (Klinedinst et al., 2013)
            Atg1
            suppressible
            wnd
            (Shen and Ganetzky, 2009)
            chb
            enhanceable
            wnd
            (Lowery et al., 2010)
            Dad1
            suppressible
            wnd
            (Zhang et al., 2016)
            faf
            suppressible
            wnd
            (Collins et al., 2006)
            Fmr1
            suppressible
            wnd
            (Russo and DiAntonio, 2019)
            Fsn
            suppressible
            wnd
            (Wu et al., 2007)
            fzr
            suppressible
            wnd
            (Neuert et al., 2017)
            hiw
            suppressible
            wnd
            (Russo and DiAntonio, 2019, Huang et al., 2012, Collins et al., 2006)
            Rae1
            suppressible
            wnd
            (Tian et al., 2011)
            Rheb
            suppressible
            wnd
            (Wong et al., 2015)
            sgg
            suppressible
            wnd
            (Franciscovich et al., 2008)
            shot
            suppressible
            wnd
            (Valakh et al., 2013)
            SkpA
            suppressible
            wnd
            (Brace et al., 2014)
            SkpA|faf
            suppressible
            wnd
            (Brace et al., 2014)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-45
            Cytogenetic map
            76B9-76B9
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            76B9-76B9
            Limits computationally determined from genome sequence between P{lacW}l(3)L3809L3809 and P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-45

            (FlyBase, 2016)

            3-43.1

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (17)
            Genomic Clones (24)
            cDNA Clones (134)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: wnd CG8789

            (Collins et al., 2006)
            Source for database merge of
            Additional comments
            Other Comments

            wnd is essential for the hiw synaptic overgrowth phenotype.

            (Collins et al., 2006)

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            (Kiger et al., 2003)
            Origin and Etymology
            Discoverer
            Etymology

            Wallenda is named after the Flying Wallendas, an acrobat troupe famous for their world record stunts on the circus highwire.

            (Collins et al., 2006)
            Identification
            External Crossreferences and Linkouts ( 64 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            modMine - A data warehouse for the modENCODE project
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (11)
            Reported As
            Symbol Synonym
            CG8789
            (Neuert et al., 2017, Lindsley et al., 2013, Ni et al., 2011.7.19, Lowery et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Urasaki et al., 2008, Collins et al., 2006, Zhang et al., 2006)
            DLK
            (Brace and DiAntonio, 2017, Chen et al., 2016, Grill et al., 2016, Araújo, 2015, Stone et al., 2014, Horiuchi et al., 2007)
            DLK/ZPK
            (Morrison et al., 2000)
            MAPKKK
            (Horiuchi et al., 2007)
            Wallenda
            (Mishra et al., 2021)
            Wnd
            (Goel and Dickman, 2021, Layalle et al., 2021, La Marca and Richardson, 2020, Liu et al., 2020, Nye et al., 2020, Brace and DiAntonio, 2017, Hao and Collins, 2017, Schimizzi et al., 2016, Araújo, 2015, Frank et al., 2013, Kim et al., 2013, Zhang et al., 2013, Fang and Bonini, 2012, Huang et al., 2012, Baril et al., 2009)
            Wnd/DLK
            (Xiong et al., 2012)
            wallenda
            (Cirrincione and Rieger, 2020)
            wnd
            (Ji et al., 2022, Bush et al., 2021, Yamaguchi et al., 2021, Li et al., 2020, Hao et al., 2019, Myat et al., 2019, Russo and DiAntonio, 2019, Sapar and Han, 2019, Sun et al., 2019, Sun et al., 2019, Li-Kroeger et al., 2018, Mecklenburg et al., 2018, Akbergenova and Littleton, 2017, Borgen et al., 2017, Jordán-Álvarez et al., 2017, Li et al., 2017, Ma et al., 2017, Muzzopappa et al., 2017, Neuert et al., 2017, Chen et al., 2016, Clandinin and Owens, 2016-, Feoktistov and Herman, 2016, Hao et al., 2016, Ma et al., 2016, Marmor-Kollet and Schuldiner, 2016, Voelzmann et al., 2016, Zhang et al., 2016, Wong et al., 2015, Zhan et al., 2015, Brace et al., 2014, Sopko et al., 2014, Stone et al., 2014, Kim et al., 2013, Klinedinst et al., 2013, Lindsley et al., 2013, Valakh et al., 2013, Wang et al., 2013, Bhattacharya et al., 2012, Huang et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nechipurenko and Broihier, 2012, Shin and Diantonio, 2011, Venken et al., 2011, Venken et al., 2011, Zacharogianni et al., 2011, Cooper et al., 2010, Lowery et al., 2010, Neisch et al., 2010, Xiong et al., 2010, Miller et al., 2009, Shen and Ganetzky, 2009, Franciscovich et al., 2008, Horiuchi et al., 2007, Wu et al., 2007, Collins et al., 2006)
            Name Synonyms
            CG8789
            Dual Leucine Zipper Kinase
            (Brace and DiAntonio, 2017)
            Wallenda
            (Ramond et al., 2020, Akbergenova and Littleton, 2017, Brace and DiAntonio, 2017, Hao and Collins, 2017, Grill et al., 2016, Ma et al., 2016, Araújo, 2015, Copf, 2015, Frank et al., 2013, Beck et al., 2012, Huang et al., 2012, Nezis, 2012, Wang and Jin, 2011, Neisch et al., 2010, Franciscovich et al., 2008, Horiuchi et al., 2007, Collins et al., 2006)
            dual leucine zipper-bearing kinase
            (Horiuchi et al., 2007)
            wallenda
            (Russo and DiAntonio, 2019, Feoktistov and Herman, 2016, Marmor-Kollet and Schuldiner, 2016, Valakh et al., 2013, Wang et al., 2013, Nechipurenko and Broihier, 2012, Tian et al., 2011, Zacharogianni et al., 2011, Massaro et al., 2009, Miller et al., 2009, Shen and Ganetzky, 2009, Wu et al., 2007)
            Secondary FlyBase IDs
              Datasets (8)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (8)
              Result
              Result Type
              Title
              scRNAseq_2020_Cattenoz_NI_seq_clustering
              Clustering analysis of hemocytes from non-infested third instar larvae
              scRNAseq_2020_Cattenoz_WI_seq_clustering
              Clustering analysis of hemocytes from wasp-infested third instar larvae
              scRNAseq_2020_Cho_NI72LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
              scRNAseq_2020_Cho_NI96LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI120LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
              scRNAseq_2020_Cho_WI96LG_seq_clustering
              Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI96HL_seq_clustering
              Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI120HL_seq_clustering
              Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
              References (131)