FlyBase Allele Report: Dmel\tau[MR22]

General Information

Symbol

Dmel\tau^MR22

Species

D. melanogaster

Name

FlyBase ID

FBal0151385

Feature type

allele

Associated gene

Dmel\tau

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

recombination

(Doerflinger et al., 2003)

P-element activity

(Doerflinger et al., 2003)

Progenitor genotype

P{EP}tau^EP3203

(Doerflinger et al., 2003)

Caused by aberration

Df(3R)MR22

Cytology

Description

62kb deletion extending proximally from P{EP}tau^EP3203, removing almost all the tau locus, including the exons that encode the microtubule binding domain.

(Doerflinger et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA with tau^EP3203

(Tsuda et al., 2017)

CEA with shot³

(Voelzmann et al., 2016)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Sofola et al., 2010)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Wang et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Phenotypes in the Hsap\APP^{1-40.Scer\UAS.T:SS-nec} Alzheimer's Disease model are suppressed when tau^MR22 is transheterozygous with tau^EP3203.

(Sofola et al., 2010)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage (with tau^EP3203)

(Sofola et al., 2010)

Phenotype Manifest In

oocyte nucleus | germline clone

(Tian and Deng, 2009)

Detailed Description

Statement

Reference

tau^MR22/+ larvae do not exhibit specific accumulation of a subset of synaptic cargo in axons, as compared to controls.

(Barber et al., 2017)

tau^MR22/tau^EP3203 mutant flies exhibit mild climbing defects compared to controls.

(Sofola et al., 2010)

The oocyte nucleus is mislocalised to the central or lateral region of the oocyte in 58% of stage 10 egg chambers of females containing homozygous tau^MR22 germline clones.

(Tian and Deng, 2009)

Germline and follicle cell clones of Df(3R)MR22 have no microtubule defects.

(Doerflinger et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

tau^MR22/tau[+] is a suppressor of abnormal neuroanatomy | pupal stage phenotype of Scer\GAL4^ppk.PG, par-1^HMS00405

(Herzmann et al., 2017)

tau^MR22/tau[+] is a suppressor | partially of abnormal neuroanatomy | somatic clone | pupal stage phenotype of par-1^Δ-16

(Herzmann et al., 2017)

tau^MR22/tau^EP3203 is a suppressor of abnormal locomotor behavior | adult stage | progressive | RU486 conditional phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^{elav.Switch.PO}

(Sofola et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

tau^MR22 is an enhancer of terminal tracheal cell | embryonic stage phenotype of shot³

(Ricolo and Araujo, 2020)

tau^MR22 is an enhancer of tracheal lumen | embryonic stage phenotype of shot³

(Ricolo and Araujo, 2020)

Suppressor of

Statement

Reference

tau^MR22/tau[+] is a suppressor of larval multidendritic class IV neuron | pupal stage phenotype of Scer\GAL4^ppk.PG, par-1^HMS00405

(Herzmann et al., 2017)

tau^MR22/tau[+] is a suppressor of dendrite | pupal stage phenotype of Scer\GAL4^ppk.PG, par-1^HMS00405

(Herzmann et al., 2017)

tau^MR22/tau[+] is a suppressor | partially of larval multidendritic class IV neuron | somatic clone | pupal stage phenotype of par-1^Δ-16

(Herzmann et al., 2017)

NOT Suppressor of

Statement

Reference

tau^MR22/tau[+] is a non-suppressor of axon | larval stage phenotype of Scer\GAL4^BG380, par-1^UAS.cSa

(Barber et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

tau^MR22/+ fails to suppress the axonal transport defects seen in flies expressing par-1^Scer\UAS.cSa under the control of Scer\GAL4^BG380.

(Barber et al., 2017)

The pruning defects observed in class IV dendritic arborizing neurons of pupae expressing par-1^HMS00405 under the control of Scer\GAL4^ppk.PG or in par-1^Δ-16 mutant MARCM clones are significantly suppressed by combination with a single copy of tau^MR22.

(Herzmann et al., 2017)

Xenogenetic Interactions

Statement

Reference

tau^MR22/tau^EP3203 suppresses the climbing defects seen in flies expressing Hsap\APP^{Arctic.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^{elav.Switch.PO} from 2 day post-eclosion onwards (expression induced by feeding flies RU486). This rescue is further enhanced by feeding the flies lithium in adulthood.

(Sofola et al., 2010)

Complementation and Rescue Data

Rescued by

tau^MR22 is rescued by tau^UASp.mGFP6/Scer\GAL4^{VP16.mat.αTub67C}

(Tian and Deng, 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9530

w^*; Df(3R)MR22, e^s tau^MR22/TM3, P{ActGFP}JMR2, Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Tau dfc

(Sofola et al., 2010)

dTau^-

(Feuillette et al., 2010)

dtau^MR22

(Tsuda et al., 2017)

tau^Df(3R)MR22

(Tian and Deng, 2009)

tau^MR22

(Goodman et al., 2024, Ricolo and Araujo, 2020, Barber et al., 2017, Herzmann et al., 2017, Nam, 2016, Voelzmann et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (12)

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