FlyBase Allele Report: Dmel\tau[EP3203]

General Information

Symbol

Dmel\tau^EP3203

Species

D. melanogaster

Name

FlyBase ID

FBal0151387

Feature type

allele

Associated gene

Dmel\tau

Associated Insertion(s)

P{EP}tau^EP3203

Carried in Construct

Also Known As

EP(3)3203

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Doerflinger et al., 2003)

Progenitor genotype

Associated Insertion(s)

P{EP}tau^EP3203

Cytology

Description

P{EP} insertion in the first intron.

(Doerflinger et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:27,652,818..27,652,818 [+]

(Talmat-Amar et al., 2018, Feuillette et al., 2010, Yeh et al., 2010, Doerflinger et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA

(Talmat-Amar et al., 2018)

CEA with tau^MR22

(Tsuda et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Sofola et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Phenotypes in the Hsap\APP^{1-40.Scer\UAS.T:SS-nec} Alzheimer's Disease model are suppressed when tau^EP3203 is transheterozygous with tau^MR22.

(Sofola et al., 2010)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage (with tau^MR22)

(Sofola et al., 2010)

fertile

(Doerflinger et al., 2003)

viable

(Doerflinger et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

tau^MR22/tau^EP3203 mutant flies exhibit mild climbing defects compared to controls.

(Sofola et al., 2010)

Homozygotes have no obvious morphological or behavioural defects. The organisation of microtubules in the follicle and germline cells is indistinguishable from wild type.

(Doerflinger et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

tau^EP3203/tau^EP3203 is a suppressor of bang sensitive phenotype of kcc^DHS1

(Holth et al., 2013)

tau[+]/tau^EP3203 is a suppressor of bang sensitive phenotype of kcc^DHS1

(Holth et al., 2013)

tau^EP3203/Df(3R)MR22 is a suppressor of bang sensitive phenotype of eas²

(Holth et al., 2013)

tau^MR22/tau^EP3203 is a suppressor of abnormal locomotor behavior | adult stage | progressive | RU486 conditional phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^{elav.Switch.PO}

(Sofola et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

tau^EP3203/tau^EP3203 or tau^EP3203/+ significantly partially suppresses bang-sensitive behavior in kcc^DHS1/kcc^DHS1 flies, and Df(3R)MR22/tau^EP3203 significantly partially suppresses bang-sensitive behavior in eas²/eas² flies.

(Holth et al., 2013)

Xenogenetic Interactions

Statement

Reference

tau^MR22/tau^EP3203 suppresses the climbing defects seen in flies expressing Hsap\APP^{Arctic.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^{elav.Switch.PO} from 2 day post-eclosion onwards (expression induced by feeding flies RU486). This rescue is further enhanced by feeding the flies lithium in adulthood.

(Sofola et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17098

w¹¹¹⁸; P{EP}tau^EP3203

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dtau^EP3203

(Tsuda et al., 2017)

tau^EP(3)3202

(Yeh et al., 2010)

tau^EP3203

(Burnouf et al., 2016, Holth et al., 2013)

tau^ep3203

(Talmat-Amar et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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