FlyBase Allele Report: Dmel\wnd[GL00282]

General Information

Symbol

Dmel\wnd^GL00282

Species

D. melanogaster

Name

FlyBase ID

FBal0262751

Feature type

allele

Associated gene

Dmel\wnd

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00282}

Also Known As

UAS-wallenda-RNAi, UAS-wnd-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00282}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00282

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Russo and DiAntonio, 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Females heterozygous for wnd^GL00282 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to wnd^GL00282 males results in: 78% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of abnormal size | third instar larval stage phenotype of hiw^ND9

(Russo and DiAntonio, 2019)

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of hiw^ND8

(Russo and DiAntonio, 2019)

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of abnormal size | third instar larval stage phenotype of hiw^ND8

(Russo and DiAntonio, 2019)

NOT Suppressor of

Statement

Reference

wnd^GL00282/Scer\GAL4^tey-5053A is a non-suppressor of abnormal neuroanatomy | cell autonomous | third instar larval stage | conditional phenotype of Scer\GAL4^tey-5053A, raw^GD7727

(Hao et al., 2019)

Other

Statement

Reference

Scer\GAL4^tey-5053A, raw^dcp-1, wnd^GL00282 has abnormal neuroanatomy | third instar larval stage phenotype

(Hao et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of hiw^ND8

(Russo and DiAntonio, 2019)

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of hiw^ND8

(Russo and DiAntonio, 2019)

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

wnd^GL00282/Scer\GAL4^elav.PU is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Fmr1^Δ50M

(Russo and DiAntonio, 2019)

NOT Suppressor of

Statement

Reference

wnd^GL00282/Scer\GAL4^tey-5053A is a non-suppressor of axon | cell autonomous | third instar larval stage | conditional phenotype of Scer\GAL4^tey-5053A, raw^GD7727

(Hao et al., 2019)

wnd^GL00282/Scer\GAL4^tey-5053A is a non-suppressor of embryonic/larval motor neuron | cell autonomous | third instar larval stage | conditional phenotype of Scer\GAL4^tey-5053A, raw^GD7727

(Hao et al., 2019)

Other

Statement

Reference

Scer\GAL4^tey-5053A, raw^dcp-1, wnd^GL00282 has axon | third instar larval stage phenotype

(Hao et al., 2019)

Scer\GAL4^tey-5053A, raw^dcp-1, wnd^GL00282 has embryonic/larval motor neuron | third instar larval stage phenotype

(Hao et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

In raw^dcp-1 homozygotes that also express wnd^GL00282 under the control of Scer\GAL4^tey-5053A, injured axons exhibit severely decreased new growth/sprouting compared to controls.

(Hao et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35369

y¹ sc^* v¹ sev²¹; P{TRiP.GL00282}attP2

NIG-Fly

GL00282

y¹ sc^* v¹ sev²¹; P{TRiP.GL00282}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

wnd^GL00282

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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