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FB2026_02
,
released June 18, 2026
pelado, pldo
Cullin-RING E3 ubiquitin ligase - Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation - catalyzes ubiquitination and subsequent degradation of AGO1, thereby exposing miRNAs for degradation
Please see the JBrowse view of Dmel\Dora for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Stop-codon suppression (UGA) postulated; FBrf0234051.
Gene model reviewed during 6.25
A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).
None of the polypeptides share 100% sequence identity.
Component of the SCF-like E3 ubiquitin-protein ligase complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dora using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Dora in JBrowse1-61
1-60.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New stable cell line derived from OSC : An OSC cell line stably expressing flag-tagged Spyo\Cas9 was generated. Additionally, new stable cell lines were derived from the OSC[Cas9] cell line: OSC cell lines stably expressing HA-tagged Dora, and a knockout of Dora in which a hygromycin resistance gene was inserted into its open reading frame, were generated. New stable cell lines were then generated from the Dora and Dora-KO: cell line stably expressing Rren\LUC fused to the 3'UTR of Tom.
New stable cell line derived from S2-unspecified : Clonal S2 cells harboring mutations in Dora were created.
Source for merge of: CG17757 CG32542
Source for merge of: CG15037 CG7307 CG7317
Annotations CG17757 and CG32542 merged as CG34401 in release 5.2 of the genome annotation.
Annotations CG15037, CG7307 and CG7317 merged as CG32542 in release 3 of the genome annotation.
Source for identity of: Dora CG34401
The gene is named 'Dorado' after a fish that preys on octopuses from the Argonauta genus, as the gene and its orthologs are proposed to mediate target-directed miRNA degradation (TDMD) through the ubiquitination of an Argonaute protein.
