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FB2021_03, released June 15, 2021

Gene: Dmel\Arp2

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General Information
Symbol
Dmel\Arp2
Species
D. melanogaster
Name
Actin-related protein 2
Annotation Symbol
CG9901
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011742
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Actin-related protein 2 (Arp2) encodes one of the actin-related proteins within the Arp2/3 complex, which is the basic actin nucleator of eukaryotes. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Arp14D, Actin-related protein 14D

Key Links
Genomic Location
Cytogenetic map
14E1-14E1
Sequence location
X:16,548,290..16,553,968 [-]
Recombination map
1-54
RefSeq locus
NC_004354 REGION:16548290..16553968
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
contributes_to actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000233596
(assigned by GO_Central )
(Gaudet et al., 2011)
enables structural constituent of cytoskeleton
inferred from sequence or structural similarity with HGNC:169
(Hudson and Cooley, 2002)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from mutant phenotype
(Sander et al., 2013)
involved_in cell morphogenesis
inferred from mutant phenotype
(D'Ambrosio and Vale, 2010)
involved_in positive regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Koch et al., 2014)
involved_in regulation of filopodium assembly
inferred from mutant phenotype
(Sander et al., 2013)
involved_in terminal button organization
inferred from mutant phenotype
(Koch et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in Arp2/3 complex-mediated actin nucleation
inferred from biological aspect of ancestor with PANTHER:PTN000233596
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:169
(Hudson and Cooley, 2002)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in actin filament
inferred from sequence or structural similarity with SGD:S000002187
(Fyrberg et al., 1994)
part_of Arp2/3 protein complex
inferred from biological aspect of ancestor with PANTHER:PTN000233596
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:169
(Hudson and Cooley, 2002)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the actin family. ARP2 subfamily. (P45888)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Actin-related protein 2 (Arp2) encodes one of the actin-related proteins within the Arp2/3 complex, which is the basic actin nucleator of eukaryotes. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
ACTIN-RELATED PROTEIN 2/3 COMPLEX -
The Actin-related protein 2/3 complex is involved in the organization of the actin cytoskeleton, in particular, the nucleation of branched actin filaments. (Adapted from FBrf0144947).
ACTIN-RELATED PROTEINS -
Actin-related proteins (Arp) share significant sequence identity with actins. Arps broadly fall into two groups: nuclear Arps, involved in chromatin remodeling; and cytoplasmic Arps, associated with actin. (Adapted from PMID:21859859).
Protein Function (UniProtKB)
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
(UniProt, P45888)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Arp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Arp2-RA
FBtr0074295
NM_078648
2219
394
Arp2-RB
FBtr0112868
NM_001103531
2475
394
Arp2-RC
FBtr0310673
NM_001272692
2217
399
Additional Transcript Data and Comments
Reported size (kB)

3.0 (northern blot)

(Hong and Ganetzky, 1996)

1.188 (longest cDNA)

(Fyrberg et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Arp2-PA
FBpp0074070
44.7
394
6.13
NP_523372
AAF48621
Arp2-PB
FBpp0111781
44.7
394
6.13
NP_001097001
ABW09432
Arp2-PC
FBpp0302793
45.3
399
5.88
NP_001259621
AGB95463
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

394 aa isoforms: Arp2-PA, Arp2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

395 (aa)

(Hong and Ganetzky, 1996, Fyrberg et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the Arp2/3 complex.

(UniProt, P45888)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arp2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Arp2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Arp2
Transgenic constructs containing regulatory region of Arp2
Aberrations (Deficiencies and Duplications) ( 7 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal locomotor behavior | third instar larval stage, with Scer\GAL4Ubi.PU
abnormal neuroanatomy, with Scer\GAL4C57
abnormal neuroanatomy | larval stage, with Scer\GAL4Ubi.PU
abnormal neuroanatomy | larval stage, with Scer\GAL4VGlut-OK371
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
visible, with Scer\GAL4pnr-MD237
visible | somatic clone
visible | somatic clone - Minute background
Phenotype manifest in
Allele
actin cytoskeleton, with Scer\GAL4Hml.Δ
bouton, with Scer\GAL4C57
dorsocentral bristle, with Scer\GAL4sca.PU
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4Ubi.PU
eye | somatic clone
eye disc | somatic clone | third instar larval stage
eye photoreceptor cell | somatic clone - Minute background
lens | somatic clone - Minute background
mesothoracic tergum, with Scer\GAL4pnr-MD237
microchaeta, with Scer\GAL4sca.PU
neuromuscular junction, with Scer\GAL4C57
ommatidium | somatic clone - Minute background
synapse, with Scer\GAL4C57
tormogen cell, with Scer\GAL4pnr-MD237
trichogen cell | increased number, with Scer\GAL4pnr-MD237
type Ib terminal bouton | larval stage, with Scer\GAL4Ubi.PU
type Ib terminal bouton | larval stage, with Scer\GAL4VGlut-OK371
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (41)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ACTR2
14 of 15
Yes
Yes
Hsap\ACTA2
2 of 15
No
No
Hsap\ACTB
2 of 15
No
No
4  
Hsap\ACTBL2
2 of 15
No
No
Hsap\ACTC1
2 of 15
No
No
1  
Hsap\ACTL6A
2 of 15
No
No
2  
Hsap\ACTL6B
2 of 15
No
No
1  
Hsap\ACTL8
2 of 15
No
No
Hsap\ACTL9
2 of 15
No
No
Hsap\ACTL10
2 of 15
No
No
Hsap\ACTR1A
2 of 15
No
No
1  
Hsap\ACTR1B
2 of 15
No
No
1  
Hsap\ACTR3B
2 of 15
No
No
1  
Hsap\ACTR3
2 of 15
No
No
1  
Hsap\ACTRT3
2 of 15
No
No
Hsap\POTEE
2 of 15
No
No
Hsap\POTEF
2 of 15
No
No
Hsap\POTEI
2 of 15
No
No
Hsap\POTEJ
2 of 15
No
No
Hsap\ACTA1
1 of 15
No
No
Hsap\ACTG2
1 of 15
No
No
Hsap\ACTL7A
1 of 15
No
No
Hsap\ACTL7B
1 of 15
No
No
Hsap\ACTR3C
1 of 15
No
No
Hsap\ACTR6
1 of 15
No
No
Hsap\ACTR8
1 of 15
No
No
Hsap\ACTR10
1 of 15
No
No
Hsap\ACTRT1
1 of 15
No
No
Hsap\ACTRT2
1 of 15
No
No
Hsap\APOC3
1 of 15
No
Yes
Hsap\ATP10A
1 of 15
No
No
1  
Hsap\BACE1
1 of 15
No
No
6  
Hsap\LOC100288966
1 of 15
No
Yes
Hsap\LOC102723502
1 of 15
No
Yes
Hsap\POTEB2
1 of 15
No
No
Hsap\POTEB3
1 of 15
No
Yes
Hsap\POTEB
1 of 15
No
No
Hsap\POTEC
1 of 15
No
No
Hsap\POTED
1 of 15
No
No
Hsap\POTEG
1 of 15
No
No
Hsap\POTEH
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (28)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Actr2
14 of 15
Yes
Yes
Mmus\Acta1
2 of 15
No
No
Mmus\Acta2
2 of 15
No
No
Mmus\Actbl2
2 of 15
No
No
Mmus\Actb
2 of 15
No
No
Mmus\Actc1
2 of 15
No
No
Mmus\Acte1
2 of 15
No
No
Mmus\Actg1
2 of 15
No
No
Mmus\Actg2
2 of 15
No
No
Mmus\Actl6a
2 of 15
No
No
Mmus\Actl6b
2 of 15
No
No
Mmus\Actl9
2 of 15
No
No
Mmus\Actl10
2 of 15
No
No
Mmus\Actr1b
2 of 15
No
No
Mmus\Actr3b
2 of 15
No
No
Mmus\Actrt3
2 of 15
No
No
Mmus\Actl7a
1 of 15
No
No
Mmus\Actl7b
1 of 15
No
No
Mmus\Actl11
1 of 15
No
No
Mmus\Actr1a
1 of 15
No
No
Mmus\Actr3
1 of 15
No
No
Mmus\Actr6
1 of 15
No
No
Mmus\Actr8
1 of 15
No
No
Mmus\Actr10
1 of 15
No
No
Mmus\Actrt1
1 of 15
No
No
Mmus\Actrt2
1 of 15
No
No
Mmus\Ankrd36
1 of 15
No
Yes
Mmus\Atp1b1
1 of 15
No
No
Rattus norvegicus (Norway rat) (30)
Rnor\Actr2
13 of 13
Yes
Yes
Rnor\Acta1
2 of 13
No
No
Rnor\Actbl2
2 of 13
No
No
Rnor\Actb
2 of 13
No
No
Rnor\Actc1
2 of 13
No
No
Rnor\Actg2
2 of 13
No
No
Rnor\Actl6a
2 of 13
No
No
Rnor\Actl6b
2 of 13
No
No
Rnor\Actl9b
2 of 13
No
No
Rnor\Actl9
2 of 13
No
No
Rnor\Actl10
2 of 13
No
No
Rnor\Actr1a
2 of 13
No
No
Rnor\Actr1b
2 of 13
No
No
Rnor\Actr3b
2 of 13
No
No
Rnor\Actrt3
2 of 13
No
No
Rnor\Acta2
1 of 13
No
No
Rnor\Actg1
1 of 13
No
No
Rnor\Actl7a
1 of 13
No
No
Rnor\Actl7b
1 of 13
No
No
Rnor\Actl11
1 of 13
No
No
Rnor\Actr3
1 of 13
No
No
Rnor\Actr6
1 of 13
No
No
Rnor\Actr8
1 of 13
No
No
Rnor\Actr10
1 of 13
No
No
Rnor\Actrt1
1 of 13
No
No
Rnor\Actrt2
1 of 13
No
No
Rnor\LOC302827
1 of 13
No
Yes
Rnor\LOC100361457
1 of 13
No
No
Rnor\LOC102552318
1 of 13
No
No
Rnor\Potef
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\actr2
13 of 12
Yes
Yes
Xtro\act3
2 of 12
No
No
Xtro\acta1
2 of 12
No
No
Xtro\acta2
2 of 12
No
No
Xtro\actb
2 of 12
No
No
Xtro\actc1
2 of 12
No
No
Xtro\actg1
2 of 12
No
No
Xtro\actl6a
2 of 12
No
No
Xtro\actr1a
2 of 12
No
No
Xtro\actr3
2 of 12
No
No
Xtro\actr6
1 of 12
No
No
Xtro\actr10
1 of 12
No
No
Danio rerio (Zebrafish) (22)
Drer\actr2a
13 of 15
Yes
Yes
Drer\actr2b
13 of 15
Yes
Yes
Drer\zgc:101810
7 of 15
No
Yes
Drer\acta1a
2 of 15
No
No
Drer\acta1b
2 of 15
No
No
Drer\acta2
2 of 15
No
No
Drer\actb1
2 of 15
No
No
Drer\actb2
2 of 15
No
No
Drer\actc1b
2 of 15
No
No
Drer\actc1c
2 of 15
No
No
Drer\actl6a
2 of 15
No
No
Drer\actl6b
2 of 15
No
No
Drer\actr1
2 of 15
No
No
Drer\actr3b
2 of 15
No
No
Drer\actr3
2 of 15
No
No
Drer\si:ch73-187m15.4
2 of 15
No
No
Drer\si:ch211-241j12.3
2 of 15
No
No
Drer\zgc:86709
2 of 15
No
No
Drer\actc1a
1 of 15
No
No
Drer\actr6
1 of 15
No
No
Drer\actr8
1 of 15
No
No
Drer\actr10
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\arx-2
13 of 15
Yes
Yes
Cele\act-4
2 of 15
No
No
Cele\arp-1
2 of 15
No
No
Cele\arx-1
2 of 15
No
No
Cele\act-1
1 of 15
No
No
Cele\act-2
1 of 15
No
No
Cele\act-5
1 of 15
No
No
Cele\arp-6
1 of 15
No
No
Cele\arp-11
1 of 15
No
No
Cele\F42C5.9
1 of 15
No
Yes
Cele\swsn-6
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\ARP2
8 of 9
Yes
Yes
Atha\ACT2
1 of 9
No
No
Atha\ACT3
1 of 9
No
No
Atha\ACT4
1 of 9
No
No
Atha\ACT7
1 of 9
No
No
Atha\ACT8
1 of 9
No
No
Atha\ACT9
1 of 9
No
No
Atha\ACT11
1 of 9
No
No
Atha\ACT12
1 of 9
No
No
Atha\ARP4
1 of 9
No
No
Atha\ARP6
1 of 9
No
No
Atha\ARP7
1 of 9
No
Yes
Atha\AT2G42100
1 of 9
No
No
Atha\AT2G42170
1 of 9
No
No
Atha\DIS1
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (8)
Scer\ARP2
12 of 15
Yes
Yes
Scer\ACT1
1 of 15
No
No
0  
Scer\ARP1
1 of 15
No
No
Scer\ARP3
1 of 15
No
No
Scer\ARP4
1 of 15
No
No
Scer\ARP7
1 of 15
No
No
Scer\ARP8
1 of 15
No
No
Scer\ARP9
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\arp2
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908OZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008223
Drosophila simulans
Dsim\GD15743
Drosophila sechellia
Dsec\GM13391
Drosophila erecta
Dere\GG19317
Drosophila yakuba
Dyak\GE15964
Drosophila ananassae
Dana\GF20797
Drosophila pseudoobscura pseudoobscura
Dpse\GA22112
Drosophila pseudoobscura pseudoobscura
Dpse\Arp2D
Drosophila persimilis
Dper\GL19308
Drosophila willistoni
Dwil\GK25245
Drosophila virilis
Dvir\GJ19344
Drosophila mojavensis
Dmoj\GI15155
Drosophila grimshawi
Dgri\GH24891
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150543 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011776
Glossina morsitans
Tsetse fly
Gmor\GMOY008591
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02718
Mayetiola destructor
Hessian fly
Mdes\Mdes003380
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011750
Anopheles darlingi
American malaria mosquito
Adar\ADAC006346
Anopheles gambiae
Malaria mosquito
Agam\AGAP000985
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000683
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05BE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000082
Danaus plexippus
Monarch butterfly
Dple\DPOGS205530-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011294
Apis florea
Little honeybee
Aflo\3256908532
Apis mellifera
Western honey bee
Amel\GB51588
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22154
Bombus terrestris
Buff-tailed bumblebee
Bter\15212132
Linepithema humile
Argentine ant
Lhum\LH11677
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00159c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005125
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11120
Tribolium castaneum
Red flour beetle
Tcas\TC000144
Pediculus humanus
Human body louse
Phum\PHUM137960
Rhodnius prolixus
Kissing bug
Rpro\RPRC009875
Rhodnius prolixus
Kissing bug
Rpro\RPRC012919
Cimex lectularius
Bed bug
Clec\CLEC005481
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007128
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04803
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X057M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011566
Ixodes scapularis
Black-legged tick
Isca\ISCW000900
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61743.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77758.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g01400
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_209234
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08WH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Arp2
Ciona intestinalis
Vase tunicate
Cint\LOC100185499
Gallus gallus
Domestic chicken
Ggal\ACTR2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Act5C
4 of 10
Act42A
4 of 10
Act57B
4 of 10
Act79B
4 of 10
Act87E
4 of 10
Act88F
4 of 10
Arp1
4 of 10
Arp3
4 of 10
Arp53D
4 of 10
Bap55
4 of 10
Arp6
3 of 10
Arp8
3 of 10
Arp10
3 of 10
Arp5
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ACTR2; actin related protein 2
    14 of 15
    604221
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Abp1
        suppressible
        Arp2
        (Koch et al., 2012)
        External Data
        Subunit Structure (UniProtKB)
        Component of the Arp2/3 complex.
        (UniProt, P45888 )
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-54
        Cytogenetic map
        14E1-14E1
        Sequence location
        X:16,548,290..16,553,968 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        14E1-14E1
        Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        14D-14D
        (Fyrberg, 1994.3.15)
        14D1-14D1
        (Hong and Ganetzky, 1996)
        14D-14D
        (determined by in situ hybridisation)
        (Fyrberg et al., 1994)
        Experimentally Determined Recombination Data
        Location

        1-54

        (FlyBase, 2016)

        1-55.5

        (Comeron et al., 2012)
        Left of (cM)
        (Legent et al., 2012)
        Right of (cM)
        (Legent et al., 2012)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (9)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (81)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Arp2 Arp14D

          (FlyBase, 2009-)
          Source for database merge of
          Additional comments

          FlyBase Curator comment: 'Arp14D' renamed to 'Arp2' to rationalize the nomenclature of Actin-related protein (Arp) genes (by orthology with the mammalian and yeast genes) and better reflect community usage.

          (FlyBase, 2009-)

          "l(1)G0455" may affect "Arp14D".

          (Peter et al., 2002)
          Other Comments

          Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.

          (Philips et al., 2005)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          The region that includes para contains a complex of neurally expressed genes, Cnx14D, Arp14D, Pp2B-14D and Cap. These five genes may represent a functionally related group sharing some coordinate regulatory mechanism.

          (Hong and Ganetzky, 1996)

          Isolation and characterisation of actin-related proteins Arp14D, Arp53D, Arp66B and Arp87C.

          (Fyrberg et al., 1994)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 52 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB
          EMBL-EBI Single Cell Expression Atlas
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
          Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (10)
          Reported As
          Symbol Synonym
          ARP14D
          (Fyrberg, 1994.3.15)
          ARP2
          (Reed et al., 2012, Goldstein and Gunawardena, 2000)
          Actr14D
          Arp14D
          (Kwon et al., 2013, Legent et al., 2012, Friedman et al., 2011, Rohn et al., 2011, D'Ambrosio and Vale, 2010, Popodi et al., 2010-, Venken et al., 2010)
          Arp2
          (Bischoff et al., 2021, Martin et al., 2021, Sallee et al., 2021, Chougule et al., 2020, Davidson and Wood, 2020, Deng et al., 2020, Lv et al., 2020, Schroeder et al., 2020, Thestrup et al., 2020, Wang et al., 2020, Weiner et al., 2020, Zheng et al., 2020, Blake-Hedges and Megraw, 2019, Gao et al., 2019, Gao et al., 2019, Hurst et al., 2019, Myat et al., 2019, Yuan et al., 2019, Caridi et al., 2018, Salazar and Yamamoto, 2018, Tsai et al., 2018, Sharma et al., 2017, Rousso et al., 2016, Goins and Mullins, 2015, Hsiao et al., 2015, Kollmar, 2015.9.15, Rodal et al., 2015, Haelterman et al., 2014, Koch et al., 2014, Ingerman et al., 2013, Yamamoto et al., 2013-, Koch et al., 2012, Legent et al., 2012, Mukherjee et al., 2011, Serio et al., 2010, Richardson and Baylies, 2008, Schäfer et al., 2008, Iwasa and Mullins, 2007, Kollmar and Odronitz, 2006, Frank et al., 2005, Noguchi et al., 2005, Beltzner and Pollard, 2004, Bogdan et al., 2004, Noguchi et al., 2004, Rogers et al., 2003, Hudson and Cooley, 2002, Jacinto et al., 2002, Kiehart and Franke, 2002, Miller, 2002, Rorth, 2002, Tal et al., 2002)
          CG9901
          (Hosono et al., 2015, Haelterman et al., 2014, Yano et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Hudson and Cooley, 2002, Goldstein and Gunawardena, 2000)
          arp2
          (Sander et al., 2013, Nahm et al., 2010, Fricke et al., 2009, Frankel and Mooseker, 1996)
          Name Synonyms
          Actin-related protein 14 Da
          (Yano et al., 2012)
          Actin-related protein 14D
          (Legent et al., 2012, Fyrberg et al., 1994)
          Actin-related protein 2
          Arp14D
          (Kong et al., 2010)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (122)