FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Arp2
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General Information
Symbol
Dmel\Arp2
Species
D. melanogaster
Name
Actin-related protein 2
Annotation Symbol
CG9901
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011742
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Actin-related protein 2 (Arp2) encodes one of the actin-related proteins within the Arp2/3 complex, which is the basic actin nucleator of eukaryotes. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Arp14D, Actin-related protein 14D

Key Links
Genomic Location
Cytogenetic map
14E1-14E1
Sequence location
Recombination map
1-54
RefSeq locus
NC_004354 REGION:16548290..16553968
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
contributes_to actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000233596
(GO Reference Genome Project, 2011-)
enables structural constituent of cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000940351
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P61160
(Hudson and Cooley, 2002)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from mutant phenotype
(Sander et al., 2013)
involved_in lamellipodium assembly
inferred from mutant phenotype
(Rötte et al., 2024)
involved_in positive regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Koch et al., 2014)
involved_in regulation of filopodium assembly
inferred from mutant phenotype
(Sander et al., 2013)
involved_in terminal button organization
inferred from mutant phenotype
(Koch et al., 2014)
involved_in wound healing, spreading of epidermal cells
inferred from mutant phenotype
(Rötte et al., 2024)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in Arp2/3 complex-mediated actin nucleation
inferred from biological aspect of ancestor with PANTHER:PTN000233596
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P61160
(Hudson and Cooley, 2002)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in actin filament
inferred from sequence or structural similarity with SGD:S000002187
(Fyrberg et al., 1994)
part_of Arp2/3 protein complex
inferred from biological aspect of ancestor with PANTHER:PTN000233596
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P61160
(Hudson and Cooley, 2002)
is_active_in cell cortex
inferred from biological aspect of ancestor with PANTHER:PTN000233596
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the actin family. ARP2 subfamily. (P45888)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Actin-related protein 2 (Arp2) encodes one of the actin-related proteins within the Arp2/3 complex, which is the basic actin nucleator of eukaryotes. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
ACTIN-RELATED PROTEIN 2/3 COMPLEX ARPC3A VARIANT -
The Actin-related protein 2/3 complex is involved in the organization of the actin cytoskeleton, in particular, the nucleation of branched actin filaments. (Adapted from FBrf0144947).
ACTIN-RELATED PROTEINS -
Actin-related proteins (Arp) share significant sequence identity with actins. Arps broadly fall into two groups: nuclear Arps, involved in chromatin remodeling; and cytoplasmic Arps, associated with actin. (Adapted from PMID:21859859).
ACTIN-RELATED PROTEIN 2/3 COMPLEX ARPC3B VARIANT -
The Actin-related protein 2/3 complex is involved in the organization of the actin cytoskeleton, in particular, the nucleation of branched actin filaments. (Adapted from FBrf0144947).
Protein Function (UniProtKB)
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
(UniProt, P45888)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Arp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P45888)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Arp2-RA
FBtr0074295
NM_078648
2219
394
Arp2-RB
FBtr0112868
NM_001103531
2475
394
Arp2-RC
FBtr0310673
NM_001272692
2217
399
Additional Transcript Data and Comments
Reported size (kB)

3.0 (northern blot)

(Hong and Ganetzky, 1996)

1.188 (longest cDNA)

(Fyrberg et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Arp2-PA
FBpp0074070
44.7
394
6.13
NP_523372
AAF48621
Arp2-PB
FBpp0111781
44.7
394
6.13
NP_001097001
ABW09432
Arp2-PC
FBpp0302793
45.3
399
5.88
P45888
NP_001259621
AGB95463
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

394 aa isoforms: Arp2-PA, Arp2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

395 (aa)

(Hong and Ganetzky, 1996, Fyrberg et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the Arp2/3 complex.

(UniProt, P45888)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arp2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.71

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Arp2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Arp2
Transgenic constructs containing regulatory region of Arp2
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal locomotor behavior | third instar larval stage, with Scer\GAL4Ubi.PU
abnormal neuroanatomy, with Scer\GAL4C57
abnormal neuroanatomy | larval stage, with Scer\GAL4Ubi.PU
abnormal neuroanatomy | larval stage, with Scer\GAL4VGlut1-OK371
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal wound healing | P-stage, with Scer\GAL4A58
visible, with Scer\GAL4pnr-MD237
visible | somatic clone
visible | somatic clone - Minute background
Phenotype manifest in
Allele
actin cytoskeleton, with Scer\GAL4Hml.Δ
bouton, with Scer\GAL4C57
dorsocentral bristle, with Scer\GAL4sca.PU
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4Ubi.PU
eye | somatic clone
eye disc | somatic clone | third instar larval stage
eye photoreceptor cell | somatic clone - Minute background
lamellipodium | P-stage, with Scer\GAL4A58
larval tracheocyte | larval stage, with Scer\GAL4btl.PS
leg disc | P-stage, with Scer\GAL4Dll-em212
lens | somatic clone - Minute background
mesonotum, with Scer\GAL4pnr-MD237
microchaeta, with Scer\GAL4sca.PU
neuromuscular junction, with Scer\GAL4C57
ommatidium | somatic clone - Minute background
synapse, with Scer\GAL4C57
tormogen cell, with Scer\GAL4pnr-MD237
tracheocyte | P-stage, with Scer\GAL4btl.PS
trichogen cell | increased number, with Scer\GAL4pnr-MD237
type Ib terminal bouton | larval stage, with Scer\GAL4Ubi.PU
type Ib terminal bouton | larval stage, with Scer\GAL4VGlut1-OK371
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (42)
Hsap\ACTR2
14 of 14
Yes
Yes
Hsap\ACTA1
3 of 14
No
No
Hsap\ACTBL2
3 of 14
No
No
Hsap\ACTC1
3 of 14
No
No
1  
Hsap\ACTL8
3 of 14
No
Yes
Hsap\ACTL9
3 of 14
No
No
Hsap\ACTR1A
3 of 14
No
No
1  
Hsap\ACTR1B
3 of 14
No
No
1  
Hsap\ACTR3
3 of 14
No
No
1  
Hsap\ACTRT3
3 of 14
No
No
Hsap\POTEE
3 of 14
No
No
Hsap\POTEI
3 of 14
No
No
Hsap\POTEJ
3 of 14
No
No
Hsap\ACTA2
2 of 14
No
No
Hsap\ACTB
2 of 14
No
No
5  
Hsap\ACTG1
2 of 14
No
No
1  
Hsap\ACTG2
2 of 14
No
No
Hsap\ACTL6A
2 of 14
No
No
2  
Hsap\ACTL6B
2 of 14
No
No
1  
Hsap\ACTR3B
2 of 14
No
No
1  
Hsap\ACTR6
2 of 14
No
No
1  
Hsap\ACTR8
2 of 14
No
No
Hsap\ACTRT1
2 of 14
No
No
Hsap\ACTRT2
2 of 14
No
No
Hsap\POTEF
2 of 14
No
No
Hsap\ACTL7A
1 of 14
No
No
Hsap\ACTL7B
1 of 14
No
No
Hsap\ACTL10
1 of 14
No
No
Hsap\ACTR3C
1 of 14
No
No
Hsap\ACTR5
1 of 14
No
No
Hsap\ACTR10
1 of 14
No
No
Hsap\LOC100288966
1 of 14
No
No
Hsap\LOC102723502
1 of 14
No
No
Hsap\POTEB2
1 of 14
No
No
Hsap\POTEB3
1 of 14
No
No
Hsap\POTEB
1 of 14
No
No
Hsap\POTEC
1 of 14
No
No
Hsap\POTED
1 of 14
No
No
Hsap\POTEG
1 of 14
No
No
Hsap\POTEH
1 of 14
No
No
Hsap\POTEKP
1 of 14
No
No
Hsap\POTEM
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (31)
Rnor\Actr2
14 of 14
Yes
Yes
Rnor\Acta1
3 of 14
No
No
Rnor\Actbl2
3 of 14
No
No
Rnor\Actb
3 of 14
No
No
Rnor\Actc1
3 of 14
No
No
Rnor\Actg2
3 of 14
No
No
Rnor\Acta2
2 of 14
No
No
Rnor\Actg1
2 of 14
No
No
Rnor\Actl6a
2 of 14
No
No
Rnor\Actl6b
2 of 14
No
No
Rnor\Actl9b
2 of 14
No
No
Rnor\Actl9
2 of 14
No
No
Rnor\Actl10
2 of 14
No
No
Rnor\Actr1a
2 of 14
No
No
Rnor\Actr1b
2 of 14
No
No
Rnor\Actr3b
2 of 14
No
No
Rnor\Actr3
2 of 14
No
No
Rnor\Actr8
2 of 14
No
No
Rnor\Actrt1
2 of 14
No
No
Rnor\Actrt2
2 of 14
No
No
Rnor\Actrt3
2 of 14
No
No
Rnor\LOC100361457
2 of 14
No
No
Rnor\LOC102552318
2 of 14
No
No
Rnor\Actl7a
1 of 14
No
No
Rnor\Actl7b
1 of 14
No
No
Rnor\Actl11
1 of 14
No
No
Rnor\Actr5
1 of 14
No
No
Rnor\Actr6
1 of 14
No
No
Rnor\Actr10
1 of 14
No
No
Rnor\LOC302827
1 of 14
No
Yes
Rnor\Potef
1 of 14
No
No
Mus musculus (laboratory mouse) (28)
Mmus\Actr2
14 of 14
Yes
Yes
Mmus\Acta1
3 of 14
No
No
Mmus\Acta2
3 of 14
No
No
Mmus\Actbl2
3 of 14
No
No
Mmus\Actb
3 of 14
No
No
Mmus\Actc1
3 of 14
No
No
Mmus\Actg1
3 of 14
No
No
Mmus\Actg2
3 of 14
No
No
Mmus\Actrt3
3 of 14
No
No
Mmus\Acte1
2 of 14
No
No
Mmus\Actl6a
2 of 14
No
No
Mmus\Actl6b
2 of 14
No
No
Mmus\Actl7a
2 of 14
No
No
Mmus\Actl9
2 of 14
No
No
Mmus\Actl10
2 of 14
No
No
Mmus\Actr1a
2 of 14
No
No
Mmus\Actr1b
2 of 14
No
No
Mmus\Actr3b
2 of 14
No
No
Mmus\Actr3
2 of 14
No
No
Mmus\Actr8
2 of 14
No
No
Mmus\Actrt1
2 of 14
No
No
Mmus\Actrt2
2 of 14
No
No
Mmus\Actl7b
1 of 14
No
No
Mmus\Actl11
1 of 14
No
No
Mmus\Actr5
1 of 14
No
No
Mmus\Actr6
1 of 14
No
No
Mmus\Actr10
1 of 14
No
No
Mmus\Ankrd36
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (15)
Xtro\actr2
11 of 13
Yes
Yes
Xtro\acta1
2 of 13
No
No
Xtro\acta4
2 of 13
No
No
Xtro\actb
2 of 13
No
No
Xtro\actc1
2 of 13
No
No
Xtro\actg1
2 of 13
No
No
Xtro\acta2
1 of 13
No
No
Xtro\actl6a
1 of 13
No
No
Xtro\actr1a
1 of 13
No
No
Xtro\actr3
1 of 13
No
No
Xtro\actr6
1 of 13
No
No
Xtro\actrt2
1 of 13
No
No
Xtro\klhl32
1 of 13
No
No
Xtro\men1
1 of 13
No
No
Xtro\MGC75582
1 of 13
No
No
Danio rerio (Zebrafish) (23)
Drer\actr2a
14 of 14
Yes
Yes
Drer\actr2b
14 of 14
Yes
Yes
Drer\zgc:101810
12 of 14
No
Yes
Drer\acta1a
3 of 14
No
No
Drer\acta1b
3 of 14
No
No
Drer\actb1
3 of 14
No
No
Drer\actb2
3 of 14
No
No
Drer\actc1a
3 of 14
No
No
Drer\actc2
3 of 14
No
No
Drer\acte1
3 of 14
No
No
Drer\acta2
2 of 14
No
No
Drer\actc1b
2 of 14
No
No
Drer\actc1c
2 of 14
No
Yes
Drer\actl6a
2 of 14
No
No
Drer\actl6b
2 of 14
No
No
Drer\actr1b
2 of 14
No
No
Drer\actr3b
2 of 14
No
No
Drer\actr3
2 of 14
No
No
Drer\actr10
2 of 14
No
No
Drer\si:ch211-241j12.3
2 of 14
No
No
Drer\actr5
1 of 14
No
No
Drer\actr6
1 of 14
No
No
Drer\actr8
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\arx-2
14 of 14
Yes
Yes
Cele\act-1
3 of 14
No
No
Cele\act-2
3 of 14
No
No
Cele\act-3
3 of 14
No
No
Cele\act-5
3 of 14
No
No
Cele\act-4
2 of 14
No
No
Cele\arp-1
2 of 14
No
No
Cele\arx-1
2 of 14
No
No
Cele\F42C5.9
2 of 14
No
No
Cele\swsn-6
2 of 14
No
No
Cele\arp-6
1 of 14
No
No
Cele\arp-11
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (14)
Agam\AgaP_AGAP000985
12 of 12
Yes
Yes
Agam\AgaP_AGAP001676
3 of 12
No
No
Agam\AgaP_AGAP002127
3 of 12
No
No
Agam\AgaP_AGAP005095
3 of 12
No
No
Agam\AgaP_AGAP011514
3 of 12
No
No
Agam\AgaP_AGAP011515
3 of 12
No
No
Agam\AgaP_AGAP011516
3 of 12
No
No
Agam\ACT5C_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP005110
2 of 12
No
No
Agam\AgaP_AGAP005857
2 of 12
No
No
Agam\AgaP_AGAP008687
2 of 12
No
No
Agam\AgaP_AGAP010671
2 of 12
No
No
Agam\AgaP_AGAP004488
1 of 12
No
No
Agam\AgaP_AGAP012077
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\ARP2
12 of 13
Yes
Yes
Atha\ACT1
3 of 13
No
No
Atha\ACT2
3 of 13
No
No
Atha\ACT3
3 of 13
No
No
Atha\ACT4
3 of 13
No
No
Atha\ACT7
3 of 13
No
No
Atha\ACT8
3 of 13
No
No
Atha\ACT9
3 of 13
No
No
Atha\ACT11
3 of 13
No
No
Atha\ACT12
3 of 13
No
No
Atha\ARP4
3 of 13
No
No
Atha\AT2G42100
3 of 13
No
No
Atha\AT2G42170
3 of 13
No
No
Atha\DIS1
3 of 13
No
No
Atha\ARP6
2 of 13
No
No
Atha\ARP7
2 of 13
No
No
Atha\ARP9
2 of 13
No
No
Atha\ARP4A
1 of 13
No
No
Atha\ARP5
1 of 13
No
No
Atha\ARP8
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\ARP2
12 of 13
Yes
Yes
Scer\ACT1
2 of 13
No
No
0  
Scer\ARP1
2 of 13
No
No
Scer\ARP8
2 of 13
No
No
Scer\ARP3
1 of 13
No
No
Scer\ARP4
1 of 13
No
No
Scer\ARP5
1 of 13
No
No
Scer\ARP7
1 of 13
No
No
Scer\ARP9
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (9)
Spom\arp2
12 of 12
Yes
Yes
Spom\act1
2 of 12
No
No
Spom\alp5
2 of 12
No
No
Spom\arp1
2 of 12
No
No
Spom\arp8
2 of 12
No
No
Spom\arp3
1 of 12
No
No
Spom\arp5
1 of 12
No
No
Spom\arp9
1 of 12
No
No
Spom\arp42
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Arp2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (14)
Act5C
5 of 13
Act42A
5 of 13
Act57B
5 of 13
Act79B
5 of 13
Act87E
5 of 13
Act88F
5 of 13
Arp1
5 of 13
Arp3
4 of 13
Arp6
4 of 13
Arp8
4 of 13
Arp53D
4 of 13
Bap55
4 of 13
Arp5
3 of 13
Arp10
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ACTR2; actin related protein 2
    14 of 14
    604221
        ACTA1; actin alpha 1, skeletal muscle
        3 of 14
        102610
        ACTBL2; actin beta like 2
        3 of 14
        614835
            ACTC1; actin alpha cardiac muscle 1
            3 of 14
            ACTIN, ALPHA, CARDIAC MUSCLE; ACTC1
             
            ACTL8; actin like 8
            3 of 14
            621132
                ACTL9; actin like 9
                3 of 14
                619251
                ACTR1A; actin related protein 1A
                3 of 14
                605143
                     
                    ACTR1B; actin related protein 1B
                    3 of 14
                    605144
                         
                        ACTR3; actin related protein 3
                        3 of 14
                        604222
                             
                            ACTRT3; actin related protein T3
                            3 of 14
                            608534
                                POTEE; POTE ankyrin domain family member E
                                3 of 14
                                608914
                                    POTEI; POTE ankyrin domain family member I
                                    3 of 14
                                        POTEJ; POTE ankyrin domain family member J
                                        3 of 14
                                            Functional Complementation Data
                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                            Interactions
                                            Summary of Physical Interactions
                                            Summary of Genetic Interactions
                                            Interaction Browsers
                                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                                            Please look at the allele data for full details of the genetic interactions
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Abp1
                                            suppressible
                                            Arp2
                                            (Koch et al., 2012)
                                            Dora
                                            suppressible
                                            Arp2
                                            (Molina-Pelayo et al., 2022)
                                            External Data
                                            Subunit Structure (UniProtKB)
                                            Component of the Arp2/3 complex.
                                            (UniProt, P45888 )
                                            Linkouts
                                            DroID - A comprehensive database of gene and protein interactions.
                                            MIST (genetic) - An integrated Molecular Interaction Database
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Pathways
                                            Signaling Pathways (FlyBase)
                                            Metabolic Pathways
                                            FlyBase
                                            External Links
                                            External Data
                                            Linkouts
                                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                            Class of Gene
                                            Genomic Location and Detailed Mapping Data
                                            Chromosome (arm)
                                            X
                                            Recombination map
                                            1-54
                                            Cytogenetic map
                                            14E1-14E1
                                            Sequence location
                                            FlyBase Computed Cytological Location
                                            Cytogenetic map
                                            Evidence for location
                                            14E1-14E1
                                            Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
                                            Experimentally Determined Cytological Location
                                            Cytogenetic map
                                            Notes
                                            References
                                            14D-14D
                                            (Fyrberg, 1994.3.15)
                                            14D1-14D1
                                            (Hong and Ganetzky, 1996)
                                            14D-14D
                                            (determined by in situ hybridisation)
                                            (Fyrberg et al., 1994)
                                            Experimentally Determined Recombination Data
                                            Location

                                            1-54

                                            (FlyBase, 2016)

                                            1-55.5

                                            (Comeron et al., 2012)
                                            Left of (cM)
                                            (Legent et al., 2012)
                                            Right of (cM)
                                            (Legent et al., 2012)
                                            Notes
                                            Stocks and Reagents
                                            Stocks (9)
                                            Genomic Clones (9)
                                             

                                            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                            cDNA Clones (78)
                                             

                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                            cDNA clones, fully sequenced
                                            BDGP DGC clones
                                            Other clones
                                              Drosophila Genomics Resource Center cDNA clones

                                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                              cDNA Clones, End Sequenced (ESTs)
                                              BDGP DGC clones
                                              Other clones
                                              RNAi and Array Information
                                              Linkouts
                                              DRSC - Results frm RNAi screens
                                              Antibody Information
                                              Laboratory Generated Antibodies
                                               
                                              Commercially Available Antibodies
                                               
                                              Cell Line Information
                                              Publicly Available Cell Lines
                                               
                                                Other Stable Cell Lines
                                                 
                                                  Other Comments

                                                  Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.

                                                  (Philips et al., 2005)

                                                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                                  (Kiger et al., 2003)

                                                  The region that includes para contains a complex of neurally expressed genes, Cnx14D, Arp14D, Pp2B-14D and Cap. These five genes may represent a functionally related group sharing some coordinate regulatory mechanism.

                                                  (Hong and Ganetzky, 1996)

                                                  Isolation and characterisation of actin-related proteins Arp14D, Arp53D, Arp66B and Arp87C.

                                                  (Fyrberg et al., 1994)
                                                  Relationship to Other Genes
                                                  Source for database merge of
                                                  Additional comments

                                                  "l(1)G0455" may affect "Arp14D".

                                                  (Peter et al., 2002)
                                                  Nomenclature History
                                                  Source for database identify of

                                                  Source for identity of: Arp2 Arp14D

                                                  (FlyBase, 2009-)
                                                  Nomenclature comments

                                                  'Arp14D' renamed to 'Arp2' to rationalize the nomenclature of Actin-related protein (Arp) genes (by orthology with the mammalian and yeast genes) and better reflect community usage.

                                                  (FlyBase, 2009-)
                                                  Etymology
                                                  Synonyms and Secondary IDs (11)
                                                  Reported As
                                                  Symbol Synonym
                                                  ARP14D
                                                  (Fyrberg, 1994.3.15)
                                                  ARP2
                                                  (Zakrzewski et al., 2021, Reed et al., 2012, Goldstein and Gunawardena, 2000)
                                                  Actr14D
                                                  Arp14D
                                                  (Okuda et al., 2022, Xie et al., 2021, Kwon et al., 2013, Legent et al., 2012, Friedman et al., 2011, Rohn et al., 2011, D'Ambrosio and Vale, 2010, Popodi et al., 2010-, Venken et al., 2010)
                                                  Arp14d
                                                  (Pradhan et al., 2023)
                                                  Arp2
                                                  (Sanhueza et al., 2025, Berry et al., 2024, De Groef et al., 2024, Lee et al., 2024, Mancheno-Ferris et al., 2024, Parkhurst, 2024.9.4, Pinot and Le Borgne, 2024, Tam and Harris, 2024, Cazzagon et al., 2023, Faria et al., 2023, Fernandez-Gonzalez and Harris, 2023, Molina-Pelayo et al., 2022, Papagiannouli, 2022, Rout et al., 2022, Bischoff and Bogdan, 2021, Bischoff et al., 2021, Hirschhäuser et al., 2021, Johnson, 2021, Kilo et al., 2021, Loganathan et al., 2021, Martin et al., 2021, Pang et al., 2021, Sallee et al., 2021, Sarkar et al., 2021, Chougule et al., 2020, Davidson and Wood, 2020, Deng et al., 2020, Dubey et al., 2020, Ko and Martin, 2020, Lv et al., 2020, Schroeder et al., 2020, Thestrup et al., 2020, Wang et al., 2020, Weiner et al., 2020, Zheng et al., 2020, Blake-Hedges and Megraw, 2019, Gao et al., 2019, Gao et al., 2019, Hurst et al., 2019, Myat et al., 2019, Yuan et al., 2019, Caridi et al., 2018, Salazar and Yamamoto, 2018, Tsai et al., 2018, Sharma et al., 2017, Rousso et al., 2016, Goins and Mullins, 2015, Hsiao et al., 2015, Kollmar, 2015.9.15, Rodal et al., 2015, Haelterman et al., 2014, Koch et al., 2014, Ingerman et al., 2013, Yamamoto et al., 2013-, Koch et al., 2012, Legent et al., 2012, Mukherjee et al., 2011, Serio et al., 2010, Richardson and Baylies, 2008, Schäfer et al., 2008, Iwasa and Mullins, 2007, Kollmar and Odronitz, 2006, Frank et al., 2005, Noguchi et al., 2005, Beltzner and Pollard, 2004, Bogdan et al., 2004, Noguchi et al., 2004, Rogers et al., 2003, Hudson and Cooley, 2002, Jacinto et al., 2002, Kiehart and Franke, 2002, Miller, 2002, Rorth, 2002, Tal et al., 2002)
                                                  CG9901
                                                  (National Institute of Genetics Fly Stocks, 2023-, Hosono et al., 2015, Haelterman et al., 2014, Yano et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Hudson and Cooley, 2002, Goldstein and Gunawardena, 2000)
                                                  arp2
                                                  (Lehne and Bogdan, 2023, Bourouliti and Skoulakis, 2022, Sander et al., 2013, Nahm et al., 2010, Fricke et al., 2009, Frankel and Mooseker, 1996)
                                                  Name Synonyms
                                                  Actin-related protein 14 Da
                                                  (Yano et al., 2012)
                                                  Actin-related protein 14D
                                                  (Legent et al., 2012, Fyrberg et al., 1994)
                                                  Actin-related protein 2
                                                  Arp14D
                                                  (Kong et al., 2010)
                                                  Secondary FlyBase IDs
                                                    Datasets (0)
                                                    Study focus (0)
                                                    Experimental Role
                                                    Project
                                                    Project Type
                                                    Title
                                                    Study result (0)
                                                    Result
                                                    Result Type
                                                    Title
                                                    External Crossreferences and Linkouts ( 54 )
                                                    Sequence Crossreferences
                                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                    Other crossreferences
                                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                    FlyMine - An integrated database for Drosophila genomics
                                                    InterPro - A database of protein families, domains and functional sites
                                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                                    Linkouts
                                                    Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                    DroID - A comprehensive database of gene and protein interactions.
                                                    DRSC - Results frm RNAi screens
                                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                    Flygut - An atlas of the Drosophila adult midgut
                                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                    MIST (genetic) - An integrated Molecular Interaction Database
                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                                    References (166)