FlyBase Gene Report: Dmel\Bap55

General Information

Symbol

Dmel\Bap55

Species

D. melanogaster

Name

Brahma associated protein 55kD

Annotation Symbol

CG6546

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025716

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Brahma associated protein 55kD (Bap55) encodes a member of two chromatin remodeling complexes. As part of the Brahma complex, it is needed for cell growth and survival in the wing imaginal disc; as a member of the TIP60 complex, it is thought to regulate dendrite wiring specificity in olfactory projection neurons. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Arp4

Key Links

Genomic Location

Cytogenetic map

54B7-54B7

Sequence location

2R:17,429,353..17,430,963 [-]

Recombination map

2-82

RefSeq locus

NT_033778 REGION:17429353..17430963

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables chromatin binding

inferred from biological aspect of ancestor with PANTHER:PTN001732543

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in dendrite guidance

inferred from mutant phenotype

(Tea and Luo, 2011)

involved_in DNA repair-dependent chromatin remodeling

inferred from direct assay

(Kusch et al., 2004)

involved_in mitotic cell cycle

inferred from high throughput mutant phenotype

(Ducat et al., 2008)

involved_in positive regulation of DNA-templated transcription

inferred from direct assay

(Kal et al., 2000)

involved_in regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Bonnay et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred from sequence or structural similarity with SGD:S000003617

(Kal et al., 2000)

inferred from biological aspect of ancestor with PANTHER:PTN001732543

(GO Reference Genome Project, 2011-)

involved_in nervous system development

inferred from biological aspect of ancestor with PANTHER:PTN000940400

(GO Reference Genome Project, 2011-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001732543

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of brahma complex

inferred from direct assay

(Barish et al., 2020, Chalkley et al., 2008, Mohrmann et al., 2004, Kal et al., 2000)

part_of NuA4 histone acetyltransferase complex

inferred from direct assay

(Kusch et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of NuA4 histone acetyltransferase complex

inferred from biological aspect of ancestor with PANTHER:PTN001732543

(GO Reference Genome Project, 2011-)

part_of SWI/SNF complex

inferred from biological aspect of ancestor with PANTHER:PTN001732543

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ACTIN-RELATED PROTEINS

BRAHMA ASSOCIATED PROTEINS COMPLEX

TIP60 COMPLEX

POLYBROMO-CONTAINING BRAHMA ASSOCIATED PROTEINS COMPLEX

NON-CANONICAL BRAHMA ASSOCIATED PROTEINS COMPLEX

SWR1 COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ACTIN-RELATED PROTEINS -: Actin-related proteins (Arp) share significant sequence identity with actins. Arps broadly fall into two groups: nuclear Arps, involved in chromatin remodeling; and cytoplasmic Arps, associated with actin. (Adapted from PMID:21859859).
BRAHMA ASSOCIATED PROTEINS COMPLEX -: The Brahma associated proteins (BAP) complex is an ATP-dependent chromatin remodeling complex. (Adapted from FBrf0192510.)
TIP60 COMPLEX -: The Tip60 chromatin remodeling complex acetylates nucleosomal phospho-histone H2Av and exchanges it with unmodified H2Av. (Adapted from FBrf0185742).
POLYBROMO-CONTAINING BRAHMA ASSOCIATED PROTEINS COMPLEX -: Brahma (BRM) complexes are ATP-dependent chromatin remodeling complexes. The Polybromo-containing Brahma associated proteins (PBAP) complex is distinguished by the presence of polybromo and Bap170 subunits. (Adapted from FBrf0192510.)
NON-CANONICAL BRAHMA ASSOCIATED PROTEINS COMPLEX -: Brahma (BRM) complexes are ATP-dependent chromatin remodeling complexes. The non-canonical BAP (ncBAP) complex is distinguished by the presence of a Bicra subunit. (Adapted from FBrf0247407.)
SWR1 COMPLEX -: In D.mel, the SWR1 complex is an ATP-dependent histone exchanger that incorporates the histone H2A variant, His2Av. (Adapted from FBrf0245697.)

Summary (Interactive Fly)

member of both the Brahma and the Tat interactive protein 60 kD (TIP60) ATP-dependent chromatin remodeling complexes - functions through the TIP60 complex to regulate dendrite wiring specificity in olfactory projection neurons - as a member of the Brahma complex it is needed for cell growth and survival in the wing imaginal disc

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Bap55 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K012)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Bap55-RA

FBtr0086960

NM_137365

1473

425

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Bap55-PA

FBpp0086115

47.3

425

5.17

Q7K012

NP_611209

AAF57868

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

The brm core complex appears to comprise 10 polypeptides. These include brm, mor, osa, Bap60, Snr1, Bap111, Bap55, Bap170, Bap26,and Act42A or Act5C proteins.

(Kal et al., 2000)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7K012

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Bap55 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bap55_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.02

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of brahma complex

inferred from direct assay

(Barish et al., 2020, Chalkley et al., 2008, Mohrmann et al., 2004, Kal et al., 2000)

part_of NuA4 histone acetyltransferase complex

inferred from direct assay

(Kusch et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Bap55 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Bap55

View exonic expression by tissue for Dmel\Bap55

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025716

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36956/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025716

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025716

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025716

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6546

Flygut - An atlas of the Drosophila adult midgut

FBgn0025716

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Bap55

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Bap55

Transgenic constructs containing regulatory region of Bap55

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7147

(Ryder, 2004.4.26)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Bap55^GD11955

lethal, with Scer\GAL4^pnr-MD237

Bap55^GD11955

lethal | recessive

Bap55^LL05955

lethal - all die before end of larval stage, with Scer\GAL4^Tub.PU

Bap55^GD11955

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Bap55^GD11955

Other Phenotypes

Allele

abnormal cytokinesis | spermatogenesis, with Scer\GAL4^VP16.bam

Bap55^GD11955

abnormal neuroanatomy, with Bap55^LL05955, Scer\GAL4^GH146.PB

Bap55^UAS.cTa

abnormal neuroanatomy, with Bap55^UAS.cTa, Scer\GAL4^GH146.PB

Bap55^LL05955

abnormal neuroanatomy | recessive

Bap55^LL05955

decreased cell number | recessive

Bap55^LL05955

decreased size | adult stage, with Scer\GAL4^ey.PU

Bap55^GD11955

suppressor of variegation | dominant, with In(1)w^m4

Bap55^EY15967

visible, with Scer\GAL4^pnr-MD237

Bap55^GD11955

visible | adult stage, with Scer\GAL4^ey.PU

Bap55^GD11955

Phenotype manifest in

Allele

adult antennal lobe projection neuron DL1 adPN

Bap55^LL05955

adult antennal lobe projection neuron DL1 adPN, with Bap55^LL05955, Scer\GAL4^GH146.PB

Bap55^UAS.cTa

adult antennal lobe projection neuron DL1 adPN, with Bap55^UAS.cTa, Scer\GAL4^GH146.PB

Bap55^LL05955

chromatin | spermatogenesis, with Scer\GAL4^VP16.bam

Bap55^GD11955

eye, with Scer\GAL4^ey.PU

Bap55^GD11955

larval brain | larval stage, with Scer\GAL4^insc-Mz1407

Bap55^GD11955

mesonotum, with Scer\GAL4^pnr-MD237

Bap55^GD11955

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (41)

Hsap\ACTL6A

13 of 14

Yes

Hsap\ACTL6B

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

Rnor\Actl6a

13 of 14

Yes

Rnor\Actl6b

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC102552318

1 of 14

Rnor\Potef

1 of 14

Mus musculus (laboratory mouse) (27)

Mmus\Actl6a

13 of 14

Yes

Mmus\Actl6b

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (15)

Xtro\actl6a

11 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (21)

Drer\actl6a

13 of 14

Yes

Drer\actl6b

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Drer\si:ch211-241j12.3

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\swsn-6

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP008687

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (19)

Atha\ARP4

13 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Yes

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\ARP4

8 of 13

Yes

Scer\ARP9

3 of 13

Yes

Scer\ACT1

2 of 13

Scer\ARP7

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\alp5

10 of 12

Yes

Spom\arp42

9 of 12

Yes

Spom\arp9

3 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Bap55. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (14)

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ACTL6B; actin like 6B

model of developmental and epileptic encephalopathy 76

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ACTL6A; actin like 6A

13 of 14

604958

ACTL6B; actin like 6B

12 of 14

612458

developmental and epileptic encephalopathy 76

ACTA1; actin alpha 1, skeletal muscle

3 of 14

102610

ACTBL2; actin beta like 2

3 of 14

614835

ACTC1; actin alpha cardiac muscle 1

3 of 14

ACTIN, ALPHA, CARDIAC MUSCLE; ACTC1

ACTL9; actin like 9

3 of 14

619251

SPERMATOGENIC FAILURE 53; SPGF53

spermatogenic failure 53

ACTR1A; actin related protein 1A

3 of 14

605143

ACTR1B; actin related protein 1B

3 of 14

605144

ACTRT3; actin related protein T3

3 of 14

608534

POTEE; POTE ankyrin domain family member E

3 of 14

608914

POTEI; POTE ankyrin domain family member I

3 of 14

POTEJ; POTE ankyrin domain family member J

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Bap55

Hsap\ACTL6A

(Tea and Luo, 2011)

Bap55

Hsap\ACTL6B

(Tea and Luo, 2011)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Bap55 - Bap60

experimental knowledge based, anti tag coimmunoprecipitation, Identification by mass spectrometry

(Barish et al., 2020, Guruharsha et al., 2011)

Bap55 - Bicra

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Barish et al., 2020)

Bap55 - Brd7-9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Barish et al., 2020)

Bap55 - Clk

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Kwok et al., 2015)

Bap55 - DMAP1

anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based

(Goto et al., 2014, Guruharsha et al., 2011)

Bap55 - MED14

experimental knowledge based

(Guruharsha et al., 2011)

Bap55 - MED18

experimental knowledge based

(Guruharsha et al., 2011)

Bap55 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Bap55 - Snr1

experimental knowledge based

(Guruharsha et al., 2011)

Bap55 - Stat92E

pull down, anti tag western blot

(Tu et al., 2024)

Bap55 - Tet

anti tag coimmunoprecipitation, Identification by mass spectrometry, pull down, anti tag western blot

(Tu et al., 2024)

Bap55 - Trl

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Lomaev et al., 2017, Nakayama et al., 2012)

Bap55 - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Bap55 - akirin

anti tag coimmunoprecipitation, anti tag western blot

(Bonnay et al., 2014)

Bap55 - d4

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Barish et al., 2020)

Bap55 - e(y)2

anti bait coimmunoprecipitation, peptide massfingerprinting

(Kopytova et al., 2010)

Bap55 - mor

experimental knowledge based

(Guruharsha et al., 2011)

Bap55 - osa

anti bait coimmunoprecipitation, molecular weight estimation by staining

(Collins et al., 1999)

Bap55 - pont

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kusch et al., 2004)

Bap55 - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Bap55 - sd

anti bait coimmunoprecipitation, peptide massfingerprinting

(Jin et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62650

DroID - A comprehensive database of gene and protein interactions.

FBgn0025716

MIST (protein-protein) - An integrated Molecular Interaction Database

36956

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ATP-dependent chromatin remodeling

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7K012

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-82

Cytogenetic map

54B7-54B7

Sequence location

2R:17,429,353..17,430,963 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

54B7-54B7

Limits computationally determined from genome sequence between P{EP}l(2)k01209^EP2177&P{lacW}k11012a and P{lacW}l(2)k07433^k07433

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

54A2-54B18

(determined by in situ hybridisation)

(Papoulas et al., 1998)

Experimentally Determined Recombination Data

Location

2-82

(FlyBase, 2016)

2-86.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

21174

y¹ w^67c23; P{EPgy2}Bap55^EY15967/CyO

31708

y¹ v¹; P{TRiP.HM04015}attP2/TM3, Sb¹

80757

y¹ sc^* v¹ sev²¹; P{TOE.GS02220}attP40

34488

y¹ w¹; wg^Sp-1/CyO, y⁺; M{UAS-Bap55.T}ZH-86Fb

34495

y¹ w¹; P{neoFRT}40A P{FRT(w^hs)}G13 cn¹ PBac{SAstopDsRed}Bap55^LL05955 bw¹/CyO, bw¹

Kyoto

141736

y^* w^*; P{neoFRT}40A P{FRT(w^hs)}G13 cn¹ PBac{SAstopDsRed}Bap55^LL05955 bw¹/CyO, S^* bw¹

NIG-Fly

6546R-1

P{NIG.6546R}1

VDRC

v24703

w¹¹¹⁸; P{GD11955}v24703/CyO

v24704

w¹¹¹⁸; P{GD11955}v24704/CyO

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (103)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD29458

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025716

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025716

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lomaev et al., 2017, Armstrong et al., 2002)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype cannot be observed when the screen is performed without Cdc27 dsRNA.

(Goshima et al., 2007)

dsRNA has been made from templates generated with primers directed against this gene. RNAi of Bap55 disrupts the dendritic routing patterns of the ddaD and ddaE neurons, resulting in aberrantly oriented primary dendrites. The overall arborization of these neurons is reduced. Additionally, RNAi causes defects in muscle and defects in dendrite morphogenesis.

(Parrish et al., 2006)

dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

(Echard et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Bap55 CG6546

(FlyBase, 1996-)

Additional comments

Source for merge of Bap55 CG6546 was sequence comparison ( date:030604 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

ARP4

(Hong and Choi, 2016)

Arp4

(Schroeder et al., 2020, Kollmar, 2015.9.15, Kollmar and Odronitz, 2006)

BAF53

(Ullah et al., 2007)

BAF55

(Innis and Cabot, 2020)

BAP47

(Clapier and Cairns, 2009)

Baf53

(Ullah et al., 2007)

Bap55

(Erokhin et al., 2023, Yheskel et al., 2023, Ecovoiu et al., 2022, McKowen et al., 2022, Molnar et al., 2022, Erokhin et al., 2021, Prozzillo et al., 2021, Tian and Smith-Bolton, 2021, Barish et al., 2020, Bosch et al., 2020, Chetverina et al., 2020, Takai et al., 2020, Bailetti et al., 2019, Chubak et al., 2019, Jiang et al., 2019, Gene Disruption Project members, 2018-, Mashtalir et al., 2018, McCarthy et al., 2018, Rust et al., 2018, Lomaev et al., 2017, Transgenic RNAi Project members, 2017-, Schwartz et al., 2016, Bischof and FlyORF project members, 2014.6.20, Bonnay et al., 2014, Jin et al., 2013, Kockmann et al., 2013, Moshkin et al., 2013, Puram and Bonni, 2013, Japanese National Institute of Genetics, 2012.5.21, Maheshwari and Barbash, 2012, Nakayama et al., 2012, Pressman et al., 2012, van der Harst et al., 2012, Friedman et al., 2011, Kallappagoudar et al., 2010, Mourikis et al., 2010, Terriente-Félix and de Celis, 2009, Bakal et al., 2007, Georlette et al., 2007, Goshima et al., 2007, Parrish et al., 2006)

CG6546

(Hosono et al., 2015, Ducat et al., 2008, Ni et al., 2008, Goshima et al., 2007, Kusch et al., 2004, Loop et al., 2004, Orian et al., 2003)

bap55

(Kwok et al., 2015, Bonnay et al., 2014, Kopytova et al., 2010, Echard et al., 2004)

Name Synonyms

BRM-associated protein 55

(Papoulas et al., 1998)

Brahma associated protein 55 kD

(Tea and Luo, 2011)

Brahma associated protein 55kD

brahma associated protein of 55kD

(Parrish et al., 2006)

Secondary FlyBase IDs

FBgn0034216

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36956

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K012

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7K012

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K012

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025716

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36956/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025716

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025716

FlyMine - An integrated database for Drosophila genomics

FBgn0025716

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6546

MARRVEL_MODEL - MARRVEL (model organism gene)

36956

Linkouts

BioGRID - A database of protein and genetic interactions.

62650

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025716

DroID - A comprehensive database of gene and protein interactions.

FBgn0025716

DRSC - Results frm RNAi screens

FBgn0025716

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bap55_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025716

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025716

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6546

Flygut - An atlas of the Drosophila adult midgut

FBgn0025716

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0025716

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012175

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ATP-dependent chromatin remodeling

MIST (protein-protein) - An integrated Molecular Interaction Database

36956

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7K012

References (140)

The following external sites may use different assemblies or annotations than FlyBase.

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