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Citation
Clapier, C.R., Cairns, B.R. (2009). The Biology of Chromatin Remodeling Complexes.  A. Rev. Biochem. 78(): 273--304.
FlyBase ID
FBrf0228920
Publication Type
Review
Abstract

The packaging of chromosomal DNA by nucleosomes condenses and organizes the genome, but occludes many regulatory DNA elements. However, this constraint also allows nucleosomes and other chromatin components to actively participate in the regulation of transcription, chromosome segregation, DNA replication, and DNA repair. To enable dynamic access to packaged DNA and to tailor nucleosome composition in chromosomal regions, cells have evolved a set of specialized chromatin remodeling complexes (remodelers). Remodelers use the energy of ATP hydrolysis to move, destabilize, eject, or restructure nucleosomes. Here, we address many aspects of remodeler biology: their targeting, mechanism, regulation, shared and unique properties, and specialization for particular biological processes. We also address roles for remodelers in development, cancer, and human syndromes.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    A. Rev. Biochem.
    Title
    Annual Review of Biochemistry
    Publication Year
    1932-
    ISBN/ISSN
    0066-4154
    Data From Reference