FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\MRG15
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General Information
Symbol
Dmel\MRG15
Species
D. melanogaster
Name
MORF-related gene 15
Annotation Symbol
CG6363
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027378
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
MORF-related gene 15 (MRG15) encodes a protein that contributes to histone acetylation. It is involved in chromatin organization and chromosome separation. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dMRG15, DmMRG15, l(3)j6A3

Key Links
Genomic Location
Cytogenetic map
88E11-88E11
Sequence location
Recombination map
3-56
RefSeq locus
NT_033777 REGION:15276440..15278109
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Huang et al., 2017)
enables enzyme regulator activity
inferred from direct assay
(Huang et al., 2017)
enables histone H4K20me3 reader activity
inferred from direct assay
(Moore et al., 2010)
enables protein binding
inferred from physical interaction with FLYBASE:Cap-H2; FB:FBgn0037831
(Smith et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables promoter-specific chromatin binding
inferred from biological aspect of ancestor with PANTHER:PTN000093963
(GO Reference Genome Project, 2011-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in chromosome organization
inferred from mutant phenotype
(Smith et al., 2013)
inferred from genetic interaction with FLYBASE:Cap-H2; FB:FBgn0037831
(Smith et al., 2013)
involved_in chromosome separation
inferred from mutant phenotype
(Smith et al., 2013)
inferred from genetic interaction with FLYBASE:glu; FB:FBgn0015391,FLYBASE:Cap-H2; FB:FBgn0037831
(Smith et al., 2013)
involved_in DNA repair-dependent chromatin remodeling
inferred from direct assay
(Kusch et al., 2004)
involved_in heterochromatin formation
inferred from mutant phenotype
(Qi et al., 2006)
involved_in positive regulation of gene expression
inferred from genetic interaction with FLYBASE:ash1; FB:FBgn0005386
(Huang et al., 2017)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from electronic annotation with InterPro:IPR008676
(InterPro Project Members, 2004-)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR008676
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000093963
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
part_of histone acetyltransferase complex
inferred from physical interaction with FLYBASE:pont; FB:FBgn0040078
(Kusch et al., 2004)
part_of histone methyltransferase complex
inferred from physical interaction with FLYBASE:ash1; FB:FBgn0005386,FLYBASE:Caf1-55; FB:FBgn0263979
(Huang et al., 2017)
part_of NuA4 histone acetyltransferase complex
inferred from direct assay
(Kusch et al., 2004)
located_in nucleus
inferred from direct assay
(Smith et al., 2013, Kusch et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of NuA4 histone acetyltransferase complex
inferred from biological aspect of ancestor with PANTHER:PTN000093963
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from electronic annotation with InterPro:IPR008676
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
MORF-related gene 15 (MRG15) encodes a protein that contributes to histone acetylation. It is involved in chromatin organization and chromosome separation. [Date last reviewed: 2019-08-01]
Gene Group (FlyBase)
TIP60 COMPLEX -
The Tip60 chromatin remodeling complex acetylates nucleosomal phospho-histone H2Av and exchanges it with unmodified H2Av. (Adapted from FBrf0185742).
SWR1 COMPLEX -
In D.mel, the SWR1 complex is an ATP-dependent histone exchanger that incorporates the histone H2A variant, His2Av. (Adapted from FBrf0245697.)
Protein Function (UniProtKB)
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:15528408).
(UniProt, Q9Y0I1)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\MRG15 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9Y0I1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
MRG15-RA
FBtr0083125
NM_142185
1496
424
MRG15-RB
FBtr0333921
NM_001275659
1511
429
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
MRG15-PA
FBpp0082579
47.2
424
8.38
Q9Y0I1
NP_650442
AAF55161
MRG15-PB
FBpp0306049
47.7
429
8.38
A0A0B4KHJ7
NP_001262588
AGB95969
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the NuA4 histone acetyltransferase complex at least composed of dom/Domino, Brd8, MRG15, YL-1, MrgBP, pont/Pontin, rept/Reptin, DMAP1, Tip60, Ing3, Nipped-A, E(Pc), Gas41 and Bap55 (PubMed:32432549). Component of a SWR1-like complex at least composed of dom/Domino, Brd8, MrgBP, YL-1, Gas41, Bap55, Arp6, DMAP1, MRG15, pont/Pontin, rept/Reptin and Hcf (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex which contains dom/Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, pont, rept, Ing3, Act87E, Bap55, MRG15, MrgBP, Gas41 and YL-1 (PubMed:15528408).

(UniProt, Q9Y0I1)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MRG15 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.50

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of histone acetyltransferase complex
inferred from physical interaction with FLYBASE:pont; FB:FBgn0040078
(Kusch et al., 2004)
part_of histone methyltransferase complex
inferred from physical interaction with FLYBASE:ash1; FB:FBgn0005386,FLYBASE:Caf1-55; FB:FBgn0263979
(Huang et al., 2017)
part_of NuA4 histone acetyltransferase complex
inferred from direct assay
(Kusch et al., 2004)
located_in nucleus
inferred from direct assay
(Smith et al., 2013, Kusch et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\MRG15 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of MRG15
Transgenic constructs containing regulatory region of MRG15
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage, with Scer\GAL4Tub.PU
lethal - all die before end of prepupal stage, with Scer\GAL469B
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
partially lethal
partially lethal (with Df(3R)BSC741)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Tn10\tetRrtTA.Act5C
Other Phenotypes
Allele
abnormal cytokinesis | spermatogenesis, with Scer\GAL4VP16.bam
non-suppressor of variegation, with T(1;4)wm258-21
short lived, with Tn10\tetRrtTA.Act5C
short lived | male limited, with Scer\GAL4Act5C.Switch.PR
some die during larval stage (with Df(3R)BSC741)
some die during P-stage (with Df(3R)BSC741)
some die during pupal stage, with Scer\GAL4pnr-MD237
suppressor of variegation | dominant, with T(1;4)wm258-21
Phenotype manifest in
Allele
chromatin | spermatogenesis, with Scer\GAL4VP16.bam
embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4Tub.PU
meiotic spindle | spermatogenesis, with Scer\GAL4VP16.bam
meiotic spindle pole | increased number | spermatogenesis, with Scer\GAL4VP16.bam
polytene chromosome | third instar larval stage, with Scer\GAL4Tub.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\MORF4L1
13 of 14
Yes
Yes
1  
Hsap\MORF4L2
10 of 14
No
Yes
1  
Hsap\MSL3
4 of 14
No
No
Hsap\MSL3P1
2 of 14
No
No
Hsap\ARID4A
1 of 14
No
No
Hsap\ARID4B
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Morf4l1
12 of 14
Yes
Yes
Rnor\Morf4l2
11 of 14
No
Yes
Rnor\Msl3l2
4 of 14
No
No
Rnor\Msl3
4 of 14
No
No
Rnor\Arid4a
1 of 14
No
No
Rnor\Arid4b
1 of 14
No
No
Rnor\RGD1564748
1 of 14
No
Yes
Mus musculus (laboratory mouse) (10)
Mmus\Morf4l1
12 of 14
Yes
Yes
Mmus\Morf4l2
11 of 14
No
Yes
Mmus\Msl3
4 of 14
No
No
Mmus\Msl3l2
3 of 14
No
No
Mmus\Arid4a
1 of 14
No
No
Mmus\Arid4b
1 of 14
No
No
Mmus\Gm5073
1 of 14
No
Yes
Mmus\Gm5123
1 of 14
No
Yes
Mmus\Gm5755
1 of 14
No
Yes
Mmus\Morf4l1b
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\morf4l1
8 of 13
Yes
Yes
Xtro\mindy2
1 of 13
No
Yes
Xtro\msl3
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\morf4l1
14 of 14
Yes
Yes
Drer\arid4a
1 of 14
No
No
Drer\arid4b
1 of 14
No
No
Drer\cacna1bb
1 of 14
No
No
Drer\kat5a
1 of 14
No
No
Drer\kat5b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\mrg-1
11 of 14
Yes
Yes
Cele\cec-7
4 of 14
No
Yes
Cele\arid-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP001795
12 of 12
Yes
Yes
Agam\AgaP_AGAP001917
3 of 12
No
No
Agam\AgaP_AGAP007503
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT4G37280
13 of 13
Yes
Yes
Atha\AT1G02740
12 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\EAF3
13 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\alp13
12 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:MRG15. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
msl-3
5 of 13
dpy
1 of 13
htk
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MORF4L1; mortality factor 4 like 1
    13 of 14
    607303
         
        MORF4L2; mortality factor 4 like 2
        10 of 14
        300409
             
            MSL3; MSL complex subunit 3
            4 of 14
            300609
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            MRG15 - Atg4a
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - CG15356
            anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot
            (Moshkin et al., 2009)
            MRG15 - CG3815
            anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot
            (Moshkin et al., 2009)
            MRG15 - CG8677
            anti bait coimmunoprecipitation, western blot
            (Hanai et al., 2008)
            MRG15 - Caf1-55
            anti bait coimmunoprecipitation, western blot, affinity technology, molecular weight estimation by staining
            (Schmähling et al., 2018, Huang et al., 2017)
            MRG15 - Cap-H2
            anti tag coimmunoprecipitation, anti tag western blot, two hybrid, western blot
            (Wallace et al., 2015, Smith et al., 2013)
            MRG15 - Cyp6a13
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - HDAC1
            affinity chromatography technology, molecular sieving, molecular weight estimation by staining, western blot, anti tag coimmunoprecipitation, anti tag western blot
            (Lee et al., 2009)
            MRG15 - His3
            surface plasmon resonance, predetermined participant
            (Moore et al., 2010)
            MRG15 - His4
            surface plasmon resonance, predetermined participant
            (Moore et al., 2010)
            MRG15 - Hmgs
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - Hsp22
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - JMJD6
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - Kdm5
            anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry, molecular sieving, ion exchange chromatography, affinity chromatography technology
            (Lee et al., 2009, Moshkin et al., 2009)
            MRG15 - Lst8
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - Nap1
            anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry
            (Moshkin et al., 2009)
            MRG15 - Pcyt2
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - SPE
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - Swt1
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - Syp
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - Tap42
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - Tip60
            anti bait coimmunoprecipitation, western blot
            (Kusch et al., 2004)
            MRG15 - Vap33
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - asf1
            anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot
            (Moshkin et al., 2009)
            MRG15 - ash1
            anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, affinity technology, molecular weight estimation by staining, tandem affinity purification, Identification by mass spectrometry
            (Schmähling et al., 2018, Huang et al., 2017)
            MRG15 - hiro
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - igl
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - mts
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - nwk
            experimental knowledge based
            (Guruharsha et al., 2011)
            MRG15 - pont
            anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
            (Kusch et al., 2004)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            dom
            enhanceable
            MRG15
            (Kwon et al., 2013)
            External Data
            Subunit Structure (UniProtKB)
            Component of the NuA4 histone acetyltransferase complex at least composed of dom/Domino, Brd8, MRG15, YL-1, MrgBP, pont/Pontin, rept/Reptin, DMAP1, Tip60, Ing3, Nipped-A, E(Pc), Gas41 and Bap55 (PubMed:32432549). Component of a SWR1-like complex at least composed of dom/Domino, Brd8, MrgBP, YL-1, Gas41, Bap55, Arp6, DMAP1, MRG15, pont/Pontin, rept/Reptin and Hcf (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex which contains dom/Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, pont, rept, Ing3, Act87E, Bap55, MRG15, MrgBP, Gas41 and YL-1 (PubMed:15528408).
            (UniProt, Q9Y0I1 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-56
            Cytogenetic map
            88E11-88E11
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            88E11-88E11
            Limits computationally determined from genome sequence between P{lacW}Hsc70-4L3929 and P{lacW}MRG15j6A3
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            88E9-88E12
            (Bertram, 1999.5.17)
            88E11-88E12
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            88E11-88E12
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            3-56

            (FlyBase, 2016)

            3-56.1

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (9)
            Genomic Clones (23)
            cDNA Clones (132)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Boija et al., 2017, Huang et al., 2017, Riddle et al., 2012, Kusch et al., 2004)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                DNA-protein interactions: genome-wide binding profile assayed for MRG15 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

                (Filion et al., 2010)

                MRG15 gene function limits survival during larval and adult stages of development.

                (Zhang et al., 2010)

                FlyBase curator comment: LD18041 stated to correspond to l(3)neo43, though BLAST of LD18041 vs R3.2 predicted genes identifies MRG15 but not CG14865.

                (Spradling et al., 1999)
                Relationship to Other Genes
                Source for database merge of
                Additional comments
                Nomenclature History
                Source for database identify of

                Source for identity of: MRG15 CG6363

                (Zheng, 1999.11)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (11)
                Reported As
                Symbol Synonym
                CG6363
                (Çiçek et al., 2016, Hosono et al., 2015, Lu et al., 2014, Smith et al., 2013, Voßfeldt et al., 2012, Ni et al., 2011.7.19, Zhang et al., 2010, Keleman et al., 2009.8.5, Butcher et al., 2004, Kusch et al., 2004)
                DmMRG15
                (Marin and Baker, 2000, Pannuti and Lucchesi, 2000)
                Dmrg15
                (Bertram and Thompson, 2001)
                MRG-15
                (McCarthy et al., 2022)
                MRG15
                (Jayakrishnan et al., 2025, Jayakrishnan et al., 2024, Zhimulev et al., 2024, Yheskel et al., 2023, Richards et al., 2022, Aughey et al., 2021, Prozzillo et al., 2021, Wang et al., 2020, Delandre and Marshall, 2019, Luzhin et al., 2019, McCarthy et al., 2018, Rennie et al., 2018, Schmähling et al., 2018, Boija et al., 2017, El-Sharnouby et al., 2017, Ulianov et al., 2016, Wallace et al., 2015, Comoglio and Paro, 2014, Ho et al., 2014, Zhimulev et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Li and Zhou, 2013, Matzat et al., 2013, Moshkin et al., 2013, Neumüller et al., 2013, Wang et al., 2013, Voßfeldt et al., 2012, Joyce et al., 2011, Kharchenko et al., 2011, Stenberg and Larsson, 2011, Filion et al., 2010, Moore et al., 2010, Zhang et al., 2010, Clapier and Cairns, 2009, Cook et al., 2009.2.28, Moshkin et al., 2009, Doheny et al., 2008, Bouazoune and Brehm, 2006, Pai et al., 2004)
                Mrg15
                (Merigliano et al., 2017, Smith et al., 2013, Lee et al., 2009)
                dMRG15
                (Bailetti et al., 2019, Moore et al., 2010, Hanai et al., 2008, Qi et al., 2006, Dai et al., 2005)
                dMrg15
                (Raisner and Madhani, 2006, Jin, 2005, Kusch et al., 2004, Kusch et al., 2004)
                l(3)j6A3
                (Spradling et al., 1999)
                mrg15
                (Huang et al., 2017)
                Name Synonyms
                MORF-related gene 15
                MRG15
                Secondary FlyBase IDs
                • FBgn0024526
                Datasets (2)
                Study focus (2)
                Experimental Role
                Project
                Project Type
                Title
                • transgene_used
                FBGSE22069
                Protein profiling reveals five principal chromatin types in Drosophila cells.
                • bait_protein
                modENCODE_chromatin_proteins_cells
                Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 51 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                PDB - An information portal to biological macromolecular structures
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                References (108)