FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term heterochromatin formation ID (Ontology) GO:0031507 (Gene Ontology)
Definition An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.[ PubMed:25192661 PubMed:33827924 ]
Also Known As "chromatin silencing" ; "chromatin-mediated silencing" ; "establishment of heterochromatin architecture" (for all, see Synonyms field below)
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 heterochromatin formation (all annotations which use CV term, excluding "NOT" statements)
     involved_in | heterochromatin formation       --
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chromatin organization
 |__heterochromatin organization________________________
negative regulation of gene expression                  |
 |__negative regulation of gene expression, epigenetic__|
cellular component organization                         |
 |__cellular component assembly_________________________|
epigenetic regulation of gene expression                |
 |__negative regulation of gene expression, epigenetic__|
cellular component biogenesis                           |
 |__cellular component assembly_________________________|
                                                        heterochromatin formation  190 rec.
                                                         |__constitutive heterochromatin formation 46 rec.
                                                         |   |__DNA methylation-dependent constitutive heterochromatin formation(+) 3 rec.
                                                         |   |__pericentric heterochromatin formation(+) 7 rec.
                                                         |   |__silent mating-type cassette heterochromatin formation(+)
                                                         |   |__subtelomeric heterochromatin formation 7 rec.
                                                         |   |__transposable element silencing by heterochromatin formation(+) 33 rec.
                                                         |__dosage compensation by inactivation of X chromosome
                                                         |   |__inactivation of paternal X chromosome by genomic imprinting
                                                         |   |__random inactivation of X chromosome
                                                         |__facultative heterochromatin formation 8 rec.
                                                         |   |__rDNA heterochromatin formation(+) 2 rec.
                                                         |   |__siRNA-independent facultative heterochromatin formation(+)
                                                         |   |__siRNA-mediated facultative heterochromatin formation(+)
                                                         |__heterochromatin boundary formation 11 rec.
                                                         |__regulation of heterochromatin formation 23 rec.
                                                         |   |__negative regulation of heterochromatin formation(+) 10 rec.
                                                         |   |__positive regulation of heterochromatin formation(+) 11 rec.
                                                         |   |__regulation of pericentric heterochromatin formation(+) 2 rec.
                                                         |   |__regulation of rDNA heterochromatin formation(+)
                                                         |   |__regulation of regulatory ncRNA-mediated heterochromatin formation(+) 1 rec.
                                                         |   |__regulation of silent mating-type cassette heterochromatin formation(+)
                                                         |   |__regulation of siRNA-independent facultative heterochromatin formation
                                                         |__regulatory ncRNA-mediated heterochromatin formation 35 rec.
                                                             |__piRNA-mediated heterochromatin formation(+) 24 rec.
                                                             |__regulation of regulatory ncRNA-mediated heterochromatin formation(+) 1 rec.
                                                             |__siRNA-mediated heterochromatin formation(+) 6 rec.
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Is a cellular component assembly
negative regulation of gene expression, epigenetic
heterochromatin organization
Part of
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Synonyms
  • "chromatin silencing" EXACT
    "chromatin-mediated silencing" EXACT
    "establishment of chromatin silencing" RELATED
    "establishment of heterochromatic silencing" RELATED
    "establishment of heterochromatin architecture" EXACT
    "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" NARROW
    "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" NARROW
    "heterochromatic silencing" RELATED
    "heterochromatin assembly" EXACT
    "heterochromatin assembly involved in chromatin silencing" RELATED
    "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" NARROW
    "heterochromatin assembly involved in chromatin silencing at pericentric region" NARROW
    "heterochromatin formation involved in chromatin silencing" RELATED
    "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" NARROW
    "heterochromatin formation involved in chromatin silencing at pericentric region" NARROW
    "heterochromatin maintenance" BROAD
    "TGS" BROAD
    "transcriptional gene silencing" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-5334118 "DNA methylation"