FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\osa
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General Information
Symbol
Dmel\osa
Species
D. melanogaster
Name
osa
Annotation Symbol
CG7467
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261885
Gene Model Status
Current
Stock Availability
35 publicly available
Gene Summary
osa (osa) encodes a subunit of the BAP chromatin remodeling complex. It antagonizes Wnt target gene expression and limits the self-renewal of neural and intestinal stem cells. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

eld, eyelid, C819, l(3)00090

Key Links
Genomic Location
Cytogenetic map
90C1-90C2
Sequence location
Recombination map
3-61
RefSeq locus
NT_033777 REGION:17687818..17718350
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables DNA binding
inferred from direct assay
(Collins et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR001606, InterPro:IPR036431
(InterPro Project Members, 2004-)
non-traceable author statement
(Treisman et al., 1997)
contributes_to nucleosome binding
inferred from biological aspect of ancestor with PANTHER:PTN000291886
(GO Reference Genome Project, 2011-)
Biological Process (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in imaginal disc-derived leg morphogenesis
inferred from mutant phenotype
(Terriente-Félix and de Celis, 2009)
involved_in imaginal disc-derived wing margin morphogenesis
inferred from mutant phenotype
(Terriente-Félix and de Celis, 2009)
inferred from mutant phenotype
(Treisman et al., 1997)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Terriente-Félix and de Celis, 2009)
involved_in negative regulation of neuroblast proliferation
inferred from genetic interaction with FLYBASE:numb; FB:FBgn0002973
(Janssens et al., 2014)
inferred from genetic interaction with FLYBASE:brat; FB:FBgn0010300
(Janssens et al., 2014)
involved_in neuroblast fate commitment
inferred from mutant phenotype
(Eroglu et al., 2014)
involved_in photoreceptor cell differentiation
inferred from mutant phenotype
(Treisman et al., 1997)
involved_in positive regulation of DNA-templated transcription
inferred from direct assay
(Kal et al., 2000)
inferred from physical interaction with FLYBASE:ham; FB:FBgn0045852
(Eroglu et al., 2014)
involved_in regulation of DNA-templated transcription
inferred from mutant phenotype
(Vazquez et al., 1999)
inferred from direct assay
(Collins et al., 1999)
involved_in regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Bonnay et al., 2014)
involved_in segment specification
inferred from mutant phenotype
(Treisman et al., 1997)
involved_in wing disc dorsal/ventral pattern formation
inferred from genetic interaction with FLYBASE:Bx; FB:FBgn0265598,FLYBASE:ap; FB:FBgn0267978
(Bejarano et al., 2008)
involved_in Wnt signaling pathway
inferred from mutant phenotype
(Treisman et al., 1997)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in chromatin remodeling
inferred from electronic annotation with InterPro:IPR021906
(InterPro Project Members, 2004-)
involved_in positive regulation of DNA-templated transcription
inferred from biological aspect of ancestor with PANTHER:PTN000291886
(GO Reference Genome Project, 2011-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000291886
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
part_of brahma complex
inferred from direct assay
(Barish et al., 2020, Mohrmann et al., 2004, Kal et al., 2000)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from direct assay
(Treisman et al., 1997)
located_in polytene chromosome
inferred from direct assay
(Collins et al., 1999)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
part_of brahma complex
inferred from electronic annotation with InterPro:IPR021906
(InterPro Project Members, 2004-)
part_of nBAF complex
inferred from biological aspect of ancestor with PANTHER:PTN002652024
(GO Reference Genome Project, 2011-)
is_active_in nucleoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000291886
(GO Reference Genome Project, 2011-)
part_of SWI/SNF complex
inferred from electronic annotation with InterPro:IPR021906
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000291886
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
osa (osa) encodes a subunit of the BAP chromatin remodeling complex. It antagonizes Wnt target gene expression and limits the self-renewal of neural and intestinal stem cells. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
BRAHMA ASSOCIATED PROTEINS COMPLEX -
The Brahma associated proteins (BAP) complex is an ATP-dependent chromatin remodeling complex. (Adapted from FBrf0192510.)
A-T RICH INTERACTION DOMAIN TRANSCRIPTION REGULATORS -
The A-T Rich Interaction Domain (ARID) transcription regulators are non-sequence specific DNA binding proteins. The ARID domain comprises a variant helix-turn-helix motif, accompanied by additional DNA-contacting loop structures. Many have roles in chromatin remodelling and regulation of general transcription. (Adapted from PMID:15922553).
Protein Function (UniProtKB)
Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Acts as an essential coactivator for Zeste, which recruits the whole complex to specific genes. In contrast, it acts as a corepressor for Wg target genes, possibly via an interaction with Pan and Gro. It also acts as a negative regulator for proneural achaete-scute, when it is directly recruited by Pan and Chi. Also represses E2f activation.
(UniProt, Q8IN94)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
osa: osa (J.A. Kennison)
Isolated as a dominant suppressor of the antenna to leg transformation in Pc2 AntpNs double heterozygotes. Also acts as a dominant suppressor of AntpNs, Pc and Pcl alleles. Recessive embryonic lethality associated with all alleles. Also fails to complement In(3R)Antprv1 for viability.
Summary (Interactive Fly)

transcription factor - Bright family - associates with the Brahma chromatin remodeling complex - antagonizes Wingless signaling during Drosophila development and affects patterning of the eye imaginal disc

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\osa for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IN94)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
osa-RA
FBtr0089582
NM_169775
10675
2703
osa-RB
FBtr0089581
NM_079668
10714
2716
osa-RC
FBtr0089583
NM_206506
10234
2556
osa-RD
FBtr0301487
NM_001170168
10423
2716
osa-RE
FBtr0335024
NM_001275751
9940
2555
osa-RF
FBtr0335025
NM_001275752
10243
2559
Additional Transcript Data and Comments
Reported size (kB)

10.601 (sequence analysis)

(Treisman et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
osa-PA
FBpp0088544
282.9
2703
7.49
NP_732263
AAF55457
osa-PB
FBpp0088543
284.1
2716
7.45
Q8IN94
NP_524392
AAN13750
osa-PC
FBpp0088962
269.0
2556
7.46
Q7KSE8
NP_996228
AAS65166
osa-PD
FBpp0290702
284.1
2716
7.45
Q8IN94
NP_001163639
ACZ94935
osa-PE
FBpp0307030
268.8
2555
7.46
A0A0B4KHB1
NP_001262680
AGB96060
osa-PF
FBpp0307031
269.3
2559
7.50
A0A0B4KGD1
NP_001262681
AGB96061
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2716 aa isoforms: osa-PB, osa-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

2715 (aa)

(Treisman et al., 1997)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the Brahma complex, which is composed of Brm, Osa, Mor, Snr1/Bap45, Bap111/Dalao, Bap55, Bap60 and Bap47. Interacts with Pnr and Chi via its EHD domain.

(UniProt, Q8IN94)
Domain

The ARID domains mediates the binding to DNA.

(UniProt, Q8IN94)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\osa using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
organism | ubiquitous
(Treisman et al., 1997)
larval stage
wing disc
(Treisman et al., 1997)
embryonic/larval salivary gland
• chromosome
(Collins et al., 1999)
eye disc morphogenetic furrow | anterior to
(Treisman et al., 1997)
eye disc
(Treisman et al., 1997)
third instar larval stage
embryonic/larval fat body
(Banreti et al., 2014)
Additional Descriptive Data

Protein was localized along the entire length of all chromosomes. In vitro binding assays showed that osa protein bound DNA without sequence specificity.

(Collins et al., 1999, Treisman et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of brahma complex
inferred from direct assay
(Barish et al., 2020, Mohrmann et al., 2004, Kal et al., 2000)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from direct assay
(Treisman et al., 1997)
located_in polytene chromosome
inferred from direct assay
(Collins et al., 1999)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.0}osaMI02292-TG4.0
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
eye-antennal disc
(Lee et al., 2018)
Reporter: PBac{754.P.FSVS-0}osaCPTI003089
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\osa in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 66 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of osa
Transgenic constructs containing regulatory region of osa
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4bi-omb-Gal4
lethal, with Scer\GAL4Bx-MS1096
lethal, with Scer\GAL4c564
lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH
lethal, with Scer\GAL4insc-Mz1407
lethal, with Scer\GAL4pnr-MD237
lethal (with Df(3R)BSC790)
lethal (with osa1)
lethal (with osa2)
lethal (with osaArv1)
lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive
lethal | embryonic stage | recessive
lethal | embryonic stage | recessive | rescuable maternal effect
lethal | recessive
lethal - all die before end of pupal stage | somatic clone
lethal - all die during embryonic stage | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy | adult stage, with Scer\GAL4Fer2.2359
abnormal neuroanatomy | larval stage, with Scer\GAL4GMR9D11
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | larval stage, with Scer\GAL4wor.PA
abnormal neuroanatomy | larval stage | somatic clone
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size, with Scer\GAL4en-e16E
decreased cell number | adult stage, with Scer\GAL4Fer2.2359
decreased cell number | adult stage, with Scer\GAL4NP0001
enhancer of variegation | dominant, with P{hsp26-pt-T}39C-5
enhancer of variegation | dominant, with P{hsp26-pt-T}39C-27
enhancer of variegation | dominant, with P{hsp26-pt-T}39C-31
increased cell death | somatic clone
increased cell death | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
non-enhancer of variegation, with In(1)wm4
non-enhancer of variegation, with P{wA}4-4
non-suppressor of variegation, with In(1)wm4
non-suppressor of variegation, with P{wA}4-4
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during embryonic stage | recessive
some die during pupal stage | somatic clone
visible, with Scer\GAL4bi-omb-Gal4
visible, with Scer\GAL4dpp.3KK
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4MD-638
visible, with Scer\GAL4nub-AC-62
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4salm-459.2
visible, with Scer\GAL4vg.PM
visible | adult stage, with Scer\GAL4en.PU
visible | cell autonomous | somatic clone
visible | dominant
visible | heat sensitive, with Scer\GAL4salm-459.2
visible | male, with Scer\GAL4MD-638
Phenotype manifest in
Allele
adult dopaminergic PAM neuron | adult stage | decreased number, with Scer\GAL4Fer2.2359
adult gut, with Scer\GAL4NP0001
campaniform sensillum of dorsal radius, with Scer\GAL4bi-omb-Gal4
denticle | ectopic | germline clone | maternal effect
dorsocentral bristle, with Scer\GAL4pnr-MD237
dorsocentral bristle | increased number
dorsocentral bristle | increased number (with osa4H)
dorsocentral bristle | increased number (with osa14060)
embryonic/first instar larval cuticle | germline clone
embryonic/first instar larval cuticle | germline clone | maternal effect
embryonic epidermis | germline clone
embryonic head | germline clone | maternal effect
embryonic segment | germline clone
embryonic segment | germline clone | maternal effect
external sensory organ precursor cell | increased number (with osa4H)
external sensory organ precursor cell | increased number (with osa14060)
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye | somatic clone
eye-antennal disc | somatic clone
eye disc, with Scer\GAL4ey.PU
eye disc | somatic clone
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
leg | somatic clone | increased number
leg sensillum | somatic clone | increased number
leg ventral compartment | somatic clone
macrochaeta, with Scer\GAL4pnr-MD237
macrochaeta | dorsal, with Scer\GAL4pnr-MD237
macrochaeta | ectopic, with Scer\GAL4pnr-MD237
Malpighian tubule tip cell
mesonotum | somatic clone
microchaeta, with Scer\GAL4pnr-MD237
microchaeta | dorsal, with Scer\GAL4pnr-MD237
microchaeta | ectopic, with Scer\GAL4pnr-MD237
photoreceptor neuron | somatic clone
posterior crossvein, with Scer\GAL4en.PU
pupa, with Scer\GAL4bi-omb-Gal4
retina | somatic clone
scutellar bristle, with Scer\GAL4pnr-MD237
tarsal segment | somatic clone
thorax, with Scer\GAL4pnr-MD237
type II neuroblast | increased number, with Scer\GAL4wor.PA
type II neuroblast | somatic clone | increased number
ventral denticle belt | germline clone
wing
wing, with Scer\GAL4bi-omb-Gal4
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4vg.PM
wing & macrochaeta
wing | ectopic
wing blade | cell autonomous | somatic clone
wing blade anterior compartment | dorsal | somatic clone
wing cell, with Scer\GAL4salm-459.2
wing disc
wing disc | somatic clone
wing hair | cell autonomous | ectopic | somatic clone
wing hair | ectopic, with Scer\GAL4MD-638
wing hair | ectopic, with Scer\GAL4nub-AC-62
wing hair | ectopic | heat sensitive, with Scer\GAL4salm-459.2
wing hinge, with Scer\GAL4vg.PM
wing margin | cell autonomous | somatic clone
wing margin | heat sensitive, with Scer\GAL4salm-459.2
wing margin bristle | ectopic
wing margin bristle | ectopic, with Scer\GAL4bi-omb-Gal4
wing margin bristle | ectopic | somatic clone
wing pouch | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
wing sensillum | cell autonomous | ectopic | somatic clone
wing sensillum | ectopic, with Scer\GAL4MD-638
wing sensillum | ectopic, with Scer\GAL4nub-AC-62
wing sensillum | ectopic | heat sensitive, with Scer\GAL4salm-459.2
wing vein, with Scer\GAL4bi-omb-Gal4
wing vein, with Scer\GAL4dpp.3KK
wing vein, with Scer\GAL4MD-638
wing vein | cell autonomous | somatic clone
wing vein | ectopic, with Scer\GAL4C-765
wing vein | ectopic, with Scer\GAL4en-e16E
wing vein | ectopic, with Scer\GAL4MD-638
wing vein | ectopic, with Scer\GAL4nub-AC-62
wing vein | ectopic, with Scer\GAL4salm-459.2
wing vein | heat sensitive, with Scer\GAL4salm-459.2
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (10)
Hsap\ARID1A
12 of 14
Yes
Yes
Hsap\ARID1B
12 of 14
Yes
Yes
Hsap\ARID2
1 of 14
No
No
Hsap\ARID3A
1 of 14
No
No
Hsap\ARID3B
1 of 14
No
No
Hsap\ARID3C
1 of 14
No
No
Hsap\ARID4A
1 of 14
No
No
Hsap\ARID4B
1 of 14
No
No
Hsap\ARID5A
1 of 14
No
No
Hsap\ARID5B
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (9)
Rnor\Arid1a
12 of 14
Yes
Yes
Rnor\Arid1b
11 of 14
No
Yes
Rnor\Arid2
1 of 14
No
No
Rnor\Arid3a
1 of 14
No
No
Rnor\Arid3b
1 of 14
No
No
Rnor\Arid3c
1 of 14
No
No
Rnor\Arid4a
1 of 14
No
No
Rnor\Arid4b
1 of 14
No
No
Rnor\Arid5a
1 of 14
No
No
Mus musculus (laboratory mouse) (10)
Mmus\Arid1b
12 of 14
Yes
Yes
Mmus\Arid1a
11 of 14
No
Yes
Mmus\Arid2
1 of 14
No
No
Mmus\Arid3a
1 of 14
No
No
Mmus\Arid3b
1 of 14
No
No
Mmus\Arid3c
1 of 14
No
No
Mmus\Arid4a
1 of 14
No
No
Mmus\Arid4b
1 of 14
No
No
Mmus\Arid5a
1 of 14
No
No
Mmus\Arid5b
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\arid1b
7 of 13
Yes
Yes
Xtro\arid1a
6 of 13
No
Yes
Xtro\arid2
1 of 13
No
No
Xtro\arid3a
1 of 13
No
No
Xtro\arid4a
1 of 13
No
No
Xtro\arid5b
1 of 13
No
Yes
Xtro\cdc7
1 of 13
No
No
Xtro\hoxa6
1 of 13
No
No
Xtro\isyna1
1 of 13
No
No
Xtro\pcdh7
1 of 13
No
No
Danio rerio (Zebrafish) (13)
Drer\arid1aa
11 of 14
Yes
Yes
Drer\arid1ab
11 of 14
Yes
Yes
Drer\arid1b
11 of 14
Yes
Yes
Drer\arid2
1 of 14
No
No
Drer\arid3b
1 of 14
No
No
Drer\arid3c
1 of 14
No
No
Drer\arid4a
1 of 14
No
No
Drer\arid4b
1 of 14
No
No
Drer\arid5a
1 of 14
No
No
Drer\arid5b
1 of 14
No
No
Drer\arid6
1 of 14
No
Yes
Drer\tomm20a
1 of 14
No
No
Drer\zgc:77151
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\let-526
10 of 14
Yes
Yes
Cele\cfi-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP001786
10 of 12
Yes
Yes
Agam\AgaP_AGAP004021
1 of 12
No
No
Agam\AgaP_AGAP005156
1 of 12
No
No
Agam\AgaP_AGAP006990
1 of 12
No
No
Agam\AgaP_AGAP007503
1 of 12
No
No
Agam\AgaP_AGAP012313
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\AT1G04880
2 of 13
Yes
No
Atha\AT1G55650
2 of 13
Yes
No
Atha\AT1G76110
2 of 13
Yes
No
Atha\AT3G13350
2 of 13
Yes
No
Atha\LFR
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ECM5
2 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rsc9
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:osa. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
retn
2 of 13
Bap170
1 of 13
htk
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
osaGL00372
model of  Coffin-Siris syndrome 1
CEA
(MacPherson et al., 2023)
model of  Coffin-Siris syndrome 2
CEA
(MacPherson et al., 2023)
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ARID1A; AT-rich interaction domain 1A
12 of 14
603024
ARID1B; AT-rich interaction domain 1B
12 of 14
614556
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
osa - Act5C
anti bait coimmunoprecipitation, molecular weight estimation by staining
(Collins et al., 1999)
osa - Bap111
protein cross-linking with a bifunctional reagent, Identification by mass spectrometry, anti bait coimmunoprecipitation, molecular weight estimation by staining
(Mashtalir et al., 2018, Collins et al., 1999)
osa - Bap55
anti bait coimmunoprecipitation, molecular weight estimation by staining
(Collins et al., 1999)
osa - Bap60
anti tag coimmunoprecipitation, Identification by mass spectrometry, protein cross-linking with a bifunctional reagent, experimental knowledge based, anti bait coimmunoprecipitation, molecular weight estimation by staining
(Barish et al., 2020, Mashtalir et al., 2018, Guruharsha et al., 2011, Collins et al., 1999)
osa - CG17002
experimental knowledge based
(Guruharsha et al., 2011)
osa - Cdk8
experimental knowledge based
(Guruharsha et al., 2011)
osa - Chi
nuclear magnetic resonance
(Fiedler et al., 2015)
osa - Cpsf6
experimental knowledge based
(Guruharsha et al., 2011)
osa - CycE
anti bait coimmunoprecipitation, western blot
(Baig et al., 2010)
osa - EcR
proximity-dependent biotin identification, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot
(Mazina et al., 2020)
osa - Larp4B
experimental knowledge based
(Guruharsha et al., 2011)
osa - MED14
experimental knowledge based
(Guruharsha et al., 2011)
osa - MED17
experimental knowledge based
(Guruharsha et al., 2011)
osa - MED18
experimental knowledge based
(Guruharsha et al., 2011)
osa - MED23
experimental knowledge based
(Guruharsha et al., 2011)
osa - Ptip
experimental knowledge based
(Guruharsha et al., 2011)
osa - Snr1
anti bait coimmunoprecipitation, western blot, coimmunoprecipitation, molecular weight estimation by staining
(Marenda et al., 2003, Collins et al., 1999)
osa - Sumo
anti tag coimmunoprecipitation, comigration in sds page, anti tag western blot
(Pirone et al., 2017)
osa - Usp10
experimental knowledge based
(Guruharsha et al., 2011)
osa - brm
anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry, peptide massfingerprinting, ion exchange chromatography, molecular sieving, experimental knowledge based
(Tilly et al., 2021, Nakayama et al., 2012, Guruharsha et al., 2011, Chalkley et al., 2008, Mohrmann et al., 2004, Kal et al., 2000, Collins et al., 1999)
osa - d4
anti tag coimmunoprecipitation, Identification by mass spectrometry, protein cross-linking with a bifunctional reagent
(Barish et al., 2020, Mashtalir et al., 2018)
osa - dsh
experimental knowledge based
(Guruharsha et al., 2011)
osa - ebi
experimental knowledge based
(Guruharsha et al., 2011)
osa - mor
anti bait coimmunoprecipitation, western blot, ion exchange chromatography, molecular sieving, experimental knowledge based, peptide massfingerprinting
(Guruharsha et al., 2011, Chalkley et al., 2008, Mohrmann et al., 2004, Collins et al., 1999)
osa - polybromo
protein cross-linking with a bifunctional reagent, Identification by mass spectrometry
(Mashtalir et al., 2018)
osa - psq
anti bait coimmunoprecipitation, western blot
(Chetverina et al., 2022)
osa - sd
anti tag coimmunoprecipitation, anti tag western blot
(Jin et al., 2013)
osa - su(Hw)
anti bait coimmunoprecipitation, western blot
(Vorobyeva et al., 2013)
osa - tna
anti bait coimmunoprecipitation, western blot, two hybrid
(Monribot-Villanueva et al., 2013)
osa - yki
anti bait coimmunoprecipitation, peptide massfingerprinting
(Jin et al., 2013)
osa - z
far western blotting, autoradiography
(Kal et al., 2000)
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
osa
enhanceable
brm
(Gutierrez et al., 2003, Collins et al., 1999)
osa
suppressible
brm
(Collins et al., 1999)
osa
enhanceable
corto
(Lopez et al., 2001)
osa
suppressible
geminin
(Herr et al., 2010)
osa
suppressible
htt
(Dietz et al., 2015)
osa
enhanceable
mor
(Collins et al., 1999)
osa
enhanceable
Snr1
(Collins et al., 1999)
osa
enhanceable
Sumo
(Monribot-Villanueva et al., 2013)
osa
enhanceable
tara
(Gutierrez et al., 2003)
osa
enhanceable
tna
(Gutierrez et al., 2003)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Antp
suppressible
osa
(Ragab et al., 2006, Vazquez et al., 1999)
Antp|Pc
suppressible
osa
(Kennison and Tamkun, 1988)
ap|Bx
suppressible
osa
(Bejarano et al., 2008)
asf1
suppressible
osa
(Moshkin et al., 2002)
brat
enhanceable
osa
(Janssens et al., 2014)
brm
enhanceable
osa
(Gutierrez et al., 2003, Collins et al., 1999)
bs
enhanceable
osa
(Terriente-Félix and de Celis, 2009)
bs
suppressible
osa|brm
(Terriente-Félix and de Celis, 2009)
Bx
suppressible
osa
(Bejarano et al., 2008, Milan et al., 2004)
Bx
enhanceable
osa
(Bejarano et al., 2008, Milan et al., 2004)
Chi
enhanceable
osa
(Heitzler et al., 2003)
Chi
suppressible
osa
(Heitzler et al., 2003)
corto
enhanceable
osa
(Lopez et al., 2001)
ct
enhanceable
osa
(Krupp et al., 2005)
ct
suppressible
osa
(Krupp et al., 2005)
CycE
suppressible
osa
(Brumby et al., 2004, Brumby et al., 2002)
Dp|E2f1
enhanceable
osa
(Staehling-Hampton et al., 1999)
dpp
enhanceable
osa
(Treisman et al., 1997)
Dref
suppressible
osa
(Nakamura et al., 2008, Hirose et al., 2001)
E2f1|Dp
enhanceable
osa
(Staehling-Hampton et al., 1999)
E(z)
enhanceable
osa
(Bajusz et al., 2001)
E(z)
suppressible
osa
(Bajusz et al., 2001)
foxo
suppressible
osa
(Martínez Corrales et al., 2022)
gcm
suppressible
osa
(Popkova et al., 2012)
gcm
enhanceable
osa|brm
(Popkova et al., 2012)
gcm
enhanceable
osa
(Popkova et al., 2012)
Kr
enhanceable
osa
(Abrell et al., 2000, Carrera et al., 1998)
lz
enhanceable
osa
(Kaminker et al., 2001)
Marcal1
suppressible
osa
(Morimoto et al., 2016)
Marcal1
enhanceable
osa
(Morimoto et al., 2016)
mor
suppressible
osa
(Collins et al., 1999)
net
enhanceable
osa
(Terriente-Félix and de Celis, 2009, Marenda et al., 2004)
net|px
suppressible
osa|brm
(Terriente-Félix and de Celis, 2009)
Pc
suppressible
osa
(Kennison and Tamkun, 1988)
peb
enhanceable
osa
(Wilk et al., 2004)
pnr
enhanceable
osa
(Heitzler et al., 2003)
Ras85D
enhanceable
osa
(Terriente-Félix and de Celis, 2009)
Ras85D
suppressible
osa
(Terriente-Félix and de Celis, 2009)
rl
enhanceable
osa
(Terriente-Félix and de Celis, 2009)
ro
suppressible
osa
(Chanut et al., 2000, Treisman et al., 1997)
sd
enhanceable
osa
(Jin et al., 2013)
sev|Ras85D
suppressible
osa
(Maixner et al., 1998)
sgg
enhanceable
osa
(Collins and Treisman, 2000)
sgg
suppressible
osa
(Collins and Treisman, 2000)
tara
enhanceable
osa
(Gutierrez et al., 2003)
tna
enhanceable
osa
(Monribot-Villanueva et al., 2013, Gutierrez et al., 2003)
tou
suppressible
osa
(Vanolst et al., 2005)
External Data
Subunit Structure (UniProtKB)
Component of the Brahma complex, which is composed of Brm, Osa, Mor, Snr1/Bap45, Bap111/Dalao, Bap55, Bap60 and Bap47. Interacts with Pnr and Chi via its EHD domain.
(UniProt, Q8IN94 )
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-61
Cytogenetic map
90C1-90C2
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
90C1-90C2
(determined by in situ hybridisation); Limits computationally determined from genome sequence between P{PZ}l(3)0788207882 and P{EP}cpoEP3679
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Location from complementation analysis with deficiency and duplication chromosomes (details unspecified).
(Kennison and Tamkun, 1988)
90C1-90C1
(determined by in situ hybridisation)
(Molnar et al., 2006)
90C1-90C2
(Treisman, 1998.3.9)
90C5-90C8
(determined by in situ hybridisation)
(Spradling et al., 1999)
90C1-90C2
(determined by in situ hybridisation)
(Treisman et al., 1997)
90B-90C
(determined by in situ hybridisation)
(Kennison, 1995)
90C5-90C8
90C7--8
(BDGP Project Members, 1994-1999)
90B1-90D1
(Kennison and Tamkun, 1988)
Experimentally Determined Recombination Data
Location

3-61

(FlyBase, 2016)

3-60.2

(Comeron et al., 2012)

3-60.0

(Kennison and Tamkun, 1988)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (35)
Genomic Clones (35)
cDNA Clones (68)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Eroglu et al., 2014, Vorobyeva et al., 2013, Collins et al., 1999)

    monoclonal

    (Treisman et al., 1997)
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        osa acts as a positive modulator of ap activity in the wing. osa mediates activation of some ap target genes and repression of others.

        (Milan et al., 2004)

        D.melanogaster contains two distinct brahma (BRM) complexes: the BAP complex, defined by the presence of osa protein and the absence of both polybromo and Bap170 proteins, and the PBAP complex, which contains the polybromo and Bap170 proteins but lacks the osa protein.

        (Mohrmann et al., 2004)

        osa negatively regulates neural expression of ac/sc.

        (Heitzler et al., 2003)

        Area matching Drosophila EST AA201670.

        (Davies, 2001.3.15)

        brm interacts with osa to regulate the expression of the Antp P2 promoter.

        (Vazquez et al., 1999)

        osa may be involved in signalling through N or wg pathways. osa protein is expressed ubiquitously in the early embryos and in imaginal discs and is localised to the nucleus where results suggests it counteracts the effects of wg on its target genes.

        (Treisman et al., 1997)

        Mosaic analysis in eye discs suggests a function for osa in cell proliferation and/or survival and neuronal differentiation.

        (Treisman et al., 1997)

        Mutations in osa enhance the phentype of mutations in brm.

        (Vazquez et al., 1995)

        Mutations cannot rescue the lethality of the Df(1)ph-2-Psc1 interaction, demonstrating that trx group mutations cannot suppress Pc group phenotypes.

        (Cheng et al., 1994)

        Dosage-dependent modifier of AntpNs.

        (Talbert and Garber, 1994)

        Identification: dominant suppressor of the antenna to leg transformation in Pc2 AntpNs double heterozygotes.

        (Lindsley and Zimm, 1992)

        Dominant suppressor of AntpNs, Pc and Pcl alleles. Recessive embryonic lethality is associated with all alleles.

        (Lindsley and Zimm, 1992)

        osa is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Alleles of Pc, Pcl, Scm, Dll, brm, kto, Scr and trx show clear dominant enhancement or suppression of AntpScx, whereas alleles of vtd, Vha55, Su(Pc)37D, urd, mor, skd and osa do not.

        (Kennison and Tamkun, 1988)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: osa eld

        (Vazquez et al., 1999, Maixner et al., 1998)

        Source for merge of: osa l(3)j9C3

        (Spradling et al., 1999)

        Source for merge of: osa C819

        (Terriente-Félix and de Celis, 2009)

        Source for merge of: osa anon-WO0118547.314 anon-WO0172774.126

        (FlyBase, 1996-)
        Additional comments

        Source for merge of osa anon-WO0118547.314 anon-WO0172774.126 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)

        Fails to complement In(3R)Antprv1 for viability.

        Nomenclature History
        Source for database identify of

        Source for identity of: osa CG7467

        (Gong, 1999.11)
        Nomenclature comments
        Etymology

        "osa" means "fate" in Norwegian.

        (Kennison, 1995)
        Synonyms and Secondary IDs (17)
        Reported As
        Symbol Synonym
        ARID1B
        (Huber et al., 2023)
        C819
        (Molnar et al., 2006)
        CG7467
        (Meadows, 2017.1.11, Hosono et al., 2015, Azad et al., 2012, Bridon et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Khokhar et al., 2008, Ni et al., 2008, Molnar et al., 2006, Klebes et al., 2005, Stempfl et al., 2002)
        E(E2F)3C
        (Staehling-Hampton et al., 1999)
        OSA
        (Vorobyeva et al., 2025, Tilly et al., 2021, Fursova et al., 2020, Mashtalir et al., 2018, Liu et al., 2017, L Black et al., 2016, Kingston and Tamkun, 2014, Vorobyeva et al., 2013, Moshkin et al., 2012, Schuettengruber et al., 2011, Mills, 2010, Clapier and Cairns, 2009, Moshkin et al., 2009, Soshnikova et al., 2008, Moshkin et al., 2007, Schwartz and Pirrotta, 2007, Ataman, 2006, Bouazoune and Brehm, 2006, Eberharter and Becker, 2004, Taylor-Harding et al., 2004)
        Osa
        (Erokhin et al., 2023, Flanagan et al., 2022, Ray et al., 2022, Cenik and Shilatifard, 2021, Chaouch and Lasko, 2021, Erokhin et al., 2021, Barish et al., 2020, Chetverina et al., 2020, Mazina et al., 2020, Onishi et al., 2020, Rosales-Vega et al., 2018, Liu and Jin, 2017, Liu and Jin, 2017, Monribot-Villanueva et al., 2017, Pirone et al., 2017, Song et al., 2017, Banreti et al., 2014, Bonnay et al., 2014, Eroglu et al., 2014, Waldholm et al., 2011, Baig et al., 2010, Mudiganti et al., 2010, Swaminathan et al., 2010, Glavic et al., 2009, Nie et al., 2009, Vorobyeva et al., 2009, Diop et al., 2008, Martin et al., 2007, Schuettengruber et al., 2007, Secombe et al., 2007, Carrera et al., 2004, Klochendler-Yeivin et al., 2002, Collins et al., 1999)
        anon-WO0118547.314
        anon-WO0172774.126
        eld
        (Luschnig et al., 2004, Luschnig et al., 2004, Begun, 2001, Abrell et al., 2000, Begun and Whitley, 2000, Spradling et al., 1999, Thomas and Wassarman, 1999, Collins et al., 1998, Treisman, 1998.3.9, Treisman et al., 1997, Fauvarque et al., 1995)
        en(lz)4F/4H
        (Kaminker et al., 2001)
        eyelid
        (Clapier and Cairns, 2009)
        l(3)00090
        (Carrera et al., 1998)
        l(3)04539
        (Maixner et al., 1998)
        l(3)j9C3
        osa
        (Li et al., 2025, Martinez, 2025, Niederhuber et al., 2024, Heigwer et al., 2023, Titlow et al., 2023, Cammarata-Mouchtouris et al., 2022, Ding et al., 2022, Marcogliese et al., 2022, McKowen et al., 2022, Miozzo et al., 2022, Molnar et al., 2022, Bilder et al., 2021, Tian and Smith-Bolton, 2021, Luo et al., 2020, Chubak et al., 2019, Jiang et al., 2019, Valanne et al., 2019, Yee et al., 2019, Dasari et al., 2018, Lee et al., 2018, Richardson and Portela, 2018, Rohde et al., 2017, Sharma et al., 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Xie et al., 2017, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Morimoto et al., 2016, Testa and Dworkin, 2016, Dietz et al., 2015, Fiedler et al., 2015, Fischer et al., 2015, Gene Disruption Project members, 2015-, Nikalayevich and Ohkura, 2015, Sopko et al., 2015, Wang et al., 2015, Ashwal-Fluss et al., 2014, Bonnay et al., 2014, Eroglu et al., 2014, Janssens et al., 2014, Rogers et al., 2014, Yan et al., 2014, Bengani et al., 2013, de Celis et al., 2013.9.11, Jin et al., 2013, Monribot-Villanueva et al., 2013, Petruk et al., 2013, Sen et al., 2013, Sen et al., 2013, Vasanthi et al., 2013, Zeng et al., 2013, Antao et al., 2012, Azad et al., 2012, Bridon et al., 2012, Follmer et al., 2012, Hainaut et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nakayama et al., 2012, Nowak et al., 2012, Popkova et al., 2012, Tokusumi et al., 2012, Valadez-Graham et al., 2012, Vonhoff et al., 2012, Zraly and Dingwall, 2012, Curtis et al., 2011, Di Stefano et al., 2011, Kirilly et al., 2011, Neumüller et al., 2011, Toku et al., 2011, Arancio et al., 2010, Gan et al., 2010, Herr et al., 2010, Salzer et al., 2010, Smulders-Srinivasan et al., 2010, Swaminathan et al., 2010, Ayroles et al., 2009, Schaaf et al., 2009, Terriente-Félix and de Celis, 2009, Carrera et al., 2008, Chalkley et al., 2008, Cukier et al., 2008, Khokhar et al., 2008, Melicharek et al., 2008, Nakamura et al., 2008, Petruk et al., 2008, Remaud et al., 2008, Vázquez et al., 2008, Beltran et al., 2007, Buszczak et al., 2007, Chang et al., 2007, Dietzl et al., 2007, Kankel et al., 2007, Dworkin and Gibson, 2006, Dworkin and Gibson., 2006, Molnar et al., 2006, Mathew et al., 2005, Marenda et al., 2003, Hirose et al., 2001)
        p300
        (Kal et al., 2000)
        Name Synonyms
        eye lid
        (Shandala et al., 1998)
        eyelid
        (Tulin et al., 2002, Abrell et al., 2000, Bonini and Fortini, 1999, Treisman et al., 1997)
        osa
        (Salzer et al., 2010, Bejarano et al., 2008, Cukier et al., 2008, Remaud et al., 2008)
        Secondary FlyBase IDs
        • FBgn0003013
        • FBgn0010708
        • FBgn0011421
        • FBgn0015384
        • FBgn0046467
        • FBgn0062101
        • FBgn0259443
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 72 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        References (328)