FlyBase Gene Report: Dmel\corto

General Information

Symbol

Dmel\corto

Species

D. melanogaster

Name

corto

Annotation Symbol

CG2530

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010313

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

corto (corto) encodes an Enhancer of Trithorax and Polycomb (ETP) protein that physically interacts with several Polycomb proteins (encoded by Pc, ph-d, ph-p, esc, E(z)) and ETP (encoded by Trl, Dsp1). It also interacts with the product of CycG, with the methylated product of RpL12 (RPL12K3me3), and co-regulates the transcription of genes involved in ribosome biogenesis. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(3)neo31, ccf, Centrosomal and chromosomal factor, l(3)07128

Key Links

Genomic Location

Cytogenetic map

82E7-82E7

Sequence location

3R:5,077,779..5,087,072 [-]

Recombination map

3-47.1

RefSeq locus

NT_033777 REGION:5077779..5087072

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from direct assay

(Kodjabachian et al., 1998)

enables identical protein binding

inferred from physical interaction with UniProtKB:P41046

(Salvaing et al., 2003)

enables protein binding

inferred from physical interaction with UniProtKB:P39769

(Salvaing et al., 2003)

inferred from physical interaction with UniProtKB:P42124

(Salvaing et al., 2003)

inferred from physical interaction with UniProtKB:Q24338

(Salvaing et al., 2003)

inferred from physical interaction with UniProtKB:Q9VHA0

(Salvaing et al., 2003)

enables protein homodimerization activity

inferred from physical interaction with UniProtKB:P41046

(Salvaing et al., 2003)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in epithelium development

inferred from genetic interaction with FLYBASE:Abd-B; FB:FBgn0000015

(Salvaing et al., 2008)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Rougeot et al., 2013)

involved_in mitotic chromosome condensation

inferred from mutant phenotype

(Kodjabachian et al., 1998)

involved_in regulation of gene expression

inferred from direct assay

(Coléno-Costes et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in heterochromatin formation

inferred by curator from GO:0035098

(Salvaing et al., 2003)

inferred by curator from GO:0035102

(Salvaing et al., 2003)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Kodjabachian et al., 1998)

located_in cytoplasm

inferred from high throughput direct assay

(Sarov et al., 2016)

part_of ESC/E(Z) complex

inferred from physical interaction with UniProtKB:P42124

(Salvaing et al., 2003)

inferred from physical interaction with UniProtKB:Q24338

(Salvaing et al., 2003)

located_in nucleus

inferred from direct assay

(Kodjabachian et al., 1998)

located_in polytene chromosome

inferred from direct assay

(Salvaing et al., 2003)

part_of PRC1 complex

inferred from physical interaction with UniProtKB:P39769

(Salvaing et al., 2003)

inferred from physical interaction with UniProtKB:Q9VHA0

(Salvaing et al., 2003)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Essential protein required for proper condensation of mitotic chromosomes and progression through mitosis (PubMed:9463384). Binds to specific polytene chromosome sites, many of which are shared with the posterior sex combs (Psc) protein (PubMed:9463384). Involved in maintaining Abd-B repression outside its normal expression domain (PubMed:18286205, PubMed:18667003).

(UniProt, P41046)

Summary (Interactive Fly)

Chromodomain protein - partners with CycG which regulates the activity of Corto at chromatin - acts alternatively as an enhancer of TrxG and an Enhancer of PcG

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\corto for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P41046)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

corto-RA

FBtr0078844

NM_079507

3036

550

corto-RB

FBtr0308118

NM_001259992

3537

550

corto-RC

FBtr0308119

NM_001259993

9294

550

corto-RD

FBtr0308120

NM_001259994

3352

550

corto-RE

FBtr0345141

NM_001300237

2992

550

Additional Transcript Data and Comments

Reported size (kB)

3.6, 3.2 (northern blot)

(Kodjabachian et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

corto-PA

FBpp0078485

58.8

550

10.32

FBpp0300440

58.8

550

10.32

FBpp0300441

58.8

550

10.32

FBpp0300442

58.8

550

10.32

FBpp0311362

58.8

550

10.32

P41046

NP_001287166

AHN57165

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

550 aa isoforms: corto-PA, corto-PB, corto-PC, corto-PD, corto-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

550 (aa); 68 (kD observed); 59 (kD predicted)

(Kodjabachian et al., 1998)

Comments

corto protein binds to ~100 sites on polytene chromosomes. It shares a number of polytene chromosome binding sites with Psc protein.

(Kodjabachian et al., 1998)

Amino acid sequence is substantially different from that of g1304060

(FlyBase, 1992-)

External Data

Subunit Structure (UniProtKB)

Homodimer (PubMed:12771214). Interacts with esc, Trl, E(z), scm and ph-p in vitro (PubMed:12771214). Found in vivo in an esc-containing complex, which may be the Esc/E(z) complex (PubMed:12771214). Also found in vivo in a Pc-containing complex that may be the PRC1 complex, but does not interact with Pc directly (PubMed:12771214). Interacts with cyclin CycG (PubMed:18286205).

(UniProt, P41046)

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\corto using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.29

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

gnathal primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Kodjabachian et al., 1998)

embryonic stage 9 -- 17

Comment: reference states >=4 hr AEL

(Kodjabachian et al., 1998)

larval stage & pupal stage & adult stage

(Kodjabachian et al., 1998)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

corto protein is a nuclear protein. It is associated with condensing chromosomes in early prophase. It continues to be associated with chromosomes in metaphase and anaphase while in telophase, the signal decreases and spreads throughout the nucleus. corto protein is also observed in centrosomes.

(Kodjabachian et al., 1998)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Kodjabachian et al., 1998)

located_in cytoplasm

inferred from high throughput direct assay

(Sarov et al., 2016)

part_of ESC/E(Z) complex

inferred from physical interaction with UniProtKB:P42124

(Salvaing et al., 2003)

inferred from physical interaction with UniProtKB:Q24338

(Salvaing et al., 2003)

located_in nucleus

inferred from direct assay

(Kodjabachian et al., 1998)

located_in polytene chromosome

inferred from direct assay

(Salvaing et al., 2003)

part_of PRC1 complex

inferred from physical interaction with UniProtKB:P39769

(Salvaing et al., 2003)

inferred from physical interaction with UniProtKB:Q9VHA0

(Salvaing et al., 2003)

Expression Deduced from Reporters

Reporter: P{A92}corto^82E.A46

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

organism | 10-90% egg length

(O'Kane and Gehring, 1987)

embryonic stage 5 -- 17

organism | 10-90% egg length

(O'Kane and Gehring, 1987)

embryonic stage 10

organism | restricted

Comment: NOT gut

(O'Kane and Gehring, 1987)

embryonic stage 11

(O'Kane and Gehring, 1987)

Reporter: P{PZ}corto^07128b

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult optic lobe

(Vosshall, 1998.8.10)

adult central complex

(Vosshall, 1998.8.10)

adult brain | restricted

(Vosshall, 1998.8.10)

adult Malpighian tubule Type II cell

(Wang et al., 2004)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\corto in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\corto

View exonic expression by tissue for Dmel\corto

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010313

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40616/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010313

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010313

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010313

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2530

Flygut - An atlas of the Drosophila adult midgut

FBgn0010313

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\corto

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 25 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of corto

Transgenic constructs containing regulatory region of corto

Aberrations (Deficiencies and Duplications) ( 10 )

Inferred from experimentation ( 10 )

Gene disrupted in

Df(3R)2-2

(BDGP Project Members, 1994-1999)

Df(3R)6-7

(Lopez et al., 2001, Megraw and Kaufman, 1998.10.2)

Df(3R)110

(Megraw and Kaufman, 1998.10.2)

Df(3R)ED5100

(Roote, 2004.7.20)

Df(3R)ED5138

(Roote, 2004.7.20, Ryder and Roote, 2004.11.10)

Df(3R)ED5142

(Ryder and Roote, 2004.11.10)

Df(3R)Exel6143

(Ryder, 2004.4.26)

Gene not disrupted in

Df(3R)2-2

(Spradling et al., 1999)

Df(3R)3-4

(Megraw and Kaufman, 1998.10.2)

Df(3R)107

(Megraw and Kaufman, 1998.10.2)

Df(3R)110

(Megraw and Kaufman, 1998.10.2)

Df(3R)Z1

(Megraw and Kaufman, 1998.10.2)

Gene partially disrupted in

Df(3R)ED5100

(Ryder and Roote, 2004.11.10)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(3R)6-7)

corto⁴²⁰

lethal | recessive

lethal | recessive | heat sensitive

corto^tsT18

partially lethal - majority die, with Scer\GAL4^Act5C.PU

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

partially lethal - majority die, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

partially lethal - majority die (with Df(3R)ED5100)

corto^07128b

viable

corto^82E.A46

viable, with Scer\GAL4^Act5C.PU

corto^{ΔCD.UASp.Tag:FLAG,Tag:HA}

viable, with Scer\GAL4^da.G32

corto^{ΔCD.UASp.Tag:FLAG,Tag:HA}

Sterility

Allele

female sterile

corto^neo31

Other Phenotypes

Allele

abnormal developmental rate | larval stage | recessive

corto⁴²⁰

abnormal mitotic cell cycle | recessive

corto⁴²⁰

abnormal size, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

abnormal size | adult stage

corto⁴²⁰

abnormal size | larval stage

corto⁴²⁰

abnormal song

corto³⁶⁹

homeotic, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

melanotic mass phenotype

corto⁴²⁰

short lived

corto⁴²⁰

some die during larval stage

some die during pupal stage

visible, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

visible | adult stage, with Scer\GAL4^Bx-MS1096

corto^UAS.cKa

visible | adult stage, with Scer\GAL4^hs.PB

corto^UAS.cKa

visible | adult stage, with Scer\GAL4^sd.PU

corto^UAS.cKa

visible | adult stage (with corto⁴²⁰)

corto^07128b

visible | adult stage (with corto^07128b)

visible | adult stage (with corto^l1)

corto^07128b

visible | adult stage (with Df(3R)6-7)

corto^l1

visible | dominant

visible | recessive

corto⁴²⁰

visible | somatic clone

corto⁴²⁰

wild-type

corto^t9

Phenotype manifest in

Allele

adult abdomen & macrochaeta

corto⁴²⁰

adult cuticle

corto⁴²⁰

adult head

corto⁴²⁰

adult thorax & macrochaeta

corto⁴²⁰

arista, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

arista, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

egg chorion

corto^neo31

embryonic/larval crystal cell

embryonic/larval lymph gland

corto⁴²⁰

embryonic/larval plasmatocyte

corto^07128b

embryonic/larval salivary gland | embryonic stage

corto⁴²⁰

external sensory organ | adult stage

corto⁴²⁰

eye

corto⁴²⁰

gastric caecum

corto⁴²⁰

genitalia, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

germline cell | male, with Scer\GAL4^{VP16.nanos.UTR}

corto^EP775

haltere, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

humeral bristle

corto⁴²⁰

imaginal disc

corto⁴²⁰

larval brain

corto⁴²⁰

leg, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

leg | ectopic, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

macrochaeta

corto^BG00525

macrochaeta | increased number, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

male genitalia, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

melanotic mass

corto⁴²⁰

posterior crossvein

corto⁴²⁰

postpronotum

corto⁴²⁰

prothoracic tarsal segment 2

corto⁴²⁰

ring gland

corto⁴²⁰

scutellar bristle, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

scutellum, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

sex comb

corto⁴²⁰

sex comb, with Scer\GAL4^da.G32

corto^{CD.UASp.Tag:FLAG,Tag:HA,Tag:NLS(Unk)}

sex comb | ectopic

corto⁴²⁰

sex comb | increased number

corto⁴²⁰

trichogen cell | increased number

corto⁴²⁰

wing, with Scer\GAL4^ptc-559.1

corto^UAS.cKa

wing (with Df(3R)6-7)

corto⁴²⁰

wing disc | larval stage

corto⁴²⁰

wing vein | ectopic

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

corto^UAS.cKa

wing vein | ectopic, with Scer\GAL4^hs.PB

corto^UAS.cKa

wing vein | ectopic, with Scer\GAL4^sd.PU

corto^UAS.cKa

wing vein | ectopic (with corto⁴²⁰)

corto^07128b

wing vein | ectopic (with corto^07128b)

wing vein | ectopic (with corto^l1)

corto^07128b

wing vein | ectopic (with Df(3R)6-7)

wing vein | ectopic | somatic clone

corto⁴²⁰

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP013096

5 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:corto. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

corto

two hybrid, fluorescent resonance energy transfer, fluorescence microscopy, pull down, autoradiography

(Nil et al., 2019, Salvaing et al., 2003)

corto - CycG

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, two hybrid, anti bait coimmunoprecipitation, western blot

(Salvaing et al., 2008)

corto - Dsp1

anti bait coimmunoprecipitation, western blot, far western blotting, autoradiography, pull down

(Salvaing et al., 2006)

corto - E(z)

anti bait coimmunoprecipitation, western blot, pull down, autoradiography, two hybrid

(Peng et al., 2016, Salvaing et al., 2003)

corto - EloA

anti tag coimmunoprecipitation, anti tag western blot

(Rougeot et al., 2013)

corto - EloB

anti tag coimmunoprecipitation, anti tag western blot

(Rougeot et al., 2013)

corto - EloC

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Rougeot et al., 2013)

corto - Lamtor3

pull down, western blot, two hybrid

(Mouchel-Vielh et al., 2011)

corto - Pc

anti tag coimmunoprecipitation, western blot

(Salvaing et al., 2003)

corto - RpL12

anti tag coimmunoprecipitation, anti tag western blot, pull down, Identification by mass spectrometry, surface plasmon resonance, predetermined participant

(Grunchec et al., 2022, Coléno-Costes et al., 2012)

corto - Scm

two hybrid, pull down, autoradiography

(Salvaing et al., 2003)

corto - Trl

two hybrid, pull down, autoradiography

(Salvaing et al., 2003)

corto - esc

anti tag coimmunoprecipitation, western blot, two hybrid, pull down, autoradiography

(Salvaing et al., 2003)

corto - ph-p

pull down, autoradiography, two hybrid

(Salvaing et al., 2003)

corto - piwi

anti bait coimmunoprecipitation, western blot

(Peng et al., 2016)

corto - rl

anti bait coimmunoprecipitation, western blot, pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Mouchel-Vielh et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

corto

enhanceable

E(z)

(Kodjabachian et al., 1998)

corto

suppressible

EloA

(Rougeot et al., 2013)

corto

suppressible

EloB

(Rougeot et al., 2013)

corto

suppressible

EloC

(Rougeot et al., 2013)

corto

enhanceable

osa

(Lopez et al., 2001)

corto

enhanceable

Trl

(Lopez et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Abd-B

enhanceable

corto

(Salvaing et al., 2008)

Abd-B

enhanceable

corto|CycG

(Salvaing et al., 2008)

enhanceable

corto

(Mouchel-Vielh et al., 2011)

CycG

enhanceable

corto

(Salvaing et al., 2008)

Lamtor3

enhanceable

corto

(Mouchel-Vielh et al., 2011)

mxc

enhanceable

corto

(Lopez et al., 2001)

osa

enhanceable

corto

(Lopez et al., 2001)

enhanceable

corto

(Kodjabachian et al., 1998)

Pcl

enhanceable

corto

(Lopez et al., 2001)

ph-d

enhanceable

corto

(Kodjabachian et al., 1998)

ph-p

enhanceable

corto

(Kodjabachian et al., 1998)

rho

enhanceable

corto

(Mouchel-Vielh et al., 2011)

suppressible

corto

(Mouchel-Vielh et al., 2011)

enhanceable

corto

(Mouchel-Vielh et al., 2011)

Snr1

enhanceable

corto

(Marenda et al., 2004)

Trl

enhanceable

corto

(Lopez et al., 2001)

External Data

Subunit Structure (UniProtKB)

(UniProt, P41046 )

Linkouts

BioGRID - A database of protein and genetic interactions.

65830

DroID - A comprehensive database of gene and protein interactions.

FBgn0010313

MIST (genetic) - An integrated Molecular Interaction Database

40616

MIST (protein-protein) - An integrated Molecular Interaction Database

40616

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.1

Cytogenetic map

82E7-82E7

Sequence location

3R:5,077,779..5,087,072 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

82E7-82E7

Limits computationally determined from genome sequence between P{PZ}l(3)02733⁰²⁷³³ and P{EP}EP974

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

82E-82E

(Kodjabachian, 1995.8.29)

82E5-82E7

(determined by in situ hybridisation) 82F1--8 (determined by in situ hybridisation)

(Spradling et al., 1999)

82E-82E

(determined by in situ hybridisation)

(Kodjabachian, 1995.1.19, Kodjabachian and Rosset, 1995, Cooley et al., 1988)

82E6-82E7

82F1--8

(BDGP Project Members, 1994-1999)

Stated to map to 42A (though subsequent information (FBrf0075177) corrected this to 82E).

(Kodjabachian et al., 1993)

Experimentally Determined Recombination Data

Location

3-47.1

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

(Kodjabachian, 1995.8.29)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4789

corto^tsT18/TM6B

4788

corto^l1/TM3, Sb¹

12724

w¹¹¹⁸; P{GT1}corto^BG00083

42268

w¹¹¹⁸; PBac{corto-GFP.FPTB}VK00037

44691

y¹ w^*; Mi{MIC}corto^MI06833

21796

y¹ w^67c23; P{Mae-UAS.6.11}corto^DP00099

35456

y¹ sc^* v¹ sev²¹; P{TRiP.GL00382}attP2

42629

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02464}attP40

107884

107883

GL00382

y¹ sc^* v¹ sev²¹; P{TRiP.GL00382}attP2

VDRC

v318889

PBac{fTRG00368.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (112)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010313

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010313

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Peng et al., 2016, Kodjabachian et al., 1998)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

(Harvie et al., 1998)

Mutations in corto affect progression through mitosis and interact with Polycomb group mutations.

(Kodjabachian et al., 1998)

Overexpression of corto causes embryonic or late larval lethality depending on the time and amount of product delivered. Adult escapers show phenotypes suggesting a reduction in the number of imaginal cells.

(Kodjabachian and Rosset, 1995)

Hypomorphic mutations in corto lead to a neoplastic tumoral phenotype affecting the imaginal discs and the optic lobes of the brain.

(Kodjabachian et al., 1994)

Identification: Expression of the enhancer trap insertion P{A92}corto^82E.A46.

(Kodjabachian et al., 1993)

Relationship to Other Genes

Source for database merge of

Source for merge of: corto l(3)neo31

(Spradling et al., 1999)

Source for merge of: corto anon-WO02059370.59

(FlyBase, 1996-)

Additional comments

Source for merge of corto anon-WO02059370.59 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: corto CG2530

(Guan, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

7128

(Harvie et al., 1998)

CG2530

(Rougeot et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Quinones-Coello, 2007, Norga et al., 2003)

CP-1

(Takamura, 1994.12.12)

Ccf

(Brock and van Lohuizen, 2001)

Corto

(Ko et al., 2023, Hafer et al., 2022, Chetverina et al., 2021, Rust et al., 2020, Eliazer and Buszczak, 2011, Salvaing et al., 2007)

anon-WO02059370.59

ccf

(Lopez et al., 1999, van Lohuizen, 1999, Kodjabachian et al., 1998, Kodjabachian, 1995.8.29)

corto

(Grunchec et al., 2022, McCarthy et al., 2022, Anqueira-González et al., 2021, Michki et al., 2021, Ogienko et al., 2020, Overton et al., 2020, Meltzer et al., 2019, Peng et al., 2016, Sarov et al., 2016, Shlyueva et al., 2016, Dupont et al., 2015, Matzat et al., 2013, Rougeot et al., 2013, Sen et al., 2013, Butchar et al., 2012, Coléno-Costes et al., 2012, Spokony and White, 2012.11.14, Curtis et al., 2011, Grimberg et al., 2011, Lin et al., 2011, Mouchel-Vielh et al., 2011, Seong et al., 2011, Pauli et al., 2010, Skora and Spradling, 2010, Smulders-Srinivasan et al., 2010, Moran and Kyriacou, 2009, Cukier et al., 2008, Lee et al., 2008, Salvaing et al., 2008, Salvaing et al., 2008, Gibert et al., 2007, Kankel et al., 2007, Morozova et al., 2007, Quinones-Coello, 2007, Reiter et al., 2007, Salvaing et al., 2006)

l(3)07128

(Spradling et al., 1999)

l(3)neo31

(Megraw and Kaufman, 1998.10.2, BDGP Project Members, 1994-1999, Edgar and O'Farrell, 1989, Cooley et al., 1988)

l(3)neo32

Name Synonyms

Centrosomal and chromosomal factor

(van Lohuizen, 1999)

Corto

(Nil et al., 2019)

centrosomal and chromosomal factor

(Kodjabachian et al., 1998)

corto

(Cukier et al., 2008, Salvaing et al., 2008, Gibert et al., 2007, Morozova et al., 2007, Salvaing et al., 2006)

Secondary FlyBase IDs

FBgn0010917
FBgn0011464
FBgn0011465
FBgn0016125
FBgn0066000

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 59 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40616

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P41046

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P41046

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LGR6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P41046

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010313

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40616/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010313

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010313

FlyMine - An integrated database for Drosophila genomics

FBgn0010313

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2530

MARRVEL_MODEL - MARRVEL (model organism gene)

40616

Linkouts

BioGRID - A database of protein and genetic interactions.

65830

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010313

DroID - A comprehensive database of gene and protein interactions.

FBgn0010313

DRSC - Results frm RNAi screens

FBgn0010313

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010313

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010313

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2530

Flygut - An atlas of the Drosophila adult midgut

FBgn0010313

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014556

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

40616

MIST (protein-protein) - An integrated Molecular Interaction Database

40616

References (116)

The following external sites may use different assemblies or annotations than FlyBase.

-1.29

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