FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
corto, E(z)
FlyBase ID
FBig0000104243
Interaction Network
Interactions Browser links
corto network
E(z) network
Reported Interactions
FBrf0160909-6.PD.A
Reference
Salvaing et al., 2003
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
corto 

Corto

bait

GST tag

corto 
E(z) 

E(z)

prey

[35]S label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
corto 
chromo domain
sufficient binding region
aa 127-203
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced and labeled by in vitro translation.

(Salvaing et al., 2003)
FBrf0160909-8.Y2H
Reference
Salvaing et al., 2003
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
corto 

Corto

bait

fused to LexA DNA-binding domain

corto 
corto 
E(z) 

E(z)

prey

fused to B42 activation domain

E(z) 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
E(z) 
N terminal region
sufficient binding region
aa 1-315

coordinates relative to E(z)-PA

corto 
Chromo domain
sufficient binding region
aa 127-203
corto 
C terminal region
sufficient binding region
aa 440-550
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Salvaing et al., 2003)

Neither full length corto or constructs containing the Chromo domain or C-terminal region of corto interact with full length E(z) in this experiment.

(Salvaing et al., 2003)

Two-hybrid system: yeast LexA-BD/B42-AD

(Salvaing et al., 2003)
FBrf0231095-2.coIP.WB
Reference
Peng et al., 2016
Description
physical association
Assay
Collection
Source/Stage
ovary / femaleadult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
corto 

Corto

bait
E(z) 

E(z)

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

corto coimmunoprecipitates piwi and E(z), but not Pc or aub.

(Peng et al., 2016)

Source was adult female ovaries of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Peng et al., 2016)
FBrf0231095-6.coIP.WB
Reference
Peng et al., 2016
Description
physical association
Assay
Collection
Source/Stage
ovary / femaleadult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
E(z) 

E(z)

bait
corto 

Corto

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

E(z) coimmunoprecipitates corto and piwi, but not Pc or aub, in ovarian extracts.

(Peng et al., 2016)

Source was adult female ovaries of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Peng et al., 2016)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)