FlyBase Allele Report: Dmel\corto[07128b]

General Information

Symbol

Dmel\corto^07128b

Species

D. melanogaster

Name

FlyBase ID

FBal0009595

Feature type

allele

Associated gene

Dmel\corto

Associated Insertion(s)

P{PZ}corto^07128b

Carried in Construct

Also Known As

corto⁰⁷¹²⁸

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}corto^07128b

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, Harvie et al., 1998)

partially lethal - majority die (with Df(3R)ED5100)

(Ryder and Roote, 2004.11.10)

visible | adult stage (with corto⁴²⁰)

(Mouchel-Vielh et al., 2011)

visible | adult stage (with corto^l1)

(Mouchel-Vielh et al., 2011)

visible | dominant

(Rougeot et al., 2013, Mouchel-Vielh et al., 2011)

Phenotype Manifest In

embryonic/larval crystal cell

(Milchanowski et al., 2004)

embryonic/larval plasmatocyte

(Milchanowski et al., 2004)

wing vein | ectopic

(Rougeot et al., 2013, Mouchel-Vielh et al., 2011)

wing vein | ectopic (with corto⁴²⁰)

(Mouchel-Vielh et al., 2011)

wing vein | ectopic (with corto^l1)

(Mouchel-Vielh et al., 2011)

Detailed Description

Statement

Reference

Over 90% of heterozygous females have an ectopic wing vein phenotype.

(Rougeot et al., 2013)

Flies carrying either corto^07128b/+, corto^07128b/corto^l1 or corto^07128b/corto⁴²⁰ exhibit ectopic wing veins that mainly arise close to longitudinal veins 2, 3, 5 and to the posterior cross-vein. Ectopic wing vein phenotype of corto^07128b/+ is nearly fully penetrant. This phenotype is more severe in flies heteroallelic for corto loss-of-function mutations: corto^07128b/corto^l1 and corto^07128b/corto⁴²⁰.

Flies carrying corto^07128b/+ do not exhibit blistered wings.

(Mouchel-Vielh et al., 2011)

The average number of crystal cells per embryo is reduced (to 14.5) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average). The number of plasmatocytes is also significantly reduced compared to wild-type embryos.

(Milchanowski et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

corto^07128b has visible | dominant phenotype, suppressible | partially by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

corto^07128b has visible | dominant phenotype, suppressible | partially by Elongin-B[+]/EloB^EP3132

(Rougeot et al., 2013)

corto^07128b has visible | dominant phenotype, suppressible | partially by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

corto^07128b has visible | dominant phenotype, suppressible | partially by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

Enhancer of

Statement

Reference

corto^07128b/corto[+] is an enhancer of visible | adult stage phenotype of Scer\GAL4^sd.PU, rl^UAS.cKa

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of visible | adult stage phenotype of bs^EY23316

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of visible | adult stage phenotype of Scer\GAL4^sd.PU, rho^EP3704

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of visible | adult stage phenotype of Lamtor3^RNAi.UASp, Scer\GAL4^sd.PU

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of homeotic | dominant phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto^07128b, corto[+], CycG^UAS.cSa, Scer\GAL4^NP3121 is an enhancer of homeotic | dominant phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

Suppressor of

Statement

Reference

corto^07128b/corto[+] is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^sd.PU, rl^Sem.MB.UAS

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is a suppressor of abnormal eye color phenotype of Hsap\MECP2^R294X.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Other

Statement

Reference

bs^EY23316, corto^07128b has visible | adult stage phenotype

(Mouchel-Vielh et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

corto^07128b has wing vein | ectopic phenotype, suppressible | partially by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

corto^07128b has wing vein | ectopic phenotype, suppressible | partially by Elongin-B[+]/EloB^EP3132

(Rougeot et al., 2013)

corto^07128b has wing vein | ectopic phenotype, suppressible | partially by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

corto^07128b has wing vein | ectopic phenotype, suppressible | partially by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

Enhancer of

Statement

Reference

corto^07128b/corto[+] is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^sd.PU, rl^UAS.cKa

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of wing vein | ectopic phenotype of bs^EY23316

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of wing | ectopic phenotype of bs^EY23316

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of wing phenotype of Scer\GAL4^sd.PU, rho^EP3704

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is an enhancer of wing vein | ectopic phenotype of Lamtor3^RNAi.UASp, Scer\GAL4^sd.PU

(Mouchel-Vielh et al., 2011)

corto^07128b is an enhancer of abdominal tergite 4 phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto^07128b, corto[+], CycG^UAS.cSa, Scer\GAL4^NP3121 is an enhancer of adult abdominal segment 6 phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto^07128b, corto[+], CycG^UAS.cSa, Scer\GAL4^NP3121 is an enhancer of adult abdominal segment 7 | ectopic phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto^07128b is an enhancer of abdominal tergite 5 phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto^07128b is an enhancer of abdominal tergite 6 phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto^07128b is an enhancer of male genitalia phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto^07128b/corto[+] is an enhancer of adult abdominal segment 6 phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto^07128b/corto[+] is an enhancer of adult abdominal segment 7 | ectopic phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto^07128b/corto[+] is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

NOT Enhancer of

Statement

Reference

corto^07128b/corto[+] is a non-enhancer of abdominal tergite 4 | female limited phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto^07128b/corto[+] is a non-enhancer of abdominal tergite 5 | female limited phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto^07128b/corto[+] is a non-enhancer of abdominal tergite 6 | female limited phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

Suppressor of

Statement

Reference

corto^07128b/corto[+] is a suppressor | partially of wing phenotype of Scer\GAL4^sd.PU, rl^Sem.MB.UAS

(Mouchel-Vielh et al., 2011)

corto^07128b/corto[+] is a suppressor of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

corto^07128b/corto[+] is a suppressor of eye phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Other

Statement

Reference

bs^EY23316, corto^07128b has wing phenotype

(Mouchel-Vielh et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the ectopic wing vein phenotype seen in corto^07128b/+ females (over 90% penetrance) is reduced if they are also heterozygous for one of EloA^G4930 (38.3% penetrance), EloB^EP3132 (26.6%), EloC^SH1520 (14.8%) or EloC^SH1299 (27.5%).

(Rougeot et al., 2013)

corto^07128b/+ enhances the ectopic wing vein phenotype induced by bs^EY23316/+. In addition, some of the trans-heterozygous flies have blistered wings which is not observed in flies that are only heterozygote for bs^EY23316.

corto^07128b/+ enhances the blistered wing phenotype induced by expression of rho^EP3704 under the control of Scer\GAL4^sd.PU.

corto^07128b/+ enhances the ectopic wing vein phenotype induced by expression of either rl^UAS.cKa or CG5110^dsRNA.UASp under the control of Scer\GAL4^sd.PU.

corto^07128b/+ lowers penetrance and expressivity of the blistered wing phenotype induced by expression of rl^Sem.MB.UAS under the control of Scer\GAL4^sd.PU.

(Mouchel-Vielh et al., 2011)

One copy of corto^07128b enhances the expressivity of the A6-A7 transformation seen in Abd-B^Fab7-1/+ males. The A6 segment has completely disappeared in 100% of male flies.

Expression of CycG^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act.NP3121 and one copy of corto^07128b enhance the A7 to A6 homeotic transformation seen in the few Abd-B^Fab7-1/+ male escapers.

corto^07128b enhances the frequency of cuticle defects and rotated genitalia seen in males when CycG^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^da.G32. The frequency of female cuticle defects is also increased. The cuticle defects seen in females expressing CycG^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act.NP3121 are not enhanced in the presence of one copy of corto^07128b.

(Salvaing et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

corto^neo32

(BDGP Project Members, 1994-1999)

Fails to complement

corto⁰⁵²⁵⁹

(BDGP Project Members, 1994-1999)

corto^06934b

(BDGP Project Members, 1994-1999)

corto⁰⁰¹⁴⁴

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11716

P{PZ}TAF1C-like^07128a; P{PZ}corto^07128b ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Separable from: CG10496^07128a. Evidence suggests that the "l(3)07128" line contains 2 P{PZ} insertions; one at 57E (P{PZ}CG10496^07128a) corresponding to the site of the flanking sequence AQ073341, and one at 82E (P{PZ}corto^07128b) which causes a mutation in corto.

(FlyBase, 1996-)

Comments

Complements: l(3)00714⁰⁰⁷¹⁴. Complements: l(3)01107⁰¹¹⁰⁷. Complements: atms⁰¹⁴⁵⁶. Complements: l(3)j4B9^j4B9. Complements: atms^rK509.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

07128b

(Cukier et al., 2008)

P11716

(Milchanowski et al., 2004)

corto⁰⁷¹²⁸

(Rougeot et al., 2013, Salvaing et al., 2008, Salvaing et al., 2008)

corto^07128b

(Mouchel-Vielh et al., 2011, Smulders-Srinivasan et al., 2010)

l(3)07128

(Spradling et al., 1999)

l(3)07128⁰⁷¹²⁸

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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