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General Information
Symbol
Hsap\MECP2Δ166.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0294768
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulates expression of the Hsap\MECP2 e2 isoform with the methyl-CpG-binding domain and N-terminal portion of the protein removed.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\MECP2Δ166.Scer\UAS in MN5 motoneurons (via Scer\GAL4futsch-C380 and Scer\GAL80Cha.3.3P) does not cause any obvious dendritic defects.

Expression via Scer\GAL4GMR.PU disrupts the external structure of the eye, resulting in a 'glassy' effect on the surface. Ommatidia are disorganized and interommatidial bristles are partially lost.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by osa[+]/osaEY09619

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl2

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl3

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl5

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl09645

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by ScmD1/Scm[+]

Suppressed by
Statement
Reference

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by crolc04670/crol[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by crol[+]/crole04017

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by osa[+]/osa308

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by Scme01989/Scm[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by ScmET50/Scm[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by Scm[+]/ScmM36

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by Smre04377/Smr[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by ScmM56/Scm[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by Scm4/Scm[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by Smre04389/Smr[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by Asx[+]/AsxEY07384

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by AsxXF23/Asx[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by corto07128b/corto[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by corto[+]/cortoc03244

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by cortoe02822/corto[+]

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by osa00090/osa[+]

NOT suppressed by
Statement
Reference

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by osa[+]/osaEY09619

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl2

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl3

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl5

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl09645

Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by ScmD1/Scm[+]

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\MECP2Δ166.Scer\UAS
Hsap\MECP2Δ166.UAS
Name Synonyms
Secondary FlyBase IDs
    References (4)