Open Close
General Information
Symbol
Dmel\AsxXF23
Species
D. melanogaster
Name
FlyBase ID
FBal0029011
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous AsxXF23 mutant clones cause various wing defects including crumpled wings.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference

    AsxXF23/Asx[+] is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

    AsxXF23/Asx[+] is an enhancer of visible | recessive | homeotic phenotype of mxcM1

    Suppressor of
    Other
    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    AsxXF23/Asx[+] is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

    AsxXF23/Asx[+] is an enhancer of leg | ectopic phenotype of hhMrt

    AsxXF23/Asx[+] is an enhancer of wing | anterior phenotype of hhMrt

    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference

    AsxXF23/Asx[+] is a non-suppressor of eye phenotype of Scer\GAL4ey.PH, asf1UAS.cMa

    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of AsxXF23.

    2% of AsxXF23/+ ; HcfHR1 males have defects in rotation of the genitalia.

    Df(2R)vg-D, AsxXF23, Pcl15/+ flies have almost normal wings. If the flies also carry jing22F3, the arrangement of wing bristles at the posterior wing margin becomes disorganised and there is an increase in the appearance of cuticle patches containing a high density of small trichomes, indicative of a partial wing-to-haltere transformation.

    Df(2R)vg-D, AsxXF23, Pcl15/+ animals show an average of 2.5 extra sex combs hairs in either the second of third leg.

    The addition of lolalk02512/+ to homozygous AsxXF23 animals shows a partial homeotic transformation of A6 to A5 in the abdomen.

    AsxXF23/+ does not suppress the rough eye phenotype due to Scer\GAL4ey.PH; asf1Scer\UAS.cMa.

    No significant modification of the number of sex combs is seen in AsxXF23/+ corto420/+ double heterozygotes compared to AsxXF23/+ single heterozygotes.

    The addition of heterozygous AsxXF23 has no effect on the Pairing sensitive silencing effect seen in wMcp.scs'.21 and wMcp.y.scs'.1 alleles, or the eye colour phenotype of wMcp.y.scs'.1/ywe.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+) and wMcp.scs'.21/ywe.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) double heterozygous insertions.

    Weak suppressor of eye pigment phenotype of wT81.

    Hemizygous mxcM1 males show weak homeotic phenotypes. Some enhancement of homeotic transformations is seen in mxcM1/Y in trans with one mutant copy of AsxXF23.

    Xenogenetic Interactions
    Statement
    Reference

    The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of AsxXF23.

    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (2)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Ectopic abd-A is present in parasegments 2-6 in the epidermal cells. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior. By 12 hours the expression is more uniform.

    Weak derepression of en expression.

    Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    References (25)