hh2/hhMrt mutant adults exhibit smaller wings with an ectopic crossvein, as compared to controls.
hhMrt/+ flies have wing phenotypes described in three classes of increasing severity: in class I (68% of hhMrt/+ wings) the distal anterior wing region is slightly expanded and the L2 wing vein partially duplicated; in class II (23%) the distal anterior wing region is expanded and rounded, the L2 wing vein is frequently duplicated (proximally) and absent (distally), and the L3 wing vein is thickened (distally); in class III (9%) the anterior compartment is almost completely rounded, all class II phenotypes are present but more severe, and there is frequent loss of sensory bristles in the anterior wing region.
hhMrt heterozygous mutants exhibit duplication of anterior structures in the wing, such as the L3 wing vein.
Over two-thirds of heterozygous wings show anterior overgrowths.
hhMrt flies show wing vein defects (interior loss and extra veins at the margin) and anterior overgrowth.
hhMrt/+ adult wings show ectopic longitudinal vein L3 tissue.
hhMrt/+ animals exhibit a range of wing phenotypes resulting from different degrees of anterior to posterior transformation of the anterior wing blade.
hhMrt/+ embryos have defects in germ cell migration: and about 60% of the stage 13 to 16 embryos have four or more mispositioned germ cells (n=25). These defects are more severe in hhMrt/hhunspecified embryos: >90% of stage 13 to 16 have ten or more mispositioned germ cells (n = 20).
Wing is mis-shapen due to anterior overgrowth, with loss of wing veins in the interior and extra veins near the margins.
Heterozygotes show a wing phenotype which varies between clear overgrowth of the wing to slight disorganisation of the wing margin and the addition of extra vein material.
Heterozygotes show variable wing defects. Class IV wings show expansion of the distal anterior region and partial duplication of vein 2.
Heterozygous adults show overgrowth and wing patterning defects limited to the anterior part of the wing.
Heterozygotes display expansion of the distal, anterior wing region and accompanying defects in anterior wing veins L2 and L3. Imaginal wing discs are overgrown to varying extents in the anterior regions and display partial duplication of distal wing structures. Wing phenotype is temperature sensitive, penetrance and expressivity are higher at 20oC than 25oC and is more extreme when the hhMrt chromosome is inherited from the father. Posterior wing compartment is unaffected. Homozygous pharate adults dissected from the pupal case display duplications of distal leg, haltere and antennae. Heterozygotes display eye malformations; in some cases the eye is enlarged and misshapen with a rough phenotype.
Overgrowth and ectopic venation in the anterior distal portions of the wing.
Deformed wings, extra veins form in the anterior compartment and wing blades display an expansion along the anterodistal edge. Wing discs display an enlargement of the anterior portion of the wing blade.
Heterozygote shows partial transformation of anterior wing to posterior (triple row bristles replaced by double row bristles in patches). A network of extra veins appears in the anterior compartment, beginning at the distal edge in the least affected flies and covering the entire anterior compartment in the more extreme cases. Wing blade expanded anteriorly at the distal edge. Wing blade expansion and extra veins resemble phenotypes seen in en1 homozygotes in the presence of Minute mutations. Bubbles often form in the wing blade. More rarely, a mirror-image outgrowth from the anterior edge is present. Mirror-image duplications sometimes appear in halteres. Legs sometimes appear deformed (similar to phenotype of "enlethal" clones induced in the larva). Dominant phenotypes strongly temperature-sensitive. Penetrance greater than 99% at 18oC (with strong expressivity) but only 30-40% at 29oC (with very weak expressivity). Shows paternal effect. Penetrance greater when mutant allele inherited from father than when inherited from mother. hhMrt/+/+ indistinguishable from hhMrt/+.