Open Close
General Information
Symbol
Dmel\ph-d401
Species
D. melanogaster
Name
FlyBase ID
FBal0013751
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ph401
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Mutation in ph-d.

Small deletion within the ph-d locus.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ph-d401 mutants exhibit an A4 to A5 abdominal segment transformation phenotype.

The rate of mitotic segregation defects seen in ph-d401 embryos is not significantly higher than those seen in wild type.

ph-d401/Df(3R)ry27 mutant flies exhibit the same number of legs with sex combs (2.0) as in wild-type or ph-d401/+ heterozygotes.

ph-d401/Df(3R)ry619 mutant flies exhibit the same number of legs with sex combs (2.0) as in wild-type or ph-d401/Tp(3;3)MRS heterozygotes.

0% of ph-d401/Y; en54/+ double heterozygotes do not have a gap in the fourth wing vein at 25 or 29oC.

Mutation changes the level of w expression in ph-plac+3 flies; eye colour is darker.

Hemizygous males occasionally have sex combs on the second legs and often show a partial transformation of abdominal segment A4 towards A5, at both 25 and 29oC. Hemizygous males occasionally show a partial transformation of abdominal segment A1 to A2 at 25oC. The penetrance of this phenotype increases at 29oC.

Adults viable.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

ph-d401 has sex comb | ectopic phenotype, non-enhanceable by pds5e3

ph-d401 has abdominal segment | adult stage phenotype, non-enhanceable by pds5e3

ph-d401 has sex comb | ectopic phenotype, non-enhanceable by pds5e6

ph-d401 has abdominal segment | adult stage phenotype, non-enhanceable by pds5e6

Suppressed by
Statement
Reference

ph-d401 has sex comb | ectopic phenotype, suppressible by vtd6

ph-d401 has sex comb | ectopic phenotype, suppressible | partially by vtd80Fh-36

NOT suppressed by
Statement
Reference

ph-d401 has sex comb | ectopic phenotype, non-suppressible by SMC1exc46

ph-d401 has abdominal segment | adult stage phenotype, non-suppressible by SMC1exc46

ph-d401 has sex comb | ectopic phenotype, non-suppressible by Nipped-B407

Enhancer of
Statement
Reference

ph-d[+]/ph-d401 is an enhancer of leg | ectopic phenotype of hhMrt

ph-d[+]/ph-d401 is an enhancer of wing | anterior phenotype of hhMrt

Other
Additional Comments
Genetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is exacerbated by combination with a single copy of ph-d401.

ph-p602 ph-d401; Pc5/+ flies show a weak wing to haltere transformation. ph-p604 ph-d401; Pc5/+ flies show a weak wing to haltere transformation. ph-p600 ph-d401; Pc5/+ flies show a weak wing to haltere transformation. ph-p603 ph-d401; Pc5/+ flies show a weak wing to haltere transformation. Df(1)ph-601; Pc5/+ flies show a weak wing to haltere transformation.

Xenogenetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is exacerbated by combination with a single copy of ph-d401.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (18)