FlyBase Allele Report: Dmel\Psc[1]

General Information

Symbol

Dmel\Psc¹

Species

D. melanogaster

Name

FlyBase ID

FBal0013980

Feature type

allele

Associated gene

Dmel\Psc

Associated Insertion(s)

Carried in Construct

Also Known As

Psc^IIN48

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Muller et al., 1999, Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Wu and Howe, 1995, Adler et al., 1991, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Wu and Howe, 1995, Brunk and Adler, 1990)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates leukemia

modeled by abd-A^UAS.Tag:HA

(Ponrathnam et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | dominant

(Brunk et al., 1991)

abnormal mitotic cell cycle | embryonic stage

(O'Dor et al., 2006)

homeotic

(Morimoto et al., 2016)

lethal - all die during embryonic stage | recessive

(Wu and Howe, 1995, Martin and Adler, 1993, Tearle and Nusslein-Volhard, 1987)

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

non-suppressor of variegation | dominant, with In(1)w^m4

(Doheny et al., 2008)

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

(Doheny et al., 2008)

some die during embryonic stage | recessive

(Wu and Howe, 1995, Martin and Adler, 1993, Tearle and Nusslein-Volhard, 1987)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-27

(Boivin et al., 2003)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-31

(Boivin et al., 2003)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M1

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M2

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M3

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M10

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{wA}4-4

(Boivin et al., 2003)

visible | dominant

(Wu and Howe, 1995, Tearle and Nusslein-Volhard, 1987)

visible | dominant | homeotic

(Ruhf et al., 2001)

Phenotype Manifest In

anaphase | embryonic stage

(O'Dor et al., 2006)

embryonic abdomen

(Jurgens, 1985)

embryonic head

(Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)

embryonic thorax

(Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)

mesothoracic leg

(Ruhf et al., 2001, Tearle and Nusslein-Volhard, 1987)

mesothoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

metathoracic leg

(Tearle and Nusslein-Volhard, 1987)

metathoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

pigment cell

(Wu and Howe, 1995, Brunk et al., 1991)

sex comb

(Morimoto et al., 2016)

sex comb | ectopic

(Schaaf et al., 2013)

sex comb | increased number

(Brown and Kassis, 2010)

sex comb tooth | ectopic

(Nishioka et al., 2018)

telophase | embryonic stage

(O'Dor et al., 2006)

Detailed Description

Statement

Reference

Psc¹ dominantly leads to ectopic sex comb teeth on the second leg of males, as compared to controls.

(Nishioka et al., 2018)

Psc¹ heterozygous males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.

(Morimoto et al., 2016)

One copy of Psc¹ is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Psc¹ is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Psc¹ embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. Most of these chromatin bridges are probably resolved because large irregularly-shaped nuclei and polyploid nuclei are only seen at a low penetrance. Psc¹ embryos also show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters and have a late telophase appearance. There is no evidence of metaphase defects in these embryos although a small number show chromatin bridges that persist to the prometaphase stage.

(O'Dor et al., 2006)

Psc¹ males have ectopic sex combs on the second and third leg.

(Ragab, 2006)

Psc¹/+ has no effect on the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5. Psc¹/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-27, P{hsp26-pt-T}39C-31 and P{wA}4-4.

(Boivin et al., 2003)

A significant change in repression of the w^H19.UZA gene compared to offspring from the same cross carrying the balancer chromosome is observed in Psc¹ flies. Transgenic flies with Psc¹ and the w^H19.UZA gene, show de-repression in the eye phenotype when compared to non-mutant control siblings.

(Erhardt et al., 2003)

Transformation of second to first leg.

(Ruhf et al., 2001)

Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosome.

(Cryderman et al., 1999)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is darker.

(Fauvarque et al., 1995)

Slight suppression of z¹ In(1)w^m4 but strongly suppresses z¹ In(1)rst³. Suppressor of z¹ w^zl, z^v77h w^zl and z¹ w^zm but has no effect on z^v77h w^zm.

(Judd, 1995)

Has a dominant adult homeotic effect.

(Wu and Howe, 1995)

No homeotic phenotype and the mutation cannot enhance the homeotic phenotypes of Pc group mutants (FBrf0049524). Heterozygotes with Df(1)ph-2 are lethal.

(Cheng et al., 1994)

In z¹ w^zm strain mutation causes reduction of eye pigmentation. Slightly suppress w phenotype in a e(y) background.

(Georgiev, 1994)

Embryonic lethal or semi-lethal when heterozygous with ph-d². Unhatched larvae carry segmentation defects or polarity defects.

(McKeon et al., 1994)

Lack longitudinal tracts but longitudinal glia differentiate though fail to form an orientated scaffold.

(Jacobs, 1993)

Homozygous embryos have head defects.

(Martin and Adler, 1993)

Hypomorphic with respect to homeotic function.

(Simon et al., 1992)

Does not exhibit dominant flightlessness.

(Cripps and Sparrow, 1989)

Homozygous embryos show partial transformation of head and thorax into abdominal structures. This phenotype is enhanced in combination with other Pc like mutants. Heterozygous males sometimes have sex combs on the second and third legs.

(Tearle and Nusslein-Volhard, 1987)

Embryos have head defects, with a transformation of head, thorax and abdomen segments into more posterior structures. In Psc¹ Asx^unspecified double mutants, all denticle bands are similar to each other, and resemble A8 of wild-type embryos, although the thorax appears less transformed as the Keilin's organs are present. Head involution does not occur. A prominent abdominal denticle appears on the dorsal surface of the head and a few abdominal denticles are found behind the floor of the pharynx. Psc¹ Asx^unspecified Pcl^unspecified triple mutant embryos are characterised by a tandem array of posterior abdominal segments including up to four abdominal denticle bands in the head region. This phenotype is suppressed in embryos also lacking the bithorax complex region.

(Jurgens, 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Psc¹ has visible | dominant phenotype, enhanceable by psq[+]/psq⁰²⁴⁰³

(Huang et al., 2002)

NOT Enhanced by

Statement

Reference

Psc¹ has visible | homeotic phenotype, non-enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Suppressed by

Statement

Reference

Psc¹ has homeotic phenotype, suppressible by Marcal1[+]/Marcal1^del

(Morimoto et al., 2016)

Enhancer of

Statement

Reference

Psc[+]/Psc¹ is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Psc[+]/Psc¹ is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Psc[+]/Psc¹ is an enhancer of visible | recessive | homeotic phenotype of mxc^M1

(Saget et al., 1998)

NOT Enhancer of

Statement

Reference

Psc[+]/Psc¹ is a non-enhancer of abnormal eye color phenotype of w^RNAi.GMR

(Ji et al., 2012)

Suppressor of

Statement

Reference

Psc[+]/Psc¹ is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Psc[+]/Psc¹ is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Psc¹ is a suppressor | partially of abnormal eye color phenotype of w^ph-p.lac+3/w¹¹¹⁸

(Bloyer et al., 2003)

Psc¹ is a suppressor of abnormal eye color phenotype of w^T81

(Netter et al., 1998)

Psc¹ is a suppressor of visible phenotype of ct^pN2s

(Melnikova et al., 1996)

Psc¹ is a suppressor of visible phenotype of ct^n2s

(Melnikova et al., 1996)

NOT Suppressor of

Statement

Reference

Psc[+]/Psc¹ is a non-suppressor of abnormal eye color phenotype of w^RNAi.GMR

(Ji et al., 2012)

Other

Statement

Reference

Marcal1^del, Psc¹ has lethal phenotype

(Morimoto et al., 2016)

Psc¹, Su(z)2[+]/Su(z)2^4-31 has lethal phenotype

(Emmons et al., 2009)

MRG15^j6A3, Psc[+]/Psc¹ has visible | dominant phenotype

(Qi et al., 2006)

Asx^XF23, Psc¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

Psc¹, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc[+]/Psc¹, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc[+]/Psc¹, brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc[+]/Psc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc¹, brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Psc¹ has sex comb tooth | ectopic phenotype, enhanceable by mbf1[+]/mbf1²

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, enhanceable by pcm[+]/pcm^hs.PG

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, enhanceable by E(z)[+]/E(z)⁷³¹

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, enhanceable by pcm^hs.PG/mbf1[+]/mbf1², pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Psc¹ has leg phenotype, enhanceable by psq[+]/psq⁰²⁴⁰³

(Huang et al., 2002)

Psc¹ has sex comb | ectopic phenotype, enhanceable by psq[+]/psq⁰²⁴⁰³

(Huang et al., 2002)

Psc¹ has phenotype, enhanceable by mxc^M1

(Docquier et al., 1996)

NOT Enhanced by

Statement

Reference

Psc¹ has sex comb tooth | ectopic phenotype, non-enhanceable by mbf1[+]/mbf1²/mbf1^+t4574

(Nishioka et al., 2018)

Psc¹ has sex comb | ectopic phenotype, non-enhanceable by pds5^e3

(Schaaf et al., 2013)

Psc¹ has sex comb | ectopic phenotype, non-enhanceable by pds5^e6

(Schaaf et al., 2013)

Psc¹ has sex comb | increased number phenotype, non-enhanceable by Spps¹/Spps¹

(Brown and Kassis, 2010)

Psc¹ has phenotype, non-enhanceable by lolal^k02512/lolal[+]

(Mishra et al., 2003)

Psc¹ has phenotype, non-enhanceable by Alh^unspecified

(Perrin et al., 2003)

Psc¹ has mesothoracic leg phenotype, non-enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Suppressed by

Statement

Reference

Psc¹, mbf1[+]/mbf1² has posterior wing margin | male phenotype, suppressible by pcm^Δ1

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, suppressible by pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, suppressible by pcm⁵/pcm⁵

(Nishioka et al., 2018)

Psc¹ has sex comb phenotype, suppressible by Marcal1[+]/Marcal1^del

(Morimoto et al., 2016)

Psc¹ has sex comb | ectopic phenotype, suppressible by vtd⁶

(Schaaf et al., 2013)

Psc¹ has sex comb | ectopic phenotype, suppressible by vtd^80Fh-36

(Schaaf et al., 2013)

NOT suppressed by

Statement

Reference

Psc¹ has sex comb tooth | ectopic phenotype, non-suppressible by pcm^hs.PG, pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, non-suppressible by mbf1[+]/mbf1², pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, non-suppressible by pcm^hs.PG, pcm⁵/pcm⁵

(Nishioka et al., 2018)

Psc¹ has sex comb tooth | ectopic phenotype, non-suppressible by mbf1[+]/mbf1², pcm⁵/pcm⁵

(Nishioka et al., 2018)

Psc¹ has sex comb | ectopic phenotype, non-suppressible by SMC1^exc46

(Schaaf et al., 2013)

Psc¹ has sex comb | ectopic phenotype, non-suppressible by Nipped-B⁴⁰⁷

(Schaaf et al., 2013)

Psc¹ has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Psc¹ has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Psc¹ has phenotype, non-suppressible by lolal^k02512/lolal[+]

(Mishra et al., 2003)

Psc¹ has phenotype, non-suppressible by Alh^unspecified

(Perrin et al., 2003)

Enhancer of

Statement

Reference

Psc[+]/Psc¹ is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Psc[+]/Psc¹ is an enhancer of adult abdominal segment 5 phenotype of E(z)^Trm

(Bajusz et al., 2001)

Psc[+]/Psc¹ is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Psc[+]/Psc¹ is an enhancer of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Psc¹ is an enhancer of wing phenotype of ci^W

(Randsholt et al., 2000)

Psc[+]/Psc¹ is an enhancer of leg | ectopic phenotype of hh^Mrt

(Randsholt et al., 2000)

Psc[+]/Psc¹ is an enhancer of wing | anterior phenotype of hh^Mrt

(Randsholt et al., 2000)

Psc¹ is an enhancer of phenotype of mxc^M1

(Docquier et al., 1996)

NOT Enhancer of

Statement

Reference

Psc[+]/Psc¹ is a non-enhancer of phenotype of lolal^k02512

(Mishra et al., 2003)

Psc¹ is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

Suppressor of

Statement

Reference

Psc[+]/Psc¹ is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Psc[+]/Psc¹ is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Psc¹ is a suppressor of wing phenotype of sd^Fab-X

(Bantignies et al., 2003)

Psc[+]/Psc¹ is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Psc[+]/Psc¹ is a suppressor of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Psc[+]/Psc¹ is a suppressor of adult prothoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Psc¹ is a suppressor of wing phenotype of ct^pN2s

(Melnikova et al., 1996)

Psc¹ is a suppressor of wing phenotype of ct^n2s

(Melnikova et al., 1996)

Psc¹ is a suppressor of phenotype of z¹

(Wu and Howe, 1995, Martin and Adler, 1993, Brunk et al., 1991)

Psc[+]/Psc¹ is a suppressor of phenotype of z¹

(Brunk and Adler, 1990)

NOT Suppressor of

Statement

Reference

Psc[+]/Psc¹ is a non-suppressor of phenotype of lolal^k02512

(Mishra et al., 2003)

Psc¹ is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Psc[+]/Psc¹ is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

Other

Statement

Reference

Psc¹, mbf1[+]/mbf1² has posterior wing margin | male phenotype

(Nishioka et al., 2018)

MRG15^j6A3, Psc[+]/Psc¹ has mesothoracic leg & sex comb | ectopic phenotype

(Qi et al., 2006)

MRG15^j6A3, Psc[+]/Psc¹ has metathoracic leg & sex comb | ectopic phenotype

(Qi et al., 2006)

Psc[+]/Psc¹, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc[+]/Psc¹, brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc[+]/Psc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc¹, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc¹, brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc¹, inv^W has wing phenotype

(Randsholt et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Psc¹, mbf1² double heterozygotes show adult wing defects along the posterior wing margin in males, which are suppressed by pcm^Δ1 hemizygosity.

The ectopic sex comb teeth phenotype of Psc¹ heterozygous males is partially suppressed by homozygosity for either pcm^Δ1 or pcm⁵ and is exacerbated by the heat-shock-induced expression of pcm^hs.PG, by heterozygosity for E(z)⁷³¹ or (incrementally) by heterozygosity and homozygosity for mbf1²; the phenotype suppression by either pcm^Δ1 or pcm⁵ homozygosity is annulled either by heterozygosity for mbf1² or by the heat-shock-induced expression of pcm^hs.PG; the phenotype enhancement induced by mbf1² heterozygosity is annulled by one copy of mbf1^+t4574. The ectopic sex comb teeth phenotype of Psc¹ heterozygous males is also exacerbated by the triple combinations of heterozygosity for mbf1², homozygosity for either pcm^Δ1 or pcm⁵ and heat-shock-induced expression of pcm^hs.PG.

(Nishioka et al., 2018)

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of Psc¹.

The homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs characteristic for Psc¹/+ males is partially suppressed by Marcal1^del heterozygosity but combination with two copies of Marcal1^del is lethal.

(Morimoto et al., 2016)

Psc¹ +/+ Su(z)2^4-31 animals are not viable.

(Emmons et al., 2009)

rept⁰⁶⁹⁴⁵ Psc¹ double heterozygous males have ectopic sex combs on the second and third legs (40% and 2% of flies respectively).

Psc¹/+ ; rept^ex1/+ double heterozygous males do not have ectopic sex combs on either the second or third legs.

Psc¹/+ ; MRG15^j6A3/+ double heterozygous males have ectopic sex combs on the second and third legs (38% and 11% of flies respectively).

MRG15^ex1 shows no interaction (in terms of ectopic sex comb phenotype) when in double heterozygous combination with Psc¹.

(Qi et al., 2006)

Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Psc¹ mutants.

(Ragab, 2006)

The addition of heterozygous, Psc¹ to lolal^k02512/+ animals shows enhancement or suppression.

(Mishra et al., 2003)

Psc¹ psq⁰²⁴⁰³ heterozygous males show a remarkable increase in the number of ectopic sex comb teeth compared to Psc¹ single heterozygotes.

(Huang et al., 2002)

Psc¹/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

No significant modification of the number of sex combs is seen in Psc¹/+ corto⁴²⁰/+ double heterozygotes compared to Psc¹/+ single heterozygotes.

(Lopez et al., 2001)

inv^W/Psc¹ wings exhibit a wing phenotype (similar to the gain of function ci phenotype).

(Randsholt et al., 2000)

Mutant heterozygotes show a strong suppression of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to darker eyes.

(Cavalli, 1999)

The addition of Psc¹ suppresses the Pairing sensitive silencing effect seen in w^Mcp.scs'.21 and w^Mcp.y.scs'.1 and strongly suppresses the double insertion combinations of w^Mcp.scs'.21/y^we.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) and the eye colour phenotype of w^Mcp.y.scs'.1/y^we.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+).

(Muller et al., 1999)

Weak suppressor of eye pigment phenotype of w^T81.

(Netter et al., 1998)

Hemizygous mxc^M1 males show weak homeotic phenotypes. Strong enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of Psc¹.

(Saget et al., 1998)

Has no effect on the phenotypes of ct^2s, ct^4s and ct⁶, where the wing margin enhancer is completely blocked.

(Melnikova et al., 1996)

Suppression of z¹ eye color, towards wild-type colour. Eye color of heterozygous females which are also z¹/z¹ : dull red. Eye color of heterozygous males which are also z¹, w^is/Y: almost wild type.

(Wu and Howe, 1995)

Dominant suppressor of the z-w interaction.

(Martin and Adler, 1993)

Dominant suppressor of the z¹-w interaction.

(Brunk et al., 1991)

Dominant suppressor of the z¹ interaction with w.

(Brunk and Adler, 1990)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is ameliorated by combination with a single copy of Psc¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Fails to complement

Psc^Arp.1

(Brunk et al., 1991)

Psc^14P4

(Brunk et al., 1991)

Psc^1.d20

(Brunk et al., 1991)

Psc^vgD

(Brunk et al., 1991)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4200

cn¹ Psc¹ bw¹ speck¹/CyO

Kyoto

107627

cn¹ Psc¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

Comments

Alleles of Su(z)2 do not complement Psc¹.

(Jurgens, 1985)

Fails to complement: Su(z)2^D.c16. Fails to complement: Su(z)2¹. Complements: Su(z)2^1.a1. Complements: Su(z)2^1.b7. Complements: Su(z)2^Arp.1. Complements: Su(z)2^Arp.2. Fails to complement: Su(z)2⁴. Complements: Su(z)3¹. Fails to complement: Su(z)3^1.y. Complements: Su(z)2^Arp1. Complements: Su(z)2^Arp.4. Complements: l(2)49Dc¹.

(Brunk et al., 1991)

abd-A is seen in parasegments 2 to 6 at 9 hours, by 12 hours expression has become much weaker. By 9 hours Abd-B is seen throughout the A-P axis.

(Simon et al., 1992)

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

Lethal when heterozygous with Su(z)2¹ or Su(z)2⁵, and shows reduced viability when heterozygous with Su(z)2⁴.

(Wu and Howe, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

IIN48

Psc

(Brunk et al., 1991)

Psc^IIN48

(Rusch and Kaufman, 2000, Mallin et al., 1998, Gindhart and Kaufman, 1995, Weigmann and Lehner, 1995, Simon et al., 1993, Simon et al., 1992, Jurgens, 1985)

Psc^IIN

(Tearle and Nusslein-Volhard, 1987)

l(2)Psc^IIN48

(Cripps and Sparrow, 1989)

psc^IIN48

(Jacobs, 1993)

Name Synonyms

Secondary FlyBase IDs

References (77)

Report Sections

Open Close