Nucleotide substitution: G2325A. Amino acid replacement: R741K.
Mutation lies in the SET domain at the C terminus of E(z).
Amino acid replacement: R?K.
G10634699A
G2325A
R741K | E(z)-PA; R741K | E(z)-PB; R746K | E(z)-PC
R741K
Differs from E(z)TrmTG in having a second silent mutation.
Heterozygotes show a strong trx-like phenotype. Partial transformation of the third thoracic segment (T3) into T2, the fifth abdominal segment (A5) into A4 and A6 into A5 is seen. A7 is rarely modified. Transformation of T1 towards T2 (a reduced number of sex comb teeth and the appearance of ectopic apical bristles on the T1 legs) is also seen. Homozygotes and hemizygotes die as fully developed pharate adults which can survive for 1 or 2 days if dissected out of the pupal case. A5 to A4 and A6 to A5 transformations are more extreme in E(z)Trm/In(3L)Ez2 hemizygotes than in E(z)Trm heterozygotes. Homozygotes also have a very strong trx-like phenotype; not only the haltere but also the central part of the humerus is also transformed into wing tissue (indicating transformation of T3 and T1 towards T2 respectively). A7 is also partially transformed into A6 (indicated by the appearance of a rudimentary seventh tergite) in both homozygotes and E(z)Trm/In(3L)Ez2 hemizygotes. The ventral genitalia of both sexes are frequently replaced by leg tissue in homozygotes and clones of anterior wing tissue appear on the posterior wing blades. E(z)son1 strongly suppresses the trx-like phenotype (transformation of T1 to T2, T3 to T2 and A5 to A4) seen in E(z)Trm heterozygotes; phenotype is nearly wild-type. E(z)son2 strongly suppresses the trx-like phenotype (transformation of T1 to T2, T3 to T2 and A5 to A4) seen in E(z)Trm heterozygotes. Some weak transformation of T3 to T2 (appearance of apical bristles on the third leg) is still seen. E(z)son3 strongly suppresses the trx-like phenotype (transformation of T1 to T2, T3 to T2 and A5 to A4) seen in E(z)Trm heterozygotes; phenotype is nearly wild-type. 50% of E(z)60/E(z)Trm flies show weak transformation of T1 to T2, 75% show weak transformation of T3 to T2, 24% show strong transformation of T3 to T2 and 100% show transformation of A5 to A4. The E(z)Trm phenotype is suppressed by sodium butyrate.
E(z)Trm, z1 has abnormal eye color phenotype
E(z)Trm/In(3L)Ez2, z1 has abnormal eye color phenotype
E(z)[+]/E(z)Trm, z1 has abnormal eye color phenotype
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by AsxP1/Asx[+]
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by AsxP1/Asx[+]
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by Pp1-87B+t5.8
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by Pp1-87B+t5.8
E(z)Trm has adult metathoracic segment phenotype, enhanceable by Pp1-87B+t5.8
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by Pp1-87B+t6.5
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by Pp1-87B+t6.5
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by Pp1-87B+t6.5
E(z)Trm has adult metathoracic segment phenotype, enhanceable by Pp1-87B+t6.5
E(z)Trm has adult prothoracic segment phenotype, enhanceable by Pp1-87B+t6.5
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by Psc[+]/Psc1
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by Psc[+]/Psc1
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by Df(3R)red-P93/+
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by Snr1unspecified/Snr1[+]
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by Snr1unspecified/Snr1[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by Trl[+]/TrlR85
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by Trl[+]/TrlR85
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by Trl[+]/TrlR85
E(z)Trm has adult prothoracic segment phenotype, enhanceable by Trl[+]/TrlR85
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by ash21/ash11
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by ash21/ash11
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by ash21/ash11
E(z)Trm has adult metathoracic segment phenotype, enhanceable by ash21/ash11
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by Df(3R)red-P93/+
E(z)Trm has adult prothoracic segment phenotype, enhanceable by ash21/ash11
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by ash1[+]/ash122
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by ash1[+]/ash122
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by ash1[+]/ash122
E(z)Trm has adult metathoracic segment phenotype, enhanceable by ash1[+]/ash122
E(z)Trm has adult prothoracic segment phenotype, enhanceable by ash1[+]/ash122
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by aurA87Ac-3
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by aurA87Ac-3
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by aurA87Ac-3
E(z)Trm has adult metathoracic segment phenotype, enhanceable by aurA87Ac-3
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by Df(3R)red-P93/+
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by aurA87Ac-4
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by aurA87Ac-4
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by aurA87Ac-4
E(z)Trm has adult metathoracic segment phenotype, enhanceable by aurA87Ac-4
E(z)Trm has adult prothoracic segment phenotype, enhanceable by aurA87Ac-4
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by brm[+]/brm2
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by brm[+]/brm2
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by brm[+]/brm2
E(z)Trm has adult metathoracic segment phenotype, enhanceable by brm[+]/brm2
E(z)Trm has adult prothoracic segment phenotype, enhanceable by brm[+]/brm2
E(z)Trm has adult metathoracic segment phenotype, enhanceable by Df(3R)red-P93/+
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by kto[+]/kto1
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by kto[+]/kto1
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by osa2/osa[+]
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by osa2/osa[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by osa2/osa[+]
E(z)Trm has adult prothoracic segment phenotype, enhanceable by osa2/osa[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by Nsf2urd-2/urd[+]
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by Nsf2urd-2/urd[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by vtd2/vtd[+]
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by vtd2/vtd[+]
E(z)Trm has adult prothoracic segment phenotype, enhanceable by Df(3R)red-P93/+
E(z)Trm has adult mesothoracic segment | ectopic phenotype, enhanceable by Psc[+]/Psce22
E(z)Trm has adult prothoracic segment phenotype, enhanceable by Psc[+]/Psce22
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)1
E(z)Trm has adult abdominal segment 5 phenotype, enhanceable by E(Pc)[+]/E(Pc)1
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, enhanceable by Pp1-87B+t5.8
E(z)Trm/E(z)60 has adult abdominal segment 4 | ectopic phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-103
E(z)Trm/E(z)60 has adult abdominal segment 5 phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-103
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Pc1/Pc[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by ph-p[+]/ph-p410
E(z)Trm has adult prothoracic segment phenotype, suppressible by Df(2L)DS6
E(z)Trm has adult prothoracic segment phenotype, suppressible by Df(2L)TW65
E(z)Trm has adult prothoracic segment phenotype, suppressible by Df(3R)E79
E(z)Trm has adult prothoracic segment phenotype, suppressible by Mi-21/Mi-2[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by Pp1-87B87Bg-3
E(z)Trm has adult prothoracic segment phenotype, suppressible by Pp1-87B87Bg-6
E(z)Trm has adult prothoracic segment phenotype, suppressible by Su(var)2-101
E(z)Trm has adult prothoracic segment phenotype, suppressible by Su(var)2-105
E(z)Trm has adult prothoracic segment phenotype, suppressible by Tp(3;Y)ry506-85C/+
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Pp1-87B87Bg-3
E(z)Trm has adult prothoracic segment phenotype, suppressible by esc10/esc[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by esc2/esc[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by pho[+]/pho1
E(z)Trm has adult prothoracic segment phenotype, suppressible by skd2/skd[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by sls1/sls[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by sxc[+]/sxc4
E(z)Trm has adult prothoracic segment phenotype, suppressible by Nsf2urd-2/urd[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by vtd2/vtd[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by Pc1/Pc[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Psc[+]/Psce22
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Tp(3;Y)ry506-85C/+
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by esc10/esc[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by esc2/esc[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by pho[+]/pho1
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Pcl[+]/PclR5
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Df(2L)TW161
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Df(2L)TW65
E(z)Trm/E(z)60 has adult mesothoracic segment | ectopic phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-103
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Df(3R)E79
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Mi-21/Mi-2[+]
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Pc1/Pc[+]
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Pp1-87B87Bg-3
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Psc[+]/Psce22
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by Tp(3;Y)ry506-85C/+
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by esc10/esc[+]
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by esc2/esc[+]
E(z)Trm has adult abdominal segment 5 phenotype, suppressible by pho[+]/pho1
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Pcl[+]/PclR5
E(z)Trm/E(z)60 has adult metathoracic segment phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-103
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by AsxP1/Asx[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Df(2L)DS6
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Df(2L)TW161
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Df(2L)TW65
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Df(2R)Su(z)25/+
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Df(3R)E79
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by E(Pc)[+]/E(Pc)1
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Mi-21/Mi-2[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Pc1/Pc[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Pp1-87B87Bg-3
E(z)Trm/E(z)60 has adult prothoracic segment phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-103
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Pp1-87B87Bg-6
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Psc[+]/Psc1
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Psc[+]/Psce22
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Sce[+]/Sce1
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by ScmD1/Scm[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Snr1unspecified/Snr1[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Su(var)2-101
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Su(var)2-105
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Tp(3;Y)ry506-85C/+
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Trl[+]/TrlR85
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Pcl[+]/PclR5
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by esc10/esc[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by esc2/esc[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by kto[+]/kto1
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by osa2/osa[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by ph-p[+]/ph-p410
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by pho[+]/pho1
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by skd2/skd[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by sls1/sls[+]
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by sxc[+]/sxc4
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by Nsf2urd-2/urd[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Df(2L)TW161
E(z)Trm has adult mesothoracic segment | ectopic phenotype, suppressible by vtd2/vtd[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by Pcl[+]/PclR5
E(z)Trm has adult metathoracic segment phenotype, suppressible by AsxP1/Asx[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by Df(2L)DS6
E(z)Trm has adult metathoracic segment phenotype, suppressible by Df(2L)TW161
E(z)Trm has adult metathoracic segment phenotype, suppressible by Df(2L)TW65
E(z)Trm has adult metathoracic segment phenotype, suppressible by Df(2R)Su(z)25/+
E(z)Trm has adult metathoracic segment phenotype, suppressible by Df(3R)E79
E(z)Trm has adult metathoracic segment phenotype, suppressible by E(Pc)[+]/E(Pc)1
E(z)Trm has adult metathoracic segment phenotype, suppressible by Mi-21/Mi-2[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Df(2L)TW65
E(z)Trm has adult metathoracic segment phenotype, suppressible by Pc1/Pc[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by Pp1-87B87Bg-3
E(z)Trm has adult metathoracic segment phenotype, suppressible by Pp1-87B87Bg-6
E(z)Trm has adult metathoracic segment phenotype, suppressible by Psc[+]/Psc1
E(z)Trm has adult metathoracic segment phenotype, suppressible by Psc[+]/Psce22
E(z)Trm has adult metathoracic segment phenotype, suppressible by Sce[+]/Sce1
E(z)Trm has adult metathoracic segment phenotype, suppressible by ScmD1/Scm[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by Snr1unspecified/Snr1[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by Su(var)2-101
E(z)Trm has adult metathoracic segment phenotype, suppressible by Su(var)2-105
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Df(3R)E79
E(z)Trm has adult metathoracic segment phenotype, suppressible by Tp(3;Y)ry506-85C/+
E(z)Trm has adult metathoracic segment phenotype, suppressible by Trl[+]/TrlR85
E(z)Trm has adult metathoracic segment phenotype, suppressible by esc10/esc[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by esc2/esc[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by kto[+]/kto1
E(z)Trm has adult metathoracic segment phenotype, suppressible by osa2/osa[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by ph-p[+]/ph-p410
E(z)Trm has adult metathoracic segment phenotype, suppressible by pho[+]/pho1
E(z)Trm has adult metathoracic segment phenotype, suppressible by skd2/skd[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by sls1/sls[+]
E(z)Trm has adult abdominal segment 4 | ectopic phenotype, suppressible by Mi-21/Mi-2[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc4
E(z)Trm has adult metathoracic segment phenotype, suppressible by Nsf2urd-2/urd[+]
E(z)Trm has adult metathoracic segment phenotype, suppressible by vtd2/vtd[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by Df(2R)Su(z)25/+
E(z)Trm has adult prothoracic segment phenotype, suppressible by E(Pc)[+]/E(Pc)1
E(z)Trm has adult prothoracic segment phenotype, suppressible by Pcl[+]/PclR5
E(z)Trm has adult prothoracic segment phenotype, suppressible by Psc[+]/Psc1
E(z)Trm has adult prothoracic segment phenotype, suppressible by Sce[+]/Sce1
E(z)Trm has adult prothoracic segment phenotype, suppressible by ScmD1/Scm[+]
E(z)Trm has adult prothoracic segment phenotype, suppressible by Trl[+]/TrlR85
E(z)Trm, z1 has pigment cell phenotype
E(z)Trm/In(3L)Ez2, z1 has pigment cell phenotype
E(z)[+]/E(z)Trm, z1 has pigment cell phenotype
E(z)Trm stocks are poorly viable and fertile and over time they spontaneously acquire modifiers that suppress the dominant phenotype and increase the viability.