FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\E(z)+t8.8
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General Information
Symbol
Dmel\E(z)+t8.8
Species
D. melanogaster
Name
FlyBase ID
FBal0033656
Feature type
allele
Associated gene
Dmel\E(z)
Associated Insertion(s)
Carried in Construct
P{E(z)B}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Mounkes et al., 1992)
wild_type
(Mounkes et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Mounkes et al., 1992)
wild_type
(Mounkes et al., 1992)
Mutagen
in vitro construct
(Jones and Gelbart, 1993, Mounkes et al., 1992)
Progenitor genotype
Carried in construct
P{E(z)B}
Cytology
Description

8.8 genomic fragment extending from coordinates -3.6kb to +5.2kb, including E(z) transcription unit.

(Mounkes et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
E(z)
Encoded product / tool
E(z)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:10,632,726..10,642,364 [-]
Linked to:
EcoRI-EcoRI restriction fragment
Comment:

Approximate endpoints of rescue fragment described as extending from coordinates -3.6kb to +5.2kb on the genomic map. The endpoints fall very close to EcoRI restriction fragments on the map in Figure 1 of FBrf0055584.

(Jones and Gelbart, 1993, Mounkes et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Suppresses the lethality associated with E(z)son alleles and reduces their suppressor of nos effect.

      (Pelegri and Lehmann, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      E(z)+t8.8 is an enhancer of sex comb | ectopic phenotype of Pc16

      (Campbell et al., 1995)

      E(z)+t8.8 is an enhancer of sex comb | ectopic phenotype of esc2/esc5

      (Campbell et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Enhances the extra sex comb phenotype of Pc16. Enhances the homeotic transformation of esc2/esc5.

      (Campbell et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      E(z)+t8.8 rescues E(z)Trm

      (Bajusz et al., 2001)

      E(z)+t8.8 rescues Df(3L)lxd6/E(z)61

      (Jones and Gelbart, 1993)

      E(z)+t8.8 rescues E(z)1

      (Jones and Gelbart, 1993)

      E(z)+t8.8 rescues E(z)61

      (Jones and Gelbart, 1993)

      E(z)+t8.8 rescues E(z)62

      (Jones and Gelbart, 1993)

      E(z)+t8.8 rescues E(z)63

      (Jones and Gelbart, 1993)

      E(z)+t8.8 rescues E(z)64

      (Jones and Gelbart, 1993)

      E(z)+t8.8 rescues E(z)unspecified

      (Mounkes et al., 1992)
      Comments

      Strongly alleviates the trx-like phenotypes of E(z)Trm/+ flies.

      (Bajusz et al., 2001)

      E(z)+t8.8 fully rescues hemizygous lethality of E(z)1, E(z)61, E(z)62, E(z)63 and E(z)64 and the maternal effect embryonic lethality of E(z)61/Df(3L)lxd6 reared at 29oC. E(z)+t8.8 behaves like a copy of E(z)+ with respect to modification of z eye colour.

      (Jones and Gelbart, 1993)

      Fully rescues the hemizygous lethality of E(z) alleles.

      (Mounkes et al., 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Jones and Gelbart.

      (Campbell et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      E(z)+t8.8
      Name Synonyms
      Secondary FlyBase IDs
        References (5)