FlyBase Allele Report: Dmel\esc[5]

General Information

Symbol

Dmel\esc⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0003825

Feature type

allele

Associated gene

Dmel\esc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cheng et al., 1994, McKeon and Brock, 1991, Glicksman and Brower, 1990)

Mutagen

Progenitor genotype

Cytology

Description

Mutation results in premature termination of the protein at the beginning of WD2.

(Sathe and Harte, 1995)

Nucleotide substitution: C?T.

(Sathe and Harte, 1995)

Amino acid replacement: Q171term.

(Sathe and Harte, 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:11,828,227..11,828,227 [-]

Nucleotide change:

C11828227T

Reported nucleotide change:

C?T

Amino acid change:

Q171term | esc-PA

Reported amino acid change:

Q171term

(Sathe and Harte, 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Song et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | maternal effect (with esc^N174S)

(Cyrus et al., 2025)

lethal - all die before end of larval stage | maternal effect (with esc^R282S)

(Cyrus et al., 2025)

lethal - all die before end of P-stage | maternal effect (with esc^R216G)

(Cyrus et al., 2025)

lethal - all die before end of P-stage | maternal effect (with esc^T2A-H238Y)

(Cyrus et al., 2025)

lethal - all die during embryonic stage | maternal effect (with esc²)

(Choi et al., 2000)

non-enhancer of variegation, with Dp(1;Y)Bar^SCV

(Sinclair et al., 1998)

non-enhancer of variegation, with In(1)w^m4

(Sinclair et al., 1998)

non-suppressor of variegation, with Dp(1;Y)Bar^SCV

(Sinclair et al., 1998)

non-suppressor of variegation, with In(1)w^m4

(Sinclair et al., 1998)

partially lethal (with esc^N174S)

(Cyrus et al., 2025)

partially lethal - majority die (with esc^H238Y.KI)

(Cyrus et al., 2025)

partially lethal - majority die (with esc^R282S)

(Cyrus et al., 2025)

partially lethal - majority live (with esc^R216G)

(Cyrus et al., 2025)

partially lethal - majority live (with esc^T2A-H238Y)

(Cyrus et al., 2025)

partially lethal - majority live (with esc^T32P)

(Cyrus et al., 2025)

some die during embryonic stage | maternal effect (with esc²)

(Choi et al., 2000)

viable (with esc^I254V)

(Cyrus et al., 2025)

viable (with esc^T2A-Ref)

(Cyrus et al., 2025)

visible | adult stage (with esc^T2A-H238Y)

(Cyrus et al., 2025)

visible | adult stage | male limited (with esc^H238Y.KI)

(Cyrus et al., 2025)

visible | adult stage | male limited (with esc^N174S)

(Cyrus et al., 2025)

visible | adult stage | male limited (with esc^R216G)

(Cyrus et al., 2025)

visible | adult stage | male limited (with esc^R282S)

(Cyrus et al., 2025)

Phenotype Manifest In

embryonic abdominal segment 8 | ectopic | maternal effect (with esc²)

(Choi et al., 2000)

embryonic midgut constriction

(McKeon and Brock, 1991)

embryonic midgut constriction | maternal effect (with esc²)

(Choi et al., 2000)

notum | maternal effect (with esc^T2A-H238Y)

(Cyrus et al., 2025)

sex comb | increased number (with esc^H238Y.KI)

(Cyrus et al., 2025)

sex comb | increased number (with esc^N174S)

(Cyrus et al., 2025)

sex comb | increased number (with esc^R216G)

(Cyrus et al., 2025)

sex comb | increased number (with esc^R282S)

(Cyrus et al., 2025)

sex comb | increased number (with esc^T2A-H238Y)

(Cyrus et al., 2025)

ventral denticle belt | maternal effect (with esc²)

(Choi et al., 2000)

wing | maternal effect (with esc^T2A-H238Y)

(Cyrus et al., 2025)

Detailed Description

Statement

Reference

All denticle belts of embryos derived from a esc²/esc⁵ stock are rectangular in shape, indicating a transformation to the eighth abdominal segment. Midgut constrictions are partial or not formed in these embryos.

(Choi et al., 2000)

Does not affect the position effect variegation (PEV) at the w locus caused by In(1)w^m4 or PEV at the B locus caused by Dp(1;Y)B^SCV.

(Sinclair et al., 1998)

Lack midgut constrictions.

(McKeon and Brock, 1991)

Less than 10% of esc⁵/Dp(2;2)GYL animals (having two copies of paternally derived zygotic esc function, but no maternal esc function) survive past the third larval instar stage.

(Glicksman and Brower, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

esc⁵/esc[+] is a non-enhancer of decreased size | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

esc⁵/esc[+] is a non-enhancer of visible | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

esc⁵/esc[+] is a suppressor | partially of decreased size | somatic clone | adult stage phenotype of Scer\GAL4^rn-GAL4, egr^UAS.cMa

(Harris et al., 2020)

esc⁵/esc[+] is a suppressor | partially of visible | somatic clone | adult stage phenotype of Scer\GAL4^rn-GAL4, egr^UAS.cMa

(Harris et al., 2020)

esc⁵/esc[+] is a suppressor of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

NOT Suppressor of

Statement

Reference

esc⁵/esc[+] is a non-suppressor of decreased size | somatic clone | adult stage phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

esc⁵/esc[+] is a non-suppressor of visible | somatic clone | adult stage phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

esc²/esc⁵ has sex comb | ectopic phenotype, enhanceable by E(z)^+t8.8

(Campbell et al., 1995)

NOT Enhancer of

Statement

Reference

esc⁵/esc[+] is a non-enhancer of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

esc⁵/esc[+] is a suppressor | partially of wing | somatic clone phenotype of Scer\GAL4^rn-GAL4, egr^UAS.cMa

(Harris et al., 2020)

esc⁵/esc[+] is a suppressor of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

NOT Suppressor of

Statement

Reference

esc⁵/esc[+] is a non-suppressor of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

3142

106875

Notes on Origin

Discoverer

Struhl.

Comments

The expression of Antp, Scr and Ubx protein in esc^- mutants has been studied.

(Glicksman and Brower, 1988)

Ubx, Scr and Antp, protein expression has been studied in esc²/esc⁵ embryos lacking both maternal and zygotic esc function, and in esc⁵/Dp(2;2)GYL embryos lacking maternal but having two copies of paternally derived zygotic esc function.

(Glicksman and Brower, 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

esc⁵

(Cyrus et al., 2025, Lucas et al., 2021, Harris et al., 2020, Bahrampour et al., 2019, Curt et al., 2019, Leatham-Jensen et al., 2019, Song et al., 2018, Yaghmaeian Salmani et al., 2018, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5, Choi et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (23)

Report Sections