FlyBase Allele Report: Dmel\trx[B11]

General Information

Symbol

Dmel\trx^B11

Species

D. melanogaster

Name

FlyBase ID

FBal0032908

Feature type

allele

Associated gene

Dmel\trx

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Jones and Gelbart, 1993, Breen and Harte, 1991)

loss of function allele

(Smith et al., 2004, Breen, 1999, Breen et al., 1995, Breen and Harte, 1993)

Mutagen

gamma ray

(Mortin et al., 1992, Breen and Harte, 1991)

Progenitor genotype

Cytology

Description

trx^B11 is associated with an 833bp deletion. It could encode truncated proteins consisting of 8.6% and 17.7% of the N terminus of TRXI and TRXII respectively.

(Breen, 1999)

Deletion that truncates the 3726 residue protein after residue 658.

(Breen et al., 1995)

Frameshift deletion in the amino terminal portion that terminates the open reading frame after 17.5% of its length.

(Kuzin et al., 1994)

Small frame-shifting deletion in the common exon 3.

(Breen and Harte, 1993)

800bp deletion within the coding region.

(Breen and Harte, 1991)

Deletion of DNA, leading to a frameshift that terminates the open reading frame after the first 658 residues.

(Mazo et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:14,273,513..14,274,479 [-]

Comment:

Reported as a deletion of 833 nucleotides (2817-3649 in GB:M31617) leading to a frameshift and early translation termination. In the reference sequence, the span between the deletion endpoints is 967 bases.

(Mazo et al., 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | embryonic stage (with trx^E2)

(Farmer et al., 2025)

abnormal mitotic cell cycle | larval stage (with trx^E3)

(Muyrers-Chen et al., 2004)

abnormal mitotic cell cycle | larval stage (with trx^JY16)

(Muyrers-Chen et al., 2004)

decreased occurrence of cell division | larval stage

(Muyrers-Chen et al., 2004)

lethal

(Mazo et al., 1990)

lethal | recessive

(Breen and Harte, 1993, Mortin et al., 1992)

lethal - all die during embryonic stage

(Farmer et al., 2025, Kuzin et al., 1994)

lethal - all die during embryonic stage | recessive

(Breen, 1999)

some die during embryonic stage

(Kuzin et al., 1994)

some die during embryonic stage | recessive

(Breen, 1999)

visible | dominant

(Mollaaghababa et al., 2001)

visible | dominant | homeotic

(Breen, 1999, Milne et al., 1999)

visible | dominant | homeotic | male

(Ogasawara et al., 2007)

visible | homeotic (with trx¹)

(Rudenko et al., 2003)

Phenotype Manifest In

abdominal segment 5

(Milne et al., 1999)

abdominal tergite 5

(Milne et al., 1999)

adult abdominal segment 5

(Mollaaghababa et al., 2001)

adult abdominal segment 5 | ectopic | male

(Ogasawara et al., 2007)

adult abdominal segment 6

(Mollaaghababa et al., 2001)

adult abdominal segment 6 | male

(Ogasawara et al., 2007)

adult abdominal segment 7

(Mollaaghababa et al., 2001)

embryonic/first instar larval cuticle

(Muyrers-Chen et al., 2004)

embryonic/larval heart | embryonic stage (with trx^E2)

(Farmer et al., 2025)

embryonic/larval midgut | embryonic stage

(Breen et al., 1995)

embryonic midgut constriction 1

(Breen and Harte, 1993)

embryonic midgut constriction 2

(Breen and Harte, 1993)

haltere | ectopic (with trx¹)

(Rudenko et al., 2003)

larval brain | larval stage (with trx^E3)

(Muyrers-Chen et al., 2004)

larval brain | larval stage (with trx^JY16)

(Muyrers-Chen et al., 2004)

larval cardial cell | embryonic stage (with trx^E2)

(Farmer et al., 2025)

ventral denticle belt

(Muyrers-Chen et al., 2004)

wing (with trx¹)

(Rudenko et al., 2003)

Detailed Description

Statement

Reference

Double heterozygous stuxnet^d77;trx^B11 females display tergite boundary defects that are not observed in stuxnet^d77 heterozygote females. stuxnet^d77/Y;trx^B11/+ males are lethal.

Double heterozygous stuxnet²;trx^B11 females display tergite boundary defects that are not observed in stuxnet² single heterozygote females.

(Du et al., 2016)

27.9% of heterozygous males show anterior transformation of segment A6 to A5.

(Ogasawara et al., 2007)

Homozygous embryos show defects in cuticle patterning: 33% lack all the denticle belts and 3% show transformation of one segment to another (although denticle belts are present).

The brains of trx^JY16/trx^B11 and trx^E3/trx^B11 larvae show a severe reduction in BrdU incorporation compared to wild type. Brain squashes are characterised by global chromatin decondensation, resembling 'prophase-like' chromatin.

(Muyrers-Chen et al., 2004)

trx¹/trx^B11 flies show transformations of wing to haltere; 49% show strong transformation, 34% show weak transformation and 16% show no transformation.

(Rudenko et al., 2003)

Heterozygotes show mild anterior transformations of the fifth, sixth, and seventh abdominal segments.

(Mollaaghababa et al., 2001)

4.5% of heterozygous adults show at least one transformation phenotype.

(Breen, 1999)

Abdominal segment of heterozygous males is transformed anteriorly. Haltere is normal.

(Milne et al., 1999)

Heterozygotes do not have an apical bristle on the T3 legs.

(Sedkov et al., 1999)

Homozygous embryos exhibit altered gut morphology by stage 15. Loss of trx in en^F4 flies causes female sterility.

(Breen et al., 1995)

Individuals die before or upon hatching.

(Kuzin et al., 1994)

Abnormal midgut morphology: only the second midgut constriction appears in its normal position. The first and third constrictions appear posterior to their wild-type positions.

(Breen and Harte, 1993)

Reduction in size of all ventral setal belts, third thoracic ventral setal belt has the appearance of the second thoracic ventral setal belt and the posterior abdominal ventral setal belts show transformation to an identity like that of a normal second thoracic ventral setal belt.

(Breen and Harte, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

trx^B11 has visible | dominant | homeotic | male phenotype, enhanceable by scf¹/scf[+]

(Ogasawara et al., 2007)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Asx³/Asx[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Asx^XF23/Asx[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by E(Pc)[+]/E(Pc)¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by E(z)[+]/E(z)⁵

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Psc[+]/Psc¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Sce[+]/Sce^D1

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Scm^D1/Scm[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Scm^M56/Scm[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)2¹/Su(z)2[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)4[+]/Su(z)4¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)6[+]/Su(z)6¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)7[+]/Su(z)7¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Trl[+]/Trl^R85

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by mxc[+]/mxc^G48

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by sxc[+]/sxc¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Kdm5^k06801/lid[+]

(Gildea et al., 2000)

ash1[+]/ash1¹⁷, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

ash1[+]/ash1¹⁷, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawc^EF520

(Zorin et al., 1999)

ash1[+]/ash1¹⁷, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+

(Zorin et al., 1999)

ash1¹⁷, trx^B11 has visible | homeotic phenotype, enhanceable by lawc^EF520

(Zorin et al., 1999)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawc^EF520

(Zorin et al., 1999)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+

(Zorin et al., 1999)

ash1[+]/ash1¹⁷, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^ul

(Gerasimova and Corces, 1998)

ash1[+]/ash1¹⁷, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^T6

(Gerasimova and Corces, 1998)

ash1[+]/ash1¹⁷, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)^T16/mod(mdg4)[+]

(Gerasimova and Corces, 1998)

mod(mdg4)^T6, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by ash1[+]/ash1¹⁷

(Gerasimova and Corces, 1998)

NOT Enhanced by

Statement

Reference

trx^B11 has visible | dominant | homeotic phenotype, non-enhanceable by lawc^p1

(Zorin et al., 1999)

trx^B11 has visible | dominant | homeotic phenotype, non-enhanceable by lawc^EF520

(Zorin et al., 1999)

trx^B11 has visible | dominant | homeotic phenotype, non-enhanceable by lawc⁺¹⁰

(Zorin et al., 1999)

trx^B11 has visible | dominant | homeotic phenotype, non-enhanceable by Df(1)RA2

(Zorin et al., 1999)

trx^B11 has visible | homeotic phenotype, non-enhanceable by lawc^p1

(Gerasimova and Corces, 1998)

Suppressed by

Statement

Reference

ash1¹⁷, trx^B11/trx[+] has visible | dominant phenotype, suppressible | partially by His2Av⁰⁵¹⁴⁶

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11/trx[+] has visible | dominant phenotype, suppressible | partially by His2Av⁸¹⁰

(Swaminathan et al., 2005)

trx^B11/trx¹ has visible | homeotic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B^87Bg-6

(Rudenko et al., 2003)

trx^B11/trx¹ has visible | homeotic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B¹

(Rudenko et al., 2003)

ash1[+]/ash1¹⁷, trx^B11 has visible | dominant | homeotic phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by Pc³/Pc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by Pcl⁷/Pcl[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by Psc[+]/Psc^Arp1

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by Scm^Suz302/Scm[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc¹⁰/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc²¹/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc⁵/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc⁹/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxc¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxc^M1

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by ph-d[+]/ph-d⁵⁰³

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by pho^b/pho[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by sxc[+]/sxc⁴

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has visible | dominant | homeotic phenotype, suppressible by sxc[+]/sxc⁵

(Gildea et al., 2000)

NOT suppressed by

Statement

Reference

trx^B11/trx¹ has visible | homeotic phenotype, non-suppressible by Pp1-87B^UAS.Tag:HA/Scer\GAL4^arm.PS

(Rudenko et al., 2003)

Enhancer of

Statement

Reference

trx^B11, trx[+], ash1[+], ash1¹⁷ is an enhancer of visible | homeotic phenotype of lawc^p1

(Zorin et al., 1999)

trx^B11 is an enhancer of visible | dominant | homeotic phenotype of mod(mdg4)^ul

(Gerasimova and Corces, 1998)

trx^B11/trx[+] is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, mod(mdg4)^T16/mod(mdg4)[+]

(Gerasimova and Corces, 1998)

trx^B11 is an enhancer of visible | homeotic phenotype of ash1¹⁷, mod(mdg4)^ul

(Gerasimova and Corces, 1998)

trx^B11 is an enhancer of visible | homeotic phenotype of ash1¹⁷, mod(mdg4)^T6

(Gerasimova and Corces, 1998)

Other

Statement

Reference

stx², trx^B11/trx[+] has visible | adult stage phenotype

(Du et al., 2016)

stx^d77, trx^B11/trx[+] has lethal phenotype

(Du et al., 2016)

stx^d77, trx^B11/trx[+] has visible | adult stage phenotype

(Du et al., 2016)

ash1¹⁷, trx^B11/trx[+] has visible | dominant phenotype

(Swaminathan et al., 2005)

ash1[+]/ash1¹⁷, trx^B11 has visible phenotype

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11 has visible | homeotic phenotype

(Ruhf et al., 2001, Zorin et al., 1999, Gerasimova and Corces, 1998)

ash1¹⁷, trx^B11/trx[+] has visible | homeotic phenotype

(Ruhf et al., 2001)

ash1[+]/ash1¹⁷, trx^B11 has visible | homeotic phenotype

(Ruhf et al., 2001)

Asx¹³, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)6¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)7¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Trl^R85, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx³, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Kdm5^k06801, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

sxc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx³/Asx[+], trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx^XF23/Asx[+], trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

E(Pc)¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

+/Df(2L)Mdh, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2L)cl-h3/+, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2R)Pu-D17/+, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2R)or-BR6/+, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(3L)Ar14-8/+, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(3L)vin6/+, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc[+]/Psc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Sce[+]/Sce^D1, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)4[+]/Su(z)4¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)6[+]/Su(z)6¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)7[+]/Su(z)7¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Trl[+]/Trl^R85, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Kdm5^k06801/lid[+], trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

sxc[+]/sxc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

E(Pc)[+]/E(Pc)¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Sce^D1, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx^XF23, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)4¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

lawc^p1/lawc^EF520, trx^B11 has lethal phenotype

(Zorin et al., 1999)

Df(1)RA2/lawc^p1, trx^B11 has lethal phenotype

(Zorin et al., 1999)

mod(mdg4)^T6, trx^B11 has visible | dominant | homeotic phenotype

(Gerasimova and Corces, 1998)

mod(mdg4)^T16, trx^B11 has visible | dominant | homeotic phenotype

(Gerasimova and Corces, 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

trx^B11 has adult abdominal segment 6 | male phenotype, enhanceable by scf¹/scf[+]

(Ogasawara et al., 2007)

trx^B11 has adult abdominal segment 5 | ectopic | male phenotype, enhanceable by scf¹/scf[+]

(Ogasawara et al., 2007)

trx^B11 has adult abdominal segment 5 phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^I-R35-R7

(Mollaaghababa et al., 2001)

trx^B11 has adult abdominal segment 5 phenotype, enhanceable by Hsc70-4^II-R35-R2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Asx³/Asx[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Asx^XF23/Asx[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by E(Pc)[+]/E(Pc)¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by E(z)[+]/E(z)⁵

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Psc[+]/Psc¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Sce[+]/Sce^D1

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Scm^D1/Scm[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Scm^M56/Scm[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)2¹/Su(z)2[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)4[+]/Su(z)4¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)6[+]/Su(z)6¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)7[+]/Su(z)7¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Trl[+]/Trl^R85

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by mxc[+]/mxc^G48

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by sxc[+]/sxc¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, enhanceable by Kdm5^k06801/lid[+]

(Gildea et al., 2000)

ash1[+]/ash1¹⁷, trx^B11 has haltere phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

ash1[+]/ash1¹⁷, trx^B11 has metathoracic leg phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

ash1¹⁷, trx^B11 has metathoracic leg phenotype, enhanceable by lawc^EF520

(Zorin et al., 1999)

ash1¹⁷, trx^B11/trx[+] has haltere phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

ash1¹⁷, trx^B11/trx[+] has metathoracic leg phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

ash1¹⁷, trx^B11/trx[+] has haltere phenotype, enhanceable by lawc[+]/lawc^EF520

(Zorin et al., 1999)

brm², trx^B11/trx[+] has haltere phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

brm², trx^B11/trx[+] has metathoracic leg phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

mod(mdg4)^T6, trx^B11 has haltere phenotype, enhanceable by ash1[+]/ash1¹⁷

(Gerasimova and Corces, 1998)

NOT Enhanced by

Statement

Reference

trx^B11 has adult abdominal segment 5 phenotype, non-enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+]

(Mollaaghababa et al., 2001)

trx^B11 has adult abdominal segment 5 phenotype, non-enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

trx^B11 has adult abdominal segment 5 phenotype, non-enhanceable by Hsc70-4^II-R35-R7/Hsc70-4[+]

(Mollaaghababa et al., 2001)

trx^B11 has phenotype, non-enhanceable by Asx³

(Milne et al., 1999)

trx^B11 has phenotype, non-enhanceable by Asx⁸

(Milne et al., 1999)

trx^B11 has phenotype, non-enhanceable by trr¹

(Sedkov et al., 1999)

Suppressed by

Statement

Reference

ash1¹⁷, trx^B11/trx[+] has mesothoracic tibial apical bristle | ectopic phenotype, suppressible | partially by His2Av⁸¹⁰

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11/trx[+] has metathoracic leg phenotype, suppressible | partially by His2Av⁰⁵¹⁴⁶

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11/trx[+] has metathoracic leg phenotype, suppressible | partially by His2Av⁸¹⁰

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11/trx[+] has mesothoracic tibial apical bristle | ectopic phenotype, suppressible | partially by His2Av⁰⁵¹⁴⁶

(Swaminathan et al., 2005)

trx^B11 has embryonic/first instar larval cuticle phenotype, suppressible by Hsap\KMT2A^{UAS.C.Tag:FLAG}/Scer\GAL4^{VP16.mat.αTub67C}

(Muyrers-Chen et al., 2004)

trx^B11/trx¹ has wing phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B^87Bg-6

(Rudenko et al., 2003)

trx^B11/trx¹ has haltere | ectopic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B^87Bg-6

(Rudenko et al., 2003)

trx^B11/trx¹ has wing phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B¹

(Rudenko et al., 2003)

trx^B11/trx¹ has haltere | ectopic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B¹

(Rudenko et al., 2003)

trx^B11 has adult abdominal segment 5 phenotype, suppressible by Hsc70-4^+t14/Hsc70-4[+]

(Mollaaghababa et al., 2001)

trx^B11 has adult abdominal segment 5 phenotype, suppressible by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Mollaaghababa et al., 2001)

trx^B11 has adult abdominal segment 5 phenotype, suppressible by Hsc70-4^PB2/Hsc70-4[+]

(Mollaaghababa et al., 2001)

ash1[+]/ash1¹⁷, trx^B11 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

ash1¹⁷, trx^B11/trx[+] has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by Pc³/Pc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by Pcl⁷/Pcl[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by Psc[+]/Psc^Arp1

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by Scm^Suz302/Scm[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by esc¹⁰/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by esc²¹/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by esc⁵/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by esc⁹/esc[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc¹

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc^M1

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by ph-d[+]/ph-d⁵⁰³

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by pho^b/pho[+]

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc⁴

(Gildea et al., 2000)

ash1¹⁷, trx^B11/trx[+] has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc⁵

(Gildea et al., 2000)

NOT suppressed by

Statement

Reference

trx^B11 has embryonic/first instar larval cuticle phenotype, non-suppressible by Hsap\KMT2A::Hsap\AFF1^UAS.cMa/Scer\GAL4^{VP16.mat.αTub67C}

(Muyrers-Chen et al., 2004)

trx^B11/trx¹ has wing phenotype, non-suppressible by Pp1-87B^UAS.Tag:HA/Scer\GAL4^arm.PS

(Rudenko et al., 2003)

trx^B11/trx¹ has haltere | ectopic phenotype, non-suppressible by Pp1-87B^UAS.Tag:HA/Scer\GAL4^arm.PS

(Rudenko et al., 2003)

trx^B11 has phenotype, non-suppressible by Asx³

(Milne et al., 1999)

trx^B11 has phenotype, non-suppressible by Asx⁸

(Milne et al., 1999)

trx^B11 has phenotype, non-suppressible by trr¹

(Sedkov et al., 1999)

Enhancer of

Statement

Reference

trx^B11 is an enhancer of haltere phenotype of Asx^P1

(Milne et al., 1999)

trx^B11, trx[+], ash1[+], ash1¹⁷ is an enhancer of arista phenotype of lawc^p1

(Zorin et al., 1999)

trx^B11 is an enhancer of haltere phenotype of mod(mdg4)^ul

(Gerasimova and Corces, 1998)

trx^B11, trx[+], ash1[+], ash1¹⁷ is an enhancer of phenotype of mod(mdg4)^ul

(Gerasimova and Corces, 1998)

Other

Statement

Reference

stx^d77, trx^B11/trx[+] has abdominal tergite phenotype

(Du et al., 2016)

stx², trx^B11/trx[+] has abdominal tergite phenotype

(Du et al., 2016)

ash1¹⁷, trx^B11/trx[+] has metathoracic leg phenotype

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11/trx[+] has mesothoracic tibial apical bristle | ectopic phenotype

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11 has mesothoracic tibial apical bristle | ectopic phenotype

(Swaminathan et al., 2005)

ash1¹⁷, trx^B11 has metathoracic leg phenotype

(Swaminathan et al., 2005, Zorin et al., 1999)

Hsc70-4[+]/Hsc70-4^I-R35-R7, trx^B11 has sex comb phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^I-R35-R7, trx^B11 has sex comb phenotype

(Mollaaghababa et al., 2001)

ash1¹⁷, trx^B11/trx[+] has abdominal segment 6 phenotype

(Ruhf et al., 2001)

ash1¹⁷, trx^B11 has abdominal segment 6 phenotype

(Ruhf et al., 2001)

ash1[+]/ash1¹⁷, trx^B11 has abdominal segment 6 phenotype

(Ruhf et al., 2001)

Asx¹³, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)4¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)6¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)7¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Trl^R85, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Kdm5^k06801, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx³, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

sxc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx³/Asx[+], trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^XF23/Asx[+], trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

+/Df(2L)Mdh, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2L)cl-h3/+, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2R)Pu-D17/+, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2R)or-BR6/+, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

E(Pc)¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(3L)Ar14-8/+, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(3L)vin6/+, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc[+]/Psc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Sce[+]/Sce^D1, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)4[+]/Su(z)4¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)6[+]/Su(z)6¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)7[+]/Su(z)7¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Trl[+]/Trl^R85, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Kdm5^k06801/lid[+], trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

sxc[+]/sxc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

E(Pc)[+]/E(Pc)¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Sce^D1, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^XF23, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^P1, trx^B11 has adult metathoracic segment phenotype

(Milne et al., 1999)

ash1¹⁷, trx^B11 has haltere phenotype

(Zorin et al., 1999)

mod(mdg4)^T6, trx^B11 has haltere phenotype

(Gerasimova and Corces, 1998)

mod(mdg4)^T16, trx^B11 has haltere phenotype

(Gerasimova and Corces, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

scf¹/+ significantly enhances the penetrance of the A6 to A5 transformation phenotype that is seen in trx^B11/+ males.

(Ogasawara et al., 2007)

ash1¹⁷ trx^B11 double heterozygotes show transformations of third leg into second leg; an apical bristle appears on the third leg in 66% of cases. The frequency of the appearance of an apical bristle on the third leg decreases to 37% in ash1¹⁷ trx^B11 His2Av⁰⁵¹⁴⁶ triple heterozygotes and to 29% in ash1¹⁷ trx^B11 His2Av⁸¹⁰ triple heterozygotes.

(Swaminathan et al., 2005)

Pp1-87B^87Bg-6 dominantly suppresses the transformation of wing to haltere seen in trx¹/trx^B11 flies; 28% show strong transformation, 29% show weak transformation and 43% show no transformation.

Pp1-87B¹ dominantly suppresses the transformation of wing to haltere seen in trx¹/trx^B11 flies; 27% show strong transformation, 24% show weak transformation and 49% show no transformation.

Expression of Pp1-87B^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^arm.PS has no effect on the transformation of wing to haltere seen in trx¹/trx^B11 flies.

(Rudenko et al., 2003)

trx^B11 Hsc70-4^I-R35-R7 double heterozygotes show a reduction in the number of sex comb teeth.

(Mollaaghababa et al., 2001)

The abdominal segment A6 to A5 transformation of ash1¹⁷/+, trx^B11/+ is dominantly suppressed by dom¹⁴.

(Ruhf et al., 2001)

Double heterozygotes with Df(2L)Mdh, Df(2R)or-BR6, Df(3L)Ar14-8, Df(2L)cl-h3, Df(2R)Pu-D17, Df(3L)vin6, lid^k06801, E(Pc)¹, Psc¹, Sce^D1, Trl^R85, Su(z)7¹, Su(z)6¹, sxc¹, Su(z)4¹, Asx^XF23, Asx³ or Asx¹³ show T3 to T2 transformations. 52.1% of trx^B11 ash1¹⁷ double heterozygotes show T3 to T2 transformations. The penetrance of this phenotype is enhanced by one copy of lid^k06801, E(Pc)¹, Su(z)2¹, Psc¹, Asx^XF23, Asx³, mxc^G48, sxc¹, Sce^D1, E(z)⁵, Trl^R85, Su(z)4¹, Su(z)7¹, Su(z)6¹, Scm^D1 or Scm^M56 and suppressed by one copy of Pc³, ph-d⁵⁰³, Pcl⁷, pho^b, mxc^M1, mxc¹, esc⁵, esc⁹, esc¹⁰, esc²¹, sxc⁴, sxc⁵, Psc^Arp1 or Scm^Suz302.

(Gildea et al., 2000)

In combination with Asx^P1, the haltere is much enlarged over that seen for Asx^P1 alone, T3 is partially transformed towards T2. These phenotypes have a penetrance of close to 100%.

(Milne et al., 1999)

trr¹ neither enhances nor suppresses trx^B11 adult homeotic phenotypes.

(Sedkov et al., 1999)

The frequency of homeotic transformations in heterozygotes is not enhanced by lawc^p1, lawc^EF520, lawc⁺¹⁰ or Df(1)RA2. The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in trx^B11 ash1¹⁷ double heterozygotes is dominantly enhanced by lawc^p1. The enhancement is stronger in a lawc^p1 maternal background. The arista to leg transformation characteristic of lawc^p1 is also enhanced in these flies. The frequency of homeotic transformations in trx^B11 ash1¹⁷ double heterozygotes is dominantly enhanced by lawc^EF520 or Df(1)RA2. lawc^p1/lawc^EF520 females are viable. However, in combination with trx^B11, lawc^p1/lawc^EF520 results in lethality. lawc^p1/Df(1)RA2 females are viable. However, in combination with trx^B11, lawc^p1/Df(1)RA2 results in lethality.

(Zorin et al., 1999)

trx^B11 shows a transformation of haltere to wing in double heterozygous combination with either mod(mdg4)^T6, mod(mdg4)^ul or mod(mdg4)^T16. 14.1% of trx^B11 ash1¹⁷ double heterozygous adults show a homeotic phenotype. This is increased to 77.7% if the flies are also heterozygous for mod(mdg4)^T16, 50.4% if the flies are also heterozygous for mod(mdg4)^ul and 32.6% if the flies are also heterozygous for mod(mdg4)^T6. Dominantly enhances the effect of mod(mdg4)^ul on the y² phenotype. The combination ash1¹⁷ trx^B11 dominantly enhances the effect of mod(mdg4)^ul on the y² phenotype.

(Gerasimova and Corces, 1998)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\MLL^{Scer\UAS.C.T:Zzzz\FLAG} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} partially rescues the cuticle pattern defects seen in trx^B11 homozygous embryos: 9% of embryos have a wild-type cuticle pattern.

Expression of Hsap\MLL::Hsap\AFF1^Scer\UAS.cMa under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} fails to rescue the cuticle pattern defects seen in trx^B11 homozygous embryos.

(Muyrers-Chen et al., 2004)

Complementation and Rescue Data

Partially complements

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

(Breen, 1999)

Rescued by

trx^B11 is rescued by trx^+t34

(Breen and Harte, 1991)

Comments

Mutant phenotype can be rescued by a cosPneo element carrying the entire 25kb trx transcription unit.

(Breen and Harte, 1991)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

See also Mazo et al., PNAS 87: 2112--2116, and Breen and Harte, Mech Dev 35: 113--127.

(Breen and Harte, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

trx^B11

(Farmer et al., 2025, Du et al., 2016, Hallson et al., 2012, Fujioka et al., 2008, Vázquez et al., 2008, Ogasawara et al., 2007, Petruk et al., 2006, Petruk et al., 2006, Muyrers-Chen et al., 2004, Rudenko et al., 2003)

trx^b11

(Swaminathan et al., 2005, Muyrers-Chen et al., 2004, Gildea et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (33)

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