FlyBase Allele Report: Dmel\Hsc70-4[195]

General Information

Symbol

Dmel\Hsc70-4¹⁹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0105150

Feature type

allele

Associated gene

Dmel\Hsc70-4

Associated Insertion(s)

Carried in Construct

Also Known As

hsc4¹⁹⁵, Hsc70-4^E195

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Hing et al., 1999)

loss of function allele

(Wang and Brock, 2003)

Mutagen

ethyl methanesulfonate

(Hing et al., 1999)

Progenitor genotype

Cytology

Description

Amino acid replacement: A148V. Nucleotide substitution: C443T.

(Hing et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,244,802..15,244,802 [+]

Nucleotide change:

C15244802T

Reported nucleotide change:

C443T

Amino acid change:

Reported amino acid change:

A148V

(Hing et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Hsc70-4^54.1)

(Mollaaghababa et al., 2001)

lethal | recessive

(Hing et al., 1999)

visible | dominant | cold sensitive

(Hing et al., 1999)

Phenotype Manifest In

eye

(Hing et al., 1999)

macrochaeta | ectopic

(Hing et al., 1999)

sense organ | ectopic

(Hing et al., 1999)

wing margin

(Hing et al., 1999)

wing vein L3 & sensillum campaniformium | ectopic

(Hing et al., 1999)

Detailed Description

Statement

Reference

Hsc70-4¹⁹⁵/+ heterozygotes exhibit a wild-type number of sex combs, with 2 legs exhibiting sex combs.

(Wang and Brock, 2003)

Heterozygotes are phenotypically wild type.

(Arbeitman and Hogness, 2000)

The dominant phenotype of Hsc70-4¹⁹⁵ is enhanced at 18^oC compared to 25^oC.

(Hing et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of visible | dominant | homeotic phenotype of Pc³

(Mollaaghababa et al., 2001)

Suppressor of

Statement

Reference

Hsc70-4¹⁹⁵/Hsc70-4[+] is a suppressor of visible | dominant | homeotic phenotype of Pc³

(Mollaaghababa et al., 2001)

Other

Statement

Reference

Hsc70-4¹⁹⁵, ph-p⁴¹⁰ has viable phenotype

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+], ph-p⁴¹⁰ has viable phenotype

(Mollaaghababa et al., 2001)

EcR^C284Y, Hsc70-4¹⁹⁵/Hsc70-4[+] has visible | dominant phenotype

(Arbeitman and Hogness, 2000)

EcR^D491N/EcR[+], Hsc70-4¹⁹⁵ has visible | dominant phenotype

(Arbeitman and Hogness, 2000)

EcR^C284Y/EcR[+], Hsc70-4¹⁹⁵ has visible | dominant phenotype

(Arbeitman and Hogness, 2000)

EcR^C300Y/EcR[+], Hsc70-4¹⁹⁵ has visible | dominant phenotype

(Arbeitman and Hogness, 2000)

EcR^C300Y, Hsc70-4¹⁹⁵/Hsc70-4[+] has visible | dominant phenotype

(Arbeitman and Hogness, 2000)

EcR^D491N, Hsc70-4¹⁹⁵/Hsc70-4[+] has visible | dominant phenotype

(Arbeitman and Hogness, 2000)

Hsc70-4¹⁹⁵, dx²⁴ has lethal phenotype

(Hing et al., 1999)

Hsc70-4¹⁹⁵, Ser^Bd-3/Ser[+] has lethal phenotype

(Hing et al., 1999)

Hsc70-4¹⁹⁵, Ser^Bd-3 has lethal phenotype

(Hing et al., 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsc70-4¹⁹⁵ has phenotype, suppressible by H²/H[+]

(Hing et al., 1999)

Enhancer of

Statement

Reference

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of sex comb phenotype of Pc⁴

(Wang and Brock, 2003)

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of sex comb phenotype of ph-d²

(Wang and Brock, 2003)

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of sex comb phenotype of ph-p⁴⁰⁹

(Wang and Brock, 2003)

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of sex comb phenotype of ph-p²

(Wang and Brock, 2003)

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of abdominal tergite 4 | male phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of adult abdominal segment 4 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of adult abdominal segment 5 | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+] is an enhancer of phenotype of N^nd-1-dse

(Hing et al., 1999)

Hsc70-4¹⁹⁵ is an enhancer of wing phenotype of dx²⁴

(Hing et al., 1999)

NOT Enhancer of

Statement

Reference

Hsc70-4¹⁹⁵/Hsc70-4[+] is a non-enhancer of abdominal tergite 6 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+] is a non-enhancer of adult abdominal segment 6 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+] is a non-enhancer of adult abdominal segment 7 | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

Suppressor of

Statement

Reference

Hsc70-4¹⁹⁵/Hsc70-4[+] is a suppressor of sex comb | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+] is a suppressor of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵/Hsc70-4[+] is a suppressor of adult abdominal segment 5 phenotype of trx^B11

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵ is a suppressor of eye phenotype of N^spl-1

(Hing et al., 1999)

Hsc70-4¹⁹⁵ is a suppressor of macrochaeta phenotype of N^spl-1

(Hing et al., 1999)

Other

Statement

Reference

EcR^C284Y, Hsc70-4¹⁹⁵/Hsc70-4[+] has wing phenotype

(Arbeitman and Hogness, 2000)

EcR^D491N/EcR[+], Hsc70-4¹⁹⁵ has leg phenotype

(Arbeitman and Hogness, 2000)

EcR^C284Y/EcR[+], Hsc70-4¹⁹⁵ has wing phenotype

(Arbeitman and Hogness, 2000)

EcR^C284Y/EcR[+], Hsc70-4¹⁹⁵ has leg phenotype

(Arbeitman and Hogness, 2000)

EcR^C300Y/EcR[+], Hsc70-4¹⁹⁵ has wing phenotype

(Arbeitman and Hogness, 2000)

EcR^C300Y/EcR[+], Hsc70-4¹⁹⁵ has leg phenotype

(Arbeitman and Hogness, 2000)

EcR^C284Y, Hsc70-4¹⁹⁵/Hsc70-4[+] has leg phenotype

(Arbeitman and Hogness, 2000)

EcR^C300Y, Hsc70-4¹⁹⁵/Hsc70-4[+] has wing phenotype

(Arbeitman and Hogness, 2000)

EcR^C300Y, Hsc70-4¹⁹⁵/Hsc70-4[+] has leg phenotype

(Arbeitman and Hogness, 2000)

EcR^D491N, Hsc70-4¹⁹⁵/Hsc70-4[+] has wing phenotype

(Arbeitman and Hogness, 2000)

EcR^D491N, Hsc70-4¹⁹⁵/Hsc70-4[+] has leg phenotype

(Arbeitman and Hogness, 2000)

EcR^D491N/EcR[+], Hsc70-4¹⁹⁵ has wing phenotype

(Arbeitman and Hogness, 2000)

Df(3R)kar-D1, Hsc70-4¹⁹⁵ has eye phenotype

(Fernandez-Funez et al., 2000)

Hsc70-4¹⁹⁵, dx²⁴ has eye phenotype

(Hing et al., 1999)

Hsc70-4¹⁹⁵, dx²⁴ has leg phenotype

(Hing et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Pc⁴/Hsc70-4¹⁹⁵ mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.4 legs with sex combs, compared to 2.0 in wild-type.

ph-p⁴⁰⁹/Hsc70-4¹⁹⁵ mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 4.8 legs with sex combs, compared to 2.7 in ph-p⁴⁰⁹/+ heterozygotes.

ph-p²/Hsc70-4¹⁹⁵ mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 4.0 legs with sex combs, compared to 2.6 in ph-p²/+ heterozygotes.

(Wang and Brock, 2003)

In transheterozygous combination with EcR alleles, wings are frequently blistered and legs are often malformed.

(Arbeitman and Hogness, 2000)

Hsc70-4¹⁹⁵ in combination with Df(3R)kar-D1 produces an eye phenotype.

(Fernandez-Funez et al., 2000)

The synergistic effect of Hsc70-4¹⁹⁵ on N pathway mutants is suppressed by removing a copy of H.

(Hing et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Hsc70-4^HS1-25

(Chang et al., 2002)

Rescued by

Hsc70-4¹⁹⁵ is rescued by Hsc70-4^+t14

(Arbeitman and Hogness, 2000)

Hsc70-4¹⁹⁵ is rescued by Hsc70-4^+t14

(Hing et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

E(nd)195

(Hing et al., 1999)

E(nd)¹⁹⁵

(Mollaaghababa et al., 2001)

Hsc70-4¹⁹⁵

Hsc70-4^E195

(Chang et al., 2002)

Hsc70-4^e195

(Hennig et al., 2006)

Hsc70.4¹⁹⁵

(Wang and Brock, 2003)

hsc4¹⁹⁵

(Yang et al., 2006, Mollaaghababa et al., 2001, Arbeitman and Hogness, 2000, Hing et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (8)

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