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General Information
Symbol
Dmel\Hsc70-4195
Species
D. melanogaster
Name
FlyBase ID
FBal0105150
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hsc4195, Hsc70-4E195
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C15244802T

Reported nucleotide change:

C443T

Amino acid change:

A148V | Hsc70-4-PA; A148V | Hsc70-4-PB; A148V | Hsc70-4-PC; A148V | Hsc70-4-PD; A148V | Hsc70-4-PE; A148V | Hsc70-4-PF; A148V | Hsc70-4-PG

Reported amino acid change:

A148V

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: A148V. Nucleotide substitution: C443T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hsc70-4195/+ heterozygotes exhibit a wild-type number of sex combs, with 2 legs exhibiting sex combs.

Heterozygotes are phenotypically wild type.

The dominant phenotype of Hsc70-4195 is enhanced at 18oC compared to 25oC.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Hsc70-4195/Hsc70-4[+] is an enhancer of visible | dominant | homeotic phenotype of Pc3

Suppressor of
Statement
Reference

Hsc70-4195/Hsc70-4[+] is a suppressor of visible | dominant | homeotic phenotype of Pc3

Other
Phenotype Manifest In
Suppressed by
Statement
Reference

Hsc70-4195 has phenotype, suppressible by H2/H[+]

Enhancer of
Statement
Reference

Hsc70-4195/Hsc70-4[+] is an enhancer of sex comb phenotype of Pc4

Hsc70-4195/Hsc70-4[+] is an enhancer of sex comb phenotype of ph-d2

Hsc70-4195/Hsc70-4[+] is an enhancer of sex comb phenotype of ph-p409

Hsc70-4195/Hsc70-4[+] is an enhancer of sex comb phenotype of ph-p2

Hsc70-4195/Hsc70-4[+] is an enhancer of abdominal tergite 4 | male phenotype of Pc3

Hsc70-4195/Hsc70-4[+] is an enhancer of adult abdominal segment 4 phenotype of Pc3

Hsc70-4195/Hsc70-4[+] is an enhancer of adult abdominal segment 5 | ectopic phenotype of Pc3

Hsc70-4195/Hsc70-4[+] is an enhancer of phenotype of Nnd-1-dse

Hsc70-4195 is an enhancer of wing phenotype of dx24

NOT Enhancer of
Statement
Reference

Hsc70-4195/Hsc70-4[+] is a non-enhancer of abdominal tergite 6 phenotype of Pc3

Hsc70-4195/Hsc70-4[+] is a non-enhancer of adult abdominal segment 6 phenotype of Pc3

Hsc70-4195/Hsc70-4[+] is a non-enhancer of adult abdominal segment 7 | ectopic phenotype of Pc3

Suppressor of
Statement
Reference

Hsc70-4195/Hsc70-4[+] is a suppressor of sex comb | ectopic phenotype of ph-p410

Hsc70-4195/Hsc70-4[+] is a suppressor of adult abdominal segment 5 phenotype of trxB11

Hsc70-4195/Hsc70-4[+] is a suppressor of sex comb | ectopic phenotype of Pc3

Hsc70-4195 is a suppressor of eye phenotype of Nspl-1

Hsc70-4195 is a suppressor of macrochaeta phenotype of Nspl-1

Other
Additional Comments
Genetic Interactions
Statement
Reference

Pc4/Hsc70-4195 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.4 legs with sex combs, compared to 2.0 in wild-type.

ph-p409/Hsc70-4195 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 4.8 legs with sex combs, compared to 2.7 in ph-p409/+ heterozygotes.

ph-p2/Hsc70-4195 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 4.0 legs with sex combs, compared to 2.6 in ph-p2/+ heterozygotes.

In transheterozygous combination with EcR alleles, wings are frequently blistered and legs are often malformed.

Hsc70-4195 in combination with Df(3R)kar-D1 produces an eye phenotype.

The synergistic effect of Hsc70-4195 on N pathway mutants is suppressed by removing a copy of H.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)