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General Information
Symbol
Dmel\dx24
Species
D. melanogaster
Name
FlyBase ID
FBal0045558
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Comment:

    Frameshift after the first 59 amino acids of the open reading frame.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    8bp deletion 175bp downstream of the putative start codon, resulting in the first 59 amino acid residues of dx being fused with a 79 amino acid peptide originating from the out-of-frame sequence presumably generated by the frameshift.

    Frameshift after the first 59 amino acids of the open reading frame.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous and dx24/dx152 flies show wing vein thickening, with the severity of the phenotype being stronger in the dx24/dx152 flies.

    Hemizygous males show distal wing blade notching.

    Small deltas of extra vein material visible where the veins meet the margin.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    dx24 has lethal phenotype, enhanceable by M285M285

    Suppressed by
    Statement
    Reference

    dx24 has visible | dominant phenotype, suppressible | partially by H2/H[+]

    NOT Enhancer of
    Statement
    Reference

    dx24 is a non-enhancer of visible phenotype of HP8

    Suppressor of
    Statement
    Reference

    dx24 is a suppressor | partially of visible | dominant phenotype of H2

    NOT Suppressor of
    Statement
    Reference

    dx24 is a non-suppressor of visible phenotype of HP8

    Other
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    dx24 has wing phenotype, enhanceable by Hsc70-4195

    Suppressed by
    Statement
    Reference

    dx24 has wing vein phenotype, suppressible | partially by H2/H[+]

    dx24 has wing phenotype, suppressible | partially by H2/H[+]

    NOT suppressed by
    Statement
    Reference

    dx24 has wing phenotype, non-suppressible | partially by H2/H[+]

    NOT Enhancer of
    Statement
    Reference

    dx24 is a non-enhancer of macrochaeta phenotype of HP8

    dx24 is a non-enhancer of tormogen cell | ectopic phenotype of HP8

    dx24 is a non-enhancer of trichogen cell phenotype of HP8

    Suppressor of
    Statement
    Reference

    dx24 is a suppressor | partially of wing vein phenotype of H2

    NOT Suppressor of
    Statement
    Reference

    dx24 is a non-suppressor of macrochaeta phenotype of HP8

    dx24 is a non-suppressor of tormogen cell | ectopic phenotype of HP8

    dx24 is a non-suppressor of trichogen cell phenotype of HP8

    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Effects on wing development by dx24/Y and H2/+ are mutually levelled. dx24/Y wing phenotypes, both regarding vein broadening and spread out wings, as well as haploinsufficient vein shortening in H2 mutants are largely restored in dx24/Y, H2/+ flies. Yet the fragile wing texture typical of dx mutants remains.

    Escaper of the lethality in combination with Hsc70-4195 show tiny wings, small eyes, malformed legs and die shortly after eclosure.

    70% of dx24 flies carrying NΔECN.hs show complete rescue.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Partially rescued by
    Comments

    30% individuals carrying dxhs.PB show complete rescue.

    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (10)