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Hing, H.K., Bangalore, L., Sun, X., Artavanis-Tsakonas, S. (1999). Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling.  Europ. J. Cell Biol. 78(10): 690--697.
FlyBase ID
FBrf0123050
Publication Type
Research paper
Abstract

In our effort to dissect the Notch signaling mechanism we have conducted a screen for mutations that reduce Notch signaling activity. We recovered nine complementation groups as modifiers of the hypomorphic Notch allele notchoid. Apart from the known Notch signaling modulators Notch, Delta and mastermind we isolated alleles in vestigial, wingless, scalloped and clipped, genes known to affect wing morphogenesis. In addition, we identified mutations in Bag, the gene encoding clathrin heavy chain and a dominant mutation of the cytosolic 70 kDa heatshock cognate protein encoded by the hsc4 gene, as Notch signaling modifier. We focused our attention on the latter mutation because it displays dramatic genetic interactions with mutations of the Notch receptor as well as several additional Notch signaling pathway elements. We discuss how hsc4, a gene thought to be involved in subcellular trafficking, may affect the number of functional Notch receptors on the cell surface.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Europ. J. Cell Biol.
    Title
    European Journal of Cell Biology
    Publication Year
    1979-
    ISBN/ISSN
    0171-9335
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