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General Information
Symbol
Dmel\Hsc70-4+t14
Species
D. melanogaster
Name
FlyBase ID
FBal0105151
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
P[hsc4]
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

A 14 kb genomic DNA fragment spanning from around position -2,000 to +12,000 rescues the recessive lethality of Hsc70-4[3550] mutant and the loss of synaptic transmission in homozygous Hsc70-4[Delta19] mutants. Position of mutation on reference sequence inferred by FlyBase curator.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Included within a 14kb fragment that encompasses the Hsc70-4 open reading frame together with 5' regulator sequences and 4kb downstream from the stop codon.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of visible | dominant | homeotic phenotype of Pc3

Other
Statement
Reference
Phenotype Manifest In
NOT Enhancer of
Statement
Reference

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of sex comb | ectopic phenotype of ph-p410

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of abdominal tergite 4 | male phenotype of Pc3

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of abdominal tergite 6 phenotype of Pc3

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 4 phenotype of Pc3

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 5 | ectopic phenotype of Pc3

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 6 phenotype of Pc3

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of adult abdominal segment 7 | ectopic phenotype of Pc3

Hsc70-4+t14/Hsc70-4[+] is a non-enhancer of sex comb | ectopic phenotype of Pc3

Suppressor of
Statement
Reference

Hsc70-4+t14 is a suppressor of eye phenotype of Hsc70-4e19/Hsc70-4[+], Torey.Tag:FLAG

Hsc70-4+t14 is a suppressor of eye phenotype of Hsc70-4e3/Hsc70-4[+], Torey.Tag:FLAG

Hsc70-4+t14/Hsc70-4[+] is a suppressor of adult abdominal segment 5 phenotype of trxB11

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The addition of Hsc70-4+t14 rescues the loss of synaptic transmission in Hsc70-4Δ19 mutants.

Suppresses the dominant enhancement of EcR alleles by Hsc70-4195.

Restores the rough eye and slit bristle phenotype to Nspl-1, Hsc70-4195 double mutants. Restores viability to dx24, Hsc70-4195 double mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsc70-4+t14
Name Synonyms
Secondary FlyBase IDs
    References (8)