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General Information
Symbol
Dmel\Hsc70-4e3
Species
D. melanogaster
Name
FlyBase ID
FBal0217429
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C15244478T

Amino acid change:

S40F | Hsc70-4-PA; S40F | Hsc70-4-PB; S40F | Hsc70-4-PC; S40F | Hsc70-4-PD; S40F | Hsc70-4-PE; S40F | Hsc70-4-PF; S40F | Hsc70-4-PG

Reported amino acid change:

S40F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A single amino acid change within the ATPase domain of Hsc70-4.

Amino acid replacement: S40F.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous Hsc70-4e3 mutants significantly alleviate the rapamycin-induced growth delay found in wild-type.

Flow cytometric analysis of mosaic wing imaginal discs reveals an increased cell size and increased G2 population in Hsc70-4e3 mutant cells, relative to wild-type. This effects are acutely dosage-sensitive, as Hsc70-4e3/+ heterozygous cells are also larger than wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Hsc70-4e3/Hsc70-4[+], Torey.Tag:FLAG has eye phenotype, suppressible by Hsc70-4+t14

Enhancer of
Statement
Reference

Hsc70-4e3/Hsc70-4[+] is an enhancer of eye phenotype of Torey.Tag:FLAG

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Heterozygous Hsc70-4e3 mutants cause a further reduction in eye size of Torey.hs.T:Zzzz\FLAG mutants.

Imaginal disc cells double mutant for Hsc70-4e3 and Tsc129 exhibit a synergistic increase in cell size as compared with their single mutant counterparts. There is an exacerbation of Tsc129-induced tissue overgrowth in the presence of the Hsc70-4e3 mutation, in some cases resulting in a marked outgrowth of tissue in the anterior portion of the retina.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)